A photo of Yi Zheng.

Yi Zheng, PhD

Director, Experimental Hematology and Cancer Biology

Katherine Stewart Waters Endowed Chair

Co-Director, Cancer and Blood Diseases Institute

Professor, UC Department of Pediatrics

Phone: 513-636-0595


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Research Interests

Using transgenic and gene targeted mouse models to study the physiological and pathological roles of Rho GTPases and their regulators in hematopoiesis, neurogenesis, lung cancer development and small intestinal stem cell regulations; mechanism based, rational design of small molecule inhibitors targeting Rho GTPase signaling modules and pathologic functions in cancer and blood diseases; mouse model studies of mTor signaling function in hematopoietic stem cells and small intestinal stem cells.

Visit the Zheng Lab.

Education and Training

BS: Tsinghua University, Beijing, China, 1986.

MS: Cornell University, Ithaca, NY 1988.

PhD: Cornell University, Ithaca, NY, 1991.

Postdoctoral Fellow: Cornell University, Ithaca, NY, 1995.


View All PubMed Publications


Rac GTPase specific small molecule inhibitors. PI: Yi Zheng. National Cancer Institute. NIH - R01 CA141341. 01/01/2000 - 01/31/2014

Targeting Cdc42 in leukemia stem cells. PI: Yi Zheng, co-PI: James Mulloy. National Cancer Institute - 1R01CA150547-01. 04/01/2010 – 03/31/2015

Cincinnati Center of Excellence in Molecular Hematology. PI: Yi Zheng. NIDDK - NIH P30 DK090971. 09/30/2010 – 06/30/2015

Lineage Determination and Tissue Homeostasis in the aged Hematopoietic System. PI: Yi Zheng; co-PI: Hartmut Geiger. NIA - NIH R01AG040118. 08/01/2011 – 07/31/2016

PHARMACOLOGICAL REJUVENATION OF AGED HEMATOPOIETIC STEM CELLS. PI: Hartmut Geiger; co-PI: Yi Zheng. NIH - NIH R43 AG042986. 08/01/2012 – 07/31/2014

Targeting Leukemia-associated Rho guanine nucleotide exchange factor LARG in AML. PI: Yi Zheng; co-PI: James Mulloy. Alex’s Lemonade Stand Foundation. 07/01/2013 – 06/30/2015