Molecular and Developmental Biology Graduate Program

  • Research Facilities

    In addition to a world-class faculty, graduate students in the Molecular and Developmental Biology graduate program enjoy access to world-class facilities while conducting their research at the Cincinnati Children's Hospital Research Foundation.

    Lots of Room to Work

    Cincinnati Children's offers more research space than any other pediatric facility in the nation. Construction for our newest research expansion, the Clinical Sciences Building, will begin in June 2012 and bring our total research space to 1.4 million square feet. 

    Research Materials at Your Disposal

    Graduate students are able to use two scientific research libraries. At Cincinnati Children's, you can use the Pratt Library, and at UC you can search through the College of Medicine's library system. Between the two libraries, you have access to all major medical and scientific journals. In addition, each library has an extensive compilation of journals accessible online, often with subscriptions that allow you to access them.

    Electronic Infrastructure

    All students have access to computing facilities while at Cincinnati Children's, including workstations, high-speed Internet connections, and email accounts. In addition, the Division of Biomedical Informatics provides computational resources for such tasks as data processing and analysis.

    Access to Core Resources

    Students have access to Children's core support capabilities and facilities. These core support capabilities are resources that are available for all researchers and students at the Research Foundation. Core resources for basic and clinical research enhance investigators' access to cutting-edge technology and data analysis for a wide variety of projects.

    Learn more about our core resources:

  • Show All

    + Animal Behavioral Core

    Animal Behavioral CoreThe Animal Behavioral Core offers behavioral phenotyping of rodent models. Through the use of behavioral assays, we help Principal Investigators, postdoctoral fellows and graduate students characterize the nervous system functional integrity or abnormality in mouse and rat models.

    Directors: Charles V. Vorhees, PhD and Michael T. Williams, PhD

    + Cell Manipulations Laboratory

    The cell manipulations Laboratory offers a controlled-access clean room facility that was designed and built to perform ex vivo cell manipulations, including gene therapy protocols, for Phase 1 and 2 clinical trials.

    Co-Directors: Diana Nordling, Carolyn Lutzko, PhD

    + Cell Processing Core

    The cell processing core supplies mononuclear cells, stem cells or other enriched cell populations from peripheral blood, bone marrow and cord blood.

    Co-Directors: Diana Nordling, Carolyn Lutzko, PhD

    + Gene Expression Microarray Core

    The Gene Expression Microarray Core at Cincinnati Children’s is available to perform the expression level analysis of thousands of genes in parallel.  For most organisms it is now possible to provide a quantitative measure of the expression level of every gene. The gene expression microarray core is available for the study of developmental and disease processes, enabling scientists to achieve gene expression variation associated with disease and discovering new drug targets.

    Director: S. Steven Potter, PhD

    + Imaging Research Center

    Imaging Research CenterThe Imaging Research Center is an interdisciplinary research laboratory, operated by the Cincinnati Children's Research Foundation (CCRF) and the Department of Radiology at Cincinnati Children's Hospital Medical Center, the purpose of which is to conduct research in medical imaging related to the diagnosis and treatment of diseases in children and young adults.

    Director: Charles Dumoulin, PhD

    + Laser Capture Microdissection Microscopy

    Laser Capture Microdissection MicroscopyOur technology directly extracts single cells from any tissue section, giving you a pure cell population for analysis. The core can train researchers to operate the microdissection equipment and give general advice on preparing samples.

    Director: Xiaonan Han, PhD

    + Lenti-shRNA Library Core

    Lenti-shRNA Library CoreOur high-throughput screening allows discovery of novel genes that affect biologic pathways of interest. Our mouse and human libraries encode 160,000 shRNA clones against 32,000 genes and have been designed for automated handling and production of lentivirus. Researchers can choose either single-gene selection or whole-library screening for your research.

    Director: Jeff Molkentin, PhD

    + Pluripotent Stem Cell Facility

    Pluripotent Stem Cell FacilityThe PSCF is dedicated to providing access to high quality, well characterized, and reliably archived hESCs and iPSCs for distribution to researchers. Our facility also provides investigators with expert training in protocols for iPSC generation and techniques for the maintenance and manipulation of hESCs and iPSCs in culture as well as their differentiation into specific lineages. Our overall mission is to facilitate all aspects of pluripotent stem cell experimentation at CCHMC/UC to enhance research into human development and disease and contribute to advancing stem cell therapies for human disease.

    Co-Directors: James Wells, PhD and Chris Mayhew PhD

    + Stem Cell Processing Core Lab

    The stem cell processing core can supply mononuclear cells, stem cells or other enriched cell populations from peripheral blood, bone marrow and cord blood. 

    Co-Directors: Diana Nordling, Carolyn Lutzko, PhD

    + Transgenic and Gene Targeting Core

    The transgenic and gene targeting core specializes in embryo cryopreservation and the generation of genetically altered mice and rabbits. The laboratory is accessible to non-Research Foundation faculty. Services are provided with a user charge.

    Director: Kenneth Campbell, PhD

    + Translational Core Facility

    The Translational Core Labs include The Viral Vector Core, The Vector Production Facility, The Stem Cell Processing Lab, The Cell Manipulations Lab and the Translational Trial Development and Support Lab (TTDSL). We specialize in the translation and scale up of gene therapy and cell therapy including iPSC and HEK in addition to the patient testing associated with these trials.

    Lab Director: Punam Malik, MD

    + Vector Production Facility

    Vector Production FacilityThe vector production facility provides GMP-grade viral vectors, master cell banks and master viral banks in support of gene therapy trials.

    Director: Han van der Loo, PhD


 
  • New research facilities.

    Click for larger image.

    New Research Facilities

    New research facilities.

    In November 2008, we opened a 12-story, 415,000 square foot facility (Location S; on left) that makes Cincinnati Children's one of the largest pediatric research programs in the country, as our total research space reaches nearly 1 million square feet. Students will also spend time at the University of Cincinnati's College of Medicine (on right) while taking courses.

  • UC College of Medicine

    The Molecular and Developmental Biology Graduate Program is administered by the University of Cincinnati's College of Medicine so students have access to resources at UC. UC's Medical Sciences Building, one of the largest research-teaching structures under one roof in this country, houses extensive state-of-the-art research facilities.

  • Research display.

    Click for larger image.

    Research Display

    Research display.

    Cincinnati Children's proudly displays innovative and landmark research in the lobby of our newest research building (Location S).

  • Contact Us

    Molecular and Developmental Biology Graduate Program.
    For more information about the Molecular and Developmental Biology Program at Cincinnati Children's and the University of Cincinnati, email mdbprog@cchmc.org or call 513-636-4545. You can also apply online at our application page.