Mitoxantrone (Novantrone) is a chemotherapy medicine used to treat cancer.

This medication is given as an injection into a vein.

  • If this medication leaks out of the vein, it may cause a blue streak along the vein. Urine and the whites of the eyes may be blue-green for up to 48 hours after infusion. This is only a temporary change and it is not harmful to your child.
  • Frequent, small meals may help if your child has severe nausea.
  • Use precaution when changing your child's diapers or soiled linens for 48 hours after a dose. Use gloves during this time to avoid contact with the medication.
  • This medicine is given only in the hospital or clinic.
  • Hair loss
  • Low blood counts (decreased white blood cells needed to fight infection and decreased platelets that are necessary for proper blood clotting)
  • Liver problems
  • Lung problems (rare)
  • Heart problems
  • Headaches
  • Seizures
  • Upset stomach

Call your child's doctor if the following side effects continue longer than 24 hours:

  • Nausea
  • Vomiting
  • Diarrhea
  • Mouth sores 
  • Fever
  • Bruising or bleeding
  • Sore throat

Last Updated 11/2013