Molecular and Developmental Biology Graduate Program

  • Thomas Acciani

    Thomas AccianiHometown: Cincinnati, Ohio

    Undergraduate Institution: University of Illinois at Urbana-Champaign, Champaign, Illinois

    After graduating from the University of Illinois I became a research technician at Cincinnati Children’s Hospital Medical Center, because honestly after graduation I didn’t know exactly what I wanted to do but I knew I had a passion for research from the little exposure I saw as an undergrad. It was while working as a research technician that I was exposed to the translational side of research, one that I never saw while working in a lab as an undergraduate. The exposure to this type of translational research as well as guidance from my mentor, I realized that I wanted to pursue a career in academic research. So I began to I apply to graduate programs around the country, but after being exposed to the research atmosphere here at Cincinnati Children’s as a technician, I knew it was going to be hard for another institution to compete. Cincinnati Children’s creates a research environment that takes collaboration to another level, beyond just the sharing of ideas and possibilities and really extending a helping hand in learning new techniques and even reagents. There is no limit to the help one can receive here at Cincinnati Children’s to expand and develop training opportunities, and with the Molecular and Developmental Biology Graduate Program situated right in the hospital it was a no brainer when it came to choosing this program. Currently my thesis work is with my mentor Dr. Tim LeCras in the section of Neonatology, Perinatal, and Pulmonary Biology of the Perinatal Institute and involves examining the role of EGF receptor signaling and impact of diesel exhaust particle exposure in asthma pathogenesis.

    Publications

    Madala SK, Edukulla R, Phatak M, Schmidt S, Davidson C, Acciani TH, Korfhagen TR, Medvedovic M, LeCras TD, Wagner K, Hardie WD. Dual targeting of MEK and PI3K pathways attenuates established and progressive pulmonary fibrosis. PLoS One. 2014 Jan 27;9 (1):e86536.

    Acciani TH, Brandt EB, Khurana Hershey GK, LeCras TD. Diesel exhaust particle exposure increases severity of allergic asthma in young mice. Clin Exp Allergy. 2013 Dec; 43(12): 1406-18.

    Brandt EB, Kovacic MB, Lee GB, Gibson AM, Acciani TH, LeCras TD, Ryan PH, Budelsky AL, Khurana Hershey GK. Diesel exhaust particle induction of IL-17A contributes to severe asthma. J Allergy Clin Immunol. 2013 Nov; 132(5):1194-1204.

    Chen L, Acciani TH, LeCras TD, Lutzko C, Perl AK. Dynamic regulation of PDGFRα expression during realveolarization is dependent on FGF signaling. Am J Respir Cell Mol Biol. 2012 Oct; 47(4):517-27.

    Kramer EL, Hardie WD, Mushaben EM, Acciani TH, Pastura PA, Korfhagen TR, Hershey GK, Whitsett JA, LeCras TD. Rapamycin Decreases Airway Remodeling and Hyperreactivity in a Transgenic Model of Noninflammatory Lung Disease. J Appl Physiol. 2011 Dec; 111(6): 1760-7.

    LeCras TD, Acciani TH, Mushaben EM, Kramer EL, Pastura PA, Hardie WD, Korfhagen TR, Sivaprasad U, Ericksen M, Gibson AM, Holtzman MJ, Whitsett JA, Hershey GK. Epithelial EGF receptor signaling mediates airway hyperreactivity and remodeling in a mouse model of chronic asthma. Am J Physiol Lung Cell Mol Physiol. 2011 Mar; 300(3): L414-21.

    Kramer EL, Mushaben EM, Pastura PA, Acciani TH, Deutsch GH, Khurana Hershey GK, Korfhagen TR, Hardie WD, Whitsett JA, LeCras TD. Early growth response-1 suppresses epidermal growth factor receptor-mediated airway hyperresponsiveness and lung remodeling in mice. Am J Respir Cell Mol Biol. 2009 Oct; 41(4): 415-25.