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Health Topics

Induction and Maintenance of Anesthesia for Cardiac Surgery

Medications Before Surgery Look up a term in The Heart Center glossary.

During the preoperative visit, the anesthesiologist will discuss with the family and patient the use of preoperative medications. The decision regarding whether to administer a preoperative medication will depend on the age of the child, the type of cardiac defect present, and the anxiety level of the child.

Doctors operate on a young patient. Midazolam is the drug most commonly given before surgery. In some cases, morphine may also be used. Midazolam (or Versed®) is a short-acting benzodiazepine (sedative) which can be administered to children orally or through an intravenous catheter (IV).

The effects of this medication are very similar to diazepam (Valium®), which is a member of the same class of drugs. These effects include sedation, a marked decrease in anxiety, and amnesia. After receiving this medication, most children will not remember being taken to the operating room for surgery.

When given through an intravenous catheter, effects of midazolam can be seen within two to three minutes, as compared to oral administration which takes 15 to 20 minutes.

Children who have low oxygen saturations at rest because of congenital heart defects may benefit from sedation prior to the induction of anesthesia. The anesthesiologist and nursing staff will closely monitor the child and give supplemental oxygen if needed.

Midazolam is usually not administered as a preoperative medication to children under the age of 6 months, because children of this age usually do not derive significant benefit from this medication.

Some children experience unusual responses to midazolam, such as excessive or nonsensical talking, laughter, or seemingly increased anxiety. This last response is the least common.

Most children who experience this effect have no memory of events after the midazolam has taken effect. Parents are urged to discuss the appropriateness of this medication for their child with the anesthesiologist during the preoperative visit.

Infants under six months of age and children with Down's Syndrome will sometimes receive a medication called atropine prior to anesthesia. Atropine is known as an anticholinergic agent, which means it works on the nervous system to produce, among other things, dry mouth and increased heart rate.

These effects are beneficial prior to anesthesia because they reduce airway secretions and prevent a slow heart rate (bradycardia). They are especially important when the child does not have an intravenous catheter in place and will initially be anesthetized using anesthetic gases. Atropine can be administered by an intramuscular injection or through an IV. It may cause some children to appear red or flushed, but this is not of significant concern.

Morphine is a narcotic that produces sedation and analgesia (blocking the sensation of pain). Morphine may be used as a premedication for certain types of congenital heart defects such as Tetralogy of Fallot or other cyanotic congenital heart diseases.

The most common side effect of morphine (or any narcotic) is itching. The nose and face are the areas most likely to be perceived as itchy by the patient. Other side effects may include small hive-like blotches on the skin near the site at which the drug was given.

True allergies are uncommon. Like all narcotics, morphine reduces the patient's drive to breathe. This is not a serious concern with the doses of morphine that are used for premedication.

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Anesthesia and Medications During Surgery

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Last Updated: 09/2009