Cancer Biology
Cancer is the leading cause of death in the United States
Researchers in this group investigate how genetic and environmental factors result in cancer through disruption of cellular growth control and organismal development.
Collaborative work involving clinicians and laboratory scientists allows access to normal and cancerous human tissues and fosters the development of clinical trials.
Faculty
Paul Andreassen, PhD, Assistant Professor
Fanconi anemia and breast cancer susceptibility proteins in DNA damage responses and genetic stability [Visit the Andreassen lab]
Lionel Chow, MD, PhD, Assistant Professor
Understanding the molecular underpinnings and signaling pathways that control the growth and survival of high-grade gliomas [Visit the Chow Lab]
Jay Degen, PhD, Professor
The role of hemostatic factors and coupled signaling systems in development, inflammatory response, vessel wall disease and tumor biology [Visit Experimental Hematology and Cancer Biology]
Brian Gebelein, PhD, Assistant Professor
Patterning of the nervous and digestive systems during development [Visit the Gebelein Lab]
Rashmi Hegde, PhD, Professor
Structural biology of proteins in embryonic cellfate determination, and proteins involved in the life- and infection-cycles of the cancer-associated papillomaviruses [Visit the Hegde Lab]
James C. Mulloy, PhD, Associate Professor
Molecular mechanisms involved in leukemia induction and maintenance; mouse modeling of leukemia using primary human blood stem cells [Visit the Mulloy Lab]
Nancy Ratner, PhD, Professor
The peripheral nerve in development and disease [Visit the Ratner Lab]
Tanya V. Kalin, MD, PhD, Assistant Professor
Transcriptional regulation of DNA replication and mitosis in tumor cells in vitro and in vivo; diagnostic, prevention and treatment of lung and prostate cancers. [Visit the Kalin Lab]
Susan Waltz, PhD, Associate Professor
Molecular analysis of growth factors and receptor tyrosine kinases in tumorigenesis, organ function, and cellular trauma [Visit the Waltz Lab]
Susanne Wells, PhD, Associate Professor
Papilloma virus and cervical cancer [Visit the Susanne Wells Lab]
Christopher Wylie, PhD, Professor
(1) Control of the cytoskeleton, control of cell migration and control of early cell lineage specification, in vertebrate embryos (2) Control of gonad formation, primordial germ cell migration, oocyte maturation and egg formation [Visit the Wylie-Heasman Lab]
Yi Zheng, PhD, Professor
Molecular mechanisms of Rho GTPase signal transduction. Development of novel therapeutic reagents to inhibit Rho pathways related to human pathological conditions [Visit Experimental Hematology and Cancer Biology]
Contact Us
For more information about the Molecular and Developmental Biology Program at Cincinnati Children's and the University of Cincinnati, email mdbprog@cchmc.org or call 513-636-4545. You can also apply online at our application page.
