Bioinformatics; systems biology application in pulmonary research; lung cell type specific signaling; asthma associated pathology
Yan Xu, PhD, is an associate professor in the Department of Pediatrics, Divisions of Pulmonary Biology
and Biomedical Informatics
. Her main research interests are bioinformatics applications and systems biology. She is currently focusing on the identification of gene signatures, regulatory networks and biological pathways controlling 1) surfactant homeostasis, 2) lung maturation and 3) lung cell type specific signaling. Her research goal is to integrate the data and information from new computational methods and experimental approaches in a synergistic way to gain better understanding of molecular mechanisms underlying lung development and pathogenesis.
Education and Training
BS: Pharmacology, Shanghai Medical University, China, 1986.
MS: Pathology, Shanghai Medical University, China, 1989.
PhD: Molecular and Cellular Pharmacology, University of South Alabama, Mobile, Alabama, 1997.
View PubMed Publications
Xu Y, Yolton K, Khoury J. Earliest appropriate time for administering neurobehavioral assessment in newborn infants. Pediatrics. 2011 Jan;127(1):e69-75.
Meyer SE, Hasenstein JR, Baktula A, Velu CS, Xu Y, Wan H, Whitsett JA, Gilks CB, Grimes HL. Kruppel-like factor 5 is not required for K-RasG12D lung tumorigenesis, but represses ABCG2 expression and is associated with better disease-specific survival. Am J Pathol. 2010 Sep;177(3):1503-13.
Xu Y, Zhang M, Wang Y, Kadambi P, Dave V, Lu LJ, Whitsett JA. A systems approach to mapping transcriptional networks controlling surfactant homeostasis. BMC Genomics. 2010 Jul 26;11:451.
Xu YH, Barnes S, Sun Y, Grabowski GA. Multi-system disorders of glycosphingolipid and ganglioside metabolism. J Lipid Res. 2010 Jul;51(7):1643-75.
Chen G, Wan H, Luo F, Zhang L, Xu Y, Lewkowich I, Wills-Karp M, Whitsett JA. Foxa2 programs Th2 cell-mediated innate immunity in the developing lung. J Immunol. 2010 Jun 1;184(11):6133-41.
Xu Y, Pan W, Liu H. Self-management practices of Chinese Americans with type 2 diabetes. Nurs Health Sci. 2010 Jun;12(2):228-34.
Xu YH, Sun Y, Barnes S, Grabowski GA. Comparative therapeutic effects of velaglucerase alfa and imiglucerase in a Gaucher disease mouse model. PLoS One. 2010 May 20;5(5):e10750.
Xu Y, Martin M, Gribbins A. Learning packets in nursing education: reviving the past. Nurse Educ Pract. 2010 May;10(3):164-9.
Sun Y, Liou B, Ran H, Skelton MR, Williams MT, Vorhees CV, Kitatani K, Hannun YA, Witte DP, Xu YH, Grabowski GA. Neuronopathic Gaucher disease in the mouse: viable combined selective saposin C deficiency and mutant glucocerebrosidase (V394L) mice with glucosylsphingosine and glucosylceramide accumulation and progressive neurological deficits. Hum Mol Genet. 2010 Mar 15;19(6):1088-97.
Besnard V, Matsuzaki Y, Clark JC, Xu Y, Wert SE, Ikegami M, Stahlman MT, Weaver TE, Hunt AN, Postle AD, Whitsett JA. Conditional Deletion of Abca3 in Alveolar Type II Cells Alters Surfactant Homeostasis in Newborn and Adult Mice. Am J Physiol Lung Cell Mol Physiol. 2010 Feb 26.
Transcriptional Control of Respiratory Epithelial Progenitor Cells. Co-investigator. National Heart, Lung and Blood Institute. Sep 2007 - Sep 2011. #5R01HL090156-02.
Role of SFTPC in Pathogenesis of Interstitial Lung Disease. Co-investigator. National Institutes of Health. Dec 2008 - Nov 2013. #1R01HL086492-01A2.
Role of C/EBPa in Cytoprotection and Recovery from Lung Injury. Co-investigator. National Heart, Lung and Blood Institute. Apr 2009 - Mar 2014. #1R01HL095464-01.
Transcriptional Programming of Asthma Related Pathology in Respiratory Epithelial. Co-investigator. National Heart, Lung and Blood Institute. Apr 2009 - Mar 2014. #1R01HL095589-01.