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Division of Endocrinology is home to specialists with a wide variety of backgrounds and areas of focus. As a team, this diversity makes us better prepared to care for your child’s unique needs. Learn more about our faculty and staff.
Lawrence M. Dolan, MD Director, Division of Endocrinology
Director, Division of Endocrinology
Director, Endocrinology Clinical Laboratory
Professor, UC Department of Pediatrics
Epidemiology and genetics of obesity; insulin resistance; abnormal carbohydrate metabolism; diabetes and their relationships to the development and progression of cardiovascular disease
Lawrence M. Dolan, MD, is board-certified in pediatrics and pediatric endocrinology. He has been on the faculty of Cincinnati Children's Hospital Medical Center in the Department of Pediatrics for the University of Cincinnati College of Medicine since 1983.
Dr. Dolan is a professor of pediatrics in the Division of Endocrinology. His research focuses on the epidemiology and genetics of obesity, insulin resistance, abnormal carbohydrate metabolism, diabetes and their relationships to the development and progression of cardiovascular disease.
Dr. Dolan received his bachelor of science degree from the University of San Francisco. He received his doctor of medicine degree from the University of California at Los Angeles.
Dr. Dolan completed his pediatric internship and residency at the University of Minnesota. He also served as chief resident. He obtained fellowship training in pediatric endocrinology at the University of Virginia.
Shah AS, Dolan LM, Gao Z, Kimball TR, Urbina EM. Racial differences in arterial stiffness among adolescents and young adults with type 2 diabetes. Pediatr Diabetes. 2011 Jul 25. Epub ahead of print.
Dabelea D, Pihoker C, Talton JW, D'Agostino RB Jr, Fujimoto W, Klingensmith GJ, Lawrence JM, Linder B, Marcovina SM, Mayer-Davis EJ, Imperatore G, Dolan LM; SEARCH for Diabetes in Youth Study. Etiological approach to characterization of diabetes type: the SEARCH for Diabetes in Youth Study. Diabetes Care. 2011 Jul;34(7):1628-33.
Hilliard ME, Guilfoyle SM, Dolan LM, Hood KK. Prediction of adolescents' glycemic control 1 year after diabetes-specific family conflict: the mediating role of blood glucose monitoring adherence. Arch Pediatr Adolesc Med. 2011 Jul;165(7):624-9.
Urbina EM, Khoury PR, McCoy C, Daniels SR, Kimball TR, Dolan LM. Cardiac and vascular consequences of pre-hypertension in youth. J Clin Hypertens (Greenwich). 2011 May;13(5):332-42.
Hood KK, Rausch JR, Dolan LM. Depressive symptoms predict change in glycemic control in adolescents with type 1 diabetes: rates, magnitude, and moderators of change. Pediatr Diabetes. 2011 May 12. Epub ahead of print.Urbina EM, Dolan LM, McCoy CE, Khoury PR, Daniels SR, Kimball TR. Relationship between elevated arterial stiffness and increased left ventricular mass in adolescents and young adults. J Pediatr. 2011 May;158(5):715-21.
Shah AS, Khoury PR, Dolan LM, Ippisch HM, Urbina EM, Daniels SR, Kimball TR. The effects of obesity and type 2 diabetes mellitus on cardiac structure and function in adolescents and young adults. Diabetologia. 2011 Apr;54(4):722-30. Nommsen-Rivers LA, Dolan LM, Huang B. Timing of Stage II Lactogenesis Is Predicted by Antenatal Metabolic Health in a Cohort of Primiparas. Breastfeed Med. 2011 Apr 27. Epub ahead of print. Kaulfers AM, Bean JA, Inge TH, Dolan LM, Kalkwarf HJ. Bone loss in adolescents after bariatric surgery. Pediatrics. 2011 Apr;127(4):e956-61. Epub 2011 Mar 28. Dabelea D, Dolan LM, D'Agostino R Jr, Hernandez AM, McAteer JB, Hamman RF, Mayer-Davis EJ, Marcovina S, Lawrence JM, Pihoker C, Florez JC. Association testing of TCF7L2 polymorphisms with type 2 diabetes in multi-ethnic youth. Diabetologia. 2011 Mar;54(3):535-9.
Philippe F. Backeljauw, MD
Growth disorders; disorders of bone and calcium metabolism; Turner syndrome
Growth disorders; IGF-I therapy; Turner syndrome
Within the Division of Pediatric Endocrinology, Dr. Backeljauw's clinical emphasis relates to children with growth problems and disorders of calcium and bone metabolism. He is also the medical director of the Turner Syndrome Multidisciplinary Center of Cincinnati. From a research perspective, Dr. Backeljauw is engaged in clinical research related to growth disorders. Ongoing studies focus on IGF-I therapy in GH resistance syndromes, as well as assessment and treatment of Turner syndrome co-morbidities. He is a collaborator in several other studies, including one on the prevalence of endocrinopathies after head injury and after cancer therapy. His research efforts have resulted in more than 70 publications, including peer-reviewed original manuscripts, abstracts, and textbook chapters.
Sarah D. Corathers, MD
Assistant Professor, UC Department of Pediatrics
Effective transition between pediatric and adult health care settings; type 1 diabetes in adolescents and adults; adult care for Turner Syndrome; quality improvement in healthcare
Following completion of a combined residency program in internal medicine and pediatrics, Sarah Corathers, MD, is pursuing joint subspecialty fellowship training in endocrinology, which provides a strong background in management of diabetes and metabolic disease in both children and adults. She has a particular interest in psychosocial aspects of diabetes care for adolescents, effective transition between pediatric and adult care for individuals with chronic endocrine issues, adult care of Turner Syndrome women and quality improvement in healthcare.
MD: Wright State University, Dayton, OH, 2002.
Residency: Internal Medicine and Pediatrics, University of Cincinnati and Cincinnati Children’s Hospital Medical Center, 2002-2006.
Certification: Pediatrics 2006, Internal Medicine 2007.
Nancy A. Crimmins, MD
Obesity: etiology and treatment; maturity onset diabetes of the young; epidemiology of glucose intolerance and diabetes
MD: Indiana University School of Medicine, 2000.
Residency: Pediatrics, Cincinnati Children's Hospital Medical Center, 2003.
Fellowship: Pediatric Endocrinology, Cincinnati Children's Hospital Medical Center, 2006.
Sung V, Beebe DW, Vandyke R, Fenchel MC, Crimmins NA, Kirk S, Hiscock H, Amin R, Wake M. Does sleep duration predict metabolic risk in obese adolescents attending tertiary services? A cross-sectional study. Sleep. 2011 Jul 1;34(7):891-8. Guilfoyle SM, Crimmins NA, Hood KK. Blood glucose monitoring and glycemic control in adolescents with type 1 diabetes: meter downloads versus self-report. Pediatr Diabetes. 2011 Mar 11. Epub ahead of print.
Sabin MA, Clemens SL, Saffery R, McCallum Z, Campbell MW, Kiess W, Crimmins NA, Woo JG, Leong GM, Werther GA, Ukoumunne OC, Wake MA. New directions in childhood obesity research: how a comprehensive biorepository will allow better prediction of outcomes. BMC Med Res Methodol. 2010 Oct 22;10:100. Kenny AP, Crimmins NA, Mackay DJ, Hopkin RJ, Bove KE, Leonis MA. Concurrent course of transient neonatal diabetes with cholestasis and paucity of interlobular bile ducts: a case report. Pediatr Dev Pathol. 2009 Sep-Oct;12(5):417-20. Crimmins NA, Dolan LM, Martin LJ, Bean JA, Daniels SR, Lawson ML, Goodman E, Woo JG. Stability of adolescent body mass index during three years of follow-up. J Pediatr. 2007 Oct;151(4):383-7.Crimmins NA, Martin LJ. Polymorphisms in adiponectin receptor genes ADIPOR1 and ADIPOR2 and insulin resistance. Obes Rev. 2007 Sep;8(5):419-23.
Andrew Dauber, MD, MMSc Program Director and Director of Translational Research, Cincinnati Center for Growth Disorders
Program Director and Director of Translational Research, Cincinnati Center for Growth Disorders
Pediatric endocrinology; growth disorders; precocious puberty
Growth disorders; precocious puberty
MD: Harvard Medical School, Boston, MA, 2000.
MS: Clinical Investigation, Harvard Medical School, Boston, MA 2008.
Residency: Pediatrics, Boston Combined Residency Program in Pediatrics, Boston Children's Hospital and Boston Medical Center, Boston, MA.
Chief Resident: Pediatrics, Boston Children's Hospital, Boston, MA, 2004-2005.
Fellowship: Pediatric Endocrinology, Boston Children's Hospital, Boston, MA.
Certification: Pediatrics, Pediatric Endocrinology
Nilsson O, Guo MH, Dunbar N, Popovic J, Flynn D, Jacobsen C, Lui JC, Hirschhorn JN, Baron J, Dauber A. Short stature, accelerated bone maturation, and early growth cessation due to heterozygous aggrecan mutations. J Clin Endocrinol Metab. 2014 Aug;99(8):E1510-8.
Kerns SL, Guevara-Aguirre J, Andrew S, Geng J, Guevara C, Guevara-Aguirre M, Guo M, Oddoux C, Shen Y, Zurita A, Rosenfeld RG, Ostrer H, Hwa V, Dauber A. A novel variant in CDKN1C is associated with intrauterine growth restriction, short stature, and early-adulthood onset diabetes. Clin Endocrinol Metab. 2014 Jul 24:jc20141949. Epub ahead of print.
Dauber A, Rosenfeld RG, Hirschhorn JN. Genetic Evaluation of Short Stature. J Clin Endocrinol Metab. 2014 Jun 10:jc20141506. Epub ahead of print.
Dauber A, Ercan A, Lee J, James P, Jacobs PP, Ashline DJ, Wang SR, Miller T, Hirschhorn JN, Nigrovic PA, Sackstein R. Congenital disorder of fucosylation type 2c (LADII) presenting with short stature and developmental delay with minimal adhesion defect. Hum Mol Genet. 2014 Jun 1;23(11):2880-7.
Batey L, Moon JE, Yu Y, Wu B, Hirschhorn JN, Shen Y, Dauber A. A novel deletion of IGF1 in a patient with idiopathic short stature provides insight Into IGF1 haploinsufficiency. J Clin Endocrinol Metab. 2014 Jan;99(1):E153-9.
Dauber A, Golzio C, Guenot C, Jodelka FM, Kibaek M, Kjaergaard S, Leheup B, Martinet D, Nowaczyk MJ, Rosenfeld JA, Zeesman S, Zunich J, Beckmann JS, Hirschhorn JN, Hastings ML, Jacquemont S, Katsanis N. SCRIB and PUF60 are primary drivers of the multisystemic phenotypes of the 8q24.3 copy-number variant. Am J Hum Genet. 2013 Nov 7;93(5):798-811.
Wang SR, Carmichael H, Andrew SF, Miller TC, Moon JE, Derr MA, Hwa V, Hirschhorn JN, Dauber A. Large-scale pooled next-generation sequencing of 1077 genes to identify genetic causes of short stature. J Clin Endocrinol Metab. 2013 Aug;98(8):E1428-37.
Abreu AP, Dauber A, Macedo DB, Noel SD, Brito VN, Gill JC, Cukier P, Thompson IR, Navarro VM, Gagliardi PC, Rodrigues T, Kochi C, Longui CA, Beckers D, de Zegher F, Montenegro LR, Mendonca BB, Carroll RS, Hirschhorn JN, Latronico AC, Kaiser UB. Central precocious puberty caused by mutations in the imprinted gene MKRN3. N Engl J Med. 2013 Jun 27;368(26):2467-75.
Dauber A, Lafranchi SH, Maliga Z, Lui JC, Moon JE, McDeed C, Henke K, Zonana J, Kingman GA, Pers TH, Baron J, Rosenfeld RG, Hirschhorn JN, Harris MP, Hwa V. Novel microcephalic primordial dwarfism disorder associated with variants in the centrosomal protein ninein. J Clin Endocrinol Metab. 2012 Nov;97(11):E2140-51.
Dauber A, Yu Y, Turchin MC, Chiang CW, Meng YA, Demerath EW, Patel SR, Rich SS, Rotter JI, Schreiner PJ, Wilson JG, Shen Y, Wu BL, Hirschhorn JN. Genome-wide association of copy-number variation reveals an association between short stature and the presence of low-frequency genomic deletions. Am J Hum Genet. 2011 Dec 9;89(6):751-9.
Deborah A. Elder, MD
Diabetes; growth disorders; precocious puberty; calcium disorders
Researching type 2 diabetes in adolescents; intensified insulin therapy
Iris Gutmark-Little, MD
Turner syndrome; growth disorders; thyroid disorders; pubertal disorders; general pediatric endocrinology
BS: Louisiana State University, Baton Rouge, Louisiana 2000.MD: Johns Hopkins University School of Medicine, Baltimore, Maryland 2004.Residency: Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 2007.
Fellowship: Pediatric Endocrinology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio 2010.
Certification: General Pediatrics, American Board of Pediatrics, 2008; Pediatric Endocrinology, American Board of Pediatrics, pending 2011.
Stuart Handwerger, MD
Regulation of gene expression in human placenta and uterine decidua during differentiation.
Visit the Handwerger Lab.
Sherafat-Kazemzadeh R, Schroeder JK, Kessler CA, Handwerger S. Parathyroid Hormone-Like Hormone (PTHLH) Represses Decidualization of Human Uterine Fibroblast Cells by an Autocrine/Paracrine Mechanism. J Clin Endocrinol Metab. 2011 Feb;96(2):509-14.
Hubert MA, Sherritt SL, Bachurski CJ, Handwerger S. Involvement of transcription factor NR2F2 in human trophoblast differentiation. PLoS One. 2010 Feb 25;5(2):e9417.
Handwerger S. New insights into the regulation of human cytotrophoblast cell differentiation. Mol Cell Endocrinol. 2010 Jul 8;323(1):94-104.
Kessler CA, Bachurski CJ, Schroeder J, Stanek J, Handwerger S. TEAD1 inhibits prolactin gene expression in cultured human uterine decidual cells. Mol Cell Endocrinol. 2008 Nov 25;295(1-2):32-8.
Repaske DR, Handwerger S. Making the transition from pediatric to adult endocrinology services. Nat Clin Pract Endocrinol Metab. 2008 Sep;4(9):492-3.
Robins JC, Heizer A, Hardiman A, Hubert M, Handwerger S. Oxygen tension directs the differentiation pathway of human cytotrophoblast cells. Placenta. 2007 Nov-Dec;28(11-12):1141-6.
Eyal O, Jomain JB, Kessler C, Goffin V, Handwerger S. Autocrine prolactin inhibits human uterine decidualization: a novel role for prolactin. Biol Reprod. 2007 May;76(5):777-83.
Lomenick JP, Hubert MA, Handwerger S. Transcription factor FOXF1 regulates growth hormone variant gene expression. Am J Physiol Endocrinol Metab. 2006 Nov;291(5):E947-51.
Grinius L, Kessler C, Schroeder J, Handwerger S. Forkhead transcription factor FOXO1A is critical for induction of human decidualization. J Endocrinol. 2006 Apr;189(1):179-87.
Kessler CA, Schroeder JK, Brar AK, Handwerger S. Transcription factor ETS1 is critical for human uterine decidualization. Mol Hum Reprod. 2006 Feb;12(2):71-6.
Jonathan C. Howell, MD, PhD
Type 1 and Type 2 diabetes mellitus; endocrinopathy in bone marrow failure syndromes; growth disorders; thyroid disorders
Visit the Howell Lab.
Jonathan C. Howell, MD, PhD, is board certified in pediatrics and board eligible in pediatric endocrinology. He has been on the faculty of Cincinnati Children’s Hospital Medical Center in the Department of Pediatrics for the University of Cincinnati College of Medicine since 2012.
Dr. Howell is an assistant professor of pediatrics in the Division of Endocrinology. His main clinical focus is diabetes as well as providing care for patients with endocrine disorders, including growth, thyroid, pituitary, pubertal, and adrenal dysfunction. In 2012, he was awarded a William Cooper Procter Scholarship to support his academic career development. Dr. Howell’s research focuses on the mechanisms that control hormone cell development and function in human intestine and how it relates to diabetes and cystic fibrosis.
Dr. Howell received his bachelor of arts degree from Hanover College. He received his PhD from Indiana University and his MD from Indiana University School of Medicine.
Dr. Howell completed his pediatric internship and residency at Cincinnati Children’s Hospital Medical Center, where he also served as chief resident. He also obtained his fellowship training from Cincinnati Children’s.
BA:Hanover College, Hanover, IN, 1997.
PhD: Indiana University (Edward F. Srour, thesis adviser), Indianapolis, IN, 2003.
MD: Indiana University School of Medicine, Indianapolis, IN, 2005.
Residency: Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2005-2008.
Chief Residency: Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2008-2009.
Endocrinology Fellowship: Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2009-2012
Certification: Pediatrics, 2008.
McCracken, Kyle, Jonathan C. Howell, James M. Wells, Jason R. Spence. Generating human intestinal tissue from pluripotent stem cells in vitro. Nature Protocols. 2011. 6(12): 1920-1928.
Howell, Jonathan C, James M. Wells. Generating intestinal tissue from stem cells: potential for research and therapy. Regenerative Medicine. 2011. 6(6): 743-755.
Howell, Jonathan C, Mandi Cafasso, Philippe F. Backeljauw. Superior mesenteric artery syndrome as a presentation of Graves’ disease in adolescence. EndoTrends. 2011 17(3): 1-3.
Case, Jamie, Tamara L. Horvath, Jonathan C. Howell, Mervin C. Yoder and Edward F. Srour. Clonal multilineage differentiation of murine common pluripotent stem cells isolated from both skeletal muscle and adipose stromal cells. Annals of the New York Academy of Sciences 2004. 1044: 1-18.
Howell, Jonathan C., Wei-Hua Lee, Paul Morrison, Jin Zhong, Mervin C. Yoder, and Edward F. Srour. Pluripotent stem cells identified in multiple murine tissues. Annals of the New York Academy of Sciences 2003. 996: 158-173.
Howell, Jonathan C, Mervin C. Yoder. Adult Stem Cell Plasticity Defined. NeoReviews. 2003. 4(7): 181-186.
Royer, Cassandra L, Jonathan C. Howell, Paul R. Morrison, Edward F. Srour, Mervin C. Yoder. Muscle-derived CD45+Sca-1+c-kit- progenitor cells give rise to skeletal muscle myotubes in vitro. In Vitro Cellular and Developmental Biology -- Animal 2003. 38(9): 512-517.
Howell, Jonathan C, Mervin C. Yoder, Edward F. Srour. Hematopoietic potential of murine skeletal muscle-derived CD45-Sca-1+c-kit- cells. Experimental Hematology 2002. 30(8): 915-924.
Vivian Hwa, PhD Basic Research Director, Cincinnati Center for Growth Disorders
Basic Research Director, Cincinnati Center for Growth Disorders
Associate Professor, UC Department of Pediatrics
Molecular basis of growth disorders; defects along the GH-IGF-I Axis; STAT5B deficiency; IGF1R resistance
BS: University of Sydney, Sydney, Australia.
PhD: University of Illinois, Champaign-Urbana, IL.
Kern SL, Guevara-Aguirre J, Andrew S, Geng J, Guevara C, Guevara-Aguirre M, Guo M, Oddoux C, Shen Y, Zurita A, Rosenfeld RG, Ostrer H, Hwa V, Dauber A. A novel variant in CDKN1C is associated with intrauterine growth restriction, short stature, and early-adulthood onset diabetes. J Clin Endocrinol Metab. 2014 Jul 24. Epud ahead of print.
Feigerlova E, Swinyard M, Andrew SF, Derr MA, Farnsworth J, Rosenfeld RG, Hwa V. A novel GHR intronic variant c.266+83G>T, activates a cryptic 5’ splice site causing severe GHR deficiency and classical GH insensitivity syndrome. Horm Res Paediatr. 2013;80(6):397-405.
Varco-Merth B, Feigerlová E, Shinde Ujwal, Rosenfeld RG, Hwa V, Rotwein P. Severe growth deficiency is associated with STAT5b mutations that disrupt protein folding and activity. Mol Endocrinol. 2013 Jan;27(1):150-61.
Dauber A, LaFranchi SH, Maliga Z, Lui JC, Moon JE, McDeed C, Henke K, Zonana J, Kingman GA, Pers TH, Baron J, Rosenfeld RG, Hirschhorn JN, Harris MP, Hwa V. Novel Microcephalic Primordial Dwarfism Disorder Associated with Variants in the Centrosomal Protein Ninein. J Clin Endocrinol Metab. 2012 Nov;97(11):E2140-51.
Scalia PA, Martinez AS, Feigerlova E, Bezrodnik L, Gaillard MI, Di Giovanni D, Ballerini MG, Jasper HG, Heinrich JJ, Fang P, Domené HM, Rosenfeld RG, Hwa V. A novel missense mutation in the SH2 domain of the STAT5B gene results in a transcriptionally inactive STAT5b associated with severe IGF-I deficiency, immune dysfunction, and lack of pulmonary disease. J Clin Endocrinol Metab. 2012 May;97(5):E830-9.
Derr MA, Aisenberg J, Fang P, Tenenbaum-Rakover Y, Rosenfeld RG, Hwa V. The growth hormone receptor (GHR) c.899dupC mutation functions as a dominant negative: insights into the pathophysiology of intracellular GHR defects. J Clin Endocrinol Metab. 2011 Nov;96(11):E1896-904.
Fang P, Kofoed EM, Little BM, Ross RJM, Frank, SJ, Hwa V, Rosenfeld RG. A mutant STAT5b, associated with growth hormone insensitivity and IGF-I deficiency, cannot function as a signal transducer or transcription factor. J Clin Endocrinol Metab. 2006 Apr; 91(4):1526-34.
Hwa V, Little B, Adiyaman P, Kofoed E, Pratt KL, Ocal G, Berberoglu M, Rosenfeld RG. Severe growth hormone insensitivity resulting from total absence of signal transducer and activator of transcription 5b. J Clin Endocrinol Metab. 2005 Jul;90(7):4260-6.
Hwa V, Little B, Kofoed EM, Rosenfeld RG. Transcriptional regulation of insulin-like growth factor-I (IGF-I) by interferon-gamma (IFN-γ) requires STAT-5b. J Biol Chem. 2004 Jan 23;279(4):2728-36.
Kofoed EM*, Hwa V*, Little B, Woods KA, Buckway CK, Tsubaki J, Pratt KL, Bezrodnik L, Jasper H, Tepper A, Heinrich JJ, Rosenfeld RG. Growth hormone insensitivity associated with a STAT5b mutation. N Engl J Med. 2003 Sep 18:349(12):1139-47. *co-first authors
Jonathan D. Katz, PhD
T cells; MHC, beta cell death; islet antigens
Immunology, autoimmunity, type 1 diabetes
Jonathan D. Katz, PhD, focuses on autoimmune diabetes research. Autoimmune diabetes, also known as type 1 diabetes (T1D), is the most common pediatric autoimmune disease. Roughly 1/250 individuals develop T1D in the United States.There is currently no cure for T1D and the only treatment is daily exogenous insulin replacement therapy. Many T1D patients eventually develop secondary complications, such as hearth disease, blindness, peripheral neuropathy and renal failure.
Dr. Katz's work focuses on the role that autoreactive T lymphocytes play in the disease process. His lab interested in (1) the control of autoreactive T cells via central and peripheral tolerance, (2) the role NKT cells play in regulating autoreactive T cells, and (3) the role dendritic cells play in activating and regulating autoreactive T cells in T1D.
Most of his work uses the non-obese diabetic (NOD) mouse strain that spontaneously develops T1D with remarkable similar to the T1D seen in human patients. The availability of the NOD strain has allowed us to take a modern, reductionist molecular and cellular immunology approach to understanding the mechanism(s) and genetics underlying T1D susceptibility and disease progression. His lab makes extensive use of knockout, transgenic, regulated gene expression, targeted ablation, cell transfer and genomic studies the progression and regulation of T1D in the NOD mouse.
Katz JD, Ondr JK, Opoka RJ, Garcia Z, Janssen EM. Cutting edge: merocytic dendritic cells break T cell tolerance to beta cell antigens in nonobese diabetic mouse diabetes. J Immunol. 2010 Aug 15;185(4):1999-2003.
Pang S, Zhang L, Wang H, Yi Z, Li L, Gao L, Zhao J, Tisch R, Katz JD, Wang B. CD8(+) T cells specific for beta cells encounter their cognate antigens in the islets of NOD mice. Eur J Immunol. 2009 Oct;39(10):2716-24.
Saxena V, Ondr JK, Magnusen AF, Munn DH, Katz JD. The countervailing actions of myeloid and plasmacytoid dendritic cells control autoimmune diabetes in the nonobese diabetic mouse. J Immunol. 2007 Oct 15;179(8):5041-53.
Wojciechowski S, Tripathi P, Bourdeau T, Acero L, Grimes HL, Katz JD, Finkelman FD, Hildeman DA. Bim/Bcl-2 balance is critical for maintaining naive and memory T cell homeostasis. J Exp Med. 2007 Jul 9;204(7):1665-75.
Cain JA, Smith JA, Ondr JK, Wang B, Katz JD. NKT cells and IFN-gamma establish the regulatory environment for the control of diabetogenic T cells in the nonobese diabetic mouse. J Immunol. 2006 Feb 1;176(3):1645-54.
Vukkadapu SS, Belli JM, Ishii K, Jegga AG, Hutton JJ, Aronow BJ, Katz JD. Dynamic interaction between T cell-mediated beta-cell damage and beta-cell repair in the run up to autoimmune diabetes of the NOD mouse. Physiol Genomics. 2005 Apr 14;21(2):201-11.
Hutton JJ, Jegga AG, Kong S, Gupta A, Ebert C, Williams S, Katz JD, Aronow BJ. Microarray and comparative genomics-based identification of genes and gene regulatory regions of the mouse immune system. BMC Genomics. 2004 Oct 25;5(1):82.
Jane C. Khoury, PhD
Stroke, diabetes in pregnancy; research design and analysis.
Mahabee-Gittens EM, Xiao Y, Gordon JS, Khoury JC. Continued Importance of Family Factors in Youth Smoking Behavior. Nicotine & Tobacco Research.
Khoury JC, Dolan LM, VanDyke R, Rosenn B, Feghali M, Miodovnik M. Fetal development in women with diabetes: imprinting for a life-time? Journal of Maternal-Fetal & Neonatal Medicine. 2012; 25(1), 11-14.
VanDyke R, Ren Y, Sucharew HJ, Miodovnik M, Rosenn B, Khoury JC. Characterizing maternal glycemic control: a more informative approach using semiparametric regression. Journal of Maternal-Fetal & Neonatal Medicine. 2012; 25(1), 15-19.
Yolton K, Xu YY, Strauss D, Altaye M, Calafat AM, Khoury J. Prenatal exposure to bisphenol A and phthalates and infant neurobehavior. Neurotoxicology and Teratology. 2011; 33(5), 558-566.
Phelan KJ, Khoury J, Xu YY, Liddy S, Hornung R, Lanphear BP. A Randomized Controlled Trial of Home Injury Hazard Reduction The HOME Injury Study. Archives of Pediatrics & Adolescent Medicine. 2011;165(4), 339-345.
Xu YY, Yolton K, Khoury J. Earliest Appropriate Time for Administering Neurobehavioral Assessment in Newborn Infants. Pediatrics. 2011;127(1), E69-E75.
Armour AD, Khoury JC, Kagan RJ, Gottschlich MM. Clinical Assessment of Sleep Among Pediatric Burn Patients Does Not Correlate With Polysomnography. Journal of Burn Care & Research. 32(5), 529-534.
Mahabee-Gittens EM, Xiao Y, Gordon JS, Khoury JC. The Role of Family Influences on Adolescent Smoking in Different Racial/Ethnic Groups. Nicotine & Tobacco Research. 2011.
Bollepalli S, Dolan LM, Miodovnik M, Feghali M, Khoury JC. Asymmetric large-for-gestational-age infants of type 1 diabetic women: Morbidity and abdominal growth. Am J Perinatol. 2010; 27(8), 603-610. 2010.
Kleindorfer D, Khoury J, Moomaw CJ, Alwell K, Woo D, Flaherty ML, Khatri P, Adeoye O, Ferioli S, Broderick JP, Kissela BM. Stroke Incidence is Decreasing in Whites, but Not in Blacks: A Population-Based Estimate of Temporal Trends in Stroke Incidence from the Greater Cincinnati/Northern Kentucky Stroke Study. Stroke. 2010;41(7):1326-31.
Sarah Lawson, MD
Turner syndrome; endocrine disease related to oncologic pathology and treatment; septo-optic dysplasia.
BS: Lee University, Cleveland, TN, 2000.
MD: University of Kentucky, Lexington, KY, 2005.
Residency: Kentucky Children’s Hospital, Lexington, KY, 2005-2008.
Fellowship: Cincinnati Children’s Hospital, Cincinnati, OH.
Takahisa Nakamura, PhD
RNA-related inflammation in obesity and metabolic diseases
Dr. Nakamura received his PhD from the University of Tokyo in 2003. He completed postdoctoral training in the laboratory of Dr. Gökhan S. Hotamisligil at Harvard School of Public Health in 2013, followed by his faculty appointment at Cincinnati Children's Hospital in 2013.
PhD: University of Tokyo, 2003.
Postdoctoral Fellow: University of Tokyo, 2003-2006
Research Fellow: Harvard University, 2006-2010
Research Associate: Harvard University, 2010-2013
Takahisa Nakamura, Alessandro Arduini, Brenna Baccaro, Masato Furuhashi, and Gökhan S. Hotamisligil. Small molecule inhibitors of PKR improve glucose homeostasis in obese, diabetic mice. Diabetes. 2013 In press
Lu B, Nakamura T, Inouye K, Li J, Tang Y, Lundbäck P, Valdes-Ferrer SI, Olofsson PS, Kalb T, Roth J, Zou Y, Erlandsson-Harris H, Yang H, Ting JP, Wang H, Andersson U, Antoine DJ, Chavan SS, Hotamisligil GS, Tracey KJ. Novel role of PKR in inflammasome activation and HMGB1 release. Nature. 2012 Aug 20;488(7413):670-4. Morita M. Oike Y, Nagashima T, Kadomatsu T, Tabata M, Suzuki T, Nakamura T, Yoshida N, Okada M, Yamamoto T. Obesity resistance and increased hepatic expression of catabolism-related mRNAs in Cnot3(+/-) mice. EMBO J. 2011 Sep 6;30(22):4678-4691. Nakamura T, Furuhashi M, Li P, Cao H, Tuncman G, Sonenberg N, Gorgun CZ, Hotamisligil GS. Double-stranded RNA-dependent Protein Kinase Links Pathogen Sensing with Stress and Metabolic Homeostasis. Cell. 2010 Feb 5;140(3):338-48. Yoneda M, Suzuki T, Nakamura T, Ajima R, Yoshida Y, Kakuta S, Sudo K, Iwakura Y, Shibutani M, Mitsumori K, Yokota J, Yamamoto T. Deficiency of antiproliferative family protein Ana correlates with development of lung adenocarcinoma. Cancer Sci. 2009 Feb;100(2):224-232. Ajima R, Akiyama T, Usui M, Yoneda M, Yoshida Y, Nakamura T, Minowa O, Noda M, Tanaka S, Noda T, Yamamoto T. Osteoporotic bone formation in mice lacking tob2; involvement of Tob2 in RANK ligand expression and osteoclasts differentiation. FEBS Lett. 2008 Apr 16;582(9):1313-8. Morita M, Suzuki T, Nakamura T, Yokoyama K, Miyasaka T, Yamamoto T. Depletion of mammalian CCR4b deadenylase triggers elevation of the p27Kip1 mRNA level and impairs cell growth. Mol Cell Biol. 2007 Jul;27(13):4980-90. Nakamura T, Yao R, Ogawa T, Suzuki T, Ito C, Tsunekawa N, Inoue K, Ajima R, Miyasaka T, Yoshida Y, Ogura A, Toshimori K, Noce T, Yamamoto T, Noda T. Oligoasthenoteratozoospermia in mice lacking Cnot7, a regulator of retinoid X receptor beta. Nat Genet. 2004 May;36(5):528-33.Kimura H*, Nakamura T*, Ogawa T, Tanaka S, Shiota K. Transcription of mouse DNA methyltransferase 1 (Dnmt1) is regulated by both E2F-Rb-HDAC-dependent and -independent pathways. Nucleic Acids Res. 2003 Jun 15;31(12):3101-13. *These authors contributed equally to this work. Yoshida Y*, Nakamura T*, Komoda M, Satoh H, Suzuki T, Tsuzuku JK, Miyasaka T, Yoshida EH, Umemori H, Kunisaki RK, Tani K, Ishii S, Mori S, Suganuma M, Noda T, Yamamoto T. Mice lacking a transcriptional corepressor Tob are predisposed to cancer. Genes Dev. 2003 May 15;17(10):1201-6. *These authors contributed equally to this work.
Susan R. Rose, MD
Hypothalamic pituitary function; thyroid; disorders of growth or puberty; endocrine function in cancer survivors after head injury
MD: Case Western Reserve School of Medicine, 1980.
MEd: School Psychology, University of Dayton, 1972.
Residency: The Cleveland Clinic, 1983.
Fellowship: National Institutes of Health, 1986.
Certification: Pediatrics, 1985; Pediatric Endocrinology, 1986.
Slaughter JL, Meinzen-Derr J, Rose SR, Leslie ND, Chandrasekar R, Linard SM, Akinbi HT. The effects of gestational age and birth weight on false-positive newborn-screening rates. Pediatrics. 2010 Nov;126(5):910-6.
Kaulfers AM, Backeljauw PF, Reifschneider K, Blum S, Michaud L, Weiss M, Rose SR. Endocrine dysfunction following traumatic brain injury in children. J Pediatr. 2010 Dec;157(6):894-9.
Rose SR. Improved diagnosis of mild hypothyroidism using time-of-day normal ranges for thyrotropin. J Pediatr. 2010 Oct;157(4):662-7; 667.e1.
van der Kaay DC, de Jong FH, Rose SR, Odink RJ, Bakker-van Waarde WM, Sulkers EJ, Hokken-Koelega AC. Overnight levels of luteinizing hormone, follicle-stimulating hormone and growth hormone before and during gonadotropin-releasing hormone analogue treatment in short boys born small for gestational age. Horm Res. 2009;71(5):260-7. van der Kaay DC, Rose SR, van Dijk M, Noordam C, van Rheenen E, Hokken-Koelega AC. Reduced levels of GH during GnRH analogue treatment in pubertal short girls born small for gestational age (SGA). Clin Endocrinol (Oxf). 2009 Jun;70(6):914-9.
Dorn LD, Rose SR, Rotenstein D, Susman EJ, Huang B, Loucks TL, Berga SL. Differences in endocrine parameters and psychopathology in girls with premature adrenarche versus on-time adrenarche. J Pediatr Endocrinol Metab. 2008 May;21(5):439-48.
Eyal O, Blum S, Mueller R, Smith FO, Rose SR. Improved growth velocity during thyroid hormone therapy in children with Fanconi anemia and borderline thyroid function. Pediatr Blood Cancer. 2008 Nov;51(5):652-6.
Rose SR. Use of GnRH agonists in GH-deficient patients: arguments for and against. The case against GnRH agonists in GH-deficient patients. Pediatr Endocrinol Rev. 2008 Feb;5 Suppl 2:744, 750-4.
Elder DA, D'Alessio DA, Eyal O, Mueller R, Smith FO, Kansra AR, Rose SR. Abnormalities in glucose tolerance are common in children with fanconi anemia and associated with impaired insulin secretion. Pediatr Blood Cancer. 2008 Aug;51(2):256-60.
Kazlauskaite R, Evans AT, Villabona CV, Abdu TA, Ambrosi B, Atkinson AB, Choi CH, Clayton RN, Courtney CH, Gonc EN, Maghnie M, Rose SR, Soule SG, Tordjman K; Consortium for Evaluation of Corticotropin Test in Hypothalamic-Pituitary Adrenal Insufficiency. Corticotropin tests for hypothalamic-pituitary- adrenal insufficiency: a metaanalysis. J Clin Endocrinol Metab. 2008 Nov;93(11):4245-53.
Meilan M. Rutter, MD, FRACP
Bone health and calcium metabolism; disorders of growth, puberty and sex development; endocrine function in cancer survivors; endocrine function in neuromuscular disorders
Insulin-like growth factor-1 (IGF-1) therapy in Duchenne Muscular Dystrophy
Meilan Rutter is board-certified in Pediatrics and Pediatric Endocrinology. She is an Assistant Professor of Pediatrics in the Division of Endocrinology, and joined the faculty of Cincinnati Children's Hospital Medical Center in 2008. Currently, Dr. Rutter is assistant director of the Pediatric Endocrinology Fellowship Program.
Dr. Rutter received her degrees of Bachelor of Medicine and Bachelor of Surgery (MB, BCh) from the University of Wales College of Medicine. She completed her training in Pediatrics in New Zealand, and was admitted to Fellowship of the Royal Australasian College of Physicians (FRACP) in 1995. She underwent fellowship training in Pediatric Endocrinology at Cincinnati Children's. She completed further pediatric residency training to achieve American Board of Pediatrics specialty and subspecialty board certification.
Dr. Rutter treats children and adolescents with endocrine disorders and diabetes mellitus. She serves as a consultant for the Neuromuscular Comprehensive Care Center and the Neuro-Oncology program at Cincinnati Children's. Additionally. she is a member of the Disorders of Sex Development interdisciplinary team.
MB, BCh: University of Wales College of Medicine, Cardiff, United Kingdom.FRACP: Royal Australasian College of Physicians, New Zealand.Residency: Auckland Children's Hospital and Dunedin Hospital, New Zealand; Cincinnati Children's, Cincinnati, OH.
Fellowship: Pediatric Endocrinology, Cincinnati Children's, Cincinnati, OH.
Certification: General Pediatrics, American Board of Pediatrics, 2002; Pediatric Endocrinology, American Board of Pediatrics, 2003; Pediatrics, Fellowship of the Royal Australasian College of Physicians, 1995.
Rose SR, Rutter MM, Mueller R, Harris M, Hamon B, Fletcher Bulluck A, Smith FO. Bone mineral density is normal in children with Fanconi anemia. Pediatric Blood & Cancer. 2011 Apr. Epub ahead of print.
Bianchi ML, Biggar D, Bushby K, Rogol AD, Rutter MM, Tseng B. Endocrine aspects of Duchenne Muscular Dystrophy. Neuromuscular Disorders. 2011;21(4):298-303.
Wong BL, Rutter MM, Rose SR, Clark E, Vonderhaar K. Growth hormone therapy in Duchenne Muscular Dystrophy. Best Evidence Statement, Cincinnati Children’s Hospital Medical Center, Cincinnati, Ohio. 2009.
Rutter MM. What is an endocrinologist and why is endocrine care important for Duchenne? Action Duchenne newsletter. 2009.
Murray R, Rutter MM, Racine M, Rose SR. Report on The Endocrine Society’s 90th Annual Meeting. Highlights. 2008;16(4):1-36.
Rutter MM, Racine M, Rose SR. Report on The Endocrine Society’s 89th Annual Meeting. Highlights. 2007;15(3):2-30.
Rutter MM, Rose SR. Long-term endocrine sequelae of childhood cancer. Curr Opin Pediatr. 2007 Aug;19(4):480-7.
Rutter MM, Markoff E, Clayton L, Akeno N, Zhao G, Clemens TL, Chernausek SD. Osteoblast-specific expression of insulin-like growth factor-1 in bone of transgenic mice induces insulin-like growth factor binding protein-5. Bone. 2005 Feb;36(2):224-31.
Rutter MM, Prahalad S, Passo M, Backeljauw PF. Idiopathic hypercalcemia and eosinophilic fasciitis: a novel association. J Pediatr Endocrinol Metab. 2004 Sep;17(9):1251-4.
Rutter MM, Smith EP. Pseudohypoparathyroidism type Ia: late presentation with intact mental development. J Bone Miner Res. 1998 Jul;13(7):1208-9.
Amy S. Shah, MD, MS
Endocrinology; diabetes; lipid disorders
Amy S. Shah, MD, MS, is a board certified pediatric endocrinologist who research focuses on the risk factors that contribute to early atherosclerosis. Ongoing projects focus on understanding the role of lipids and lipoproteins to atherosclerosis and the use of non invasive imaging to assess early atherosclerosis. Dr. Shah's current research is funded by a K23 grant from the National Institutes of Health. Dr. Shah has received several prestigious awards including the International Society of Pediatric and Adolescent Diabetes Young Investigator Award.
MD: St. George’s University Medical School, Grenada, West Indies, 2004.
Pediatric Residency: Loyola University Medical Center, Maywood, IL, 2007.
Endocrine Fellowship: Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2010.
Research Fellowship: Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2011.
MS: Clinical Research, The University of Cincinnati, Cincinnati, OH, 2011.
Certifications: The American Board of Pediatrics, Subspeciality Board in Pediatric Endocrinology.
Shah AS, Dabelea D, Talton JW, Urbina EM, D`Agostino RB, Wadwa RP, Marcovina S, Hamman RF, Daniels SR, Dolan LM. Smoking and Arterial Stiffness in Youth with Type 1 Diabetes: The SEARCH CVD study. Journal of Pediatrics. 2014 Jul;165(1):110-6.
Shah AS, Gao Z, Urbina EM, Kimball TR, Dolan LM. Pre-diabetes: The Effects on Arterial Thickness and Stiffness in Obese Youth. Journal of Clinical Endocrinology and Metabolism. 2 2014 Mar;99(3):1037-43.
Shah AS, Urbina EM, Khoury PR, Kimball TR, Dolan LM. Lipids and lipoprotein ratios: The contribution to carotid intima media thickness in adolescents and young adults with type 2 diabetes mellitus. Journal of Clinical Lipidology. 2013 October;7(5):441-445.
Shah AS, Tan L, Lu JL, Davidson WS. The proteomic diversity of high density lipoproteins: Our emerging understanding of its importance in lipid transport and beyond. Journal of Lipid Research. 2013 Oct;54(10):2575-85.
Gordon SM, Davidson WS, Urbina EM, Dolan LM, Heink A, Zang H, Lu LJ, Shah AS. The effects of type 2 diabetes on lipoprotein composition and arterial stiffness in male youth. Diabetes. 2013 Aug;62(8):2958-67. ***With commentary published by von Eckardstein A, Nofer JR Diabetes August 2013 62:2662-2664.
Shah AS, Dolan LM, D’Agostino R, Standiford D. Davis C, Testaverde L, Pihoker C, Daniels SR, Urbina EM. Comparison of Mercury and Aneroid Blood Pressure Measurements in Youth. Pediatrics. 2012 May;129(5):e1205-10. PMID: 22508914
Shah AS, Dolan LM, Gao Z, Kimball TR, Urbina EM. Racial Differences in Arterial Stiffness Among Youth with Type 2 Diabetes. Pediatric Diabetes. 2012 Mar; 13(2):170-5.
Shah AS, Khoury PR, Dolan LM, Ippisch HM, Urbina EM, Daniels SR, Kimball, TR. The Effects of Obesity and Type 2 Diabetes Mellitus on Cardiac Structure and Function in Adolescents and Young Adults. Diabetologia. 2011 Apr; 54 (4):722-30.
Shah AS, Dolan LM, Gao Z, Kimball TR, Urbina EM. Clustering of Cardiovascular Risks: A Simple Method of Detecting Cardiovascular Risk in Youth. Pediatrics. 2011 Feb; 127(2):e312-8.
Shah AS, Dolan LM, Kimball TR, Gao Z, Khoury PR, Daniels SR, Urbina EM. Influence of Duration of Diabetes, Glycemic Control, and Traditional Cardiovascular Risk Factors on Early Atherosclerotic Vascular Changes in Adolescents and Young Adults with Type 2 Diabetes Mellitus. Journal of Clinical Endocrinology and Metabolism. 2009 Oct; 94(10):3740-5.
Peggy Joyce Stenger, DO
BS: University of Texas, Arlington, Texas.
DO: Texas College of Osteopathic Medicine, Fort Worth, Texas.
Residency: Pediatrics, Children's Hospital of New Mexico, Albuquerque, NM.
Fellowship: Pediatric Endocrinology, Children's Hospital Medical Center, Cincinnati, OH.
CCD: International Society Clinical Densitometry.
Certification: General Pediatrics, American Board of Pediatrics 1989; Pediatric Endocrinology, American Board of Pediatrics 1999; International Society Clinical Densitometry 2007.
James M. Wells, PhD Director, Basic Research, Division of Endocrinology
Director, Basic Research, Division of Endocrinology
Director, Pluripotent Stem Cell Center
identifying the molecular mechanisms involved in the development of the pancreas, liver and biliary system; replacement therapies, such as transplantable pancreatic beta cells for patients with type-1 diabetes; regeneration of adult tissues
Visit the Wells Lab.
The focus of his teams basic research has been to identify the molecular mechanisms involved in the embryonic development of endocrine cells including pancreatic beta cells and tissues of the gastrointestinal tract. Their translational projects have focused on identifying new approaches to improve child health in several ways: 1. To identify and use embryonic pathways to generate complex, three-dimensional organ tissues from pluripotent stem cells, 2. Use these tissues to develop new in vitro human models for diabetes and digestive disease research and 3. Develop long-term, therapeutic strategies for cell and tissue-replacement therapies.
BS: Biochemistry, Molecular and Cell Biology, University of Maine, Orono, ME, 1987.
PhD: Graduate program in Genetics, SUNY at Stony Brook, New York, 1995.
Postdoctoral Fellow: Harvard University, Cambridge MA, 1996 - 2001.
Spence JR, Mayhew CN, Rankin SA, Kuhar MF, Vallance JE, Tolle K, Hoskins EE, Kalinichenko VV, Wells SI, Zorn AM, Shroyer NF, Wells JM. Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro. Nature. 2010 Dec 12. Lin SC, Wani MA, Whitsett JA, Wells JM. Klf5 regulates lineage formation in the pre-implantation mouse embryo. Development. 2010 Dec;137(23):3953-63. Carpenter AC, Rao S, Wells JM, Campbell K, Lang RA. Generation of mice with a conditional null allele for Wntless. Genesis. 2010 Sep;48(9):554-8. Spence JR, Lange AW, Lin SC, Kaestner KH, Lowy AM, Kim I, Whitsett JA, Wells JM. Sox17 regulates organ lineage segregation of ventral foregut progenitor cells. Dev Cell. 2009 Jul;17(1):62-74. *This article is featured on the cover.
Zorn AM, Wells JM. Vertebrate endoderm development and organ formation. Annu Rev Cell Dev Biol. 2009;25:221-51 Lange AW, Keiser AR, Wells JM, Zorn AM, Whitsett JA. Sox17 promotes cell cycle progression and inhibits TGF-beta/Smad3 signaling to initiate progenitor cell behavior in the respiratory epithelium. PLoS One. 2009 May 27;4(5):e5711. Liu X, Luo M, Xie W, Wells JM, Goodheart MJ, Engelhardt FJ. Sox17 modulates Wnt3A/beta-catenin-mediated transcriptional activation of the Lef-1 promotor. Am J Physiol Lung Cell Mol Physiol. 2010 Nov;299(5):L694-710.
Murtaugh LC, Wells JM. Understanding endoderm development: more than just a series of tubes. Dev Dyn. 2011 Mar;240(3):461-2.
Howell JC, Wells JM. Generating intestinal tissue from stem cells: potential for research and therapy. Regen Med. 2011 Nov:6(6)743-55.
McCracken KW, Howell J, Wells JM*, Spence JS. Generating human intestinal tissue from pluripotent stem cells in vitro. Nat Protoc. 2011 Nov 10;6(12):1920-8. *Corresponding Author
Single Cell Dissection of Human Intestine Development. Principal Investigator. National Institutes of Heath. Sept 2013 – Aug 2018. NIH 1R01DK098350.
Control of human endocrine cell development. Contact Principal Investigator. National Institutes of Heath. April 2012 – March 2017. NIH 1R01DK092456-01.
Develop Innovative Translational Tools to Study Enteroendocrine Function in Human Intestine and Applications to Diabetes Drug Discovery. Principal Investigator. Eli Lilly Internal Sponsors: Drs. Melissa Thomas and Hsiu Chiung-Yang. Dec 2011 – Nov 2013.
Generating Human Intestinal Organoids with an ENS. Principal Investigator. National Institutes of Health. Sept 2012 – Aug 2014. NIH 1U18NS080815-01.
Generating 3-D lung organoids in vitro. Principal Investigator. National Institutes of Health. Sept 2012 – Aug 2014. NIH 1R21 HL115372-01.
KLF5 regulation of intestinal development and stem cell homeostasis. Co-Investigator. National Institutes of Health. Aug 2011 – July 2015. NIH 1R01 DK092306-01.
Transcriptional Control of Placental Differentiation. Co-Investigator. National Institutes of Health. Feb 2011 – Jan 2016. NIH R01 HD065339.
Nana-Hawa Yayah Jones, MD
Diversity and cultural competence; non-adherence in the pediatric population; information technology in healthcare; medical education
Adherence in youth with type 1 diabetes
Nana-Hawa Yayah Jones, MD, is a new clinical faculty in the division of pediatric endocrinology. Dr. Yayah Jones recently arrived in Cincinnati from St. Louis, Missouri where she completed both pediatric residency and endocrinology fellowship at Washington University's St. Louis Children's Hospital (SLCH). An additional year was spent at SLCH as a pediatric chief resident. During all the years of Dr. Yayah Jones's training she was active in fostering diversity among the medical trainees and in fact founded the Washington University Minority Medical Association (WUMMA), a group of medical trainees whose focus was on recruitment, retention and community service. As creator and president of WUMMA she became active in the resident and fellows diversity initiative created by the Barnes Jewish Hospital Center for Diversity and Cultural Competence. She mentored undergraduate student, medical students and residents throughout her training.
During fellowship she fostered a special interest in children with chronic illness who are non-adherent to their medical regimen. Dr. Yayah Jone's research efforts will be geared towards the non-adherence type 1 diabetic who is often prone to recurrent hospitalizations and diabetes complications.
Cassandra C. Brady, MD Clinical Fellow, Division of Endocrinology
Clinical Fellow, Division of Endocrinology
T2DM and neurocognitive and vascular effects; obesity and provider documentation
MD: Indiana University School of Medicine, Indianapolis, IN, 2009.
Residency: Pediatric, Vanderbilt Children’s Hospital, Nashville, TN, 2012.
Christiaan de Bruin, MD, PhD Clinical Fellow, Division of Endocrinology
MD: Erasmus MC, Rotterdam, Netherlands, 2004.
PhD: Erasmus MC, Rotterdam, Netherlands, 2009
Residency: Pediatrics, Radboud University MC, Nijmegen, Netherlands, 2014.
van der Pas R, van Esch JH, de Bruin C, Danser AH, Pereira AM, Zelissen PM, Netea-Maier R, Sprij-Mooij DM, van den Berg-Garrelds IM, van Schaik RH, Lamberts SW, van den Meiracker AH, Hofland LJ, Feelders RA. Cushing's disease and hypertension: in vivo and in vitro study of the role of the renin-angiotensin-aldosterone system and effects of medical therapy. Eur J Endocrinol. 2014 Feb 1;170(2):181-91.
van der Pas R, Gatto F, de Bruin C, Pereira AM, van Koetsveld PM, Sprij-Mooij DM, Waaijers AM, Dogan F, Schulz S, Kros JM, Lamberts SW, Hofland LJ. Preoperative normalization of cortisol levels in Cushing's disease after medical treatment: consequences for somatostatin and dopamine receptor subtype expression and in vitro response to somatostatin analogs and dopamine agonists. J Clin Endocrinol Metab. 2013 Dec;98(12):E1880-90.
van der Pas R, de Bruin C, Leebeek FW, de Maat MP, Rijken DC, Pereira AM, Romijn JA, Netea-Maier RT, Hermus AR, Zelissen PM, de Jong FH, van der Lely AJ, de Herder WW, Lamberts SW, Hofland LJ, Feelders RA. The hypercoagulable state in Cushing's disease is associated with increased levels of procoagulant factors and impaired fibrinolysis, but is not reversible after short-term biochemical remission induced by medical therapy. J Clin Endocrinol Metab. 2012 Apr;97(4):1303-10.
de Bruin C, Hofland LJ, Nieman LK, van Koetsveld PM, Waaijers AM, Sprij-Mooij DM, van Essen M, Lamberts SW, de Herder WW, Feelders RA. Mifepristone Effects on Tumor Somatostatin Receptor Expression in Two Patients with Cushing's Syndrome due to Ectopic Adrenocorticotropin Secretion. J Clin Endocrinol Metab. 2012 Feb;97(2):455-62.
Feelders RA, de Bruin C, Pereira AM, Romijn JA, Netea-Maier RT, Hermus AR, Zelissen PM, van Heerebeek R, de Jong FH, van der Lely AJ, de Herder WW, Hofland LJ, Lamberts SW. Pasireotide alone or with cabergoline and ketoconazole in Cushing's disease. N Engl J Med. 2010 May 13;362(19):1846-8.
de Bruin C, Pereira AM, Feelders RA, Romijn JA, Roelfsema F, Sprij-Mooij DM, van Aken MO, van der Lelij AJ, de Herder WW, Lamberts SW, Hofland LJ. Co-expression of dopamine and somatostatin receptor subtypes in corticotroph adenomas. J Clin Endocrinol Metab. 2009 Apr;94(4):1118-24.
de Bruin C, Meij BP, Kooistra HS, Hanson JM, Lamberts SW, Hofland LJ. Cushing’s disease in humans and dogs. Horm Res. 2009 Jan;71 Suppl 1:140-3.
de Bruin C, Feelders RA, Waaijers AM, van Koetsveld PM, Sprij-Mooij DM, Lamberts SW, Hofland LJ. Differential regulation of human dopamine D2 and somatostatin receptor subtype expression by glucocorticoids in vitro. J Mol Endocrinol. 2009 Jan;42(1):47-56.
de Bruin C, Feelders RA, Lamberts SW, Hofland LJ. Somatostatin and dopamine receptors as targets for medical treatment of Cushing’s Syndrome. Rev Endocr Metab Disord. 2009 Jun;10(2):91-102
de Bruin C, Hanson JM, Meij BP, Kooistra HS, Waaijers AM, Uitterlinden P, Lamberts SW, Hofland LJ. Expression and functional analysis of dopamine receptor subtype 2 and somatostatin receptor subtypes in canine Cushing's disease. Endocrinology. 2008 Sep;149(9):4357-66.
Marjorie C. Golekoh, MD Clinical Fellow, Division of Endocrinology
Adrenal function in children with eosinophilic esophagitis on swallowed glucocorticoid therapy; growth in children with eosinophilic esophagitis treated with swallowed glucocorticoid therapy; analysis of prospective annual adrenocorticotropin stimulation testing among survivors of intracranial tumor; a novel heterozygous insulin-like growth factor 1 receptor (IGF1R) gene deletion in a child with short stature and neurofibromatosis 1.
MD: University of Santo Tomas, Manila, Philippines, 2007.
Residency: Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH, 2012.
Certification: American Board of Pediatrics, 2012.
Vincent Horne, MD Clinical Fellow, Division of Endocrinology
MD: University of Missouri, Columbia, MO, 2011.
Residency: Pediatrics, University of Missouri, Columbia, MO.
Chijioke Ikomi, MD Clinical Fellow, Division of Endocrinology
MD: University of Ibadan, Ibadan, Nigeria.
Residency: New York Medical College, Metropolitan Hospital Centre, New York, NY.
Pranati Jha, MD Clinical Fellow, Division of Endocrinology
MBBS: Calcutta Medical College, India.
Residency: Pediatrics, Albany Medical Center, NY.
Certification: General Pediatrics, 2011.
Jose M. Jimenez Vega, MD Clinical Fellow, Division of Endocrinology
Turner syndrome, obesity
Liver function abnormalities in Turner syndrome; physical activity tracking devices
MD: Escuela Autonoma de Ciencias Medicas de Centro América , San Jose, Costa Rica, 2007.
Residency: University of Minnesota, Minneapolis, MN.
Fellowship (current): Pediatric Endocrinology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
Fuglestad A, Boys, CJ, Chang PN, Miller BS, Eckerle J, Deling, L, Fink B, Hoecker, H, Hickey M, Jimenez Vega J, Wozniak J. Behavioral and dietary factors in overweight and obesity among children and adolescents with Fetal Alcohol Spectrum Disorders. Alcolhol Clin Exp Res. 2014. Accepted.
Chinnakotla S, Bellin MD, Schwarzenberg SJ, Radosevich DM, Cook M, Dunn TB, Beilman GJ, Freeman ML, Balamurugan AN, Wilhelm J, Bland B, Jimenez-Vega JM, Hering BJ, Vickers SM, Pruett TL, Sutherland DE. Total pancreatectomy and islet autotransplantation in children for chronic pancreatitis: indication, surgical techniques, postoperative management, and long-term outcomes. Ann Surg. 2014 Jul;260(1):56-64.
Christel M. Keefe, MD Clinical Fellow, Division of Endocrinology
Growth; puberty; DSD; diabetes; CAH
Endocrine effects of steroid use; osteoporosis; delayed puberty
MD: Wright State University, Boonshoft School of Medicine, Dayton, OH.
Residency: Pediatrics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH.
Nicole M. Sheanon, MD Clinical and Research Fellow, Division of Endocrinology
Clinical and Research Fellow, Division of Endocrinology
Type 1 diabetes; Turner syndrome
Beta-cell function; Turner syndrom; type 1 diabetes
MD: University of Cincinnati, Cincinnati, OH, 2006.
Residency: Pediatrics, University of Massachusetts, Worcester, MD.
Fellowship: Cincinnati Children's Hospital Medical Center, Cincinnati, OH, completion date: 9/15/15.
Certification: Pediatrics, 2009.
Allison R. Smego, MD Clinical Fellow, Division of Endocrinology
Pediatric endocrinology; obesity
Obesity; quality improvement
MD: University of Cincinnati College of Medicine, Cincinnati, OH, 2010.
Residency: Pediatrics, Vanderbilt Children’s Hospital, Nashville, TN, 2013.
Halley M. Wasserman, MD Clinical Fellow, Division of Endocrinology
Pediatric endocrinology; disorders of bone mineralization
Bone mineral density following bariatric surgery in adolescence
MD: Northeastern Ohio Medical University, Rootstown, OH, 2009.
Sarah B. Boyd, LSW, MSSA, SWII Social Worker, Division of Social Services
Pamela S. Burwinkel, RN, BSN Registered Nurse, Division of Endocrinology
Mandi L. Cafasso, MSN, APRN, CNP Nurse Practitioner, Division of Endocrinology
Nurse Practitioner, Division of Endocrinology
Lori A. Casnellie, RN Care Manager, Division of Endocrinology
Allison K. Deisinger, RD, LD, CDE Registered Dietitian, Endocrinology
Janise M. Felblinger, MSN, APRN, CNP Nurse Practitioner, Diabetes Center
Nurse Practitioner, Diabetes Center
BSN: Xavier University, 2003.
MSN: University of Cincinnati, 2009.
Certification: Pediatric Nursing Certification Board, 2009.
Michele Hanson, MSN, APRN, CNP Nurse Practitioner, Diabetes Center
Jennifer J. Kelly, MSN, APRN, CNP Nurse Practitioner, Division of Endocrinology
Ann B. Malinowski, MSN, APRN, CNP Nurse Practitioner, Division of Endocrinology
Nancy J. Morwessel, MSN, APRN, CNP Pediatric Nurse Practitioner, Diabetes Center
Pediatric Nurse Practitioner, Diabetes Center
General pediatric diabetes care and intensified insulin therapy; quality-of-life and well-being measurement; bioethics consultation and education; bereavement follow-up.
Christine D. Osborn, RN, APRN, CNP Nurse Practitioner, Division of Endocrinology
Debra A. Standiford, MSN, APRN, CNP Pediatric Nurse Practitioner, Diabetes Center
Care of children with diabetes
Clinical research related to diabetes
Debra A. Standiford, MSN, APRN, CNP, has been an employee of Cincinnati Children's Hospital Medical Center since 1975.
From 1975 to 1977, Debra worked as a staff nurse on a chronic care unit, when she was promoted to charge nurse. She assumed the role of head nurse of the Orthopedic unit in 1978.
In 1980 and 1981, Debra worked part-time as a staff nurse on the Hematology/ Oncology unit and graduated with a bachelor's degree in nursing from the University of Cincinnati. She worked as pediatric extension program liaison in nursing education. The focus of her work was the coordination of clinical experiences for undergraduate nursing students from local universities, colleges, and schools of nursing.
Debra assisted in orienting newly employed nurses and presenting in-services for clinical and managerial nurses. During 1983 and 1984, she was acting director of Educational Services for Nursing and assumed the role of educational nurse specialist while pursuing further education. She graduated with a master's degree in nursing management from Indiana University in 1987. She was promoted to nursing director of the Neurosurgical/Tracheostomy unit.
In 1992, Debra assumed the role of diabetes research nurse. The major focus of her work was the coordination of clinical research studies related to diabetes in children and young adults.
Debra has completed postgraduate studies at the University of Cincinnati, and in 1989, was certified as a pediatric nurse practitioner. Currently, Debra works with families of children diagnosed with diabetes. She also continues to function as a coordinator of clinical research studies related to diabetes.
Diploma of Nursing: The Christ Hospital School of Nursing, Cincinnati, Ohio, 1975.
BSN: University of Cincinnati, Cincinnati, Ohio, 1981.
MSN: Nursing Administration, Indiana University, Indianapolis, Ind.,1987.
Certification: Pediatric Nurse Practitioner Program, University of Cincinnati, Cincinnati, Ohio, 1997.
Reynolds K, Liese AD, Anderson AM, Dabelea D, Standiford D, Daniels SR, Waitzfelder B, Case D, Loots B, Imperatore G, Lawrence JM. Prevalence of tobacco use and association between cardiometabolic risk factors and cigarette smoking in youth with type 1 or type 2 diabetes mellitus. J Pediatr. 2011 Apr;158(4):594-601.e1.
Liese AD, Bortsov A, Günther AL, Dabelea D, Reynolds K, Standiford DA, Liu L, Williams DE, Mayer-Davis EJ, D'Agostino RB Jr, Bell R, Marcovina S. Association of DASH diet with cardiovascular risk factors in youth with diabetes mellitus: the SEARCH for Diabetes in Youth study. Circulation. 2011 Apr 5;123(13):1410-7. Liese AD, Lawson A, Song HR, Hibbert JD, Porter DE, Nichols M, Lamichhane AP, Dabelea D, Mayer-Davis EJ, Standiford D, Liu L, Hamman RF, D'Agostino RB Jr. Evaluating geographic variation in type 1 and type 2 diabetes mellitus incidence in youth in four US regions. Health Place. 2010 May;16(3):547-56.
Writing Group for the SEARCH for Diabetes in Youth Study Group, Dabelea D, Bell RA, D'Agostino RB Jr, Imperatore G, Johansen JM, Linder B, Liu LL, Loots B, Marcovina S, Mayer-Davis EJ, Pettitt DJ, Waitzfelder B. Incidence of diabetes in youth in the United States. JAMA. 2007 Jun 27;297(24):2716-24.
Lawrence JM, Standiford DA, Loots B, Klingensmith GJ, Williams DE, Ruggiero A, Liese, AD, Bell RA, Waitzfelder BE, McKeown RE, for the SEARCH for Diabetes in Youth Study. Prevalence and Correlates of Depressed Mood among Youth with Diabetes: The SEARCH for Diabetes in Youth Study. Pediatrics. 2006; 117(4): 1348-1358.
SEARCH for Diabetes in Youth Study Group, Liese AD, D'Agostino RB Jr, Hamman RF, Kilgo PD, Lawrence JM, Liu LL, Loots B, Linder B, Marcovina S, Rodriguez B, Standiford D, Williams DE. The Burden of Diabetes Mellitus among US Youth: Prevalence Estimates from the SEARCH for Diabetes in Youth Study. Pediatrics. 2006;118(4): 1510-1518.Patton SR, Dolan LM, Mitchell MJ, Byars KC, Standiford D, Powers SW. Mealtime interactions in families of pre-schoolers with type 1 diabetes. Pediatr Diabetes. 2004 Dec;5(4):190-8. Powers SW, Byars KC, Mitchell MJ, Patton SR, Standiford DA, Dolan LM. Parent report of mealtime behavior and parenting stress in young children with type 1 diabetes and in healthy control subjects. Diabetes Care. 2002 Feb;25(2):313-8. Pinhas-Hamiel O, Standiford D, Hamiel D, Dolan LM, Cohen R, Zeitler PS. The type 2 family: a setting for development and treatment of adolescent type 2 diabetes mellitus. Arch Pediatr Adolesc Med. 1999 Oct;153(10):1063-7. Young LA, Kimball TR, Daniels SR, Standiford DA, Khoury PR, Eichelberger SM, Dolan LM. Nocturnal blood pressure in young patients with insulin-dependent diabetes mellitus: correlation with cardiac function. J Pediatr. 1998 Jul;133(1):46-50.
Amanda Sylvester, MSN, APRN, CNP Advanced Practice Registered Nurse, Division of Endocrinology
Advanced Practice Registered Nurse, Division of Endocrinology
Education Consultant, Center for Professional Excellence
Amanda Sylvester, MSN, APRN, CNP, currently works with children, adolescents and young adults diagnosed with diabetes. Her personal interests within the field include improving adherence to treatment plan between clinic visits as well as facilitating improved family coping with chronic illness. She enjoys working with quality improvement within the department and the Cincinnati Children's institution.
Past experience includes primary care prior to working with the diabetes population. Her passion has always been for working with children and their family to improve their health and outcomes.
BS: Psychology, Lipscomb University, Nashville, TN 2004.
BSN: University of Cincinnati, Cincinnati, OH 2007.
MSN/NP: University of Cincinnati, Pediatrics-Primary Care, Cincinnati, OH, 2009.
Karishma J. Tilton, MSN, APRN, CNP Nurse Practitioner, Diabetes Center
Kristen Wetherill, RD, LD, CDE Registered Dietitian, Endocrinology
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