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Research Horizons at Cincinnati Children's Research Foundation

Research Horizons Winter 2007

Explore highlights of the exciting research happening at Cincinnati Children's Research Foundation with Research Horizons. Each issue features recent studies published by Cincinnati Children's investigators. By combining cutting-edge research and education with the best in pediatric care, we are striving to improve the lives of children and families everywhere.

In addition to the following listed items, this issue includes the 2005-2006 Annual Report for the Cincinnati Children's Research Foundation.

This issue features the following news briefs:

In addition, you will find the following feature stories that highlight some of our many world-class researchers:

Letter from Thomas Boat, MD

Thomas Boat, MDIntegration of many creative efforts in research, education and clinical care has been an important goal of Cincinnati Children's Hospital Medical Center during the past year. Resulting and remarkable synergies involving many of the medical, surgical and other programs has enabled significant progress in changing the outcome for families from around the world. [more]

Bench to Bedside Research in Pediatric Digestive Diseases Yields Results

Close interaction among researchers encourages them to bring important questions from the bedside to the laboratory.What started as a National Institutes of Health (NIH)-funded "mini-center" in 2003 has grown into a thriving research center. Based at Cincinnati Children's, the Cincinnati Digestive Health Center (DHC) is now one of only 16 Digestive Disease Research Core Centers funded by the National Institutes of Diabetes and Digestive and Kidney Diseases – and the only one dedicated to pediatric research. [more]

New Data Will Help Define Teens Most Appropriate for Bariatric Surgery

Keely Kark received long-term care and support from the Surgical Weight Loss Program for Teens following her surgery.A pioneering multi-year, multicenter study on teens who undergo weight loss surgery will help to better inform parents and pediatricians about appropriate treatment options for extremely obese teenagers. Based at Cincinnati Children's, the Teen- Longitudinal Assessment of Bariatric Surgery (Teen-LABS) is the first and largest prospective study of adolescents who choose bariatric surgery. [more]

Providing Integrated Care for Duchenne Muscular Dystrophy

Providing Integrated Care for Duchenne Muscular DystrophyWith its unique interdisciplinary and proactive approach, the Neuromuscular Comprehensive Care Center at Cincinnati Children's has become a premier center for the treatment of Duchenne muscular dystrophy. According to its director, Brenda Wong, MD, the center's approach is essential not only to the quality of clinical care but also to the quality of data that can be obtained through research. [more]

Collaboration Catalyzes Progress in Organogenesis Research

Orthopaedist Alvin Crawford, MD meets with a patientChris Wylie, PhD, director of Developmental Biology at Cincinnati Children's, leads the new organogenesis initiative at Cincinnati Children's. This initiative builds on work already underway, while seeking to answer questions about how cells differentiate to form the functional cells of organs, and how differentiating cells might be used to replace damaged cells. [more]

Making a Research-Inspired Breakthrough a Treatment Reality

Jim Wells, PhDJim Wells, PhD, describes his lab in the Division of Developmental Biology at Cincinnati Children's as having a "basic science component with a spin toward applied biomedicine." His work in understanding basic endocrine pancreas development is one illustration of how scientific research shows translational potential for the treatment of childhood diseases such as Type 1 diabetes. [more]

Collaborative Uses Evidence-Based Tools to Help Treat ADHD

Tools to help treat ADHDAttention deficit hyperactivity disorder (ADHD) affects an estimated 5 to 7 percent of the population and is the most common behavioral disorder among elementary school-age children. Cincinnati Children's teamed with community physicians to form the ADHD Collaborative, a group charged with improving the care of and changing the outcome for children with ADHD. [more]