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Faculty

Antigen Presentation

Robert Colbert, MD, PhD
Dr. Colbert's laboratory studies immunological mechanisms underlying pathogenesis of auto-inflammatory diseases, in particular the role of HLA-B27 in susceptibility to spondyloarthropathies. Effects of protein misfolding on antigen presenting cells and the innate immune response are being studied.
Thomas A. Griffin, MD, PhD
Dr. Griffin's research focuses on the cellular and molecular biology of immunoproteasomes. Specific areas of interest include the molecular mechanisms that regulate immunoproteasome biosynthesis and the non-antigen presenting functions of immunoproteasomes in T cells.
Michael Jordan, MD
Dr. Jordan's lab is studying the mechanisms by which the adaptive immune response is initiated and controlled; we focus on two areas: 1) we have developed an animal model of a rare but deadly condition called hemophagocytic lymphohistiocytosis (HLH); 2) we are interested in how immune responses are initiated by vaccination, particularly in the context of cancer immunotherapy.
John Monaco, PhD
Dr. Monaco's laboratory studies the moleular mechanisms of antigen processing and presentation to T cells. The primary focus is on the specificity and biochemistry of proteasomes, and the role of Interferon-inducible proteasome subunits in the Major Histocompatibility Complex (MHC) class I antigen processing pathway.
Ramu Subbramanian, PhD
Dr. Subbramanian's lab focuses on immunological mechanisms underlying the generation of optimal host responses against the mutable RNA viruses, influenza and HIV. The lab also interfaces with ongoing clinical trials of novel vaccine approaches to emerging pathogens such as avian influenza. Laboratory research interests include: 1) novel influenza vaccination approaches geared toward generating optimal cross protection in the mouse model; 2) characterization of candidate avian influenza vaccine immunogenicity in humans; and 3) novel vaccine vector design and delivery modalities for mutable viral models.
Marsha Wills-Karp, PhD
Dr. Wills-Karp's research focuses on defining the genetic, environmental and immunological basis of allergic diseases including asthma. Specific areas of interests include: the role of T cells and cytokines in the pathogenesis of allergic disease; the role of environmental exposures (viruses, pollutants) on the development of allergic asthma; the identification of susceptibility genes for asthma; and the role of the innate immune system in asthma pathogenesis.