Acetaminophen and Codeine Phosphate (Capital and Codeine, Tylenol with Codeine)

(uh-seet-uh-MIN-oh-fin) (KOH-deen)

Acetaminophen and codeine (Capital and Codeine Phosphate, Tylenol with Codeine Phosphate) are a combination medication used to relieve pain.

They can also be used to reduce coughing.

  • Give only the amount prescribed by your child's doctor.
  • Your child should not take this medication more than five times in one day.
  • If giving your child a liquid, carefully measure each dose using an oral syringe or medicine spoon.
  • This medicine can be given with food to prevent stomach upset.
  • Do not give your child acetaminophen (Tylenol, Genapap, Panadol, Tempra) or other over-the-counter medications that contain acetaminophen while using this medication.
  • Check the labels on all over-the-counter medicines you give your child to make sure they do not contain acetaminophen. Too much acetaminophen may be harmful.
  • Do not give this medicine if your child is allergic to codeine or morphine. Contact the prescriber.
  • This medicine may make your child drowsy. Watch carefully if your child is performing a task requiring alertness, such as climbing stairs.
  • If your child requires this medicine for a long period of time, the dose may need to be slowly decreased and not stopped quickly.
  • Do not use after the expiration date on the bottle/package.
  • Keep this medication out of the reach of children.
  • Contact your doctor if you give your child too much medicine.
  • If too much medicine is taken by accident, call the Drug and Poison Information Center (DPIC) at 513-636-5111 or 1-800-222-1222, or call your child's doctor immediately.

If you have been instructed to give this medicine to your child on a regular schedule and miss a dose, give it as soon as you remember it.

However, if it is almost time for the next dose, skip the missed dose and go back to the regular dosing schedule. Do NOT give double the dose to catch up.

For any medication information related to your child's dosing schedule and/or missed doses, contact the healthcare provider who prescribed the medication.

There is a possibility for serious side effects, including slowed or difficult breathing. Children, especially those who already have breathing problems, may be more likely to have these serious side effects. Other possible side effects include:

  • Drowsiness
  • Dizziness
  • Constipation
  • Nausea
  • Difficulty breathing
  • Skin rashes, hives or itching
  • Nausea or vomiting
  • Extreme sleepiness or difficult awakening
  • Yellowing of the skin or eyes

Constipation (hard or few stools) can be a problem when taking any medication containing codeine. The doctor may also want to have your child take a medicine to help move your child's stools. Be sure to keep your child well hydrated.

Call your child's doctor if the pain and/or cough are not helped by this medicine.


Tylenol with Codeine No. 2 (acetaminophen 300 mg + codeine 15 mg)
Tylenol with Codeine No. 3 (acetaminophen 300 mg + codeine 30 mg)
Tylenol with Codeine No. 4 (acetaminophen 300 mg + codeine 60 mg)

Suspension, Alcohol Free

Acetaminophen 120 mg + codeine 12 mg per 5 mL

Elixir, 7% Alcohol

Acetaminophen 120 mg + codeine 12 mg per 5 mL

Last Updated 12/2015