Genetics and Gene Therapy
Genetic Conditions and Therapies
- Allergic disorders
- Asthma
- Atrial septal defect
- Attention deficit
- Bipolar disorder
- Cancer (Sarcomas, Neuroblastoma, Malignant Peripheral Nerve Sheath Tumors)
- Cardiac arrhythmias (Av Block, Sick Sinus Syndrome, Ventricular Tachycardia)
- Cardiac hypertrophy
- Cleft-Lip-and-Palate
- Cystic fibrosis
- Deafness
- Dilated cardiomyopathy
- Ebola Virus Hemorrhagic Fever
- Eczema
- Eye disorders
- Food allergy
- Heart failure
- Hepatitis
- Hydronephrosis
- Hyperactivity disorder
- Hypertrophic cardiomyopathy
- Inflammation
- Intestinal neoplasia & metaplasia
- Leukemia / Lymphoma
- Measles
- Multiple sclerosis
- Muscular dystrophy
- Neuromuscular disorders
- Obessive-Compulsive Disorder
- Proximal Tubular Acidosis
- Renal Fanconi Syndrome
- Schizophrenia
- Sepsis
- Short-bowel syndrome
- Substance abuse
- Valvular heart disease (Aortic Stenosis and Ebstein Anomaly of the tricuspid valve)
- Viral pathogenesis
View a complete list of the diseases that our students and faculty are fighting.
Researchers at CCHMC apply molecular technologies to the elucidation of disease mechanisms, and to the development of treatment for heritable diseases and inherited disease susceptibilities.
Gene Therapy research focuses on developing and improving gene transfer technology to treat childhood diseases at the genetic level.
Faculty
- Paul Andreassen, PhD, Assistant Professor
- Fanconi anemia and breast cancer susceptibility proteins in DNA damage responses and genetic stability [Visit the Andreassen lab]
- Timothy Cripe, MD, PhD, Associate Professor
- Reciprocal enhancement of gene transfer by combinational adenovirus transduction and plasmid DNA transfection in vitro and in vivo human gene therapy [Visit the Cripe Lab]
- Jay Degen, PhD, Professor
- The role of hemostatic factors and coupled signaling systems in development, inflammatory response, vessel wall disease and tumor biology [Visit the Degen Lab]
- Sandra Degen, PhD, Professor
- Molecular genetics of growth factors and blood coagulation proteins
- Hartmut Geiger, PhD, Assistant Professor
- Hematopoietic stem cell biology: Combining genetics and molecular biology to investigate DNA repair in hematopoietic stem cells and regulation of stem cell mobilization
- Gregory Grabowski, MD, Professor
- Molecular pathogenesis and therapy of human genetic disease
- Rashmi Hegde, PhD, Associate Professor
- Structural biology of proteins in embryonic cellfate determination, and proteins involved in the life- and infection-cycles of the cancer-associated papillomaviruses [Visit the Hegde Lab]
- Xinhua Lin, PhD, Tenured, Associate Professor
- Molecular mechanisms of cell - cell signaling in Drosophila
- Daniel Nebert, MD, Professor
- Regulation of genes, encoding receptors and drug-metabolizing enzymes important in drug - and environmental - induced toxicity and teratogenesis
- Nancy Ratner, PhD, Professor
- The peripheral nerve in development and disease
- Peter Stambrook, PhD, Professor
- Mutation and genomic instability in progession to cancer; gene therapy as a therapeutic tool for cancer
- Arnold W. Strauss, MD
- Molecular basis of disorders of mitochondrial fatty acid oxidation and the genetic causes of congenital heart disease and cardiomyopathies
- Stephanie Ware, MD, PhD, Assistant Professor
- Genetics of cardiovascular development [Visit the Ware Lab]
- Susanne Wells, PhD, Assistant Professor
- Papilloma virus and cervical cancer [Visit the Susanne Wells Lab]
- David Wieczorek, PhD, Professor
- Professor, Analysis of protein expression in normal and diseased cardiac and skeletal muscle
- Daniel Wiginton, PhD, Associate Professor
- Regulation of development and differentiation in the intestinal epithelium
- Christopher Wylie, PhD, Professor
- (1) Control of the cytoskeleton, control of cell migration and control of early cell lineage specification, in vertebrate embryos (2) Control of gonad formation, primordial germ cell migration, oocyte maturation and egg formation [Visit the Wylie-Heasman Lab]
- Yi Zheng, PhD, Professor
- Molecular mechanisms of Rho GTPase signal transduction. Development of novel therapeutic reagents to inhibit Rho pathways related to human pathological conditions
For more information about the Molecular and Developmental Biology Program at Cincinnati Children's and the University of Cincinnati, email mdbprog@cchmc.org or call 513-636-4545. You can also apply online at our application page.
