Yan Xu, PhD

Director of Bioinformatics Core, Neonatology & Pulmonary Biology; Perinatal Institute

Professor, UC Department of Pediatrics

UC Department of Biomedical Informatics

Phone 513-636-8921

Fax 513-636-7868

Email yan.xu@cchmc.org

Bioinformatics; systems biology application in pulmonary research; lung cell type specific signaling; asthma associated pathology

Yan Xu, PhD, is an associate professor for the Divisions of Pulmonary Biology and Biomedical Informatics at Cincinnati Children's within the UC Department of Pediatrics. Her main research interests are bioinformatics applications and systems biology.  She is currently focusing on the identification of gene signatures, regulatory networks and biological pathways controlling 1) surfactant homeostasis, 2) lung maturation and 3) lung cell type specific signaling. Her research goal is to integrate the data and information from new computational methods and experimental approaches in a synergistic way to gain better understanding of molecular mechanisms underlying lung development and pathogenesis.

BS: Pharmacology, Shanghai Medical University, China, 1986.

MS: Pathology, Shanghai Medical University, China, 1989.

PhD: Molecular and Cellular Pharmacology, University of South Alabama, Mobile, Alabama, 1997.

View PubMed Publications

Du Y, Guo M, Whitsett JA, Xu Y. 'LungGENS': a web-based tool for mapping single-cell gene expression in the developing lung. Thorax. 2015 Jun 30.

Bridges JP, Schehr A, Wang Y, Huo L, Besnard V, Ikegami M, Whitsett JA, Xu Y. Epithelial SCAP/INSIG/SREBP Signaling Regulates Multiple Biological Processes During Perinatal Lung Maturation. PLoS One. 2014 May 7;9(5):e91376.

Xu Y, Wang Y, Besnard V, Ikegami M, Wert SE, Heffner C, Murray SA, Donahue LR, Whitsett JA. Transcriptional programs controlling perinatal lung maturation. PLoS One. 2012;7(8):e37046.

Xu Y, Whitsett JA. Functional Genomics - Transcriptional Networks Controlling Lung Maturation and Surfactant Homeostasis.Hutton J (Ed). Pediatric Biomedical Informatics: Computer Applications in Pediatric Research (Translational Bioinformatics). 2012. Publisher: Springer.

Xu Y, Zhang M, Wang Y, Kadambi P, Dave V, Lu LJ, Whitsett JA. A systems approach to mapping transcriptional networks controlling surfactant homeostasis. BMC Genomics. 2010;11(1):451.

Xu Y, Saegusa C, Schehr A, Grant S, Whitsett JA, Ikegami M. C/EBPa is required for pulmonary cytoprotection during hyperoxia. American journal of physiology. 2009;297(2):L286-298.

Xu Y, Ikegami M, Wang Y, Matsuzaki Y, Whitsett JA. Gene expression and biological processes influenced by deletion of Stat3 in pulmonary type II epithelial cells. BMC Genomics. 2007;8:455.

Xu Y, Liu C, Clark JC, Whitsett JA. Functional genomic responses to cystic fibrosis transmembrane conductance regulator (CFTR) and CFTR(508) in the lung. J Biol Chem. 2006;281:11279-11291.

Wan H, Xu Y, Ikegami M, Stahlman MT, Kaestner KH, Ang SL, Whitsett JA. Foxa2 is required for transition to air breathing at birth. Proc Natl Acad Sci USA. 2004;101:14449-14454.

Xu Y, Clark JC, Aronow BJ, Dey CR, Liu C, Wooldridge JL, Whitsett JA. Transcriptional adaptation to cystic fibrosis transmembrane conductance regulator deficiency. J Biol Chem. 2003;278:7674-7682.

“Lung Map” Atlas Research Center. Co-Investigator. National Heart, Lung, and Blood Institute. Jan 2014-Jan 2019.

Role of SREBP Network in Surfactant Lipid Homeostasis and Lung Maturation. Principal Investigator. National Heart, Lung, and Blood Institute. Jul 2011-Jul 2015.

Transcriptional Programming of Asthma Related Pathology in Respiratory Epithelial. Co-Investigator. National Heart, Lung, and Blood Institute. Apr 2013-Mar 2018.

Airway Progenitor Cell Proliferation and Differentiation During Lung Repair. Co-Investigator. National Heart, Lung, and Blood Institute. Jan 2012-Dec 2016.

Mechanisms Underlying DICER1 Suppression of Pleuropulmonary Blastoma. Co-Investigator. St. Baldrick's Foundation. Jul 2011-Jun 2016.

Osr Transcription factors regulate embryonic lung development. Co-Investigator. National Heart, Lung, and Blood Institute. Sept 2014-Aug 2016.