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High Res

Katherine Yutzey, PhD

Professor

Professor, UC Department of Pediatrics

Phone: 513-636-8340

Fax: 513-636-5958

Email: katherine.yutzey@cchmc.org

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Specialties

Molecular regulation of heart development; valve development and disease mechanisms; cardiomyocyte proliferation, cardiac connective tissue lineages.

Visit the Yutzey Lab.

Biography

Visit Dr. Yutzey's Lab Web Site.

Katherine E. Yutzey, PhD, professor, joined the Division of Molecular Cardiovascular Biology at Cincinnati Children's Hospital Medical Center in 1995.

Dr. Yutzey is the first recipient of the Fifth Third Bank/Charlotte R. Schmidlapp Women Scholars Award and was also a recipient of a Children's Hospital Medical Center Trustee Award. Her work is also supported by grants from National Institutes of Health (NIH) and the American Heart Association.

The focus of Dr. Yutzey's research program is the regulation of normal and abnormal heart development. Congenital heart defects represent one of the most common classes of human birth defects. Increasing evidence exists for a genetic basis of certain instances of congenital heart disease.

Dr. Yutzey’s lab also studies molecular mechanisms of cardiac connective tissue cell lineage development and disease. This work focuses on heart valve development and disease as well as mechanisms of cardiac fibrosis.

Education and Training

BA: Oberlin College, Oberlin, OH, 1986.

PhD: Purdue University, West Lafayette, IN,1992

Fellowship: Cornell University Medical College, New York, NY,1992-1995.

Publications

View PubMed Publications

Sengupta, A. V.V. Kalinichenko, K.E. Yutzey. FoxO and FoxM1 transcription factors have antagonistic functions in neonatal cardiomyocyte cell cycle withdrawal and IGF1 gene regulation. Circ. Res. 112:267-277. 2013.

Carruthers, C.A., C.M. Alfieri, E.M. Joyce, S.C. Watkins, K.E. Yutzey, M.S. Sacks Gene expression and collagen fiber micromechanical interactions of the semilunar heart valve interstitial cell. Cell. Mol. Bioeng. 5:254-265.

Mead TJ, Yutzey KE. Notch pathway regulation of neural crest cell development in vivo. Dev. Dyn. 2012:241:376-389.

Chakraborty S, Yutzey KE.Tbx20 regulation of cardiac cell proliferation and lineage specialization during embryonic and fetal development in vivo. Dev. Biol. 2012:363:234-246.

Cheek JD, Wirrig EE, Alfieri CM, James JF, Yutzey KE. Differential activation of valvulogenic, chondrogenic and osteogenic pathways in mouse models of myxomatous and calcific aortic valve disease. J. Mol. Cell. Cardiol. 2012:52:689-700.

Le TT, Conley KW, Mead TJ, Rowan S, Yutzey KE, Brown NL. Requirements for Jag1-Rbpj mediated Notch signaling during early mouse lens development. Dev. Dyn. 2012:241:493-504.

Sengupta A, Chakraborty S, Paik J, Yutzey KE, and Evans-Anderson HJ. FoxO1 is required in endothelial but not myocardial cell lineages during cardiovascular development. Dev. Dyn. 2012:241:803-813.

Fujimoto KL, Tobita K, Guan J, Hashizume R, Takanari K, Alfieri CM, Yutzey KE, Wagner WR. Placement of an elastic biodegradable cardiac patch on a subacute infarcted heart leads to cellularization with early developmental cardiomyocyte characteristics. J. Card. Fail. 2012:18:585-595.

Braitsch CM, Combs MD, Quaggin SE, Yutzey KE. Pod1/Tcf21 is regulated by retinoic acid signaling and inhibits differentiation of epicardium derived cells into smooth muscle in the developing heart. Dev. Biol. 2012:368:345-357.

Hinton RB,Yutzey KE. Heart valve structure and function in development and disease. Ann Rev. Physiol. 2011:73:29-36.

Grants

The Akt/FoxO pathway in heart development.
Component Principal Investigator.
National Institutes of Health.
#P01 HL069779.
2002-2012

Twist1 regulation of valve progenitors.wist1 regulation of valve.
National Institutes of Health.
R01 HL082716.
2010-2015

Wnt signaling in heart valve development and disease.
Principal Investigator.
National Institutes of Health
#R01 HL094319
2012-2016

Cell signaling mechanisms of calcific aortic valve disease.
Principal Investigator.
National Institutes of Health.
#R01 HL114682
2012-2016

Trainee support

Differential Twist1 dimer function and gene regulation in valve progenitor cells.
Mary Lee, Fellow. K. Yutzey,
Sponsor. American Heart Association-Great Rivers Affiliate,
Pre-doctoral Fellowship
2011-2013

FOXO function in cardiomyocytes during development and disease.
Arunima Sengupta, Fellow. K. Yutzey,
Sponsor. American Heart Association-Great Rivers Affiliate
Post-doctoral Fellowship
2011-2013

Summer Undergraduate Research Fellowship (SURF).
K. Yutzey, Principal Investigator.
American Heart Association-Great Rivers Affiliate.
2012-2013

The role of COX2 in the progression of human and mouse aortic valve disease.
Elaine Wirrig, Fellow. K Yutzey,
Sponsor. NIH NHLBI Post-Doctoral Fellowship
(F32 HL110390).
2012-2014