Cincinnati Children's Hospital Medical Center

Press Release Form

Release Details
Title   Infant Pertussis Hospitalizations Lower Than Expected After Teen Vaccinations 
SubTitle  
Contact Information  
Nick Miller, 513-803-6035, nicholas.miller@cchmc.org
Release Body  

Widespread vaccination of adolescents for pertussis was associated with lower rates of infant hospitalizations for the respiratory infection than would have been expected had teens not been inoculated according to new research in Pediatrics.

Reporting their results online Oct. 21, researchers said the study underscores the importance of increasing vaccination rates among teens and adults to stem an ongoing pertussis epidemic among infants. The research was conducted by physicians at Cincinnati Children’s Hospital Medical Center and the University of Michigan.

The ongoing epidemic has been linked to waning immunity and the failure to vaccinate, according to Katherine A. Auger, MD, MSc, the study’s lead author and a pediatrician in Division of Hospital Medicine at Cincinnati Children’s.

“We know infants get pertussis from family members, including older siblings,” Auger said. “While it is encouraging to find a modest reduction in infant hospitalizations after the vaccination of adolescents began, there were still more than 1,000 infants hospitalized for pertussis in 2011. Expecting parents should discuss with their doctors the need for vaccination of all caregivers before the birth of a baby.”

The current study was initiated following recommendations by the Centers for Disease Control in 2006 to vaccinate all adolescents against pertussis. Researchers used data from the Nationwide Inpatient Sample, a database maintained by the U.S. Agency for Healthcare Research and Quality.

Investigators examined pertussis hospitalization rates for infants after the new adolescent vaccine recommendations were made and compared them to predicted hospitalization rates had adolescent vaccinations not been implemented. Hospitalization data from 2000 to 2005 – prior to the teen vaccination recommendations – were used to predict hospitalization rates had adolescent vaccinations not been implemented.

In three of the four years examined after the teen vaccination recommendations (2008-2011), investigators found lower hospitalization rates for infants than would have been expected with no adolescent vaccinations.

In 2011 for example, the expected hospitalization rate for pertussis if adolescent vaccinations had not been implemented was 12 hospitalizations per 10,000 infants. The observed rate following the teen vaccinations was significantly lower at 3.27 hospitalizations per 10,000 infants.

Pregnant women should receive pertussis vaccination during pregnancy, according to a recommendation made by the Centers for Disease Control in 2012. Auger said future research will be needed to assess how and if this policy change further affects pertussis hospitalization rates in infants.

Study authors received funding from the Robert Wood Johnson Foundation through the Clinical Scholars program.

About Cincinnati Children’s

Cincinnati Children’s Hospital Medical Center ranks third in the nation among all Honor Roll hospitals in U.S.News and World Report’s 2013 Best Children’s Hospitals ranking. It is ranked #1 for cancer and in the top 10 for nine of 10 pediatric specialties. Cincinnati Children’s is one of the top three recipients of pediatric research grants from the National Institutes of Health, and a research and teaching affiliate of the University of Cincinnati College of Medicine. The medical center is internationally recognized for improving child health and transforming delivery of care through fully integrated, globally recognized research, education and innovation. Additional information can be found at www.cincinnatichildrens.org. Connect on the Cincinnati Children’s blog, via Facebook and on Twitter.

Publish Date   2013-10-21  
Publish Time   00:01 24 hour (HH:MM) time only. AM / PM declarations will invalidate the value.
Cancer Center News

Sidebar

*Sidebar Title is required if you add any media to the page (Windows Media Video, Quick Time, Flash, Image, PDF, Audio, etc)

Sidebar Title  

Sidebar Description

Subhead

Subhead Title 

Subhead Description

YouTube

 

Media File  

Media Type

None

Screen Shot Default Screen Shot (Blue)  

Flash Aspect Ratio: 16:9  

Recent News Releases

Thursday, November 20, 2014 - Researchers Report Way to Target Hard-to-Hit Site in Disease Pathway

Researchers have successfully targeted an important molecular pathway that fuels a variety of cancers and related developmental syndromes called “Rasopathies.” Reporting their results Nov. 20 in Chemistry & Biology, scientists at Cincinnati Children’s Hospital Medical Center say they identified a class of lead compounds that successfully recognize a key target in the Ras signaling pathway – opening the door to future development of therapies that could make treatments more effective with fewer side effects.

Thursday, November 20, 2014 - Successful Outcome Prompts Early End to Sickle Cell Anemia Clinical Trial

Conclusive data show that hydroxyurea therapy offers safe and effective disease management of sickle cell anemia (SCA) and reduces the risk of stroke, prompting early termination by the National Heart Lung and Blood Institute (NHLBI) of a key clinical trial studying the drug’s efficacy. NHLBI officials issued the announcement today, about one year before the study was originally scheduled to end. The study was led by Cincinnati Children's and Principal Investigator Russell Ware, MD, director of Hematology at the medical center.

Monday, November 10, 2014 - Project Reduces “Alarm Fatigue” in Hospitals by 80 Percent

The sound of monitor alarms in hospitals can save patients’ lives, but the frequency with which the monitors go off can also lead to “alarm fatigue,” in which caregivers become densensitized to the ubiquitous beeping.

Thursday, November 06, 2014 - Cincinnati Children’s Hospital Medical Center Opens Urgent Care Center at Liberty Campus

Cincinnati Children’s Hospital Medical Center has opened its newest urgent care center at the hospital’s Liberty Campus, located on Yankee Road. This represents a continued commitment from the medical center to provide care to Greater Cincinnati’s pediatric population.

Monday, November 03, 2014 - Study Recommends Integrating Housing Data With Health Data To Improve Patient Medical Care

A study to be released in the November issue of Health Affairs shows that integrating community housing data on such code violations as mold and cockroaches with health data can identify at-risk geographical areas of medical concern and help target patients for medical interventions.