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Faculty

Asthma and Allergy

Asthma and Allergy Slide
Fred Finkelman, MD
Dr. Finkelman is interested in cytokine biology, including regulation of cytokine responses and cytokine roles in allergy, asthma, autoimmunity, and infectious diseases.
Gurjit Hershey, MD, PhD
Dr. Khurana Hershey's laboratory focuses on the genetics and development of atopic diseases including asthma. The research centers on identifying atopy susceptibility genes, and dissecting the molecular mechanisms underlying the development of allergic diseases, with a specific focus on cytokine receptors and signaling pathways.
Simon Hogan, PhD
Dr. Hogan's laboratory is focused on elucidating cellular and molecular mechanisms involved in the recruitment and effector function of eosinophils in the gastrointestinal tract. The goal of the research is to identify novel pharmaceutical targets for the treatment of patients with eosinophil-associated gastrointestinal disorders (EGID) including food allergy, eosinophilic gastroenteritis, allergic colitis and inflammatory bowel disease.
Marc E. Rothenberg, MD, PhD
Dr. Rothenburg is involved with studying the molecular and cellular basis for allergic responses, the role of chemokines in inflammation, and novel therapeutic intervention strategies in patients with allergic disorders.
Marsha Wills-Karp, PhD
Dr. Wills-Karp's research focuses on defining the genetic, environmental and immunological basis of allergic diseases including asthma. Specific areas of interests include: the role of T cells and cytokines in the pathogenesis of allergic disease; the role of environmental exposures (viruses, pollutants) on the development of allergic asthma; the identification of susceptibility genes for asthma; and the role of the innate immune system in asthma pathogenesis.
Nives Zimmermann, MD
Dr. Zimmermann's laboratory is focused on genetic and biochemical characterization of the CC chemokine receptor 3 (CCR3). CCR3, the eotaxin receptor, is a major receptor involved in regulating eosinophil trafficking in allergic responses. In one set of studies, her research has shown that treatment of eosinophils with CCR3 ligands results in marked internalization of the receptor into the early endosome compartment. The mechanism and functional consequences of this ligand-induced internalization are currently under investigation.