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MDB students meet with an Academic Advisory Committee at the beginning of their first year to design a curriculum based on individual research interests. The only requirement for the PhD degree is that students take 45 credits of academic courses during their time in the Program.
Suggested Curriculum for First Year Students
Introduction to Developmental Biology - 26DB985. 3 graduate credits The goal of this course is to provide students with understanding of fundamentals in developmental biology. They learn the basic understanding of key terminology in developmental biology (germ layer, morphogen, etc.), development of major model organisms (fly, frog, chick, mouse, zebrafish), development of the major organ systems, and the key developmental mechanisms (tissue interactions, cell adhesion, transcriptional regulation, etc.)
Biochemistry - 26GNTD872. 3 graduate credits This course applies classical and molecular techniques to problems of protein structure and function; membrane organization and dynamics; biochemistry of membrane transport processes.
Introduction to Molecular Genetics - 26GNTD871. 3 graduate credits This course covers gene expression in prokaryotes and eukaryotes, principles of gene cloning, DNA replication, mutation and repair, mouse transgenesis and a section on human disease and genetic traits.
Advanced Molecular Genetics 1: Gene Regulation - 26MG710. 4 graduate credits This challenging course brings the students up to the present day level of understanding on transcriptional regulation and chromatin structure. It deals with the primary literature, stresses an analytical approach and understanding of methodology, and involves weekly discussion sessions.
Cell Biology - 26GNTD873. 3 graduate credits This course covers membrane biology and basic cell biology. Emphases include membrane structure and generation of resting and action potentials, cell compartmentalization and organelles, protein trafficking and secretion, cytoskeleton, extracellular matrix, nuclear architecture and chromosome structure. The course integrates morphological, biochemical and biophysical approaches.
Journal Club - 26DB904-905-906. 1 graduate credit each quarter taken. The purpose ot this course is for students to learn how to critically evaluate the scientific literature and to read state-of-the-art primary research papers. During autumn and winter quarters, Journal Club is to be led by a faculty member in the Graduate Program in Molecular and Developmental Biology and during spring quarter by graduate students. Attendance is mandatory for all first and second year students. Participation in Journal Club for advanced students (3rd year and beyond) is required only during the spring quarter when they are expected to provide leadership for the group.
MDB/CHRF Seminar Series - 26DB901-902-903. 1 graduate credit each quarter taken. Every year, the Cincinnati Children's Research Foundation, with the Molecular and Developmental Biology Graduate Program, hosts a weekly seminar series. Noted researchers from across the country come to Cincinnati Children's to talk about a variety of topics within molecular and developmental biology. All students have the opportunity to meet informally with each speaker. (link to MBD seminar series)
Introduction to Biostatistics - 26BE787. 4 graduate credits Descriptive statistics, probability distributions, estimation, types of error, significance level, test of hypotheses, sample size, correlation, linear regression, non-parametric methods. Emphasizes practical-applied aspects.
Introduction to Statistics - 26BE796. 4 graduate credits Descriptive statistics, probability, estimation, statistical errors, parametric and nonparametric hypothesis testing, statistical fallacies. Emphasizes applied-practical aspects. Less material covered than in 787.
Genetics of Complex Diseases - 26BE868. 3 graduate credits Introduction to complex disease and traits. Epidemiology and genetic basis of complex diseases.
Ethics in Research - 26GNTD730. 1 graduate credit A nine-week lecture series addressing ethical issues in research including such topics as human experimentation, animal welfare, conflict of interest, and responsible authorship and publication practices.
Introduction to Functional Genomics - 26GNTD881. 3 graduate credits The course will consist of a series of lectures/seminars on the theory and use of methods of functional genomics in biomedical research. Lec-tures will be presented by some local speakers and invited experts outside the university. The course will include eight lab sessions, five on bioinformatics that will be offered in an electronic classroom and three "wet labs" that will provide hands-on experience in practical application of functional genomics principles. Prereq.: 26GNTD871. The course will be open to all COM graduate students and others by perm. of instr.
Medical Physiology I. - 26MCP841. 7 graduate credits Subcellular organ-elles, cells, tissues, organ systems and their integrated activity. Focus: cellular, muscle, cardiac, circulatory, renal, respiration, the physiology acid base, and the physiology of energy balance and temperature regulation. Prereq.: Perm. of course director.
Molecular Physiology I: Membrane Transport Proteins - 26MCP951. 4 graduate credits The goal of this course is to introduce the major concepts, litera-ture and experimental approaches related to the study of membrane transport proteins, including ion channels, pumps, and transporters. Prereq.: Perm. of instr.
Proteins: Structure, Function and Engineering - 26MG719. 4 graduate credits Designed for graduate students who have completed the first quarter of Molecular Biology of the Cell. Protein design; enzyme specificity and mechanisms of catalysis; transport physiology and enzymology; macromolecular assembly, protein-protein interactions and signal transduction; NMR and macromolecular structure. Prereq: 26GNTD872 or perm. of instr.
Mechanisms of Signal Transduction - 26MG711. 3 graduate credits Provides a research literature-based view with student discussions of examples of genetic mechanisms in cell growth and development. Topics include mechanisms of genetic recombination, aspects of Dro-sophila development, mouse molecular genetics, and genetic control of cellular growth. Prereq.: 26GNTD871.
Structural Biology - 26MG718. 2 graduate credits This course will cover structural techniques used to determine protein structure, dynamics and enzyme mechanisms. Particular emphasis will be placed on solution NMR tech-niques to problems in protein structure and enzyme mechanism. The course will consist of both lectures and a review of pertinent literature articles. Topics to be covered include NMR theory, practical aspects of biological NMR, the use of structural techniques in understanding HIV proteins, structural studies of muscle proteins, as well as mechanistic studies of ribonucleases and phosphoryl transfer enzymes.
Neuropharmacology - 26NS830. 2 graduate credits This course covers the neuro-chemical mechanisms underlying the behavioral effects of psychoactive drugs. Reference to specific neurotransmitter systems and drugs are used to illustrate general principles. Topics include drug modulation of synaptic transmission; brain adaptations to chronic drug treatments; psychotherapeutic drugs and what they tell us about the etiology of brain disorders. Prereq.: Perm. of instr
Brain and Behavior I - 26NS841. 4-10 graduate credits The first quarter of a two quarter sequence that introduces the principles and concepts of nervous system organization: structural organization, cellular neurophysiology, neuropharmacology, sensory and motor systems, higher cortical functions. Required for Neuroscience PhD students.
Brain and Behavior II - 26NS861. 4-10 graduate credits An overview of human neurological and psychiatric disorders through the various stages of human development, including seizures, schizophrenia, substance abuse, Alzheimer's disease, Parkinson's disease and other movement disorders. The course is offered during a four-week concentrated block of time. Prereq.: Perm of instr.
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