Biographies

E-mail this page

(All fields required)

Recipient's email address

Please enter a valid email.

Your name

Please enter your name.

Your email address

Please enter a valid email.

Find another Doctor or Researcher

Yi Zheng, PhD

Director, Division of Experimental Hematology and Cancer Biology; Katherine Stewart Waters Endowed Chair

Co-Director, Cancer and Blood Diseases Institute

Professor, UC Department of Pediatrics

Phone: 513-636-0595

Email: yi.zheng@cchmc.org

Show All

Specialties

Research Interests

Using transgenic and gene targeted mouse models to study the physiological and pathological roles of Rho GTPases and their regulators in hematopoiesis, neurogenesis, lung cancer development and small intestinal stem cell regulations; mechanism based, rational design of small molecule inhibitors targeting Rho GTPase signaling modules and pathologic functions in cancer and blood diseases; mouse model studies of mTor signaling function in hematopoietic stem cells and small intestinal stem cells.

Education and Training

BS: Tsinghua University, Beijing, China, 1986.

MS: Cornell University, Ithaca, NY 1988.

PhD: Cornell University, Ithaca, NY, 1991.

Postdoctoral Fellow: Cornell University, Ithaca, NY, 1995.

Publications

View PubMed Publications

George, A., Konstantinidis DG, Pushkaran, S., Koochaki, S., Malik, P., Mohandas, N., Zheng, Y., Joiner, C. H., and Kalfa, TA. Erythrocyte NADPH oxidase activity contributes to oxidative stress in sickle cell disease via a pathway involving Rac GTPases, protein kinase C, and plasma cytokines. Blood. 2012. in press

Shang, X., Marchioni, F., Evelyn, C. R., Sipes, N., Zhou, X., Seibel, W., Wortman, M., and Zheng, Y. Small molecule inhibitors targeting G-protein coupled Rho guanine nucleotide exchange factors. PNAS. 2012. in press.

Chang KH, Sanchez-Aguilera A, Shen S, Sengupta A, Madhu MN, Ficker AM, Dunn SK, Kuenzi AM, Arnett JL, Santho RA, Agirre X, Perentesis JP, Deininger MW, Zheng Y, Bustelo XR, Williams DA, Cancelas JA. Vav3 collaborates with p190-BCR-ABL in lymphoid progenitor leukemogenesis, proliferation and survival. Blood. 120(4):800-11. 2012. PMID: 22692505.

Maruvada R, Zhu L, Pearce D, Zheng Y, Perfect J, Kwon-Chung KJ, Kim KS. Cryptococcus neoformans phospholipase B1 activates host cell Rac1 for traversal across the blood-brain barrier. Cell Microbiol. 14(10):1544-53. doi: 10.1111/j.1462-5822.2012.01819.x. 2012. PMID: 22646320.

Delaney MK, Liu J, Zheng Y, Berndt MC, Du X. Role of Rac1 in Glycoprotein Ib-IX Mediated Signal Transduction and Integrin Activation. Arterioscler Thromb Vasc Biol. 32(11):2761-8. 2012. doi: 10.1161/ATVBAHA.112.254920. PMID:22995516

Shang, X., and Zheng, Y. Rational design of Rho GTPase targeting inhibitors. Methods Mol Biol. 928:29-38. 2012. PMID:22956131.

Leslie JR, Imai F, Zhou X, Lang RA, Zheng Y, Yoshida Y. RhoA is dispensable for axon guidance of sensory neurons of mouse dorsal root ganglia. Front Mol Neurosci. 5:67. 2012. PMID: 22661927.

Tan Z, Wortman M, Dillehay KL, Seibel WL, Evelyn CR, Smith SJ, Malkas LH, Zheng Y, Lu S, Dong Z. Small Molecule Targeting of PCNA Chromatin Association Inhibits Tumor Cell Growth. Mol Pharmacol 81(6):811-9. 2012. PMID:22399488.

Konstantinidis DG, Pushkaran S, Johnson JF, Cancelas JA, Manganaris S, Harris CE, Williams DA, Zheng Y, Kalfa TA. Signaling and cytoskeletal requirements in erythroblast enucleation. Blood. 119 (25):6118-27. 2012. PMID: 22461493.

Kumar S, Xu J, Perkins C, Guo F, Snapper S, Finkelman FD, Zheng Y, Filippi MD Cdc42-WASP signaling controls polarized microtubule orientation during neutrophil migration. Blood. 120(17):3563-74. 2012. doi: 10.1182/blood-2012-04-426981. PMID:22932798.

Stengel K. R., and Zheng, Y. Essential Role of Cdc42 in Ras-Induced Transformation Revealed by Gene Targeting. PLoS ONE. 7(6): e37317. 2012. doi:10.1371/journal.pone.0037317.

Dietz DM, Sun H, Lobo MK, Cahill ME, Chadwick B, Gao V, Koo JW, Mazei-Robison MS, Dias C, Maze I, Damez-Werno D, Dietz KC, Scobie KN, Ferguson D, Christoffel D, Ohnishi Y, Hodes GE, Zheng Y, Neve RL, Hahn KM, Russo SJ, Nestler EJ. Rac1 is essential in cocaine-induced structural plasticity of nucleus accumbens neurons. Nat Neurosci. 15(6):891-6. 2012. doi: 10.1038/nn.3094. PMID:22522400.

Guo, L., Moon, C., Neihaus, K., Zheng, Y., and Ratner, N. Rac1 Controls Schwann Cell Myelination through cAMP and NF2/merlin. J Neurosci. 32(48):17251-61. 2012. doi:10.1523/JNEUROSCI.2461-12.2012.

Florian, M. C., Dörr, K., Niebel, A., Daria, D., Schrezenmeier, H., Rojewski, m., Filippi, M.-D., Scharffetter-Kochanek, K., Zheng, Y., and Geiger, H. Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation. Cell Stem Cell. 10, 520-530. 2012.

Katayama K, Leslie JR, Lang RA, Zheng Y, Yoshida Y. Left-Right Locomotor Circuitry Depends on RhoA-Driven Organization of the Neuroepithelium in the Developing Spinal Cord. J Neurosci. 2012 Jul 25;32(30):10396-407. PMID:22836272.

Shang X, Marchioni F, Sipes N, Evelyn CR, Jerabek-Willemsen M, Duhr S, Seibel W, Wortman M, and Zheng Y. Rational design of RhoA subfamily GTPase-specific small molecule inhibitors. Chem Biol. 19(6):699-710. 2012. PMID:22726684.

Liu, M., Bi, F., Zhou, X., and Zheng, Y. Rho GTPase regulation by microRNAs and covalent modifications. Trends in Cell Biol. 22(7):365-73. 2012. PMID: 22572609.

Wan H, Liu C, Wert SE, Xu W, Liao Y, Zheng Y, Whitsett JA. CDC42 is required for structural patterning of the lung during development. Dev. Biol. 2012 Dec 5. doi:pii: S0012-1606(12)00649-5. 10.1016/j.ydbio.2012.11.030. [Epub ahead of print] PMID:23219958.

Akunuru S, James Zhai Q, Zheng Y. Non-small cell lung cancer stem/progenitor cells are enriched in multiple distinct phenotypic subpopulations and exhibit plasticity. Cell Death Dis. 2012 Jul 19;3:e352. doi: 10.1038/cddis.2012.93. PMID:22825470.

Bosco EE, Kumar S, Marchioni F, Biesiada J, Kordos M, Szczur K, Meller J, Seibel W, Mizrahi A, Pick E, Filippi MD, Zheng Y. Rational design of small molecule inhibitors targeting the Rac GTPase - p67phox signaling axis in inflammation. Chem Biol. 19, 228-242.

Wang PS, Wang J, Zheng Y, Pallen CJ. Loss of Protein Tyrosine Phosphatase a Increases Proliferation and Delays Maturation of Oligodendrocyte Progenitor Cells. J. Biol. Chem. 287: 12529-12540. PMID:22354965.

Grants

Training Program in Hematologic and Oncologic Diseases. Principal Investigator. National Institute of Heart, Lung, and Blood. Sep 2008 - Aug 2013. #T32 HL091805.

Rac GTPase specific small molecule inhibitors. Principal Investigator. National Cancer Institute. Jan 2000 - Jan 2014. #R01 CA141341.

Targeting Cdc42 in leukemia stem cells. Co-Principal Investigator. National Cancer Institute. Apr 2010 - Mar 2015. #1R01CA150547-01.

Cincinnati Center of Excellence in Molecular Hematology. Principal Investigator. National Institutes of Health. Sep 2010 – Aug 2015. # P30 DK090971.

Lineage Determination and Tissue Homeostasis in the aged Hematopoietic System. Contact Principal Investigator / Co-Principal Investigator. National Institutes of Health. Aug 2011 - Aug 2016.

Targeted Improvement in Stem Cell Therapy for Leukemia and Bone Marrow Failure Syndromes. Co-Principle Investigator. Apr 2011 - Mar 2016. R01 CA157537.

Pharmacological Rejuvenation of Aged Hematopoetic Stem Cells. Co-Principle Investigator. Aug 2012 - Jul 2013. R43 AG042968.