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Faculty

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Innate Immunity and Inflammation

Julio Aliberti, PhD
Dr. Aliberti's lab has two main lines of research: 1) The mechanisms of microbial recognition by innate immune system via Toll-like receptors and G-protein-coupled receptors and their role on mediating protective immunity to infection; 2) The role of Lipoxins and other anti-inflammatory lipid mediators in controlling induction of pro-inflammatory responses during infectious diseases.
Charles Caldwell, PhD
Dr. Caldwell's lab focuses on three projects: 1) the role of hypoxia inducible factor during sepsis; 2) the role of adenosine following thermal injury; and 3) developing a predictive system for humans for infections following trauma utilizing biomarkers as well as leukocyte function.
David Glass, MD
Dr. Glass' research focus is autoimmunity, especially of the chronic rheumatic diseases of childhood with the application of high throughput genomic and functional genomic methodologies.
Kasper Hoebe, PhD
Dr. Hoebe's laboratory applies a forward genetic approach using ENU mutagenesis to dissect the host immune system. Particularly, we aim to identify genes that are necessary for the immune response against invading pathogens and/or that are required for the innate-adaptive connection. Ultimately, we aim to improve our understanding of host-pathogene interaction and identify what genes are required to optimal cell-mediated or humoral responses.
Edith Janssen, PhD
Dr. Janssen's laboratory’s research aims to define the molecular and cellular mechanisms in DCs that balance the pro- and anti-inflammatory immune response to self after cell death, with the goal of translational exploitation of these mechanistic insights in order to devise effective therapeutic and preventive cancer vaccines.
Xi Jiang, PhD
Dr. Jiang's laboratory is interested in research on enteric viruses causing acute gastroenteritis in humans, particularly the human caliciviruses, including Norovirus and Sapovirus, and the human rotaviruses. His laboratory also is involved in research on the role of human milk in protection of infants from infection of these viruses.
Christopher Karp, MD
Dr. Karp's lab focuses on understanding the molecular mechanisms responsible for the regulation and dysregulation of immune responses in infectious and autoimmune human diseases.
Simon L. Newman, PhD
Dr. Newman's research focuses on innate immunity to fungi, particularly Histoplasma capsulatum. His studies are specifically aimed toward understanding the biology and biochemistry of the interaction between Histoplasma yeasts and macrophages and dendritic cells.
Marc E. Rothenberg, MD, PhD
Dr. Rothenburg is involved with studying the molecular and cellular basis for allergic responses, the role of chemokines in inflammation, and novel therapeutic intervention strategies in patients with allergic disorders.
Timothy E. Weaver, PhD
Dr. Weaver's work is to understand the structural basis for surfactant protein function and to identify the roles of these proteins in lung development and postnatal pulmonary physiology. These goals are achieved by expressing mutated/deleted surfactant protein transgenes in knockout mice and evaluating pathophysiologic changes associated with a specific mutation or loss of functional domain.
Marsha Wills-Karp, PhD
Dr. Wills-Karp's research focuses on defining the genetic, environmental and immunological basis of allergic diseases including asthma. Specific areas of interests include: the role of T cells and cytokines in the pathogenesis of allergic disease; the role of environmental exposures (viruses, pollutants) on the development of allergic asthma; the identification of susceptibility genes for asthma; and the role of the innate immune system in asthma pathogenesis.
Nives Zimmermann, MD
Dr. Zimmermann's laboratory is focused on genetic and biochemical characterization of the CC chemokine receptor 3 (CCR3). CCR3, the eotaxin receptor, is a major receptor involved in regulating eosinophil trafficking in allergic responses. In one set of studies, her research has shown that treatment of eosinophils with CCR3 ligands results in marked internalization of the receptor into the early endosome compartment. The mechanism and functional consequences of this ligand-induced internalization are currently under investigation.