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The Pulmonary Fellowship Training Program at Cincinnati Children’s offers trainees extensive opportunities to pursue basic, translational, clinical and outcomes research. We provide trainees with hands-on experience and one-on-one mentorship, preparing them to pursue their own lines of research related to pulmonary medicine.
Learn more about the wide range of research under way in the Division of Pulmonary Medicine at Cincinnati Children’s.
Christopher Karp, MD, studies abnormalities in the regulation of the inflammatory process in individuals with CF. His lab’s efforts have resulted in the description of IFRD1 as a genetic modifier affecting neutrophil differentiation (findings published in the journal Nature). Karp described the role of lipoxins in modifying the neutrophilic inflammatory response in the CF lung; this work continues to evolve, with the goal of bringing new therapies to the bedside.
William Hardie, MD, is studying the biology of lung fibrosis using a TGF-alpha transgenic mouse model, with an emphasis on identifying signaling pathways and mediators that are targetable with existing pharmacological inhibitors. His work involves the study of lung morphogenesis, acute lung injury, surfactant homeostasis and pulmonary vascular remodeling.
Narong Simakajornboon, MD, conducts basic scientific research investigating the effects of hypoxia on the developing brain.
Raouf Amin, MD, director of the Pulmonary Division and of the Cystic Fibrosis Center, is studying the use of cardiac MRI as an indicator of lung disease progression in cystic fibrosis. Cincinnati Children’s is designated as a Translational Center within the CFF TDN.
Bruce Trapnell, MD, focuses on the study of GM-CSF autoantibodies and neutrophil dysfunction in pulmonary alveolar proteinosis. He has also studied the use of serum SP-D as a biomarker of lung disease in cystic fibrosis.
Raouf Amin, MD, studies cardiovascular dysfunction in children with obstructive sleep apnea. He also conducts other sleep research related to executive functioning, sleep restriction, obesity, Trisomy 21, neuromuscular disorders, functional and Cine MRIs.
Cincinnati Children’s has been a member of the CFF-TDN since its inception in 1998. Raouf Amin, MD, and Patricia Joseph, MD, serve as principal investigators on various clinical trials. As part of the CFF-TDN, the pediatric pulmonary division at Cincinnati Children’s has participated in dozens of multicenter clinical trials in cystic fibrosis, enrolling hundreds of patients and advancing clinical research in the field of cystic fibrosis. Use of infant PFTs, strategies to improve nutritional outcomes and strategies to improve quality-of-life measures are also being studied at Cincinnati Children’s.
Patricia Joseph, MD, is interested in the complications of cystic fibrosis in adults, bone mineral density in CF and unusual organisms in CF.
Gary McPhail, MD, focuses on pulmonary outcomes in cystic fibrosis and improving adherence to consensus guidelines and evidence-based care.
Paul Boesch, DO, is interested in chronic pulmonary aspiration in children and outcomes of fundoplication.
Mathew Ednick, DO, is interested in pulmonary outcomes for children with sleep apnea.
Carolyn Kercsmar, MD, director of the Asthma Center, studies ways to improve the care of patients with asthma, including the use of exhaled nitric oxide to help guide management, and genotype / phenotype relationships in patients with asthma.
Narong Simakajornboon, MD, director of the Sleep Center, is interested in the effects of maternal smoking on control of breathing in infants during sleep and periodic limb movement disorder in children.
Michael Seid, PhD, is director of Pulmonary Outcomes Research at Cincinnati Children’s. He is an NIH-funded researcher, with a primary appointment in pulmonary medicine and a secondary appointment in clinical effectiveness. He is also a core faculty member in the Center for Health Care Quality (CHCQ) at Cincinnati Children’s, led by Peter Margolis, MD. Seid’s diverse appointments allow him – and his lab – to bridge the gap between QI and outcomes research. Seid is especially interested in barriers to pediatric healthcare, access to care and disparities in care for vulnerable children. He is very involved in the study of quality-of-life measures and improving adherence to care for patients with chronic diseases, such as cystic fibrosis.
Pulmonary fellows have a unique additional opportunity to take part in significant, hospital-wide research. The Cincinnati Cystic Fibrosis Center, part of the Division of Pulmonary Medicine, was chosen by medical center leadership to be a pilot team for Pursuing Perfection: Raising the Bar for Healthcare Performance, a project sponsored by the Robert Wood Johnson Foundation and the Institute for Healthcare Improvement. The Cystic Fibrosis Team applies systems-based tools and principles to effect desired change in many areas of cystic fibrosis care. It is an innovator in data transparency and in partnering with patients and families to effect system changes, all of which lead to improvements in cystic fibrosis care and outcomes.
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