Katherine Yutzey, PhD

Professor, UC Department of Pediatrics

Phone 513-636-8340

Fax 513-636-5958

Email katherine.yutzey@cchmc.org

Molecular regulation of heart development; valve development and disease mechanisms; cardiomyocyte proliferation, cardiac connective tissue lineages.

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Katherine E. Yutzey, PhD, is a professor who joined the Division of Molecular Cardiovascular Biology at Cincinnati Children's Hospital Medical Center within the University of Cincinnati College of Medicine in 1995.

Dr. Yutzey is the first recipient of the Fifth Third Bank/Charlotte R. Schmidlapp Women Scholars Award and was also a recipient of a Children's Hospital Medical Center Trustee Award. Her work is also supported by grants from National Institutes of Health (NIH) and the American Heart Association.

The focus of Dr. Yutzey's research program is the regulation of normal and abnormal heart development. Congenital heart defects represent one of the most common classes of human birth defects. Increasing evidence exists for a genetic basis of certain instances of congenital heart disease.

Dr. Yutzey’s lab also studies molecular mechanisms of cardiac connective tissue cell lineage development and disease.  This work focuses on heart valve development and disease as well as mechanisms of cardiac fibrosis.

BA: Oberlin College, Oberlin, OH, 1986.

PhD: Purdue University, West Lafayette, IN,1992

Fellowship: Cornell University Medical College, New York, NY,1992-1995.

View PubMed Publications

Wirrig EE, Hinton RB, Gomez MV, Yutzey KE. Cox2 inhibition reduces aortic valve calcification in vivo. Arterioscler. Thromb Vasc Biol. 2015;35:938-947.

Yutzey KE. Neuregulin1 makes heart muscle. Nature. 2015;520:445-446.

Wirrig EE, Yutzey KE. Conserved transcriptional regulatory mechanisms in aortic valve development and disease. Arterioscler Thromb Vasc Biol. 2014;34:737-741.

Cole CR, Yutzey KE, Brar AK, Goessling LS, vanVickle-Chavez SJ, Cunningham MV, Eghtesady P. Congenital heart disease linked to maternal autoimmunity against cardiac myosin. J Immunol. 2014;192:4074-4082.

Yutzey KE. Cardiovascular Biology: Switched at birth. Nature. 2014;509:572-573.

Yutzey KE, Demer LL, Body SC, Huggins GS, Towler DA, Giachelli CM, Hofmann-Bowman MA, Mortlock DP, Rogers MB, Sadeghi MM, Aikawa E. Calcific aortic valve disease: A consensus summary from the Alliance of Investigators on Calcific Aortic Valve Disease. Arterioscler Thromb Vasc Biol. 2014;34:2387-2393.

Lee MP, Ratner N, Yutzey KE. Genome-wide Twist1 occupancy in endocardial cushion cells, embryonic limb buds and peripheral nerve sheath tumor cells. BMC Genomics. 2014;15:821.

Godby RC, Munjal C, Opoka AM, Smith JM, Yutzey KE, Narmoneva DA, Hinton RB. Cross talk between NOTCH signaling and biomechanics in human aortic valve disease pathogenesis. J Cardiovasc Dev Dis. 2014;1:237-256.

Fang M, Alfieri CM, Hulin A, Conway SJ, Yutzey KE. Loss of -catenin promotes chondrogenic differentiation of aortic valve interstitial cells. Arterioscler Thromb Vasc Biol. 2014;34:2601-2608.

Sengupta A, Kalinichenko VV, Yutzey KE. FoxO and FoxM1 transcription factors have antagonistic functions in neonatal cardiomyocyte cell cycle withdrawal and IGF1 gene regulation. Circ Res. 2013;112:267-277.

Twist1 regulation of valve progenitors.wist1 regulation of valve. National Institutes of Health. 2010-2015. R01 HL082716.

Wnt/-catenin signaling and cardiac fibrosis. National Institutes of Health Component Principal Investigator. 2002-2018. P01 HL069779.

Wnt signaling in heart valve development and disease. National Institutes of Health. Principal Investigator. 2012-2016. R01 HL094319.

Cell signaling mechanisms of calcific aortic valve disease. National Institutes of Health. Principal Investigator. 2012-2016. R01 HL114682.

Summer Undergraduate Research Fellowship (SURF). American Heart Association-Great Rivers Affiliate. Principal Investigator. 2014-2015.