Faculty

Larry Patterson, MD

Research Assistant Professor

Education and Training

  • BA, Gettysburg College
  • MD, Pennsylvania State University
  • Pediatrics, Children's Hospital, Columbus
  • Pediatric Nephrology, Children's National Medical Center, Washington
  • Research Fellowship, National Institutes of Health, Bethesda

Clinical Interests

Congenital anomalies of the urinary tract

Research Interests

Dr. Patterson is broadly interested in genes expressed during urinary tract development, and the possible role of such genes in kidney anomalies. He is specifically studying the developmentally expressed genes of the Hox family. Abnormalities of those genes are associated with a variety of defects, including some in the urinary tract. Dr. Patterson is working with other scientists in the CHRF, using transgenic mice to study the function of these genes.

Representative Recent Publications

  • Erkan E, Garcia CD, Patterson LT, Mishra J, Mitsnefes MM, Kaskel FJ, Devarajan P. (2005) Induction of renal tubular cell apoptosis in focal segmental glomerulosclerosis: roles of proteinuria and Fas-dependent pathways. J Am Soc Nephrol 16:398-407.
  • Potter SS, Brunskill EW, Huntsman B, Patterson LT (2004). Use of gene chips to define genetic pathways. Handbook of stem cells. Boston, Elsevier Academic. 1: 581-587.
  • Schwab K, Witte DP, Aronow BJ, Devarajan P, Potter SS, Patterson LT. (2004) Microarray analysis of focal segmental glomerulosclerosis. Am J Nephrol 24:438-47.
  • Bock GH, Ongkingco JR, Patterson LT, Ruley EJ, Schroepfer LR, Nelson DL. Serum and urine soluble interleukin-2 receptor in idiopathic nephrotic syndrome. Pediatr Nephrol 7:523-528, 1993.
  • Dressler GR, Wilkinson JR, Rothenpieler UW, Patterson LT, Williams-Simons L, Westphal H. Deregulation of Pax-2 expression in transgenic mice generates severe kidney abnormalities. Nature 362:65-67, 1993.
  • Bock GH, Neu L, Long C, Patterson LT, Korb S, Gelpe J, Light J, Nelson DL. Plasma and urine soluble interleukin-2 receptor levels have clinical value in renal transplantation. Am J Kidney Dis 23:421-426, 1994.
  • Patterson LR, Dressler GR. The regulations of kidney development: new insights from an old model. Current Opinion in Genetics and Development 4:696-702, 1994.
  • Cho EA, Patterson LT, Brookhiser WT, Mah S, Kintner C, Dressler GR. Differential expression and regulation of cadherins during renal epithelium development. Development 125:803-12, 1998.
  • Patterson LT, Strife, CF. Acquired versus congenital scarring after childhood urinary tract infection. J Pediatr 136:2-4, 2000.
  • Patterson LT, Pembaur M and Potter SS. Hoxa 11 and Hoxd 11 regulate branching morphogenesis of the ureteric bud in the developing kidney. Development 128:2153-2161, 2001.
  • Valerius MT, Patterson LT, and Potter SS. Microarray analysis of novel cell lines representing two stages of metanephric mesenchyme differentiation. Mech Dev 112:219-232, 2002.
  • M. Todd Valerius1,2, Larry T. Patterson3, Yuxin Feng1, and S. Steven Potter1. Hoxa 11 is upstream of Integrin a8 expression in the developing kidney. *PNAS, 2002.