Robert W. Frenck, Jr., MD
Title
Professor of Pediatrics
Appointment
Professor
Email
robert.frenck@cchmc.org
Phone
513-636-4509
Fax
513-636-3959
Bio
Robert W. Frenck, Jr, MD, received his undergraduate degree from the University of California at San Diego in 1977 followed by his doctor of medicine degree from the University of Texas Health Science Center at Houston in 1981. He trained at the National Naval Medical Center in Bethesda, Maryland completing his pediatric residency in 1984. After 3 years as a general pediatrician at the US Naval Hospital, Japan, he entered pediatric infectious disease fellowship training at the University of Texas Health Science Center at Houston which he completed in 1990. Dr. Frenck is board-certified in both pediatrics and infectious diseases.
Dr. Frenck's research interests include therapeutic and vaccine clinical trials with special interest in enteric diseases. After completing a 25 year career in the Navy, Dr. Frenck joined the UCLA Center for Vaccine Research in 2004 and and served until 2006 as Director of the Center and a Professor of Pediatrics at UCLA School of Medicine. Dr. Frenck has been active in the American Academy of Pediatrics and currently serves on the Red Book Committee. He is an acknowledged authority in infectious diseases and has authored over 60 articles and book chapters on various aspects of this subject.
Credentials
BA: University of California at San Diego, San Diego, CA, 1977.
MD: University of Texas Medical School at Houston, Houston, TX, 1981.
Internship and Residency: US Naval Hospital, Bethesda, MD, 1981 - 1984.
Fellowship: Pediatric Infectious Diseases, University of Texas Medical School at Houston, Houston, TX, 1987 - 1990.
Position History
Academic Appointments
Teaching Fellow, Uniformed Services, University of Health Sciences, Bethesda, MD, June 1983 - April 1994.
Chief Resident, Department of Pediatrics, National Naval Medical Center, July 1983 - June 1984.
Clinical Instructor, University of Texas Medical School at Houston, July 1989 - June 1990.
Clinical Assistant Professor of Pediatrics, University of California at San Francisco, July 1991 - June 1993.
Assistant Professor of Pediatrics, Eastern Virginia Medical School, January 1994 – November 1996.
Assistant Professor of Pediatrics, Uniformed Services, University of the Health Sciences, April 1994 - January 1997.
Associate Professor of Pediatrics, Uniformed
Services, University of the Health Sciences, January 1997- present.
Professor of Pediatrics, University of California at Los Angeles, June 2004-present.
Administrative Appointments (current)
Member, Committee on Infectious Diseases, American Academy of Pediatrics
Member, International Affairs Committee, Pediatric Infectious Disease Society (PIDS)
Member, Public Policy Committee, PIDS
Appointments
Staff Pediatrician, US Naval Hospital, Japan, July 1984 - June 1987.
Pediatric Infectious Disease, US Naval Hospital, Oakland, CA, August 1990 - July 1993.
Chairman, Deptartment of Pediatrics, US Naval Hospital, Oakland, CA, July 1992 - June 1993.
Head, Infectious Diseases, Immunization Clinic, Inpatient Pediatrics and Performance Improvement, Department of Pediatrics, Naval Medical Center, Portsmouth, VA, July 1993 - October 1996.
Head, Clinical Investigations Branch, Naval Medical Research Unit #3 (NAMRU-3), Cairo, Egypt, November 1996 – June 1999.
Head, Enteric Disease Research Program, NAMRU-3, July 1999 – June 2004.
Awards and Honors
Magna Cum Laude, University of California at San Diego, June 1977.
Delmer J. Pascoe Award for Outstanding Staff Pediatric Educator, US Naval Hospital Oakland, 1991 - 1992.
13th Annual Naval Hospital Oakland Research Award for Staff Physicians, 1993.
Winner, Best Clinical Research Project, Tri-service Military Pediatric Conference, 1997.
Best Doctors in America, 2008
Research
Enteric diseases; vaccinology
Research Grants and Contracts
Clinical Core, Region IX Center of Excellence on Biodefense, NIAID, June 2005-May 2010, Co-Investigator.
A Phase 3, Randomized, Active-Controlled, Double-blind Trial Evaluating the Safety, Tolerability, and Immunogenicity of 3 Lots of 13-valent Pneumococcal Conjugate Vaccine in Healthy Infants Given With Routine Pediatric Vaccinations in the United States, Sept 2007-Dec 2008, Site PI.
A Phase 3, Randomized, Double-Blind Trial to Evaluate the Safety, Tolerability, and Immunogenicity of a 13 –Valent Pneumoccocal Conjugate Vaccine (13vPnC) when Administered Concomitantly with Trivalent Inactivated Influenza Vaccine in Healthy Adults 50-59 Years of Age who are Naive to 23-Valent Pneumococcal and to Evaluate the Immune Response of a Second Dose of 13vPnC Administered 5 Years After Initial 13vPnC Vaccination Polysaccharide Vaccine, Oct 2007-Dec 2012, Site PI.
A Phase 3, Randomized, Active-Controlled, Modified, Double-Blind Trial to Evaluate the Safety, Tolerability and Immunogenicity of 13-valent Pneumococcal Conjugate Vaccine (13vPnC) When Administered Over 12 Months Either as a Two Dose Regimen or With 23-valent Pneumococcal Polysaccharide Vaccine (23vPS) in Healthy Adults 60-64 Years of Age Who Are Naive to 23vPS, Dec 2007-March 2009, Site PI.
A Phase 3, Open-Label, Randomized, Multi-Center Study to Evaluate the Safety and Immunogenicity of Proquad™ Vaccine When Administered Concomitantly with Novartis Meningococcal ACWY Conjugate Vaccine to Healthy Toddlers, Mar 2008-Mar 2009, Site PI.
Publications, Most Recent
Rao, M.R.; Wierzba, T.F.; Savarino, S.J.; Abu-Elyazeed, R.; El-Ghoreb, N.; Hall, E.R.; Naficy, A.B.; Abdel-Messih, I.; Frenck, R.W.; Svennerholm, A.M.; Clemens, J.D.: Serologic Correlates of Protection against Enterotoxigenic Escherichia coli Diarrhea. JID; 2005; 191:562-570.
Mansour, A.M.; Frenck, R.W.; Darville, T.; Nakhla, I.A.; Wierzba, T.F.; Sultan, Y.; Bassiouny, M.I.; McCarthy, K.; Jacobs, R.F.: Relationship between intracranial granulomas and cerebrospinal fluid levels of interferon-gamma (IFN-) and interleukin-10 (IL-10) in patients with tuberculous meningitis. Clin Diag Lab Immunol; 2005; 12:363-5.
Nakhla, I.; Frenck, R.W.; Teleb, N.A.; El Oun, S.; Sultan, Y.; Mansour, H.; Mahoney, F.: The Changing Epidemiology of Meningococcal Meningitis after Introduction of Bivalent A / C Polysaccharide Vaccine into School-Based Vaccination Programs in Egypt. Vaccine; 2005; 23:3288-93.
Abdel-Messih, I.A.; Wierzba, T.F.; Abu-Elyazeed, R.; Ibrahim, A.F.; Fouad, S.; Kamal, K.A.; Frenck, R.W.: Diarrhea associated with Cryptosporidium parvum among young children of the Nile River Delta in Egypt. J Trop Pediatr; 2005.
Putnam, S.D.; Sanders, J.W.; Tribble, D.R.; Rockabrand, D.R.; Riddle, M.S.; Rozmajzl, P.J.; Frenck, R.W.: Post-Treatment Changes in Escherichia coli Antimicrobial Susceptibility Rates Associated With Diarrhea Among Deployed US Military Persons Treated with Ciprofloxacin. Antimcrob Agents Chemo; 2005; 49:2571-2.
Mansour, A.; Nakhla, I.; El Sherif, I.; Sultan, Y,A.; Frenck, R.W.: Cryptococcus neoformans Var. gattii Meningitis in Egypt; a Case Report. EMRO Health Journal; 2006; 12:241-4.
Wierzba, TF.; Abdel-Messih, I.A.; Abu-Elyazeed, R.; Putnam, S.D.; Kamal, K.A.; Rozmajzl, P.; Fouad, S.A.; Fatah, A.; Zabedy, K.; Shaheen, H.I.; Sanders, J.; Frenck, R.W.: Clinic-Based Surveillance for Bacterial and Rotavirus-Associated Diarrhea in Egyptian Children. Am Soc Trop Med Hyg.; 2006; 74:148-153.
Putnam, S.D.; Sanders, J.W.; Frenck, R.W.; Monteville, M.; Riddle, M.S.; Rockabrand, D.M.; Sharp, T.W.; Frankart, C.; Tribble, D.R.: Self-Reported Description of Diarrhea among Military Populations in Operations Iraqi Freedom and Enduring Freedom. J. Travel Med; 2006; 13:92-99.
Rockabrand, D.M.; Shaheen, H.I.; Putnam, S.D.; Khalil, S.B.; Peruski, L.F.; Rozmajzl, P.J.; Savarino, S.J.; Monteville, M.; Frenck, R.W.; Svennerholm, A.M.; Sanders, J.W.: Enterotoxigenic Escherichia coli Colonization Factor Types Collected from 1997 to 2001 in U.S. Military Personnel during Operation Bright Star in Northern Egypt. Diagn Microbiol Infect Dis; 2006; 55:9-12.
El-Mohamady, H.; Abdel-Messih, I.A.; Youssef, F.G.; Farag, H.; Said, M.; Shaheen, H.I.; Rockabrand, D.M.; Luby, S.P.; Haji, R.; Sanders, J.W.; Monteville, M.R.; Klena, J.D.; Frenck, R.W.: Enteric Pathogens Associated with Diarrhea in Children in Fayoum, Egypt. Diagn Microbiol Infect Dis; 2006; 56:1-5.
Melmed, G.Y.; Ippoliti, A.F.; Papadakis, K.A.; Tran, T.T.; Birt, J.L.; Lee, S.K.; Frenck, R.W.; Targan, S.R.; Vasiliauskas, E.A.: Patients with Inflammatory Bowel Disease are at Risk for Vaccine-Preventable Illnesses. Am J. Gastroenterol; 2006; 101:1834-40.
Frenck, R.W.; Fathy, H.; Sherif, M.; Mohran, Z.; El Mohammedy;Francis, H.W.; Rockabrand, D.; Mounir, B.I.; Rozmajzl, P.; Frierson, H.: Sensitivity and Specificity of Various Tests for the Diagnosis of H. pylori in Egyptian Children. Pediatrics; 2006; 118:e1195-1202.
Monteville, M.R.; Riddle, M.S.; Baht, U.; Putnam, S.D.; Frenck, R.W.; Brooks, K.; Moustafa, M.; Bland, J.; Sanders, J.W.: Incidence, Etiology and Impact of Diarrhea Among Deployed US Military Personnel in Support of Operation Iraqi Freedom and Operation Enduring Freedom. Am Soc Trop Med Hyg; 2006; 75:762-7.
Mansour, A.M.; Nakhla, I.I.; Sultan, Y.A.; Frenck, R.W.: Brucella meningitis, first reported case in Egypt. EMRO Health Journal; 2006; 12:241-4.
Professional Organization Memberships
- Infectious Disease Society of America
- Pediatric Infectious Disease Society
- American Pediatric Society
- American Society of Microbiology
Abstracts
Khalil, S.B.; Shaheen, H.I.; Rockabrand, D.; Rozmajzl, P.; Frenck, R.W.; Peruski, L.F.; Abu-Elyazeed, R.; Savarino, S.J.: Identification of novel adhesins CS19, PCFO39 and PCFO71 in Enterotoxigenic Escherichia coli isolates from Egyptian children with diarrhea.Am Soc Microbiol, 2003; Washington, DC.
Shaheen, H.I.; Khalil, S.B.; Rockabrand, D.; Sanders, J.; Rozmajzl, P.J.; Putnam, S.; Hale, B.; Savarino, S.; Peruski, L.; Pittner, B.; Frenck, R.W.: Enterotoxigenic Escherichia coli Colonization Factor Types Collected from 1989 to 2001 in U.S. Military Personnel during Operation Bright Star in Northern Egypt.Am Soc Microbiol, 2003; Washington, DC.
Rozmajzl, P.J.; El-Nady, T.; McAvin, J.; Rockabrand, D.M.; Welsh, M.; Atchley, D.H.; Putnam, S.D.; Frenck, R.W.: Detection of Campylobacter spp. in Diarrheal Stool Specimens by Real-time Fluorescence PCR in Personnel Assigned to Incirlik Air Force Base, Turkey.Am Soc Microbiol, 2003; Washington, DC.
Rozmajzl, P.J.; Atchley, D.; Rockabrand, D.M.; Welsh, M.; Putnam, S.D.; El-Nady, T.; Sanders, J.; Frenck, R.W.: Detection and Speciation of Campylobacter jejuni and coli in Diarrheal Stool Specimens by TaqMan Real-time Fluorescence PCR.Am Soc Microbiol, 2003; Washington, DC.
El-Mohamady, H.; Francis, W.M.; Rockabrand, D.; Rozmajzl, P.; Wierzba, T.; Frenck, R.: Detection of Enterotoxigenic Escherichia coli-specific Secretory IgA in Breast Milk of Mothers from Abu Homos Egypt.Am Soc Microbiol, 2003; Washington, DC.
Mohran, Z.; Fathy, H.; Hakam, A.; Rockabrand, D.; Rozmajzl, P.; Frenck, R.: Antimicrobial Susceptibility Testing of H. pylori Isolates from Egyptian Children.Am Soc Microbiol, 2003; Washington, DC.
Savarino, S.; Abu-Elyazeed, R.; Rao, M.; Frenck, R.W.; Abdel-Messih, I.; Hall, E.; Putnam, S.; El-Mohamady, H.; Wierzba, T.; Pittner, B.; Kamal, K.; Moyer, P.; Morsy, B.; Svennerholm, A.; Lee, Y.; Clemens, J.: Efficacy of an Oral, Inactivated Whole-Cell Enterotoxigenic E. coli / Cholera Toxin B Subunit Vaccine in Egyptian Infants.National Foundation for Infectious Diseases 6th Annual Conference on Vaccine Research, 2003; Washington DC.
Mansour, A.; Darville, T.; Nakhla, I.; Bassiouny, M.I.; Wierzba, T.; Sultan, Y.A.; El-Shafeey, M.; Abd-El Wahab, M.; Soliman, H.; Riddle, M.; Jacobs, R.F.; Frenck, R.W.: Prognostic criteria of Interferon gamma (INF-g) and Interleukin-10 (IL 10) in granuloma formation in tuberculous meningitis.American Society of Tropical Medicine and Hygiene, 2003; Philadelphia, PA.
Frenck, R.W.; Sterling, L.; Nakhla, I.; Pittner, B.T.; El Mohammdy, H.; Francis, W.; Bassily, S.; Gad El Karim, F.M.; Karnell, A.; El Ghorab, N.; Wierzba, T.; Rao, M.; Lee, J.; Svennerholm, A.M.; Kamal, K.; Clemens, J.; Savarino, S.J.: Phase II Trial of An Oral Enterotoxigenic (ETEC) Vaccine Co-Administered With Routine Childhood Immunizations In Egyptian Infants.American Society of Tropical Medicine and Hygiene, 2003; Philadelphia, PA.
Riddle, M.S.; Sanders, J.W.; Putnam, S.D.; Tribble, D.R.; Rozmajzl, P.J.; Rockabrand, D.M.; Frenck, R.W.: Campylobacter Infection at the 'Tip of the Spear': A Case Series Study among Deployed US Military Personnel to Incirlik Air Base, Turkey.American Society of Tropical Medicine and Hygiene, 2003; Philadelphia, PA.
Sanders, J.W.; Tribble, D.R.; Putnam, S.D.; Riddle, M.S.; Kilbane, E.; Fox, A.; Ruck, R.; Murphy, E.; Lim, M.; Johnston, J.; Rozmajzl, P.J.; Rockabrand, D.M.; Villanueva, P.D.; Frenck, R.W.: Traveler's Diarrhea among Deployed U.S. Military Personnel Assigned to Incirlik Air Base, Turkey.American Society of Tropical Medicine and Hygiene, 2003; Philadelphia, PA.
Nakhla, I.; Mansour, A.; Bassiouny, M.I.; Sultan, Y.A.; Frenck, R.W.: Natural History of Cerebral Granulomas during Treatment for TB Meningitis. American Society of Tropical Medicine and Hygiene, 2003; Philadelphia, PA.
Fathy, H.; Sherif, M.; Mohran, Z.; El-Mohammady, H.; Francis, W.; Rockabrand, D.; Rozmajzl, P.; Frierson, H.; Frenck, R.W.: Comparison of Invasive and Non-Invasive Tests for the Diagnosis of H. pylori in Egyptian Children.XVIth International Workshop on Gastrointestinal Pathology and Helicobacter, 2003; Stockholm, Sweden.
Frenck, R.W.; Mansour, A.; Nakhla, I.; Sultan, Y.; Putnam, S.; Wierzba, T.; Morsy, M.; Knirsch, C.: Five Days of Azithromycin for the Treatment of Uncomplicated Typhoid Fever in Children and Adolescents.Infectious Disease Society of America, 2003; San Diego, CA.
Wierzba, T.F.; Abdel-Messih, I.A.; Hindawi, A.S.; Gharieb, B.A.; Putnam, S.; Rozmajzl, P.; Frenck, R.W.: Campylobacter Infection and Guillain-Barré Syndrome in Egypt.Infectious Disease Society of America, 2003; San Diego, CA.
Putnam, S.D.; Sanders, J.; Riddle, M.S.; Rockabrand, D.; Rozmajzl, P.; Frenck, R.W.: Post-Treatment Dynamics of Antimicrobial Susceptibility in Escherichia coli Associated With Travelers' Diarrhea among US Military. Am Soc Microbiol; 2004.
El-Nady, T.; Censini, S.; Fathy, H.; Rockabrand, D.; Gianfaldoni, C.; Ruggiero, P.; Del Giudice, G.; Frenck, R.W.: Genetic Virulence Profile of Helicobacter pylori from a Pediatric Egyptian Population. Am Soc Microbiol, 2004; New Orleans, LA.
Shaheen, H.I.; Khalil, S.B.; Rockabrand, D.; Sanders, J.W.; Rozmajzl, P.J.; Savarino, S.J.; Frenck, R.W.: Three Year Hospital Surveillance: Phenotypic Analysis of ETEC Strains Inducing Diarrhea in Egyptian Children.Am Soc Microbiol, 2004; New Orleans, LA.
El-Mohamady, H.; Shaheen, H.I.; Rockabrand, D.; Abdel-Messih, I.A.; Sanders, J.W.; Youssef, F.G.; Luby, S.P.; Said, M.; Monteville, M.W.; Frenck, R.W.: Surveillance for Enteric Pathogens Associated with Diarrhea in Children in Fayoum, Egypt: A Pilot Study.Am Soc Microbiol, 2004; New Orleans, LA.
Books
Frenck, R.W.; Pickering, L.K.: Campylobacter. In Principles and Practices of Pediatrics, 1st Edition; JB Lippincott Co., pp. 1074-1077, 1990.
Frenck, R.W.: Infection complications in patients with cancer. In MD Anderson Manual of Oncology for House Officers; Little Brown & Co., pp. 143-156, 1989.
Frenck, R.W.; Kohl, S.; Pickering, L.K.: Infections in children with cancer.In Clinical Pediatric Oncology, 4th edition; CV Mosby Company, 1991.
Frenck, R.W.; Kohl, S.: Herpes simplex virus.In Infections in Immunocompromised Infants and Children, 1st edition; Marcel Dekker, Inc., pp. 603-624, 1992.
Ruiz-Palacido, G.M.; Frenck, R.W.; Pickering, L.K.: Campylobacter and helicobacter.In Principles and Practice of Pediatrics, 2nd Edition; JB Lippincott Co., pp. 1173-1177, 1994.
Frenck RW, Buescher, E.S.: Musculoskeletal injuries and treatment of trauma.In Pediatric Tests and Procedures; W.B. Saunders Co., 1996.
Frenck, R.W.; Ericsson, C.D.: Protection in Travelers.In Pediatric Infectious Diseases; Churchill Livingstone Co., 1996.
Abdel Messih, I.; Frenck, R.W.: Protection in Travelers.In Pediatric Infectious Diseases; Churchill Livingstone Co., 2001.
Presentations, Most Recent
Frenck, R.W.: Treatment of Gastrointestinal Infections. Presented at the 3rd World Congress of Pediatric Infectious Diseases; 2002; Santiago, Chile.
Frenck, R.W.: Research Opportunities in the Military. Presented at the Armed Forces Infectious Disease Society; 2005; Honolulu, Hawaii.
Related Areas
This person works in these other areas at Cincinnati Children's Hospital Medical Center:
