Basilia Zingarelli, MD, PhD

Director, Basic Science Research

Professor, UC Department of Pediatrics

Phone 513-636-8704

Email basilia.zingarelli@cchmc.org

Sepsis; trauma; hemorrhagic shock and ischemia and reperfusion injury.
Visit the Zingarelli Lab.

Basilia Zingarelli, MD, PhD, came to Cincinnati Children's Hospital Medical Center in 1995 as a post-doctoral research fellow in Critical Care Medicine. She joined the faculty in 1997.

Dr. Zingarelli graduated from the Medical School of the University of Messina in Italy in 1990. She also obtained a doctorate in experimental medicine in 1997 and attended a residency in medical toxicology at the University of Messina from 1990 to 1992.

Dr. Zingarelli now directs the basic science research in the Division of Critical Care Medicine. She directs an NIH-funded research laboratory focused on the pathogenetic mechanisms of organ injury during sepsis, trauma and hemorrhage and coordinates basic science and clinical translational research projects related to other critical care conditions.

Dr. Zingarelli serves on the Executive Council of the Shock Society, a well-established international association of clinical and research scientists in the field of shock and trauma, and serves as associate editor for the journal Shock. She also serves as permanent and ad hoc member on a number of study sections at the National Institutes of Health.

MD: School of Medicine, University of Messina, Italy, 1990.

PhD: Experimental Medicine, School of Medicine, University of Messina, Italy, 1997.

Residency: Medical Toxicology, School of Medicine, University of Messina, Italy, 1990-1992.

Certification: General Medicine (Italian), 1990.

Chima RS, LaMontagne T, Piraino G, Hake PW, Denenberg A, Zingarelli B. C-peptide, a novel inhibitor of lung inflammation following hemorrhagic shock. Am J Physiol Lung Cell Mol Physiol. 2011 May;300(5):L730-9.

Solan PD, Piraino G, Hake PW, Denenberg A, O'Connor M, Lentsch A, Zingarelli B. Liver X receptor α activation with the synthetic ligand T0901317 reduces lung injury and inflammation after hemorrhage and resuscitation via inhibition of the NF-κB pathway. Shock. 2011; 35:367-374.

Kaplan JM, Hake PW, Denenberg A, Nowell M, Piraino G, Zingarelli B. Phosphorylation of extracellular signal-regulated kinase (ERK)-1/2 Is associated with the downregulation of peroxisome proliferator-activated receptor (PPAR)-γ during polymicrobial sepsis. Mol Med. 2010 Nov-Dec;16(11-12):491-7.

Zingarelli B, Piraino G, Hake PW, O'Connor M, Denenberg A, Fan H, Cook JA. Peroxisome proliferator-activated receptor {delta} regulates inflammation via NF-{kappa}B signaling in polymicrobial sepsis. Am J Pathol. 2010 Oct;177(4):1834-47.

Zingarelli B, Chima R, O'Connor M, Piraino G, Denenberg A, Hake PW. Liver apoptosis is age dependent and is reduced by activation of peroxisome proliferator-activated receptor-gamma in hemorrhagic shock. Am J Physiol Gastrointest Liver Physiol. 2010 Jan;298(1):G133-41.

Kaplan JM, Denenberg A, Monaco M, Nowell M, Wong H, Zingarelli B. Changes in peroxisome proliferator-activated receptor-gamma activity in children with septic shock. Intensive Care Med. 2010 Jan;36(1):123-30.

Zingarelli B, Hake PW, O'Connor M, Burroughs TJ, Wong HR, Solomkin JS, Lentsch AB. Lung injury after hemorrhage is age dependent: role of peroxisome proliferator-activated receptor gamma. Crit Care Med. 2009 Jun;37(6):1978-87.

Zingarelli B, Fan H, Ashton S, Piraino G, Mangeshkar P, Cook JA. Peroxisome proliferation-activated receptor (PPAR) γ is not necessary for the development of LPS-induced tolerance. Immunology. 2008;124:51-57.

Chima RS, Hake PW, Piraino G, Mangeshkar P, Denenberg A, Zingarelli B. Ciglitazone ameliorates lung inflammation by modulating the inhibitor kappaB protein kinase/nuclear factor-kappaB pathway after hemorrhagic shock. Crit Care Med. 2008 Oct;36(10):2849-57.

Vish MG, Mangeshkar P, Piraino G, Denenberg A, Hake PW, O'Connor M, Zingarelli B. Proinsulin c-peptide exerts beneficial effects in endotoxic shock in mice. Crit Care Med. 2007 May;35(5):1348-55.

Role of Eicosanoids In Shock. Co-Investigator. National Institutes of Health. Jul 2008 - Jun 2012. #R01 GM 027673.

Mechanisms of Age-Related Inflammatory Response in Hemorrhagic Shock. Principal Investigator. National Institutes of Health. Sep 2007 - Aug 2012. #R01 AG 027990.

Host response to trauma research training program. Faculty/mentor. National Institutes of Health (T32 GM08478). Jul 2003-Jun 2013.

Interferon-mediated reprogramming of Toll-like receptor signaling. Co-Investigator. National Institutes of Health. Jul 2008 - Jun 2013. #R01 GM085063.

Role of PPARgamma and PPARgamma Agonists in Septic Shock. Principal Investigator. National Institutes of Health. Jul 2008 - Jun 2013. #R01 GM 067202.

MMP-8 as a novel therapeutic target in sepsis. Co-Investigator. National Institutes of Health. Jul 2011 - Jun 2015. #R01 GM096994.