Gastroenterology, Hepatology and Nutrition

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    Faculty

    A photo of Lee Denson.

    Lee A. Denson, MD
    Medical Director, Inflammatory Bowel Disease Center

    513-636-7575

    lee.denson@cchmc.org

    Lee A. Denson, MD

    Medical Director, Inflammatory Bowel Disease Center

    Professor, UC Department of Pediatrics

    Phone: 513-636-7575

    Email: lee.denson@cchmc.org

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    Specialties

    Inflammatory bowel disease; growth failure; celiac disease

    Visit the Denson Lab.

    Biography

    The primary focus of Dr. Lee A. Denson's laboratory is to determine the molecular basis for alterations in growth hormone signaling in inflammatory bowel diseases (IBD).

    Normal growth and development are dependent upon the ability of growth hormone to regulate IGF-1 expression. Evidence from studies in children with IBD and mouse models of colitis indicates that inflammatory cytokines which are up regulated in this setting may cause an acquired GH resistance. Consequences may include growth failure, altered body composition and impaired mucosal healing.

    We are using complementary experimental and patient-based approaches to investigate regulation of growth hormone signaling in mouse models of colitis and in children with Crohn's disease. These include down regulation of the growth hormone receptor and up regulation of a family of post-receptor inhibitory proteins, the Suppressors of Cytokine Signaling (SOCS). These studies should lead to the development of more effective therapies for children with IBD and other chronic inflammatory conditions.

    Education and Training

    MD: Medical College of Virginia, Richmond, VA, 1993

    Residency: Yale-New Haven Hospital, New Haven, CT, 1993-96.

    Certification: Pediatrics, 1996 & 2002.

    Fellowship: Yale University School of Medicine, New Haven, CT, 1996-99.

    Publications

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    Mike A. Leonis, MD, PhD

    Associate Professor, UC Department of Pediatrics

    Phone: 513-636-4415

    Fax: 513-636-7805

    Email: mike.leonis@cchmc.org

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    Specialties

    Pediatric hepatology, especially acute liver failure; inflammatory disease processes of the liver; hepatoblastoma; mechanisms of hepatic tumor formation

    Education and Training

    MD: Washington University School of Medicine, St. Louis, MO, 1996.

    PhD: Washington University School of Medicine, St. Louis, MO, 1996.

    Procter Scholar: Cincinnati Children's Hospital Medical Center, 2002-2005.

    Fellowship: Cincinnati Children's, 1999-2002.

    Residency: Primary Children's Hospital Medical Center, University of Utah School of Medicine, Salt Lake City, UT, 1996-1999.

    Certification: American Board of Pediatrics, 1999; Pediatric Gastroenterology, Hepatology and Nutrition, 2003.

    Publications

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    Daniel Mallon, MD
    Pediatric Gastroenterologist, Division of Gastroenterology, Hepatology and Nutrition

    513-636-4415

    daniel.mallon@cchmc.org

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    Daniel Mallon, MD

    Pediatric Gastroenterologist, Division of Gastroenterology, Hepatology and Nutrition

    Associate Program Director for Student and Resident Education, Division of Gastroenterology, Hepatology and Nutrition

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-636-4415

    Email: daniel.mallon@cchmc.org

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    Specialties

    Clinical

    Pediatric gastroenterology; inflammatory bowel disease; constipation; gastroesophageal reflux; celiac disease

    Research

    Health professions education; primary care management of gastrointestinal problems; quality improvement

    Education and Training

    MD: Indiana University School of Medicine, Indianapolis, IN, 2007.

    Residency: Pediatrics, Seattle Children's Hospital/University of Washington School of Medicine, Seattle, WA, 2007-2010.

    Chief Resident: Pediatrics, Seattle Children's Hospital, Seattle, WA, 2010-2011.

    Fellowship: Pediatric Gastroenterology, Boston Children's Hospital/Harvard Medical School,  Boston, MA, 2011-2014.

    A photo of Scott Pentiuk, MD.

    Scott P. Pentiuk, MD
    Pediatric Gastroenterologist

    513-636-4415

    scott.pentiuk@cchmc.org

    Scott P. Pentiuk, MD

    Pediatric Gastroenterologist

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-636-4415

    Email: scott.pentiuk@cchmc.org

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    Specialties

    Feeding disorders, medical education

    Education and Training

    MD: University of Cincinnati College of Medicine, Cincinnati, Ohio, 2002.

    Residency: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 2005.

    Fellowship: Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 2008.

    Publications

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    Noah Shroyer

    Assistant Professor, UC Department of Pediatrics

    Phone: 513-636-0129

    Fax: 513-636-5581

    Email: noah.shroyer@cchmc.org

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    Specialties

    Intestinal epithelial development; colon cancer; inflammatory bowel disease.

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    Education and Training

    BS: Microbiology and Biochemistry, Louisiana State University, Baton Rouge, LA, 1995.

    PhD: Cell and Molecular Biology, Baylor College of Medicine, Houston, TX, 2001.

    Postdoctoral: Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, 2001-2005.

    Publications

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    Grants

    The role of ATOH1 as a tumor suppressor in colorectal cancer. Primary Investigator. National Cancer Institute. Jan 2010 - Dec 2014. #R01 CA142826.