Molecular and Developmental Biology Graduate Program

  • Hematopoietic System

    Mature blood cells are generated from hematopoietic stem cells (HSCs) in a process called hematopoiesis.  HSCs share the common hallmarks of all stem cells: HSCs can self-renew (can reproduce daughter cells, at least one of which is identical to the parent itself), and HSCs give rise to different kinds of mature blood cells (multi-lineage differentiation). 50 years of research on the hematopoietic system have resulted in HSCs and hematopoiesis being the best studied somatic stem cell system with routine clinical applications such as HSC transplantation.  

    The research in  the Division of Experimental Hematology focuses on understanding the biology of blood cell formation and function and to use this knowledge to develop innovative treatments of genetic and acquired diseases affecting the blood system and cancer.  A better understanding of the development and function of hematopoietic stem and progenitor cells will facilitate the rapid transfer of knowledge into innovative clinical trials in children. This is a highly collaborative effort, including not only faculty from Experimental Hematology and Hematology/Oncology, but also including members of Pulmonary Biology, Allergy/Immunology, Human Genetics, and Bioinformatics at CCRF.

    Faculty

    Paul Andreassen, PhD, Assistant Professor
    Fanconi anemia and breast cancer susceptibility proteins in DNA damage responses and genetic stability [Visit the Andreassen lab]

    John Harley, MD, PhD, Professor
    Lupus genetics, genetics and genomics [Visit Rheumatology]

    James C. Mulloy, PhD, Associate Professor
    Molecular mechanisms involved in leukemia induction and maintenance; mouse modeling of leukemia using primary human blood stem cells [Visit the Mulloy Lab]

    Steven Potter, PhD, Professor
    Studies of homeobox genes that control mammalian development using gene targeting and transgenic mice [Visit the Potter Lab]

    Marc Rothenberg, MD, PhD, Professor
    Eosinophil biology, chemokine receptor signaling pathways [Visit the Rothenberg Lab]

    Saulius Sumanas, PhD, Assistant Professor
    Molecular mechanisms of vasculogenesis and angiogenesis [Visit the Sumanas Lab]

    Stephen N. Waggoner, PhD, Assistant Professor
    Understanding the role of natural killer (NK) cells in disease pathogenesis. [Visit Rheumatology]

    Michael Williams, PhD, Associate Professor
    Interaction of stress-induced hormones and drugs of abuse on adult learning and memory abilities; physiological responses to later stressors; behavioral and physiological consequences of drug reexposure. [Visit the Michael Williams Lab]

    Yi Zheng, PhD, Professor
    Molecular mechanisms of Rho GTPase signal transduction. Development of novel therapeutic reagents to inhibit Rho pathways related to human pathological conditions [Visit Experimental Hematology and Cancer Biology

    Contact Us

    For more information about the Molecular and Developmental Biology Program at Cincinnati Children's and the University of Cincinnati, email mdbprog@cchmc.org or call 513-636-4545. You can also apply online at our application page.

 
  • Hematopoietic Diseases

    Hematopoietic Diseases.
    • Allergy
    • Asthma
    • Hypereosinophilic syndromes
    • Inflammation
    • Leukemia

    View a complete list of the diseases that our students and faculty are fighting.