Infectious Diseases

Ming Tan, PhD

Appointment

Instructor

Email

ming.tan@cchmc.org

Phone

513-636-0510

Fax

513-636-7655

Credentials

PhD University of Münster, Münster, Germany, 1997

Position History

Instructor, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 2005-present

Research associate, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 2002-2005

Research fellow, University of Cincinnati, Cincinnati, Ohio, 2000-2002

Postdoctoral fellow, University of Nebraska at Lincoln, Nebraska, 1999-2000

Research scientist, University of Münster, Münster, Germany, 1997-1999

Research

Noroviruses
Human Caliciviruses
Viral Gastroenteritis

Research Grants and Contracts

Translational Research Initiative (Cincinnati Children's Hospital Medical Center)
"Characterization of norovirus P particle as a candidate of antiviral and vaccine against noroviruses"
Principal Investigator
07/2006-06/2007

Presentations

Tan M, Fang PA, Xia M, Chachiyo T, Huang PW, Fang ZY, Jiang W, Jiang X. Noroviral P Particle: Structure, Function and Applications in Virus-Host Interaction, XIV International Congress for Virology, August 12-15, 2008, Istabus, Turkey.

Tan M. Protein-carbohydrate interaction between norovirus and histo-blood group antigen receptors. State of the Art Presentation, 3rd International Caliciviruses conference, November 10-13, 2007. Cancun/Mexico.

Tan M, Xia M, Jiang W, Jiang X. Structural and functional variation of norovirus capsid p domain. The 26th Annual Meeting of American Society for Virology, July of 2007, Corvallis/OR, USA

Tan M, Xia M, Cao S, Rao ZH, Jiang X. The terminal α-fucose and α-N-acetylgalactoseamine/β-galactose of the histo-blood group antigens are partners in norovirus-receptor interaction. The 26th Annual Meeting of American Society for Virology, July of 2007, Corvallis/OR, USA

Tan M, Cao S, Xia M, Jiang W, Li XM, Rao ZH, Jiang X. Norovirus P domain, elucidation of the host-viral interaction and beyond. The 8th international symposium on positive-strand RNA viruses. May 26-30, 2007. Washington DC, USA

Tan M, Xia M, Cao S, Lou ZY, Rao ZH, Jiang X. The major side-chains of human histo-blood group antigens are partners in norovirus-receptor interaction. The 8th international symposium on positive-strand RNA viruses. May 26-30, 2007 Washington DC, USA

Tan M, Meller J, Jiang X. (2006). The C-terminal arginine-cluster is essential for receptor-binding of norovirus capsid protein. The 25th Annual Meeting of American Society for Virology, July of 2006, Madison/WI, USA

Tan M, Jiang X. (2006). A novel antiviral and vaccine against noroviruses: the subviral P particles. University of Cincinnati Showcase 2006, April of 2006, Cincinnati/OH, USA

Tan M, Jiang X. (2005). The p domain of norovirus capsid protein forms icosahedral particles that display enhanced binding to histo-blood group antigen receptors. The XIII International Congress of Virology. July 2005. San Francisco/CA, USA

Tan M, Jiang X. (2005). The P domain of Norovirus capsid protein forms an icosahedral particle that enhances binding to histo-blood group antigen receptors. The 24th Annual Meeting of American Society for Virology, June of 2005, University Park/PA, USA

Publications, Most Recent

Tan M, Farkas T, Jiang X. (2008) Molecular Pathogenesis of Human Norovirus. In: Host Gene Responses to RNA Virus Infection. Yang DC (Eds), World Scientific, Singapore: in press.

Farkas T, Tan M, Jiang X. (2008) Norovirus gastroenteritis. P39-52, In: Emerging Infections 8. Scheld WM, Hammer SW, Hughes JM. (Eds). ASM press, Washington, DC, USA: In press.

Tan M, Jiang X. (2008) The association of histo-blood group antigens with susceptibility to norovirus infection may be strain-specific, instead of genogroup-depedent. Journal of Infectious Diseases, 198: in press.

Bu WM, Mamedova A, Tan M, Xia M, Jiang X, Hegde RS. (2008) Structural basis for the receptor binding specificity of the Norwalk virus. Journal of Virology, 82:5340-5347.

Tan M, Jin M, Duan ZJ, Jiang X, Fang ZY. (2008) Outbreak studies of a GII-3 and a GII-4 norovirus revealed an association between HBGA phenotypes and viral infection. Journal of Medical Virology. 80:1296-1301.

Tan M, Jiang X. (2008) Norovirus gastroenteritis, increased understanding and future antiviral options. Current Opinion in Investigational Drugs. 9: 146-151.

Tan M, Jiang X. (2007) Norovirus-host interaction: implications for disease control and prevention. Expert Review in Molecular Medicine. 9:1-22.

Cao S, Lou ZY, Tan M, Chen YT, Liu YJ, Zhang ZS, Zhang XJ, Jiang X, Li XM, Rao ZH. (2007) Structural basis for specific recognition of blood group trisaccharides by norovirus. Journal of Virology. 81: 5949-5957.

Tan M, Sun XJ, Jiang X. (2006) Norovirus gastroenteritis: New strategies of control and prevention. Touch Briefings: US Special Population Pediatrics Reviews. 2006 Issue 2: 21-24.

Tan M, Meller J, Jiang X. (2006). C-terminal arginine cluster is essential for receptor-binding of norovirus capsid protein. Journal of Virology. 80: 7322-7331.

Tan M, Jiang X (2005). The P domain of Norovirus capsid protein forms subviral particles that bind to histo-blood group antigen receptors.Journal of Virology. 79: 14017-14030.

Tan M, Jiang X (2005). Norovirus and its histo-blood group antigen receptors: an answer to a historical puzzle.Trends in Microbiology. 13: 285-293.

Tan M, Zhong W, Song D, Thornton S, Jiang X. (2004). The E. Coli-expressed recombinant norovirus capsid proteins maintain authentic antigenicity and receptor binding capability.Journal of Medical Virology. 74: 641-649.

Tan M, Hegde R, Jiang X (2004). The P domain of Norovirus capsid protein forms dimer and binds to histo-blood group antigen receptors.Journal of Virology. 78: 6233-6242.