Faculty

Jens W. Goebel, MD

Associate Professor of Pediatrics; Medical Director of Kidney Transplantation

Education and Training

MD University of Heidelberg (Germany)
Residency and Chief Residency Deptartment of Pediatrics, University of South Alabama
Fellowship Section of Pediatric Nephrology, Tulane University Medical Center
Certifications General Pediatrics, Pediatric Nephrology

Research Interests

Immunology

Special Interests

Pediatric kidney transplantation

Funding

Ongoing

NIH RO1 CD40 Ligand Dyregulation and HIV Pathogenesis
(PI: Claire Chougnet, PhD, Division of Molecular Immunology, Cincinnati Children's Hospital, 5% effort funded for 3 out of 5 total years beginning 01/01/05)

NIH KO8 The Cytoskeleton, Rafts and the Interleukin-2 Receptor
$332,250.00 total for 3 years beginning 06/01/03

Roche Pharmaceuticals: Development of Population Pharmacokinetic models of Mycophenolic Acid for use in Bayesian Dose Individualization in Pediatric Kidney Transplant Patients
(Co-I, PI: Sander Vinks, PhD; approved for funding in mid-2004)

Cincinnati Children's Hospital Medical Center Translational Research Initiative:
Statin Therapy for Pediatric Kidney Transplant Recipients — Molecular Basis of Cardiovascular and Immunological Effects
$50,000.00 beginning 07/01/03

Completed

Roche Pharmaceuticals: Molecular Mechanisms of Immunomodulation Affected by Daclizumab in Kidney Transplant Recipients
$37,895.00 total (completed in 2004)

National Kidney Foundation Young Investigator: Characterization of the Enrichment of the Interleukin-2 Receptor ß-Chain in Membrane Rafts of Human T-Cells
$65,000.00 total from 07/01/01 to 12/31/03

University of Kentucky Physician Scientist Award: The Cytoskeleton and Interleukin-2 Signal Transduction in T Lymphocytes
07/01/00 to 11/30/02

Publications, Most Recent

Ray P, Acheson D, Chitraker R, Cnaan A, Gibbs K, Hirschman GH, Christen E, Trachtman H, and the Investigators of the Hemolytic Uremic Syndrome-Synsorb PK Multicenter Trial (2002) Basic fibroblast growth factor among children with diarrhea-associated hemolytic uremic syndrome. J Am Soc Nephrol 13:699-707 (listed as local center PI in appendix).

Goebel J, Forrest K, Morford L, Roszman TL (2002) Differential Localization of IL-2- and -15 Receptor Chains in Membrane Rafts of Human T Cells. J Leukocyte Biol 72:199-206

Morford LA, Forrest K, Logan B, Overstreet LK, Goebel J, Brooks WH, Roszman TL (2002) Calpain II colocalizes with detergent-insoluble rafts on human and Jurkat T-cells. Biochem Biophys Res Comm 295:540-6.

Goebel J, Forrest K, Flynn D, Rao R, Roszman TL (2002) Lipid rafts, MHC Molecules and Immune Regulation. Human Immunology 63:813-20

Jensen S, Jackson EC, Simpson L, Reddy S, Goebel J (2003) Tacrolimus-Based Immunosuppression with Steroid Withdrawal in Pediatric Kidney Transplantation - 4-Year Experience at a Moderate-Volume Center. Pediatr Transplantation 7:119-24

Trachtman H, Frank R, Mahan JD, Portman R, Restaino I, Matoo TK, Tou C, Klibaner M (2003) Clinical trial of extended-release felodipine in pediatric essential hypertension. Pediatr Nephrol 18:548-53 (listed as local center PI in appendix)

Rao R, Forrest K, Logan B, Roszman TL, Goebel J (2004) Lipid Rafts in Cytokine Signaling. Cytokine and Growth Factor Reviews 15:103-10

Forrest K, Logan B, Strange J, Roszman TL, Goebel J (2005) Daclizumab Therapy in Kidney Transplantation - Different Mechanisms of Action in- versus ex-vivo? Transplant Immunology 14 (1):43-7

Mitsnefes MM, Subat-Dezulovic M, Khoury PR, Goebel J, Strife CF Increased Incidence of Anemia After Kidney Transplantation In Children: Does It Affect Graft Survival? (in press, American Journal of Transplantation)

Presentations, Most Recent

Grand Round presenter (Pediatric Kidney Transplantation) and Fellows' Day discussant, Arkansas Children's Hospital, Little Rock, AK, 05/07 to 08/01.

Speaker at the 2nd Regensburg Immunology Meeting on Soluble MHC, Immunoregulation and Tolerance in Transplantation, 03/15 to 16/02, Regensburg (Germany): Lipid rafts in immunoregulation and their relationship with MHC molecules.

Invited speaker at "Issues in Transplantation and Organ Procurement," Nashville, TN, 05/02 to 03/02, Kidneys for Kids, and 05/01 to 02/03, Everything You Always Wanted to Know About Immunosuprression But Were Afraid to Ask.

Grand Round presenter and pediatric nephrology lecturer, Nephrotic Syndrome in Children; Acute Renal Failure in Children; Congenital Hydronephrosis, Department of Pediatrics, University of South Alabama, Mobile, AL, 06/11 to 13/02.