Melphalan (Alkeran) is a chemotherapy medicine used in bone marrow transplantation and to treat cancer.

This medication is given as an injection into a vein, or as a tablet taken by mouth.

This medicine is only given in the hospital or clinic.

  • Hair loss
  • Low blood counts (decreased white blood cells needed to fight infection and decreased platelets that are needed for proper blood clotting)
  • Lung problems (rare)
  • Liver problems
  • Bladder irritation (rare)
  • Pain at injection site
  • Upset stomach
  • Mouth ulcers
  • Allergic reaction (chills, fever, rash, low blood pressure, coughing or breathing problems)
  • Unusual bleeding or bruising due to low platelet count
  • Sore throat
  • Fever over 101.5°F (38.6°C) once or 100.5°F (38°C) twice in 24 hours

Call your child's doctor if the following symptoms continue longer than 24 hours:

  • Mouth sores
  • Nausea
  • Vomiting
  • Loss of appetite
  • Rash

Last Updated 11/2013