A photo of Robert W. Frenck Jr.

Robert W. Frenck Jr., MD


  • Director, Vaccine Research Center
  • Executive Chair, Institutional Review Board (IRB)
  • Professor, UC Department of Pediatrics

About

Biography

The research that I’m most interested in is developing vaccines to prevent infections. Vaccines are the most impressive public health measure to reduce the rates of disease. I was inspired to pursue this area of pediatric patient care because infections are still the leading cause of death among children worldwide. I believe that finding methods to reduce infections among children will greatly enhance children's lives and help them grow up into healthy, happy adults.

Vaccines have saved more lives and averted more diseases than any other remedy that exists in medicine. Distributing vaccines around the globe has eliminated smallpox and has nearly eliminated polio. Furthermore, new vaccines are likely to prevent new infections, such as Ebola and COVID-19.

I am Director of the Gamble Center for Clinical Research, where my colleagues and I assess new vaccines and agents designed to prevent infections. I’m also the principal investigator of the Vaccine Treatment and Evaluation Unit (VTEU), which is funded by the National Institutes of Health (NIH).

At the Cincinnati Children’s Hospital Medical Center, we are one of nine VTEU sites that exist in the United States. Our hospital was selected as a VTEU site due to our extensive history of excellence in vaccine testing.

My research has been published in various journals, including Clinical Infectious Diseases, Open Forum Infectious Diseases, Lancet Infectious Diseases, and the Journal of Clinical Rheumatology: Practical Reports on Rheumatic and Musculoskeletal Disease. I’m an acknowledged authority in infectious diseases and have authored more than 125 articles and book chapters.

BA: University of California at San Diego, San Diego, CA, 1977.

MD: University of Texas Medical School at Houston, Houston, TX, 1981.

Internship and Residency: US Naval Hospital, Bethesda, MD, 1981-1984.

Fellowship: Pediatric Infectious Diseases, University of Texas Medical School at Houston, Houston, TX, 1987-1990.

Interests

Vaccine research; enteric diseases; travel medicine

Services and Specialties

Infectious Diseases

Interests

Enteric diseases; vaccinology

Research Areas

Infectious Diseases

Insurance Information

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Publications

Oral immunization with Shigella sonnei WRSs2 and WRSs3 vaccine strains elicits systemic and mucosal antibodies with functional anti-microbial activity. Shrivastava, S; Agnememel, AB; Ndungo, E; Islam, D; Liang, Y; Frenck, RW; Pasetti, MF. mSphere. 2024; 9:e0041923.

B memory cell responses to LPS, IVP and IpaB antigen after oral vaccination with Shigella sonnei vaccine candidates WRSs2 and WRSs3. Venkatesan, MM; Barnoy, S; Frenck, R; McNeal, M; Baqar, S. PloS one. 2024; 19:e0290987.

Safety and Immunogenicity of an Andes Virus DNA Vaccine by Needle-Free Injection: A Randomized, Controlled Phase 1 Study. Paulsen, GC; Frenck, R; Tomashek, KM; Alarcon, RM; Hensel, E; Lowe, A; Brocato, RL; Kwilas, SA; Josleyn, MD; Hooper, JW. Journal of Infectious Diseases. 2024; 229:30-38.

COVID-19 Vaccines in Children. Fayad, D; Frenck, RW. Journal of Clinical Medicine. 2024; 13:87.

Immunogenicity of NVX-CoV2373 heterologous boost against SARS-CoV-2 variants. Lyke, KE; Atmar, RL; Dominguez Islas, C; Posavad, CM; Deming, ME; Branche, AR; Johnston, C; El Sahly, HM; Edupuganti, S; Mulligan, MJ; et al. npj Vaccines. 2023; 8:98.

Evaluation of a Community COVID-19 Vaccine Ambassador Train-the-Trainer Program. Corley, AM S; Gomes, SM; Martin, KJ; Watkins, S; Lindsey, K; Frenck, RW; Mitchell, MJ; Rule, AR L; Crosby, LE. Journal of Immigrant Health. 2023; 25:1302-1306.

A Longitudinal Study of Group A Streptococcal Colonization and Pharyngitis in US Children. Frenck, RW; Laudat, F; Liang, J; Giordano-Schmidt, D; Jansen, KU; Gruber, W; Anderson, AS; Scully, IL. The Pediatric Infectious Disease Journal. 2023; 42:1045-1050.

Recommendations for Prevention and Control of Influenza in Children, 2023-2024. O’Leary, ST; Campbell, JD; Ardura, MI; Banerjee, R; Bryant, KA; Caserta, MT; Frenck, RW; Gerber, JS; John, CC; Kourtis, AP; et al. Pediatrics. 2023; 152:e2023063772.

Risk of COVID-19 after natural infection or vaccination. Rick, AM; Laurens, MB; Huang, Y; Yu, C; Martin, TC S; Rodriguez, CA; Rostad, CA; Maboa, RM; Baden, LR; El Sahly, HM; et al. EBioMedicine. 2023; 96:104799.

Recommendations for Prevention and Control of Influenza in Children, 2023-2024. COMMITTEE ON INFECTIOUS DISEASES, . Pediatrics. 2023; 152:e2023063773.

From the Blog

Can Kids Get the COVID-19 and Flu Vaccines at the Same Time?
Blog Vaccines

Can Kids Get the COVID-19 and Flu Vaccines at the Same Time?

By Bob Frenck MD10/26/2022

Cincinnati Children’s Plays Central Role in COVID-19 Vaccine Clinical Trials
Infectious Diseases and Vaccines

Cincinnati Children’s Plays Central Role in COVID-19 Vaccine Clinical Trials

Robert W. Frenck Jr., MD, Paul Spearman, MD5/22/2022

Brady, Frenck Among Co-Authors of COVID Vax ‘Mix-and-Match’ Study in NEJM
Infectious Diseases and Vaccines

Brady, Frenck Among Co-Authors of COVID Vax ‘Mix-and-Match’ Study in NEJM

Robert W. Frenck Jr., MD, Rebecca C. Brady, MD1/26/2022

9 Things for Parents to Know About the Omicron Variant
Blog Vaccines

9 Things for Parents to Know About the Omicron Variant

By Dr. Robert Frenck1/26/2022

My Child Is Fully Vaccinated – Now What?
Blog Vaccines

My Child Is Fully Vaccinated – Now What?

By Dr. Robert Frenck11/18/2021

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4.6
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