Genomics and Bioinformatics
Genomics - Conditions and Diseases
- Birth defects
- Congenital disorder of the digestive system
- Hirschsprung disease
- Infertility
- Intrauterine growth retardation
- Pre-eclampsia
- Spondyloarthritis
- Spontaneous abortion
- Uveitis
View a complete list of the diseases that our students and faculty are fighting.
Researchers in this area are applying the power of cutting-edge microarray-based expression, polymorphism, and promoter analyses to better understand questions of development, function, and pathophysiology in both experimental and human disease situations.
By combining expression, genetics, and comparative genomics technologies and analyses of diverse systems, these studies are providing insights into the structure and function of the genome during development of the lung, gut, kidney, heart, and other organs; the pathophysiology of lung and other disorders; and the regulation of gene expression.
We have assembled a world-class team of experts in the fields of bioinformatics, computational biology, computer science, developmental biology, health services research, mathematics and medicine.
Faculty
- Bruce Aronow, PhD, Associate Professor
- Control of chromatin structure and gene expression in T cell development, leukemia and in vectors for gene therapy
- Michael Bates, MD, PhD, Assistant Professor
- Digestive system development, including development of intestinal mesenchyme/smooth muscle and of the enteric nervous system; homeobox transcription factor regulation and downstream targets; intestinal differentiation and patterning; genetics of congenital disorders of the digestive system [Visit the Bates Lab]
- Mitchell Cohen, MD, Professor
- Intestinal secretion; activators of intestinal guanylate cyclase
- Robert Colbert, MD, PhD, Associate Professor
- Antigen processing and presentation in autoimmunity; immunoproteasome assembly and function
- George Daston, PhD, Volunteer Professor
- Mechanisms of chemically-induced abnormal development
- Gregory Grabowski, MD, Professor
- Molecular pathogenesis and therapy of human genetic disease
- Stuart Handwerger, MD, Professor
- Placental and decidual gene expression
- James C. Mulloy, PhD, Assistant Professor
- Molecular mechanisms involved in leukemia induction and maintenance; mouse modeling of leukemia using primary human blood stem cells [Visit the Mulloy Lab]
- Daniel Nebert, MD, Professor
- Regulation of genes, encoding receptors and drug-metabolizing enzymes important in drug - and environmental - induced toxicity and teratogenesis
For more information about the Molecular and Developmental Biology Program at Cincinnati Children's and the University of Cincinnati, email mdbprog@cchmc.org or call 513-636-4545. You can also apply online at our application page.
