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Etoposide (VP-16, VePesid")

(e-toe-POE-side)

Definition | How to take | Special instructions | Missed dose | Side effects | Warning signs | Dosage | Contact us

What is etoposide?

Etoposide (VP-16) is a medicine used to treat certain types of cancer (examples include: leukemias, Hodgkin's disease, neuroblastoma, Ewing's sarcoma, rhabdomyosarcoma, Wilm's tumor, and brain tumors).

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How to take this medication

Etoposide most frequently is given by IV infusion in the hospital. Capsules are available and are infrequently utilized.

Special Instructions

  • This medication is usually given in the hospital.
  • A nurse will be monitoring your blood pressure during the infusion of this medication.
  • If capsules are being utilized, they must be kept refrigerated.
  • Use precaution when changing your child's diapers or solid linens for 48 hours after a dose - use gloves during this time to avoid contact with the medication.
  • If too much medicine is taken by accident, call the Drug and Poison Information Center (DPIC), 513-636-5111 or 1-800-222-1222, or call your child's doctor immediately.
  • Keep this medication out of the reach of children.

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If a dose is missed

If taking oral capsules, notify your physician immediately if a dose is missed. Never double the dose to try to catch up. For any medication information related to your child's dosing schedule and/or missed doses, contact the healthcare provider who prescribed the medication.

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Side effects

Contact your child's doctor if symptoms persist or become bothersome:

  • Nausea and vomiting
  • Diarrhea
  • Loss of hair
  • Skin rash
  • Decrease in blood pressure
  • Decreased ability to fight infections
  • Allergic reactions
  • Sunburn-like skin irritation or rash may occur on areas that were previously treated with radiation therapy (radiation recall).

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Warning signs

Call your child's doctor immediately if your child develops:

  • Dizziness
  • Facial flushing
  • Difficulty breathing

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Dosage forms available

Injectable

Capsules: 50 mg

Contact us

For additional information on this or any Health Topic, please call the Family Resource Center, 513-636-7606, or your pediatrician.

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PEP 5029 9/00;
Rev. 9/05, 5/07, 9/07