Tacrolimus (Prograf)is a medicine used to prevent organ rejection after transplant. It has also been used to treat and prevent graft versus host disease (GVHD). It is available as a capsule, injection, or your pharmacist may be able to make a liquid.

  • It is best to take tacrolimus at the same time and the same way – either with or without food – each day. Changing these conditions can change the amount of medication that gets into your child's blood and impact the way it works.
  • The capsules can be opened or chewed for young children or children who are unable to swallow whole capsules. The capsules can be opened and the powder placed in a small spoonful of pudding, yogurt or other soft food.
  • Do not give your child grapefruit or grapefruit juice to drink while taking tacrolimus, unless the doctor tells you it is okay to do this. ( Grapefruit and grapefruit juice is normally avoided as amount of medication in the blood can be increased and could cause harm).
  • Keep this medication at room temperature away from moisture and sunlight.
  • Do not refrigerate.
  • Do not store in the bathroom.
  • Do not use after the expiration date on the bottle / package.
  • It is important to see your child's doctor regularly so the effects of this medicine can be watched carefully.
  • Testing of your child's blood will be done regularly while they are taking this medication.
  • Do not give any other medications, prescription or over-the-counter (OTC), without first talking to your child's doctor.
  • If too much medicine is taken by accident, call the Drug and Poison Information Center (DPIC) at 513-636-5111, or 1-800-222-1222, or call your child's doctor immediately.
  • Keep this medication out of the reach of children.

For any medication information related to your child's dosing schedule and / or missed doses, contact the healthcare provider who prescribed the medication.

  • Upset stomach (nausea)
  • Throwing up (vomiting)
  • Loose stools (diarrhea)
  • Trouble passing stool (constipation)
  • Confusion
  • Headache
  • Trouble sleeping 
  • Other possible side effects include kidney problems, increased blood pressure, hair loss, shaking, low blood count, tremors, diabetes and increased risk of infections.
  • Rash
  • Reddened face (Flushing)
  • Breathing problems
  • Fever
  • Chills
  • Chest pain
  • Red color to urine
  • Seizures

Last Updated 12/2013