Endocrine, Metabolism and Diabetes Conditions and Diagnoses

Diabetes and Pregnancy

Related Services

Clinical Trial / Research Study:

What is diabetes?

Diabetes is a condition where sufficient amounts of insulin are either not produced or the body is unable to efficiently use the insulin that is produced. Insulin is the hormone that allows glucose to enter the cells of the body to provide fuel. When glucose cannot enter the cells, it builds up in the blood.

What are the different types of diabetes?

There are three basic types of diabetes including:

Type 1 Diabetes

Also called insulin dependent diabetes mellitus (IDDM), type 1 diabetes is an autoimmune disorder in which the body's immune system destroys the cells in the pancreas that produce insulin. Type 1 diabetes accounts for 10 percent of all diabetes in the US, but 90 percent of diabetes in the pediatric age group in the US. Type 1 diabetes usually develops in children or young adults, but can start at any age.

Type 2 Diabetes

A metabolic disorder resulting from the body's inability to efficiently use insulin, type 2 diabetes used to be called non-insulin-dependent diabetes mellitus (NIDDM). It usually only develops after puberty and is affecting more and more adolescents, but becomes much more common after age 45.

Gestational Diabetes

Gestational diabetes is a condition in which the blood glucose level is elevated and other diabetic symptoms appear during pregnancy in a woman who has not previously been diagnosed with diabetes.

Diabetes is a serious disease, which, if not controlled, can be life threatening. It is often associated with long-term complications that can affect every system and part of the body. Diabetes can, among other things, contribute to eye disorders and blindness, heart disease, stroke, kidney failure, amputation, and nerve damage.

What happens with diabetes and pregnancy?

During pregnancy, the placenta supplies a growing fetus with nutrients and water, as well as produces a variety of hormones to maintain the pregnancy. In early pregnancy, hormones can cause increased insulin secretion and decreased glucose produced by the liver, which can lead to hypoglycemia (low blood glucose levels). In later pregnancy, some of these hormones (estrogen, cortisol, and human placental lactogen) can have a blocking effect on insulin, a condition called insulin resistance.

As the placenta grows, more of these hormones are produced, and insulin resistance becomes greater. Normally, the pancreas is able to make additional insulin to overcome insulin resistance, but when the production of insulin is not enough to overcome the effect of the placental hormones, gestational diabetes results or there may be worsening of pre-existing diabetes.

Why is diabetes a concern in pregnancy?

Diabetes in pregnancy can have serious consequences for the mother and the growing fetus. The severity of problems often depends on the degree of the mother's diabetic disease, especially if she has vascular (blood vessel) complications and poor blood glucose control.

It is very important for a mother to maintain very close control of her diabetes during pregnancy. Generally, the poorer the control of blood glucose and the more severe the disease and complications, the greater the risks for the pregnancy.

Maternal Complications of Diabetes on a Pregnancy

Complications for the mother depend on the degree of insulin need, the severity of complications associated with diabetes, and control of blood glucose.

Most complications occur in women with pre-existing diabetes and are more likely when there is poor control of blood glucose. Women may require more frequent insulin injections. They may have very low blood glucose levels, which can be life threatening if untreated, or they may have ketoacidosis, a condition that results from high levels of blood glucose. Ketoacidosis may also be life threatening if untreated.

Complications for Fetus and Baby

Infants of mothers with diabetes are at greater risk for several problems, especially if blood glucose levels are not carefully controlled, including the following:

  • birth defects: Birth defects are more likely in infants of mothers who are diabetic prior to pregnancy, especially insulin-dependent women who may have two to six times greater the risk of major birth defects. Some birth defects are serious enough to cause fetal death. Birth defects usually originate sometime during the first trimester of pregnancy. Overall, major birth defects may occur in about 5 to 10 percent of insulin-dependent women. Major birth defects that may occur in infants of diabetic mothers include the following:
  • heart and connecting blood vessels
  • brain and spine abnormalities
  • urinary and kidney
  • digestive tract
  • stillbirth (fetal death): Stillbirth is more likely in pregnant women with diabetes. The fetus may grow slowly in the uterus due to poor circulation or other conditions, such as high blood pressure, that can complicate diabetic pregnancy. The exact reason stillbirths occur with diabetes is unknown. The risk of stillbirth increases in women with poor blood glucose control and with blood vessel changes.
  • macrosomia: Macrosomia refers to a baby that is considerably larger than normal. All of the nutrients the fetus receives come directly from the mother's blood. If the maternal blood has too much glucose, the pancreas of the fetus senses the high glucose levels and produces more insulin in an attempt to use this glucose. The fetus converts the extra glucose to fat. Even when the mother has gestational diabetes, the fetus is able to produce all the insulin it needs. The combination of high blood glucose levels from the mother and high insulin levels in the fetus results in large deposits of fat that causes the fetus to grow excessively large.
  • birth injury: Birth injury may occur due to the baby's large size and difficulty being born.
  • hypoglycemia: Hypoglycemia is low levels of blood sugar in the baby immediately after delivery. This problem occurs if the mother's blood sugar levels have been consistently high causing the fetus to have a high level of insulin in its circulation. After delivery, the baby continues to have a high insulin level, but no longer has the high level of sugar from the mother, resulting in the newborn's blood sugar level becoming very low. The baby's blood sugar level is checked after birth, and if the level is too low, it may be necessary to give the baby glucose intravenously.
  • respiratory distress (difficulty breathing): Too much insulin or too much glucose in a baby's system may delay lung maturation and cause respiratory difficulties in babies. This is more likely if they are born before 37 weeks of pregnancy.

How is diabetes diagnosed?

Women with diabetes before pregnancy have already been diagnosed. They usually will need to control blood sugars even more carefully during pregnancy and may need frequent visits to both their medical physician and their obstetrician.
Nearly all non-diabetic pregnant women are screened for diabetes at the end of the second trimester of pregnancy. In addition to a complete medical history and physical examination, diabetes is diagnosed with a glucose screening test, which involves drinking a glucose drink followed by measurement of glucose levels after a one-hour interval.
If this test shows a blood sugar level of greater than 140 mg/dl, another test will be performed after a few days of following a special diet. The second test also involves drinking a glucose drink, and results are measured at three-hour intervals.

If results of the second test are in the abnormal range, diabetes is diagnosed.

Treatment for Diabetes

Specific treatment for diabetes will be determined by your physician based on:

  • your age, overall health, and medical history
  • extent of the disease
  • your tolerance for specific medications, procedures, or therapies
  • expectations for the course of the disease
  • your opinion or preference

Treatment for diabetes focuses on keeping blood glucose levels in the normal range. Treatment may include:

  • special diet with controlled amounts of carbohydrate
  • exercise
  • blood glucose monitoring
  • insulin injections

Managing Diabetes During the Pregnancy

Special fetal testing and monitoring may be needed for pregnant diabetics, especially those who are taking insulin (because of the increased risks for stillbirth). These tests can include the following:

  • fetal movement counting - counting the number of movements or kicks in a certain period of time, and watching for a change in activity.
  • ultrasound - a diagnostic imaging technique which uses high-frequency sound waves and a computer to create images of blood vessels, tissues, and organs. Ultrasounds are used to view internal organs as they function, and to assess blood flow through various vessels.
  • nonstress testing - a measurement of the fetal heart rate in response to the fetus' movements.
  • biophysical profile - a test that uses the nonstress test and ultrasound to examine fetal movements, heart rate, and amniotic fluid amounts.
  • doppler flow studies - a type of ultrasound which uses sound waves to measure blood flow.

Infants of diabetic mothers may be delivered vaginally or by cesarean, depending on the estimated fetal weight and the mother's health.

Contact Us

For additional information on this or any Health Topic, please call the Family Resource Center, 513-636-7606, or your pediatrician.

Rev. 11/05