Faculty Publications
The members of the Division of Allergy and Immunology at Cincinnati Children's Hospital Medical Center and the Division of Immunology at the University of Cincinnati are active as basic and clinical investigators (often in collaboration with investigators from other divisions, departments, and institutions), and as educators.
Publications (2006-2007)
Blanchard C, Wang N. Mishra A, Fulkerson PC, Jameson SC, Kirby C, Konikoff MR, Collins MH, Cohen MB, Stringer KF, Akers R, Hogan SP, Assa'ad AH, Putnam PE, Aronow BJ, Rothenberg ME. Eotaxin-3 and a uniquely conserved gene-expression profile in eosinophilic esophagitis, J Clin Invest, 2006; 116:536-547.
Yamada Y, Rothenberg ME, Lee AW, Akei HS, Brandt EB, Williams DA, Cancelas JA. The FIP1L1-PDGFR fusion gene cooperates with IL-5 to induce murine hypereosinophilic syndrome (HES)/chronic eosinophilic leukemia (CEL)-like disease, Blood, 2006; 107:4071-9.
Saito Akei H, Brant EB, Mishra A, Strait RT, Finkelman FD, Warrier MR, Hershey GKH, Blanchard C, Rothenberg ME. Epicutaneous aeroallergen exposure induces systemic Th2 immunity that predisposes to allergic nasal responses. J Allergy Clin Immunol, 2006; 118-62-9.
Hogan SP, Seidu L, Blanchard C, Groschwitz K, Mishra A, Karow ML, Ahrens R, Artis D, Murphy AJ, Valenzuela DM, Yancopoulos GD, Rothenberg ME. Resistin-like molecule (RELM)- regulates innate colonic function: barrier integry and inflammation susceptibility, J Allergy Clin Immunol, 2006; 118:257-68.
DeBrosse CW, Case JW, Putnam PE, Collins ME, Rothenberg ME. Quantity and distribution of eosinophils in the gastrointestinal tract of children, Pediatr Dev Pathol, 2006; 9:210-218.
Rothenberg ME, Doepker MP, Lewkowich IP, Chiaramonte MG, Stringer K, Finkelman FD, MacLeod CL, Ellies L, Zimmermann N. The cationic amino acid transporter 2 regulates inflammatory homeostasis in the lung, Proc Natl Acad Sci USA, 2006; 103:14895-14900.
Konikoff MR, Noel RJ, Blanchard C, Kirby C, Jameson SC, Buckmeier B, Akers R, Cohen MB, Collins MH, Assa'ad AH, Aceves SS, Putnam PE, Rothenberg ME. A randomized double-blind placebo-controlled trial of fluticasone propionate for pediatric eosinophilic esophagitis, Gastroenterology, 2006;131:1381-1391. Epub 2006 Aug 16.
Konikoff MR, Blanchard C, Kirby C, Buckmeier B, Cohen MB, Heubi JE, Putnam PE, Rothenberg ME. Potential biomarkers of eosinophilic esophagitis, Clin Gastroenterol Hepatol, 2006; 4:1328-1336. Epub 2006 Oct 21.
Fulkerson PC, Fischetti CA, McBride ML, Hassman LM, Hogan SP, Rothenberg ME. A central regulatory role for eosinophils and the eotaxin-CCR3 axis in chronic experimental allergic airway inflammation, Proc Natl Acad Sci USA, 2006; 103:16418-23. Epub 2006 Oct 23.
Fulkerson PC, Fischetti CA, Rothenberg ME. Eosinophils and CCR3 regulate IL-13-transgene-induced pulmonary remodeling, Am J Pathol, 2006; 169:2117-2126.
Stein ML, Collins MH, Villanueva JM, Kushner JP, Putnam PE, Buckmeier, BK, Filipovich AH, Assa'ad AH, Rothenberg ME. Anti-interleukin-5 (mepolizumab) therapy for eosinophilic esophagitis, J Allergy Clin Immunol, 2006; 118:1312-1319.
Blanchard, C.; Wang, N.; Stringer, K. F.; Mishra, A.; Fulkerson, P. C.; Abonia, J. P.; Jameson, S. C.; Kirby, C.; Konikoff, M. R.; Collins, M. H.; Cohen, M. B.; Akers, R.; Hogan, S. P.; Assa'ad, A. H.; Putnam, P. E.; Aronow, B. J.; Rothenberg, M. E, Eotaxin-3/CCL26 and a uniquely conserved gene-expression profile in eosinophilic esophagitis, J Clin Ivestigator, 2006; 116(2):536-47
Assa'ad, A. H.. Gastrointestinal food allergy and intolerance. Pediatr Ann 2006; 35(10): 718-26
Fiocchi, A., A. Assa'ad, S. Bahna. "Food allergy and the introduction of solid foods to infants: a consensus document. Adverse Reactions to Foods Committee, American College of Allergy, Asthma and Immunology." Ann Allergy Asthma Immunol 2006; 97(1): 10-20; quiz 21, 77.
Konikoff, M. R.; Noel, R. J.; Blanchard, C.; Kirby, C.; Jameson, S. C.; Buckmeier, B. K.; Akers, R.; Cohen, M. B.; Collins, M. H.; Assa'ad, A. H.; Aceves, S. S.; Putnam, P. E.; Rothenberg, M. E.. "A Randomized, Double-Blind, Placebo-Controlled Trial of Fluticasone Propionate for Pediatric Eosinophilic Esophagitis." Gastroenterology, 2006;131(5): 1381-91.
ML Stein, MH Collins, JM Villanueva, JP Kushner, PE Putnam, BK Buckmeier, AH Filipovich, AH Assa'ad, and ME Rothenberg. Anti–IL-5 (mepolizumab) therapy for eosinophilic esophagitis, J Allergy Clin Immunol 2006; 118(6): 1312-9
A. Assa'ad, P. Putnam, M. Collins, R. Akers, S. Jameson, C. Kirb, B. Buckmeier, J. Bullock, A. Collier, M. Konikoff, R. Noel, J. Guajardo, M. Rothenberg, Pediatric patients with eosinophilic esophagitis: An eight-year follow up J Allergy Clin Immunol 2007; 119(3):731-8
Bullock JZ, Villanueva JM, Blanchard C, Filipovich AH, Putnam PE, Collins MH, Risma KA, Akers RM, Kirby CL, Buckmeier BK, Assa'ad AH, Hogan SP, Rothenberg ME. "Interplay of adaptive th2 immunity with eotaxin-3/c-C chemokine receptor 3 in eosinophilic esophagitis." J Pediatr Gastroenterol Nutr 2007; 45(1): 22-31.
Blanchard, C., Wang, N., Stringer, K. S., Mishra, A., Fulkerson, P. C., Abonia, J. P., Jameson, S. C., Kirby, C., Konikoff, M., Collins, M. H., Cohen, M. B., Akers, R., Hogan, S. P., Assa'ad, A. H., Putnam, P. E., Aronow, B. J., and Rothenberg, M. E.: Eotaxin-3/CCL26 and a uniquely conserved gene-expression profile in eosinophilic esophagitis. Journal of Clinical Investigation 116: 536-547, 2006.
Abonia, J.P., Hallgren, J., Jones, T., Shi, T., Xu, Y., Koni, P., Flavell, R.A., Boyce, J.A., Austen, K.F., and Gurish. M.F.: α4 integrins and VCAM-1, but not MAdCAM-1, are essential for recruitment of mast cell progenitors to the inflamed lung. Blood 108: 1588-1594, 2006.
Brandt EB, Zimmermann N, Muntel EE, Yamada Y, Pope SM, Mishra A, Hogan SP, Rothenberg ME. The alpha4beta7-integrin is dynamically expressed on murine eosinophils and involved in eosinophil trafficking to the intestine. Clin Exp Allergy. 2006; 36(4):543-53.
Zimmermann N, Rothenberg ME. The arginine-arginase balance in asthma and lung inflammation. Eur J Pharmacol. 2006; 533(1-3):253-62
Rothenberg ME, Doepker MP, Lewkowich IP, Chiaramonte MG, Stringer KF, Finkelman FD, MacLeod CL, Ellies LG and Zimmermann N. The cationic amino acid transporter 2 regulates inflammatory homeostasis in the lung. Proc Natl Acad Sci USA 2006; 103:14895
Yang M, Rangasamy D, Matthaei KI, Frew AJ, Zimmermann N, Mahalingam S, Webb DC, Tremethick DJ, Thompson PJ, Hogan SP, Rothenberg ME, Cowden WB, Foster PS. Inhibition of arginase I activity by RNA interference attenuates IL-13-induced airways hyperresponsiveness. J Immunol. 2006;177:5595-603.
Bergeron C, Boulet LP, Page N, Laviolette M, Zimmermann N, Rothenberg ME, Hamid Q. Influence of cigarette smoke on the arginine pathway in asthmatic airways: increased expression of arginase I. J Allergy Clin Immunol 2007;119:391-7.
Guo JP, Nutku E, Yokoi H, Schnaar RL, Zimmermann N, Bochner BS. Siglec-8 and Siglec-F: inhibitory receptors on eosinophils, basophils and mast cells. Allergy Clin Immunol Inter – J World Allergy Org 2007;19:54-59.
Risma, K.A., R.W. Frayer, A.H. Filipovich, and J. Sumegi. 2006. Aberrant maturation of mutant perforin underlies the clinical diversity of hemophagocytic lymphohistiocytosis. J Clin Invest. 116: 182-192.
Zhang K, Johnson JA, Biroschak J, Villanueva J, Lee SM, Bleesing JJ, Risma KA, Wenstrup RJ, and AH Filipovich. 2007. Familial haemophagocytic lymphohistiocytosis in patients who are heterozygous for the A91V perforin variation is often associated with other genetic defects. Int J Immunogenet. 34(4):231-3.
Thomas H, Risma KA, Graham TB, Brody AS, Deutsch GH, Young LR, Joseph PM. 2007. A kindred of children with interstitial lung disease. Chest. 132(1):221-30.
Bullock JZ, Villanueva JM, Blanchard C, Filipovich AH, Putnam PE, Collins MH, Risma KA, Akers RM, Kirby CL, Buckmeier BK, Assa'ad AH, Hogan SP, Rothenberg ME. 2007 Interplay of adaptive th2 immunity with eotaxin-3/c-C chemokine receptor 3 in eosinophilic esophagitis. J Pediatr Gastroenterol Nutr. 45(1):22-31.
Spanier A, Lierl MB, Hornung RW. Environmental Exposures and Exhaled Nitric Oxide in Children with Asthma. J. Pediatr. 2006;149:220-6.
Lierl MB. Periodic fever syndromes: A diagnostic challenge for the allergist. In press, Allergy 2007.
