Filgrastim (G-CSF, Neupogen)


Filgrastim or G-CSF (granulocyte-colony stimulating factor) is a medication that is used in some patients to try to stimulate certain blood cells (white blood cells) to enter the circulation faster after receiving chemotherapy.

This decreases the time that you are without certain blood cells that are used to fight infections.

It is also sometimes used in combination with other medicines like ganciclovir and Septra that can cause blood counts to decrease.

  • Do not shake the vial. This may cause the drug to be less effective.
  • This medication should be kept in its original container and stored in the refrigerator.
  • This medicine is either infused through your central line catheter or given as a subcutaneous injection.
  • You or a family member will be taught how to administer this medication. Keep the syringes, needles and supplies in a safe place out of reach of children and pets.
  • This medication is frequently started 24 hours after chemotherapy is completed and continued until the neutrophils (part of the white blood cells) in the blood reach a certain level.
  • The dose should be given at approximately the same time each day.
  • Once filgrastim is discontinued, you can expect the ANC (absolute neutrophil count) or neutrophil count to decrease by approximately 50 percent within one to two days.
  • Blood counts will be monitored several times a week to determine the length of therapy.
  • If too much medicine is taken by accident, call the Drug and Poison Information Center (DPIC), 513-636-5111 or 1-800-222-1222, or call your child's doctor immediately.
  • Keep this medication out of the reach of children.

If you miss a dose of this medication, give it as soon as you remember it. However, if it is almost time for the next dose, skip the missed dose and go back to the regular dosing schedule. Do not give a double dose to catch up.

  • Bone pain, especially in the lower back, hip and breast bone
  • Lower back pain
  • Hip pain
  • Headache
  • Fluid retention
  • Severe nausea, vomiting or diarrhea
  • Unusual or easy bruising or bleeding
  • Wheezing or difficulty breathing
  • Chest pain and heart racing
  • Rash
  • Fever

Injectable: 300 mcg per 1 ml and 480 mcg per 1.6 ml

Last Updated 11/2013