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Biographies

Find another Doctor or Researcher

High Res

Katherine Yutzey, PhD

Professor

Professor, UC Department of Pediatrics

Phone: 513-636-8340

Fax: 513-636-5958

Email: katherine.yutzey@cchmc.org

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Specialties

Molecular regulation of embryonic heart development; identifying regulators of early heart lineage determination; heart chamber formation and defects

Visit the Yutzey Lab.

Biography

Visit Dr. Yutzey's Lab Web Site.

Katherine E. Yutzey, PhD, professor, joined the Division of Molecular Cardiovascular Biology at Cincinnati Children's Hospital Medical Center in 1995.

Dr. Yutzey is the first recipient of the Fifth Third Bank/Charlotte R. Schmidlapp Women Scholars Award and was also a recipient of a Children's Hospital Medical Center Trustee Award. Her work is also supported by grants from National Institutes of Health (NIH) and the American Heart Association.

The focus of Dr. Yutzey's research program is the regulation of normal and abnormal heart development. Congenital heart defects represent one of the most common classes of human birth defects. Increasing evidence exists for a genetic basis of certain instances of congenital heart disease.

Education and Training

BA: Oberlin College, Oberlin, OH, 1986.

PhD: Purdue University, West Lafayette, IN,1992

Fellowship: Cornell University Medical College, New York, NY,1992-1995.

Publications

View PubMed Publications

Wirrig EE, Hinton RB, Yutzey KE. Differential expression of cartilage and bone-related proteins in pediatric and adult diseased aortic valves. J Mol Cell Cardiol. 2010 Dec 14.

Sengupta A, Molkentin JD, Paik JH, Depinho RA, Yutzey KE. FoxO transcription factors promote cardiomyocyte survival upon induction of oxidative stress. J Biol Chem. 2010 Dec 15.

Chakraborty S, Wirrig EE, Hinton RB, Merrill WH, Spicer DB, Yutzey KE. Twist1 promotes heart valve cell proliferation and extracellular matrix gene expression during development in vivo and is expressed in human diseased aortic valves. Dev Biol. 2010 Nov 1;347(1):167-79.

Chakraborty S, Combs MD, Yutzey KE. Transcriptional regulation of heart valve progenitor cells. Pediatr Cardiol. 2010 Apr;31(3):414-21.

Alfieri CM, Cheek J, Chakraborty S, Yutzey KE. Wnt signaling in heart valve development and osteogenic gene induction. Dev Biol. 2010 Feb 15;338(2):127-35.

Hinton RB, Yutzey KE. Heart Valve Structure and Function in Development and Disease. Annu Rev Physiol. 2010 Feb 19.

Combs MD, Yutzey KE. Heart valve development: regulatory networks in development and disease. Circ Res. 2009 Aug 28;105(5):408-21. Review.

Sengupta A, Molkentin JD, Yutzey KE. FoxO transcription factors promote autophagy in cardiomyocytes. J Biol Chem. 2009 Oct 9;284(41):28319-31.

Mead TJ, Yutzey KE. Notch pathway regulation of chondrocyte differentiation and proliferation during appendicular and axial skeleton development. Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14420-5.

Grants

Notch signaling in heart valve development and disease. Principal Investigator. National Institutes of Health. 2009 - 2011. #R01 HL094319.

The function of Notch1 in heart valve development. Sponsor. American Heart Association. 2009 - 2011.

Tbx18 regulation of epicardial-derived cell proliferation, migration and differentiation in cardiac development. Sponsor. American Heart Association. 2009 - 2011.

The Akt/FoxO pathway in heart development. Component Principal Investigator. National Institutes of Health. 2002 - 2012. #P01 HL069779-06.

Twist1 regulation of valve progenitors. Principal Investigator. National Institutes of Health. 2010- 2015. #R01 HL082716.