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Cancer is the leading cause of death in the United States.
Researchers in this group investigate how genetic and environmental factors result in cancer through disruption of cellular growth control and organismal development.
Collaborative work involving clinicians and laboratory scientists allows access to normal and cancerous human tissues and fosters the development of clinical trials.
Paul Andreassen, PhD, Associate Professor Fanconi anemia and breast cancer susceptibility proteins in DNA damage responses and genetic stability [Visit the Andreassen lab]
Jose A. Cancelas Perez, MD, PhD, Associate Professor Cellular and molecular mechanisms of norm and cancer hematopoietic stem cells [Visit the Cancelas Lab]
Lionel Chow, MD, PhD, Assistant Professor Understanding the molecular underpinnings and signaling pathways that control the growth and survival of high-grade gliomas [Visit the Chow Lab]
Jay Degen, PhD, Professor The role of hemostatic factors and coupled signaling systems in development, inflammatory response, vessel wall disease and tumor biology [Visit Experimental Hematology and Cancer Biology]
Brian Gebelein, PhD, Associate ProfessorPatterning of the nervous and digestive systems during development [Visit the Gebelein Lab]
Rashmi Hegde, PhD, Professor The Hegde laboratory studies molecular mechanisms of angiogenesis in development, cancer and retinal diseases, and is involved in structure- and mechanism-based drug development [Visit the Hegde Lab]
Tanya V. Kalin, MD, PhD, Associate ProfessorMolecular biology of cancer, tumor microenvironment and metastasis. Chemotherapeutic drug development. [Visit the Kalin Lab]
Qing Richard Lu, PhD, ProfessorTranscriptional and epigenetic control of glial development and brain tumor initiation [Visit Experimental Hematology]
James C. Mulloy, PhD, ProfessorMolecular mechanisms involved in leukemia induction and maintenance; mouse modeling of leukemia using primary human blood stem cells [Visit the Mulloy Lab]
Nancy Ratner, PhD, Professor The Ratner lab studies how nerve development is subverted in cancer. We aim to identify targets for therapy in the inherited cancer predisposition syndromes neurofibromatosis type 1 and type 2. [Visit the Ratner Lab]
Susanne Wells, PhD, ProfessorPapilloma virus and cervical cancer [Visit the Susanne Wells Lab]
Kathryn Wikenheiser-Brokamp, MD, PhD, Associate ProfessorOur research aims to elucidate the molecular basis of lung development and disease with specific focus on identifying critical biologic functions of the Rb/p16, p53 and Dicer/miRNA pathways in pulmonary progenitor/stem cell growth in the context of organogenesis, repair after injury and disease pathogenesis to identify novel targets with diagnostic and therapeutic utility. [Visit Pathology]
Yi Zheng, PhD, Professor Molecular mechanisms of Rho GTPase signal transduction. Development of novel therapeutic reagents to inhibit Rho pathways related to human pathological conditions [Visit Experimental Hematology and Cancer Biology]
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