Etoposide (VP-16, VePesid)


Etoposide (VP-16) is a medicine used to treat certain types of cancer (leukemia, Hodgkin's disease, neuroblastoma, Ewing's sarcoma, rhabdomyosarcoma, Wilms tumor, brain tumors) and histiocytosis.

Etoposide is usually given by IV infusion in the hospital.

Capsules are available and not usually used.

  • Capsules: 50 mg
  • This medication is usually given in the hospital.
  • A nurse will check your blood pressure during the infusion of this medication.
  • If capsules are being used, they must be kept refrigerated.
  • Use precaution when changing your child's diapers or soiled linens for 48 hours after a dose. Use gloves during this time to avoid contact with the medicine.
  • If too much medicine is taken by accident, call the Drug and Poison Information Center (DPIC), 513-636-5111 or 1-800-222-1222, or call your child's doctor immediately.
  • Keep this medicine out of the reach of children.

If taking oral capsules, call your doctor right away if a dose is missed. Never double the dose to try to catch up.

For any information about your child's dosing schedule and/or missed doses, contact the healthcare provider who prescribed the medication.

  • Nausea and vomiting
  • Diarrhea
  • Loss of hair
  • Skin rash
  • Decrease in blood pressure
  • Decreased ability to fight infections
  • Allergic reactions
  • Sunburn-like skin irritation or rash may occur on areas that were previously treated with radiation therapy (radiation recall).
  • Dizziness
  • Facial flushing
  • Difficulty breathing

Last Updated 11/2013