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Faculty

Lymphocyte Biology

Claire A. Chougnet, PhD
Dr. Chougnet studies the interactions between antigen-presenting cells and T cells, with a special focus on the pathogenesis of the infection by the Human Immunodeficiency Virus.
George Deepe, MD
Dr. Deepe's research program involves an analysis of the protective immune response to the pathogenic fungus, Histoplasma capsulatum. His lab endeavors to determine the influence of cytokines and T cell subpopulations on host control of the fungus.
Rodney DeKoter, PhD
Dr. DeKoter's laboratory studies transcription factors that regulate the development and function of the immune system
Fred Finkelman, MD
Dr. Finkelman is interested in cytokine biology, including regulation of cytokine responses and cytokine roles in allergy, asthma, autoimmunity, and infectious diseases.
Thomas A. Griffin, MD, PhD
Dr. Griffin's research focuses on the cellular and molecular biology of immunoproteasomes. Specific areas of interest include the molecular mechanisms that regulate immunoproteasome biosynthesis and the non-antigen presenting functions of immunoproteasomes in T cells.
H. Leighton Grimes, PhD
Dr. Grimes' work centers on the Growth factor independence-1 transcription factor. We will be pursuing the activation of the Gfi1 gene by signals from the Interleukin-7 receptor, and how Gfi1 then regulates the IL7Ralpha gene.
David Hildeman, PhD
Dr. Hildeman is studying the molecular biology of antigen-specific T cells and mechanisms involved in T cell homeostasis, immunity and autoimmunity.
Jonathan D. Katz, PhD
Dr. Katz is conducting studies on the role of T cells in autoimmune diabetes through the application of standard immunological methods to transgenic and gene-targeted NOD mice and through the use of functional genomics and proteomics.
Joerg Koehl, MD
Dr. Koehl's laboratory is focused on the role of the complement system in bridging innate to adaptive immunity. The projects center on models of allergic asthma and autoimmune diseases.
John Monaco, PhD
Dr. Monaco's laboratory studies the moleular mechanisms of antigen processing and presentation to T cells. The primary focus is on the specificity and biochemistry of proteasomes, and the role of Interferon-inducible proteasome subunits in the Major Histocompatibility Complex (MHC) class I antigen processing pathway.
Ramu Subbramanian, PhD
Dr. Subbramanian's lab focuses on immunological mechanisms underlying the generation of optimal host responses against the mutable RNA viruses, influenza and HIV. The lab also interfaces with ongoing clinical trials of novel vaccine approaches to emerging pathogens such as avian influenza. Laboratory research interests include: 1) novel influenza vaccination approaches geared toward generating optimal cross protection in the mouse model; 2) characterization of candidate avian influenza vaccine immunogenicity in humans; and 3) novel vaccine vector design and delivery modalities for mutable viral models.
Marsha Wills-Karp, PhD
Dr. Wills-Karp's research focuses on defining the genetic, environmental and immunological basis of allergic diseases including asthma. Specific areas of interests include: the role of T cells and cytokines in the pathogenesis of allergic disease; the role of environmental exposures (viruses, pollutants) on the development of allergic asthma; the identification of susceptibility genes for asthma; and the role of the innate immune system in asthma pathogenesis.
Nives Zimmermann, MD
Dr. Zimmermann's laboratory is focused on genetic and biochemical characterization of the CC chemokine receptor 3 (CCR3). CCR3, the eotaxin receptor, is a major receptor involved in regulating eosinophil trafficking in allergic responses. In one set of studies, her research has shown that treatment of eosinophils with CCR3 ligands results in marked internalization of the receptor into the early endosome compartment. The mechanism and functional consequences of this ligand-induced internalization are currently under investigation.