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Research Horizons at Cincinnati Children's Research Foundation

Explore highlights of the exciting research happening at Cincinnati Children's Research Foundation with Research Horizons.Explore highlights of the exciting research happening at Cincinnati Children's Research Foundation with Research Horizons. Each issue features recent studies published by Cincinnati Children's investigators. By combining cutting-edge research and education with the best in pediatric care, we are striving to improve the lives of children and families everywhere.

This issue features these news briefs:

In addition, you will find the following feature stories that highlight some of our many world-class researchers:

Dr. Jeff Robbins: The Institute Approach: What it Means to Us

Jeff Robbins, PhD, Director, Cincinnati Children’s Heart Institute.The Institute will bring physicians, nurses and other clinical staff together with basic and translational research teams to change the way we understand, prevent and treat pediatric heart disease. It will merge the diverse activities of clinical care, research, education, operations and outcomes improvement. [more]

Pump it Up

Jeanne James, MD.Although more children with congenital heart defects survive heart surgery, some can be left with circulation problems that keep them from enjoying active lives and may even lead to
heart failure. Pediatric cardiologist and researcher Jeanne James, MD, wants to get to the bottom of why this happens. Her team’s research on how heart muscles contract is helping scientists understand heart failure and the role proteins play in heart function. [more]

Lasting Fixes

Catherine Dent Krawczeski, MD.As recently as a few decades ago, correcting a child’s heart defect was considered extraordinary. Today, the ability to fix even the most complex heart problems is pretty much taken for granted, with survival rates climbing upwards of 95 percent. For Cincinnati Children’s Catherine Dent Krawczeski, MD, that’s not good enough. [more]

Mending Broken Hearts

Bradley Marino, MD, MPP, MSCE.

Just getting a child with severe congenital heart disease better and out of the hospital seems like a happy ending. But for Cincinnati Children’s Bradley Marino, MD, MPP, MSCE, it’s where the real story begins. Dr. Marino, attending physician in the Divisions of Cardiology and Critical Care Medicine, is leading a team of researchers in an international, multi-center testing trial to assess quality of life as children who survive treatment for severe heart disease grow into adolescence and adulthood. [more]

Genetic Cartography

D. Woodrow Benson, MD, PhD.Just listening to D. Woodrow Benson, MD, PhD, describe what he does at Cincinnati Children’s is enough to wear a person out. A clinician and researcher in the Division of Cardiology, he is the principal investigator for two NIH-sponsored programs: a Specialized Center for Clinically Oriented Research and the Pediatric Heart Network. He is also director of Cardiovascular Genetics and, in his words, “a born-again geneticist.” [more]

Sleuthing the Cause of Cardiomyopathy

Stephanie Ware, MD, PhD.

Despite advances in understanding adult heart muscle disease, much about its causes in children remains a mystery. Stephanie Ware, MD, PhD, a researcher with appointments in the Division of Molecular Cardiovascular Biology and the Division of Human Genetics, is looking to change that, with some high-tech assistance.  [more]

Waste Not

Jeffery Molkentin, PhD.A Cincinnati Children’s cardiology researcher just might have the clue to stopping muscle degeneration that contributes to heart disease, muscular dystrophy and other conditions. In a paper recently published in the journal Nature Medicine, Jeffery Molkentin, PhD, and a multi-institutional team led by Cincinnati Children’s discuss how an investigational antiviral drug may have the potential to reduce muscle cell damage in Duchenne and other forms of muscular dystrophy. [more]