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Faculty

Receptors and Cell Signaling

Rhonda Cardin, PhD
Dr. Cardin's lab focuses on understanding the virus-host interactions that are important for CMV pathogenesis and immunological control of long term latent CMV infection. CMV encodes viral homologs to host proteins (such as IL-10, TNF, chemokine receptors) that interfere with the host immune response by immune evasion or by mimicry. Understanding the advantages provided by 'hijacking' of host proteins by CMV will lead to the development of effective vaccine strategies.
Monica Chiaramonte, PhD
Dr. Chiaramonte studies the immunological mechanisms underlying the pathogenesis of lung fibrosis and identifies components of both innate and adaptive immunity involved in fibrotic processes.
Fred Finkelman, MD
Dr. Finkelman is interested in cytokine biology, including regulation of cytokine responses and cytokine roles in allergy, asthma, autoimmunity, and infectious diseases.
H. Leighton Grimes, PhD
Dr. Grimes' work centers on the Growth factor independence-1 transcription factor. We will be pursuing the activation of the Gfi1 gene by signals from the Interleukin-7 receptor, and how Gfi1 then regulates the IL7Ralpha gene.
David Hildeman, PhD
Dr. Hildeman is studying the molecular biology of antigen-specific T cells and mechanisms involved in T cell homeostasis, immunity and autoimmunity.
Joerg Koehl, MD
Dr. Koehl's laboratory is focused on the role of the complement system in bridging innate to adaptive immunity. The projects center on models of allergic asthma and autoimmune diseases.
Marc E. Rothenberg, MD, PhD
Dr. Rothenburg is involved with studying the molecular and cellular basis for allergic responses, the role of chemokines in inflammation, and novel therapeutic intervention strategies in patients with allergic disorders.
Marsha Wills-Karp, PhD
Dr. Wills-Karp's research focuses on defining the genetic, environmental and immunological basis of allergic diseases including asthma. Specific areas of interests include: the role of T cells and cytokines in the pathogenesis of allergic disease; the role of environmental exposures (viruses, pollutants) on the development of allergic asthma; the identification of susceptibility genes for asthma; and the role of the innate immune system in asthma pathogenesis.