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Biographies

Find another Doctor or Researcher

High Res

You-Hai Xu, PhD

Head, Molecular Diagnostics

Assistant Professor, UC Department of Pediatrics

Phone: 513-636-4542

Fax: 513-636-4373

Email: you-hai.xu@chmcc.org

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Specialties

Research interest in translational control of protein synthesis

Biography

You-Hai Xu, PhD, is interested in the regulation of gene expression at translation level. Dr. Xu is studying the cellular effect on transgene expression in mammalian system, especially the enzyme (human acid -glucosidase) deficient ex vivo/in vivo system (Gaucher disease). He is also studying translational control mechanism of protein synthesis and associated cellular functions.

Education and Training

PhD: Shanghai Institute of Cell Biology, Shanghai, China 1987.

Publications

View PubMed Publications

Xu YH, Jia L, Quinn B, Zamzow M, Stringer K, Aronow B, Sun Y, Zhang W, Setchell KD, Grabowski GA. Global gene expression profile progression in Gaucher disease mouse models.BMC Genomics. 2011 Jan 11;12(1):20.

Xu YH, Sun Y, Barnes S, Grabowski GA. Comparative therapeutic effects of velaglucerase alfa and imiglucerase in a Gaucher disease mouse model. PLoS One. 2010 May 20;5(5):e10750.

Xu YH, Barnes S, Sun Y, Grabowski GA. Multi-system disorders of glycosphingolipid and ganglioside metabolism. J Lipid Res. 2010 Jul;51(7):1643-75.

Sun Y, Liou B, Ran H, Skelton MR, Williams MT, Vorhees CV, Kitatani K, Hannun YA, Witte DP, Xu YH, Grabowski GA. Neuronopathic Gaucher disease in the mouse: viable combined selective saposin C deficiency and mutant glucocerebrosidase (V394L) mice with glucosylsphingosine and glucosylceramide accumulation and progressive neurological deficits. Hum Mol Genet. 2010 Mar 15;19(6):1088-97.

Sun Y, Liou B, Quinn B, Ran H, Xu YH, Grabowski GA. In vivo and ex vivo evaluation of L-type calcium channel blockers on acid beta-glucosidase in Gaucher disease mouse models. PLoS One. 2009 Oct 7;4(10):e7320.

Xu YH, Reboulet R, Quinn B, Huelsken J, Witte D, Grabowski GA. Dependence of reversibility and progression of mouse neuronopathic Gaucher disease on acid beta-glucosidase residual activity levels. Mol Genet Metab. 2008 Jun;94(2):190-203.

Sun Y, Quinn B, Xu YH, Leonova T, Witte DP, Grabowski GA. Conditional expression of human acid beta-glucosidase improves the visceral phenotype in a Gaucher disease mouse model. J Lipid Res. 2006 Oct;47(10):2161-70.

Xu YH, Grabowski GA. Translation modulation of acid beta-glucosidase in HepG2 cells: participation of the PKC pathway. Mol Genet Metab. 2005 Mar;84(3):252-64. Epub 2004 Dec 29.

Xu YH, Leonova T, Grabowski GA. Cell cycle dependent intracellular distribution of two spliced isoforms of TCP/ILF3 proteins. Mol Genet Metab. 2003 Dec;80(4):426-36.