Cincinnati Children's Hospital Medical Center Logo

Faculty

Loading...

Tumor and Transplantation Immunology

Sunil K. Chatterjee, PhD
Dr. Chatterjee's laboratory is interested in construction and testing of cancer vaccines. Based on the structures of tumor-associated antigens, they have prepared a number of tumor vaccines and are testing these vaccines for their anti-tumor efficacy and studying the mechanism of induction of anti-tumor immunity. The vaccines with high potential will be tested in clinical trials.
Kasper Hoebe, PhD
Dr. Hoebe's laboratory applies a forward genetic approach using ENU mutagenesis to dissect the host immune system. Specifically, we aim to identify genes that are necessary for the immune response against invading pathogens and/or that are required for the innate-adaptive connection. Ultimately, we aim to improve our understanding of host-pathogene interaction and identify what genes are required to optimal cell-mediated or humoral responses.
Edith Janssen, PhD
Dr. Janssen's laboratory aims to define the molecular and cellular mechanisms in DCs that balance the pro- and anti-inflammatory immune response to self after cell death, with the goal of translational exploitation of these mechanistic insights in order to devise effective therapeutic and preventive cancer vaccines.
Michael Jordan, MD
Dr. Jordan's lab is studying the mechanisms by which the adaptive immune response is initiated and controlled; we focus on two areas: 1) we have developed an animal model of a rare but deadly condition called hemophagocytic lymphohistiocytosis (HLH); 2) we are interested in how immune responses are initiated by vaccination, particularly in the context of cancer immunotherapy.
Alex Lentsch, PhD
Regulation of inflammatory responses by cytokines, chemokines and adhesion molecules; mechanisms governing angiogenesis in prostate tumors.