Cyclosporine (Sandimmune, Neoral, SangCya, GenGraf) is a medicine that is used to prevent organ rejection after transplant.

It has also been used to treat other illnesses, such as aplastic anemia, severe rheumatoid arthritis, or to prevent graft versus host disease (GVHD).

It is available as a capsule, injection, or liquid.

  • It is important to take cyclosporine at the same time and the same way − either with or without food − each day. Changing these conditions can change the amount of medication that gets into your child's blood, thus affecting blood levels.
  • Capsules should be swallowed whole − do not bite, crush or chew.
  • To make the liquid cyclosporine taste better, mix with apple or orange juice in a glass cup (best at room temperature). Do not use a plastic, Styrofoam, or wax paper cup.
  • Mixing liquid cyclosporine (Neoral) with milk may cause a bad taste. 
  • Drink immediately; do not allow to stand before drinking. Rinse with more apple or orange juice to ensure that the total dose is taken.  
  • Do not eat grapefruit or drink grapefruit juice while taking cyclosporine, unless the doctor tells you it is OK to do this. (The amount of medication in the blood can be increased and could cause harm).  
  • Keep this medication at room temperature – do not refrigerate.
  • This medication has many other drug interactions with other medications. 
  • Do not change brands of cyclosporine without talking to your doctor. This could change the amount of the drug in your child’s blood. 
  • Store in a dry place away from moisture and sunlight.  Do not store in the bathroom.
  • This medication must remain in its original container.  
  • Open bottles must be used within two months.
  • It is important to see your child's doctor regularly so the effects of this medicine can be watched carefully.
  • Testing of your child's blood will be done every so often while taking this medication.  
  • Do not give any other medicine, prescription or over-the-counter (OTC), without first talking to the doctor.  
  • Keep this medication out of the reach of children.  
  • If too much medicine is taken by accident, call the Drug and Poison Information Center (DPIC), 513-636-5111 or 1-800-222-1222, or call your child's doctor immediately. 

For any medication information related to your child's dosing schedule and/or missed doses, contact the healthcare provider who prescribed the medication.

  • Upset stomach (nausea)  
  • Throwing up (vomiting)  
  • Loose stools (diarrhea)  
  • Increased need to go to the bathroom (urination)  
  • Blurred vision  
  • Confusion
  • Problems hearing  
  • Tingling of hands or feet  
  • Other possible side effects include kidney problems, increased blood pressure, hair growth, swollen or bleeding gums, shaking, liver problems, low blood count and increased risk of infections.
  • Reddened face (flushing)  
  • Breathing problems  
  • Fever  
  • Chills
  • Loose stools  
  • Chest pain  
  • Red color to urine  
  • Yellow skin (jaundice)  
  • Seizures

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