Child Health Research Career Development Award

  • CHRCDA Leadership

  • Show All

    Principal Investigator

    A photo of Dr. Arnold Strauss.

    Arnold W. Strauss, MD
    Associate Director for External Relations and Strategic Projects, Cincinnati Children's Research Foundation

    513-636-2942

    arnold.strauss@cchmc.org

    Arnold W. Strauss, MD

    Associate Director for External Relations and Strategic Projects, Cincinnati Children's Research Foundation

    Professor, UC Department of Pediatrics

    Phone: 513-636-2942

    Email: arnold.strauss@cchmc.org

    Show All

    Specialties

    Pediatric cardiology; genetic basis of pediatric heart disease

    Biography

    Arnold Strauss, MD, joined Cincinnati Children's in April, 2007, as chairman of the Department of Pediatrics at the UC College of Medicine, chief medical officer of Cincinnati Children's and director of the Cincinnati Children's Research Foundation. He is the seventh B.K. Rachford Memorial Chair in Pediatrics.

    Dr. Strauss is a distinguished pediatric cardiologist, scientist, educator and leader. Prior to his arrival at Cincinnati Children's, he was the chairman of the Department of Pediatrics at the Vanderbilt University School of Medicine and medical director of the Monroe Carell Jr. Children's Hospital at Vanderbilt, a position he held from 2000 to 2007. Under his leadership, the university built and opened a new hospital for children, expanded its pediatric faculty and increased grant funding for pediatric research. From 1981 to 2000, Strauss was director of the Division of Pediatric Cardiology at Washington University/St. Louis Children's Hospital.

    A respected scientist, Dr. Strauss' research focuses on understanding the molecular basis of disorders of mitochondrial fatty acid oxidation and the genetic causes of congenital heart disease and cardiomyopathies. He is the recipient of two of the most prestigious awards in research. In November 2006 he was awarded the American Heart Association's Basic Science Research Award for groundbreaking work that led to finding genetic defects that can cause heart failure and sudden death in infants and children. In 1991 he received the E. Mead Johnson Award for Excellence in Pediatric Research.

    Education and Training

    MD: Washington University, St. Louis, Missouri, 1970.

    Residency: Pediatrics, Children's Hospital, St. Louis, Missouri, 1970-72.

    Fellowship: Cardiology, Children's Hospital and Washington University, St. Louis, Missouri, 1972-75.

    Postdoctoral Fellowship: Merck, Sharp and Dohme Research Laboratories, Rahway, New Jersey, 1975-77.

    Publications

    View PubMed Publications

    Liebig M, Schymik I, Mueller M, Wendel U, Mayatepek E, Ruiter J, Strauss AW, Wanders RJ, Spiekerkoetter U. (2006) Neonatal screening for very long-chain acyl-coA dehydrogenase deficiency: enzymatic and molecular evaluation of neonates with elevated C14:1-carnitine levels. Pediatrics 118:1065-9.

    Khuchua Z, Yue Z, Batts L, Strauss AW. (2006) A zebrafish model of human Barth syndrome reveals the essential role of tafazzin in cardiac development and function. Circ Res 99:201-8.

    Exil VJ, Gardner CD, Rottman JN, Sims H, Bartelds B, Khuchua Z, Sindhal R, Ni G, Strauss AW. (2006) Abnormal mitochondrial bioenergetics and heart rate dysfunction in mice lacking very-long-chain acyl-CoA dehydrogenase. Am J Physiol Heart Circ Physiol 290:H1289-97.

    Bennett MJ, Russell LK, Tokunaga C, Narayan SB, Tan L, Seegmiller A, Boriack RL, Strauss AW. (2006) Reye-like syndrome resulting from novel missense mutations in mitochondrial medium- and short-chain l-3-hydroxy-acyl-CoA dehydrogenase. Mol Genet Metab 89:74-9.

    Strauss AW. (2005) Surprising? Perhaps not. Long-chain fatty acid oxidation during human fetal development. Pediatr Res 57:753-4.

    Spiekerkoetter U, Tokunaga C, Wendel U, Mayatepek E, Ijlst L, Vaz FM, van Vlies N, Overmars H, Duran M, Wijburg FA, Wanders RJ, Strauss AW. (2005) Tissue carnitine homeostasis in very-long-chain acyl-CoA dehydrogenase-deficient mice. Pediatr Res 57:760-4.

    Shekhawat PS, Matern D, Strauss AW. (2005) Fetal fatty acid oxidation disorders, their effect on maternal health and neonatal outcome: impact of expanded newborn screening on their diagnosis and management. Pediatr Res 57:78R-86R.

    Djouadi F, Aubey F, Schlemmer D, Ruiter JP, Wanders RJ, Strauss AW, Bastin J. (2005) Bezafibrate increases very-long-chain acyl-CoA dehydrogenase protein and mRNA expression in deficient fibroblasts and is a potential therapy for fatty acid oxidation disorders. Hum Mol Genet 14:2695-703.

    Browning MF, Larson C, Strauss A, Marsden DL. (2005) Normal acylcarnitine levels during confirmation of abnormal newborn screening in long-chain fatty acid oxidation defects. J Inherit Metab Dis 28:545-50.

    Strauss AW. (2004) Tandem mass spectrometry in discovery of disorders of the metabolome. J Clin Invest 113:354-6.

    Spierkerkoetter U, Khuchua Z, Yue Z, Strauss AW. (2004) The early-onset phenotype of mitochondrial trifunctional protein deficiency: a lethal disorder with multiple tissue involvement. J Inherit Metab Dis 27:294-6.

    Spiekerkoetter U, Tokunaga C, Wendel U, Mayatepek E, Exil V, Duran M, Wijburg FA, Wanders RJ, Strauss AW. (2004) Changes in blood carnitine and acylcarnitine profiles of very long-chain acyl-CoA dehydrogenase-deficient mice subjected to stress. Eur J Clin Invest 34:191-6.

    Spiekerkoetter U, Khuchua Z, Yue Z, Bennett MJ, Strauss AW. (2004) General mitochondrial trifunctional protein (TFP) deficiency as a result of either alpha- or beta-subunit mutations exhibits similar phenotypes because mutations in either subunit alter TFP complex expression and subunit turnover. Pediatr Res 55:190-6.

    Spiekerkoetter U, Bennett MJ, Ben-Zeev B, Strauss AW, Tein I. (2004) Peripheral neuropathy, episodic myoglobinuria, and respiratory failure in deficiency of the mitochondrial trifunctional protein. Muscle Nerve 29:66-72.

    McKinney JT, Longo N, Hahn SH, Matern D, Rinaldo P, Strauss AW, Dobrowolski SF. (2004) Rapid, comprehensive screening of the human medium chain acyl-CoA dehydrogenase gene. Mol Genet Metab 82:112-20.

    Strauss A, Lock JE. (2003) Pediatric cardiomyopathy--a long way to go. N Engl J Med 348:1703-5.

    Spiekerkoetter U, Sun B, Zytkovicz T, Wanders R, Strauss AW, Wendel U. (2003) MS/MS-based newborn and family screening detects asymptomatic patients with very-long-chain acyl-CoA dehydrogenase deficiency. J Pediatr 143:335-42.

    Spiekerkoetter U, Sun B, Khuchua Z, Bennett MJ, Strauss AW. (2003) Molecular and phenotypic heterogeneity in mitochondrial trifunctional protein deficiency due to beta-subunit mutations. Hum Mutat 21:598-607.

    Shekhawat P, Bennett MJ, Sadovsky Y, Nelson DM, Rakheja D, Strauss AW. (2003) Human placenta metabolizes fatty acids: implications for fetal fatty acid oxidation disorders and maternal liver diseases. Am J Physiol Endocrinol Metab 284:E1098-105.

    Khuchua Z, Wozniak DF, Bardgett ME, Yue Z, McDonald M, Boero J, Hartman RE, Sims H, Strauss AW. (2003) Deletion of the N-terminus of murine map2 by gene targeting disrupts hippocampal ca1 neuron architecture and alters contextual memory. Neuroscience 119:101-11.

    Exil VJ, Roberts RL, Sims H, McLaughlin JE, Malkin RA, Gardner CD, Ni G, Rottman JN, Strauss AW. (2003) Very-long-chain acyl-coenzyme a dehydrogenase deficiency in mice. Circ Res 93:448-55.

    Zytkovicz TH, Fitzgerald EF, Marsden D, Larson CA, Shih VE, Johnson DM, Strauss AW, Comeau AM, Eaton RB, Grady GF. (2001) Tandem mass spectrometric analysis for amino, organic, and fatty acid disorders in newborn dried blood spots: a two-year summary from the New England Newborn Screening Program. Clin Chem 47:1945-55.

    Ibdah JA, Paul H, Zhao Y, Binford S, Salleng K, Cline M, Matern D, Bennett MJ, Rinaldo P, Strauss AW. (2001) Lack of mitochondrial trifunctional protein in mice causes neonatal hypoglycemia and sudden death. J Clin Invest 107:1403-9.

    Barycki JJ, O'Brien LK, Strauss AW, Banaszak LJ. (2000) Sequestration of the active site by interdomain shifting. Crystallographic and spectroscopic evidence for distinct conformations of L-3-hydroxyacyl-CoA dehydrogenase. J Biol Chem 275:27186-96.

    Ibdah JA, Bennett MJ, Rinaldo P, Zhao Y, Gibson B, Sims HF, Strauss AW. (1999) A fetal fatty-acid oxidation disorder as a cause of liver disease in pregnant women. N Engl J Med 340:1723-31.

    Program Director

    A photo of Marc Rothenberg, MD, PhD.

    Marc E. Rothenberg, MD, PhD
    Director, Division of Allergy and Immunology

    513-803-0257

    marc.rothenberg@cchmc.org

    Marc E. Rothenberg, MD, PhD

    Director, Division of Allergy and Immunology

    Director, Cincinnati Center for Eosinophilic Disorders

    Training Director, CHRCDA (K12)

    Professor, UC Department of Pediatrics

    Phone: 513-803-0257

    Fax: 513-636-3310

    Email: marc.rothenberg@cchmc.org

    Show All

    Specialties

    Clinical Interests

    Eosinophilia; eosinophilic disorders; asthma; allergy; food allergy

    Research Interests

    Eosinophils; chemokines

    Visit the Rothenberg Lab.

    Biography

    Dr. Rothenberg is director of the Division of Allergy/Immunology at Cincinnati Children's Hospital Medical Center and tenured professor of pediatrics at Cincinnati Children’s and University of Cincinnati College of Medicine. He graduated summa cum laude with highest honors in chemistry and biochemistry from Brandeis University. He then completed the MD/PhD program at Harvard Medical School under Dr. Frank Austen, conducting studies on eosinophil hematopoiesis, as he developed the first culture system for human eosinophils. After completing residency at Children’s Hospital, Boston, Dr. Rothenberg did a fellowship in allergy/immunology and hematology at Children’s Hospital. Dr. Rothenberg did post-doctorate training with Dr. Philip Leder, Harvard Medical School, where he cloned the eotaxin chemokine. After being faculty at Harvard Medical School for one year, he came to the University of Cincinnati and Cincinnati Children's, where he has helped build a top program in research, and his division is a leader in allergy and immunology.

    His research is focused on molecular analysis of allergic inflammation, primarily on the molecular pathogenesis of eosinophilic esophagitis. His laboratory takes a multi-disciplinary approach including the development of preclinical murine models: genetics, genomics, molecular immunology, and biochemistry. Dr. Rothenberg’s awards include the 2007 E Mead Johnson Award from the Society of Pediatric Research, 2010 National Institutes of Health MERIT Award, and being elected an American Association for the Advancement of Science fellow.  He is a member of the American Society for Clinical Investigation, American Academy of Pediatrics, and Society for Pediatric Radiology. His publications number over 300. He has served on review panels for journals/grant agencies including National Institutes of Health (NIH), Burroughs Trust, and Medical Research Council of the United Kingdom. He served for four-years on the Advisory Council of National Institute of Allergy and Infectious Disease. He has been associate editor of the Journal of Allergy and Clinical Immunology since 2004. His research has been supported by sources including the NIH, Human Frontier Science Program Organization, Burroughs Wellcome Fund, Dana Foundation, and Department of Defense.

    Visit the Rothenberg Lab web site

    Education and Training

    MD, PhD: Harvard Medical School, Cambridge, MA, 1990.

    Residency: Pediatrics, Children's Hospital, Boston, MA, 1991-1992.

    Fellowship: Immunology / Allergy, Children's Hospital, Boston, MA, 1992-1994; Hematology / Oncology, Children's Hospital and Dana Farber Cancer Institute, Boston, MA, 1992-1995.

    Certification: National Board of Medical Examiners, 1991; Board of Registration in Medicine, MA, 1992; American Board of Pediatrics, 1995, 2001, 2008; Ohio State Medical Board, 1997; American Board of Allergy and Immunology, 1997, 2006.

    Publications

    Grants

    NICHHD Pediatric Center for Gene Expression and Developmental Sciences. Training Director. National Institutes of Health. Dec 2011–Nov 2016. K12 HD028827.

    Epithelial Genes in Allergic Inflammation. Co-Investigator. National Institutes of Health.  Sep 2011–Aug 2016. U19 AI070235.

    Eosinophil:M2 Macrophage:CCL11 Axis in Experimental Colitis and Pediatric Corticosteroid Resistant Ulcerative Colitis. Co-Investigator. National Institutes of Health. Apr 2012–Mar 2016. R01 DK090119-01A1.

    Immunobiology of Peanut Allergy and It’s Treatment. Co-Investigator. National Institutes of Health. Jul 2010–Jun 2015. U19 AI066738.

    Regulation of Gastrointestinal Eosinophils. Principal Investigator. National Institutes of Health. Dec 2009–Nov 2014. R37 AI045898.

    IL-13 Associated Eosinophil Lung Responses. Principal Investigator. National Institutes of Health. Aug 2009–Jul 2014. R01 AI083450.

    Immunology/allergy Fellowship Training Grant. Co-Investigator and Project Director. National Institutes of Health. Jul 2009–Jun 2014. T32 AI060515.

    Cincinnati Center for Clinical and Translational Science and Training. Co-Program Director. National Institutes of Health. Apr 2009–Mar 2015. KL2 TR000078.

    The Expression and Function of Paired Immunoglobulin-like Receptor B in Eosinophils. Co-Principal Investigator. U.S. - Israel Binational Science Foundation. Oct 2012–Sep 2016.  #201144.

    Program Co-Director

    Stuart Handwerger, MD

    Professor, UC Department of Pediatrics

    Phone: 513-636-4209

    Fax: 513-636-7486

    Email: stuart.handwerger@cchmc.org

    Show All

    Specialties

    Regulation of gene expression in human placenta and uterine decidua during differentiation.

    Visit the Handwerger Lab.

    Education and Training

    MD: University of Maryland School of Medicine, Baltimore, MD, 1964.

    Residency: Mt. Sinai Hospital, New York, NY, 1965 to 1966.

    Fellowship: Harvard Medical School, Children's Hospital Medical Center, Boston, MA, 1968 to 1969.

    Certification: Diplomate, American Board of Pediatrics, 1969; Subspecialty Boards, Pediatric Endocrinology, 1978.

    Publications

    View PubMed Publications
    A photo of James Heubi.

    James E. Heubi, MD
    Director, Clinical Translational Research Center

    513-636-4415

    james.heubi@cchmc.org

    James E. Heubi, MD

    Director, Clinical Translational Research Center

    Co-Director, Center for Clinical and Translational Science and Training

    Associate Dean, Clinical and Translational Research

    Professor, UC Department of Pediatrics

    Phone: 513-636-4415

    Fax: 513-636-4695

    Email: james.heubi@cchmc.org

    Show All

    Specialties

    Clinical Interests

    Inflammatory bowel disease; cholestatic liver disease; malabsorption

    Research Interests

    Cholesterol absorption; cholesterol metabolism; inborn errors of bile acid metabolism; bone metabolism in health and disease; TPN-related cholestasis and its treatment

    Biography

    James E. Heubi, MD, has been a practicing pediatric gastroenterologist since 1979, when he joined the staff at Cincinnati Children's Hospital Medical Center.

    Dr. Heubi's practice includes the treatment of all disorders affecting the gastrointestinal tract, liver and biliary tract and pancreas.

    Dr. Heubi's areas of practice interests include liver disease and complications related to end-stage liver disease and liver transplantation and the management of patients with "short gut" or compromised gut function requiring prolonged enteral or parenteral nutritional support.

    Dr. Heubi is the Director of General Clinical Research Center at Cincinnati Children's and is the associate dean for clinical research, University of Cincinnati College of Medicine.

    Education and Training

    MD: Indiana University School of Medicine, Indianapolis, IN, 1973.

    Residency: James Whitcomb Riley Hospital for Children, Indiana University, Indianapolis, IN, 1973 to 1975.

    Fellowship: Children's Hospital Medical Center, Cincinnati, OH, 1975 to 1978.

    Certification: Pediatric Gastroenterology and Nutrition, 1990.

    Publications

    View PubMed Publications

    A photo of Margaret Hostetter.

    Margaret K. Hostetter, MD
    Director, Division of Infectious Diseases

    513-636-4509

    margaret.hostetter@cchmc.org

    Margaret K. Hostetter, MD

    Director, Division of Infectious Diseases

    Professor, UC Department of Pediatrics

    Phone: 513-636-4509

    Email: margaret.hostetter@cchmc.org

    Show All

    Specialties

    Bacterial and fungal infections; medical evaluation of internationally adopted children

    Education and Training

    MD: Baylor College of Medicine.

    Residency: Boston Children’s Hospital.

    Training Fellowship: Boston Children’s Hospital.

    Board Certification: Pediatrics; Pediatric Infectious Diseases.
    A photo of Jeffrey Robbins, PhD.

    Jeffrey Robbins, PhD
    Director and Endowed Chair, Molecular Cardiovascular Biology

    513-636-8098

    jeffrey.robbins@cchmc.org

    Jeffrey Robbins, PhD

    Director and Endowed Chair, Molecular Cardiovascular Biology

    Executive Co-Director, Heart Institute

    Associate Chair, Children's Hospital Research Foundation

    Professor, UC Department of Pediatrics

    Phone: 513-636-8098

    Email: jeffrey.robbins@cchmc.org

    Show All

    Specialties

    Structure function relationships for the contractile proteins;  cardiac-specific gene manipulation in transgenic rabbits; the contractile protein myosin, and human heart failure; molecular studies of human valve disease

    Visit the Robbins Lab.

    Biography

    Publications

    Grants

    Cardiac Signaling in the Normal and Abnormal Heart. Principal Investigator. National Heart, Lung, and Blood Institute. Sep 2013-May 2018. #P01 HL69779.

    Proteotoxicity: an underappreciated factor in cardiac disease. North American Coordinator. Leducq Transatlantic Alliance For Cardiovascular Disease. 2011-2016.

    Molecular Exploration of Myosin-Binding Protein C. Principal Investigator, Component 4 & Core C. National Heart, Lung, and Blood Institute. Feb 2000-Nov 2014. #P01 HL059408.

    Thrombospondin 4 Regulates Adaptive ER Stress Response. Co-Principal Investigator. National Heart, Lung, and Blood Institute. Jan 2011-Dec 2014. #R01 HL105924.

    Cardiac hypertrophy intracellular signaling pathways. Co-Principal Investigator. National Heart, Lung, and Blood Institute.  Jan 2009-Dec 2014. #R01 HL1062927.


    A photo of Jeffrey Whitsett.

    Jeffrey A. Whitsett, MD
    Co-Director, Perinatal Institute

    513-803-2790

    jeffrey.whitsett@cchmc.org

    Jeffrey A. Whitsett, MD

    Co-Director, Perinatal Institute

    Chief, Section of Neonatology, Perinatal and Pulmonary Biology

    Professor, UC Department of Pediatrics

    Phone: 513-803-2790

    Fax: 513-636-7868

    Email: jeffrey.whitsett@cchmc.org

    Show All

    Specialties

    Cystic fibrosis research; lung morphogenesis; control of gene expression in the respiratory epithelium; gene delivery and therapy 

    Visit the Whitsett Lab.

    Biography

    Jeffrey A. Whitsett, MD, is chief of the Section of Neonatology, Perinatal and Pulmonary Biology at Cincinnati Children's Hospital Medical Center.

    Dr. Whitsett received his medical degree from Columbia University, in New York, and has been a faculty member since 1977. He is internationally known for his research in pulmonary medicine, as well as for his clinical expertise in neonatology.

    Dr. Whitsett has made a series of groundbreaking contributions in pulmonary medicine. His major pioneering work has been on surfactant proteins A, B, C and D, cloning their genes, and clarifying their roles in lung development.

    Throughout his career, Dr. Whitsett has had the remarkable ability to move from molecular biology, to animal models, to diagnosis and therapy of human disease. He played a critical role in making surfactant protein replacement a routine tool for treating immature lungs and respiratory distress syndrome in premature infants. His laboratory has contributed to the identification of a number of genes critical for lung formation and function. Mutations in genes regulating surfactant homeostasis were shown to cause acute and chronic lung disease in infants and adults.

    Dr. Whitsett is a member of the Institute of Medicine, National Academy of Sciences and is the recipient of the Mead Johnson Award, a National Institutes of Health (NIH) Merit Award, the first Julius Comroe Lectureship in Pulmonary Research from FASEB, the William Cooper Procter Award from Cincinnati Children's, the Amberson Lecture Award of the American Thoracic Society, the prestigious Daniel Drake Medal for scientific contributions from the University of Cincinnati College of Medicine, the International Arvo Ylppö Medal from the Finnish Foundation for Pediatric Research and the Grand Hamdan International Award on Neonatal Medicine from the United Arab Emirates.

    Dr. Whitsett is the author of more than 400 papers in both the basic science and clinical literature.

    Education and Training

    MD: Columbia University, New York, NY, 1973.

    Residency: Pediatrics, Mt. Sinai Hospital, New York City, 1974 to 1976.

    Fellowship: Neonatology, Children's Hospital Medical Center, University of Cincinnati College of Medicine, 1976 to 1977.

    Publications

    View PubMed Publications