Cancer Biology
Cancer
- Germ cell tumors
- Leukemia
- Lymphoma
- Intestinal neoplasia
- Medulloblastoma
- Rhabdomyosarcoma
- Neuroblastoma
- Neurofibromatosis
- Cervical cancer
View a complete list of the diseases that our students and faculty are fighting.
Cancer is the leading cause of death in the United States
Researchers in this group investigate how genetic and environmental factors result in cancer through disruption of cellular growth control and organismal development.
Collaborative work involving clinicians and laboratory scientists allows access to normal and cancerous human tissues and fosters the development of clinical trials.
Faculty
- Timothy Cripe, MD, PhD, Associate Professor
- Reciprocal enhancement of gene transfer by combinational adenovirus transduction and plasmid DNA transfection in vitro and in vivo human gene therapy [Visit the Cripe Lab]
- Jay Degen, PhD, Professor
- The role of hemostatic factors and coupled signaling systems in development, inflammatory response, vessel wall disease and tumor biology [Visit the Degen Lab]
- Sandra Degen, PhD, Professor
- Molecular genetics of growth factors and blood coagulation proteins
- Brian Gebelein, PhD, Assistant Professor
- Patterning of the nervous and digestive systems during development [Visit the Gebelein Lab]
- Hartmut Geiger, PhD, Assistant Professor
- Hematopoietic stem cell biology: Combining genetics and molecular biology to investigate DNA repair in hematopoietic stem cells and regulation of stem cell mobilization
- Rashmi Hegde, PhD, Associate Professor
- Structural biology of proteins in embryonic cellfate determination, and proteins involved in the life- and infection-cycles of the cancer-associated papillomaviruses [Visit the Hegde Lab]
- Xinhua Lin, PhD, Tenured, Associate Professor
- Molecular mechanisms of cell - cell signaling in Drosophila
- James C. Mulloy, PhD, Assistant Professor
- Molecular mechanisms involved in leukemia induction and maintenance; mouse modeling of leukemia using primary human blood stem cells [Visit the Mulloy Lab]
- Daniel Nebert, MD, Professor
- Regulation of genes, encoding receptors and drug-metabolizing enzymes important in drug - and environmental - induced toxicity and teratogenesis
- Nancy Ratner, PhD, Professor
- The peripheral nerve in development and disease [Visit the Ratner Lab]
- Peter Stambrook, PhD, Professor
- Mutation and genomic instability in progession to cancer; gene therapy as a therapeutic tool for cancer
- Susan Waltz, PhD, Associate Professor
- Molecular analysis of growth factors and receptor tyrosine kinases in tumorigenesis, organ function, and cellular trauma
- Susanne Wells, PhD, Assistant Professor
- Papilloma virus and cervical cancer [Visit the Susanne Wells Lab]
- Christopher Wylie, PhD, Professor
- (1) Control of the cytoskeleton, control of cell migration and control of early cell lineage specification, in vertebrate embryos (2) Control of gonad formation, primordial germ cell migration, oocyte maturation and egg formation [Visit the Wylie-Heasman Lab]
- Yi Zheng, PhD, Professor
- Molecular mechanisms of Rho GTPase signal transduction. Development of novel therapeutic reagents to inhibit Rho pathways related to human pathological conditions
For more information about the Molecular and Developmental Biology Program at Cincinnati Children's and the University of Cincinnati, email mdbprog@cchmc.org or call 513-636-4545. You can also apply online at our application page.
