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Mature blood cells are generated from hematopoietic stem cells (HSCs) in a process called hematopoiesis. HSCs share the common hallmarks of all stem cells: HSCs can self-renew (can reproduce daughter cells, at least one of which is identical to the parent itself), and HSCs give rise to different kinds of mature blood cells (multi-lineage differentiation). 50 years of research on the hematopoietic system have resulted in HSCs and hematopoiesis being the best studied somatic stem cell system with routine clinical applications such as HSC transplantation.
The research in the Division of Experimental Hematology focuses on understanding the biology of blood cell formation and function and to use this knowledge to develop innovative treatments of genetic and acquired diseases affecting the blood system and cancer. A better understanding of the development and function of hematopoietic stem and progenitor cells will facilitate the rapid transfer of knowledge into innovative clinical trials in children. This is a highly collaborative effort, including not only faculty from Experimental Hematology and Hematology/Oncology, but also including members of Pulmonary Biology, Allergy/Immunology, Human Genetics, and Bioinformatics at CCRF.
Paul Andreassen, PhD, Assistant Professor Fanconi anemia and breast cancer susceptibility proteins in DNA damage responses and genetic stability [Visit the Andreassen lab]
John Harley, MD, PhD, ProfessorLupus genetics, genetics and genomics [Visit Rheumatology]
James C. Mulloy, PhD, Associate Professor Molecular mechanisms involved in leukemia induction and maintenance; mouse modeling of leukemia using primary human blood stem cells [Visit the Mulloy Lab]
Steven Potter, PhD, ProfessorStudies of homeobox genes that control mammalian development using gene targeting and transgenic mice [Visit the Potter Lab]
Marc Rothenberg, MD, PhD, Professor Eosinophil biology, chemokine receptor signaling pathways [Visit the Rothenberg Lab]
Saulius Sumanas, PhD, Assistant ProfessorMolecular mechanisms of vasculogenesis and angiogenesis [Visit the Sumanas Lab]
Stephen N. Waggoner, PhD, Assistant ProfessorUnderstanding the role of natural killer (NK) cells in disease pathogenesis. [Visit Rheumatology]Michael Williams, PhD, Associate Professor Interaction of stress-induced hormones and drugs of abuse on adult learning and memory abilities; physiological responses to later stressors; behavioral and physiological consequences of drug reexposure. [Visit the Michael Williams Lab] Yi Zheng, PhD, Professor Molecular mechanisms of Rho GTPase signal transduction. Development of novel therapeutic reagents to inhibit Rho pathways related to human pathological conditions [Visit Experimental Hematology and Cancer Biology]
For more information about the Molecular and Developmental Biology Program at Cincinnati Children's and the University of Cincinnati, email firstname.lastname@example.org or call 513-636-4545. You can also apply online at our application page.
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