Yutaka Yoshida, PhD

Assistant Professor, UC Department of Pediatrics

Phone 513-803-0943

Email yutaka.yoshida@cchmc.org

Molecular mechanisms of neural circuit formation in the developing spinal cord.

Visit the Yoshida Lab.

BS: Keio University, 1994.

PhD: University of Tokyo, 1999.

Postdoctoral fellow: University of Tokyo, 1999-2002; Columbia University, 2002-2007.

Fukuhara K, Imai F, Ladle DR, Katayama K, Leslie JR, Arber S, Jessell TM, Yoshida Y. Specificity of monosynaptic sensory connections imposed by repellent sema3e-plexinD1 signaling. Cell Reports. In press. 2013.

Katayama K, Imai F, Campbell K, Lang RA, Zhneg Y, Yoshida Y. RhoA and Cdc42 are required in pre-migratory progenitors of the medial ganglionic eminence ventricular zone for proper cortical interneuron migration. Development. 140, 3139-3145. 2013.

Katayama K, Leslie JR, Lang RA, Zheng Y, Yoshida Y. Left-right locomotor circuitry depends upon RhoA-driven organization of the neuroepithelium in the developing spinal cord. Journal of Neuroscience. 2012 Jul 25;32(30):10396-407.

Leslie JR, Imai F, Fukuhara K, Takegahara N, Rizvi TA, Friedel RH, Wang F, Kumanogoh A, Yoshida Y. Ectopic myelinating oligodendrocytes in the dorsal spinal cord as a consequence of changing semaphorin6D signaling inhibit synapse formation. Development. 2011. 

Katayama K, Melendez J, Baumann JM, Leslie JR, Chauhan BK, Nemkul N, Lang RA, Kuan CY, Zheng Y, Yoshida Y. Loss of RhoA in neural progenitor cells causes the disruption of adherens junctions and hyperproliferationProc Natl Acad Sci U S A. May 3;108(18):7607-12. 2011.

Pecho-Vrieseling E, Sigrist M, Yoshida Y,  Jessell TM, and Arber S. Specificity of Monosynaptic Sensory-Motor Connections Encoded by Sema3e-PlexinD1Nature. 459:842-6. 2009.

Yoshida Y, Han B, Mendelsohn M, Jessell TM. PlexinA1 signaling directs the segregation of proprioceptive sensory axons in the developing spinal cordNeuron. 52:775-88. 2006.

Gu C*, Yoshida Y*, Livet J., Reimert DV, Mann F, Merte J, Henderson CE, Jessell TM, Kolodkin AL, Ginty DD. Semaphorin 3E and plexin-D1 control vascular pattern independently of neuropilins. Science. 307:265-8. 2005. (* denotes equal contribution)

Yoshida Y, Nakamura T, Komoda M, Satoh H, Suzuki T, Tsuzuku JK, Miyasaka T, Yoshida EH, Umemori H, Kunisaki RK, Tani K, Ishii S, Mori S, Suganuma M, Noda T, Yamamoto T. Mice lacking a transcriptional corepressor Tob are predisposed to cancerGenes Dev. 17:1201-6. 2003.

Yoshida Y, Tanakam S, Umemori H, Minowa O, Usui M, Ikematsu N, Hosoda E, Imamura T, Kuno J, Yamashita T, Miyazono K, Noda M, Noda T, Yamamoto T. Negative regulation of BMP/Smad signaling by Tob in osteoblastsCell. 103:1085-97. 2000.

Regulation of Sensory-Motor Connectivity by Semaphorin-Plexin Signaling. Principal Investigator. National Institutes of Health. Apr 2009 - Mar 2014. #R01NS065048.