Developmental Biology

Faculty Members

Christopher C. Wylie, PhD,  Professor ; Director; Associate Chair for Basic Science

Research Interests: Early Vertebrate Development, Xenopus, Mammal

Nadean Brown, PhD,  Assistant Professor

Research Interests: Eye Development, Mouse And Drosophila

Kenneth Campbell, PhD,  Associate Professor ; Director, Molecular and Developmental Biology Graduate Program

Research Interests: CNS Patterning, Mammal

Chiou-Fen Chuang, PhD,  Assistant Professor

Research Interests: Nervous System, C. Elegans, Laterality

Vaughn Cleghon, PhD,  Associate Professor

Research Interests: Kinase Function In Development, Signaling

Jay L. Degen, PhD,  Professor

Research Interests: Hemostatic Factor Function, Mammal

Brian Gebelein, PhD,  Assistant Professor

Research Interests: Transcriptional Regulation, Drosophila, Body Patterning, Nervous System

Janet Heasman, PhD,  Professor

Research Interests: Early Vertebrate Development, Xenopus

Rashmi S. Hegde, PhD,  Associate Professor

Research Interests: Protein Structure/Function

J. Matthew Kofron, PhD,  Research Assistant Professor

Research Interests: Imaging Manager, Ectodermal Organ Development In Vertebrates, Xenopus

Chia-Yi Kuan, MD, PhD,  Assistant Professor

Research Interests: Nervous System Patterning, Stroke, Cell Death, Mammal

James L. Lessard, PhD,  Professor ; Associate Director

Research Interests: Muscle Development, Mamma

Hung-Chi Liang, PhD,  Research Instructor

Research Interests: Affymetrix Core Manager

Xinhua Lin, PhD,  Associate Professor

Research Interests: Cell Signaling, Drosophila

Christopher Mayhew, PhD,  Research Assistant Professor

Research Interests: Human ES Biology and Differentiation

Masato Nakafuku, MD, PhD,  Professor

Research Interests: Nervous System Patterning And Stem Cells, Mammal

S. Steven Potter, PhD,  Professor ; Director, Affymetrix Core

Research Interests: Transcription Regulation And Kidney Development, Mammal

Saulius Sumanas, PhD,  Assistant Professor

Research Interests: Vascular Development, Zebrafish

James M. Wells, PhD,  Assistant Professor

Research Interests: Vertebrate Gut Development, Stem Cells, Mammal

Dan A. Wiginton, PhD,  Associate Professor

Research Interests: Gut Differentiation, Mammal

Yutaka Yoshida, PhD,  Assistant Professor

Research Interests: Nervous System, Cell Migration, Mammal, Chicken

Aaron Zorn, PhD,  Assistant Professor

Research Interests: Vertebrate Gut Development, Xenopus, Mammal

Joint Appointment Faculty Members

Bruce Aronow, PhD,  Professor

Pediatric Bioinformatics

Bioinformatics

Thomas  Bartman, MD PhD,  Assistant Professor

Pulmonary Biology and Neonatology

Cardiovascular Development, Zebrafish

Michael D. Bates, MD PhD,  Assistant Professor

Gastroenterology, Hepatology, and Nutrition

Vertebrate Gut Development, Mammal

Tiffany  Cook, PhD,  Assistant Professor

Pediatric Ophthalmology

Eye Development, Drosophila

Sandra  Degen, PhD,  Professor

Research Administration

Director, Career Development

Prasad  Devarajan, MD,  Professor

Director, Nephrology and Hypertension

Urinary Tract Differentiation, Mammal

Vladimir Kalinichenko, MD PhD,  Associate Professor

Pulmonary Biology and Neonatology

Transcriptional Regulation of Lung Embryonic Development

Richard A. Lang, PhD,  Professor

Director, Transgenic Core Facility, Pedatric Opthalmology

Visual System Development, Mammal

Jun Ma, PhD,  Associate Professor

Pediatric Bioinformatics

Transcriptional Regulation, Drosophila

Noah F. Shroyer, PhD,  Assistant Professor

Gastroenterology, Hepatology, and Nutrition

Vertebrate Gut Development, Mammal

Jeffrey A. Whitsett, MD,  Professor

Chief, Section of Neonatology, Perinatal, and Pulmonary Biology

Respiratory System, Mammal

Trainees

• Gail Deutsch, MD,  Faculty,  Brown University, Asst. Professor, Pathology
• Matthew Flick, PhD,  Faculty,  Purdue University, Res. Asst. Prof., Rheumatology
• Larry Patterson, MD,  Faculty,  College of Medicine of Pennsylvania State University, Asst. Prof., Nephrology
• Joseph Palumbo, MD,  Faculty,  Penn State University College of Medicine, Asst. Prof., Hematology
• Pramod Reddy, MBBS,  Faculty,  Guntur Medical College and Siddhartha, Asst. Prof., Urology
• Wenxia  Zhang, PhD,  Vis. Res. Sc,  Chinese Academy of Sciences, Peking University (end 1/25/08)
• Tatyana Belenkaya, PhD,  Res. Assoc.,  Russian Academy of Science
• Eric Brunskill, PhD,  Res. Assoc.,  University of Maryland
• Weiming Bu, PhD,  Res. Assoc.,  Jilin University, China
• Bharesh Chauhan*, PhD,  Res. Assoc.,  Oxford University, United Kingdom
• Lisa Ehrman, PhD,  Res. Assoc.,  University of Cincinnati
• Alfor  Lewis, PhD,  Res. Assoc.,  University of Manchester, UK
• Motoshi  Nagao, PhD,  Res. Assoc.,  Tokyo Institute of Technology
• Reena Rani, PhD,  Res. Assoc.,  Chatrapati Shahu Ji University, India
• Michael  Spencer, PhD,  Res. Assoc.,  University of Kentucky
• John  Szucsik, PhD,  Res. Assoc.,  University of Cincinnati (end 8/31/07)
• Qinghua Tao, PhD,  Res. Assoc.,  Chinese Academy of Sciences
• Jody  White, PhD,  Res. Assoc.,  California Institute of Technology
• Dianer Yang, PhD,  Res. Assoc.,  Chinese Academy of Sciences
• Kevin Burns, PhD,  Res. Fellow,  University of Cincinnati
• Sang-Wook  Cha, PhD,  Res. Fellow,  Kyungpook National University, Korea
• Chitra Dahia*, PhD,  Res. Fellow,  Indian Institute of Science
• Ying Feng, PhD,  Res. Fellow,  University of Cincinnati (end 6/30/08)
• Jing-Fen  Han, PhD,  Res. Fellow,  University of Medicine and Dentistry of New Jersey
• Avedis  Kazanjian*, PhD,  Res. Fellow,  University of Louisville
• Jay Kormish, PhD,  Res. Fellow,  University of Calgary
• Suh-Chin Lin, PhD,  Res. Fellow,  University of Texas Health Sciences, San Antonio
• Junbo Liu*, PhD,  Res. Fellow,  Fudan University
• Mayur  Madhavan, PhD,  Res. Fellow,  Miami University
• Aygun Mamedova, PhD,  Res. Fellow,  Moscow State University
• Athanasia Nikolaou, PhD,  Res. Fellow,  University of Melbourne, Australia
• Jennifer  Ondr*, PhD,  Res. Fellow,  Washington University
• Xiufang Pan*, PhD,  Res. Fellow,  Beijing Medical University (end 5/30/08)
• Timothy Plageman*, PhD,  Res. Fellow,  University of Cincinnati
• Virgilio Ponferrada*, PhD,  Res. Fellow,  Wright State University
• Sujata Rao*, PhD,  Res. Fellow,  Cornell University
• Debora  Sinner, PhD,  Res. Fellow,  University of Buenos Aires, Argentina
• Jason  Spence, PhD,  Res. Fellow,  Miami University, Ohio
• Yalikun  Suofu, PhD,  Res. Fellow,  University of Greifswald, Germany
• Emmanuel Tadjuidje, PhD,  Res. Fellow,  University of Goettengen, Germany
• Kaori  Takeshima, PhD,  Res. Fellow,  Miyazaki University, Japan
• Ilya Vilinksy, PhD,  Res. Fellow,  Cornell University
• Ronald Waclaw, PhD,  Res. Fellow,  University of Cincinnati
• Yihui Wu, PhD,  Res. Fellow,  Peking University, China
• Baotang Xie*, PhD,  Res. Fellow,  Chinese Academy of Sciences
• Yukiyo Yamamoto, PhD,  Res. Fellow,  Hokkaido University, Japan (end 7/9/07)
• Eun-Jin  Yeo*, PhD,  Res. Fellow,  Seoul National University, South Korea
• Andrew Grande, MD,  Clin. Fellow,  University of Cincinnati (end 6/30/08)
• Alan  Kenny, MD PhD,  Clin. Fellow,  University of Rochester, School of Medicine and Dentistry
• Eric Mullins, MD,  Clin. Fellow,  University of Missouri - Columbia
• Alessandro Cancelliere, ,  Grad. Stud.,  University of Cincinnati - Neuroscience
• Ying  Feng, ,  Grad. Stud.,  Xiamen University, China
• Feng He*, ,  Grad. Stud.,  Institute of Biophysics, Chinese Academy of Sciences (end 1/30/08)
• Robert  Hufnagel, ,  Grad. Stud.,  University of Cincinnati - PSTP and Neuroscience
• Gengqiang Xie*, ,  Grad. Stud.,  Institute of Biophysics, Chinese Academy of Sciences (end 1/30/08)
• Yongfei Yang, ,  Grad. Stud.,  Peking University, China
• Alison  Boardman, ,  Undergrad.,  Simpson University
• Julie Bonn, ,  Undergrad.,  University of Cincinnati
• Jeeyeon  Cha, ,  Undergrad.,  University of Cincinnati
• Felicia  Ciamacco, ,  Undergrad.,  University of Cincinnati
• Dustin  Dumont, ,  Undergrad.,  University of Cincinnati
• Elizabeth  Eichhold, ,  Undergrad.,  Xavier University
• Uma  Goyal, ,  Undergrad.,  Arizona State University
• Mansour  Haque, ,  Undergrad.,  University of Cincinnati
• Lauren  Head, ,  Undergrad.,  Xavier University
• Emily Huschart, ,  Undergrad.,  Ohio State University
• Steven  Jung, ,  Undergrad.,  University of Cincinnati
• Annie Lu, ,  Undergrad.,  University of Toronto
• Meredith  McAdams, ,  Undergrad.,  Xavier University
• Kyle McCracken, ,  Undergrad.,  Xavier University
• Nikhil Menon, ,  Undergrad.,  Ohio State University
• Susan  Mittenzwei, ,  Undergrad.,  Xavier University
• Sakura Noda, ,  Undergrad.,  Amherst College
• Evan Pflum, ,  Undergrad.,  Xavier University
• Andrew Potter, ,  Undergrad.,  University of Cincinnati
• Ashley Riesenberg, ,  Undergrad.,  University of Cincinnati
• Farah "Yasmine" Waheed, ,  Undergrad.,  University of Cincinnati
• Chris Wolfe, ,  Undergrad.,  Xavier University

Significant Accomplishments in FY08

Developmental Biology

Significant Publications in FY08

Belenkaya TY, Wu Y, Tang X, Zhou B, Cheng L, Sharma YV, Yan D, Selva EM, Lin X. The retromer complex influences Wnt secretion by recycling wntless from endosomes to the trans-Golgi network. Developmental cell. 2008 Jan;14(1):120-31.

Gabel CV, Antonie F, Chuang CF, Samuel AD, Chang C. Distinct cellular and molecular mechanisms mediate initial axon development and adult-stage axon regeneration in C. elegans. Development (Cambridge, England). 2008 Mar;135(6):1129-36.

Xie B, Charlton-Perkins M, McDonald E, Gebelein B, Cook T. Senseless functions as a molecular switch for color photoreceptor differentiation in Drosophila. Development (Cambridge, England). 2007 Dec;134(23):4243-53.

Tao Q, Nandadasa S, McCrea PD, Heasman J, Wylie C. G-protein-coupled signals control cortical actin assembly by controlling cadherin expression in the early Xenopus embryo. Development (Cambridge, England). 2007 Jul;134(14):2651-61.

Hu S, Mamedova A, Hegde RS. DNA-binding and regulation mechanisms of the SIX family of retinal determination proteins. Biochemistry. 2008 Mar 18;47(11):3586-94.

Division Highlights

Nadean Brown

Janet Heasman

Alex Kuan

James Lessard

James Wells

Division Collaboration

Collaboration with Pediatric Ophthalmology

Collaborating Faculty: Tiffany Cook

Collaboration with Pediatric Ophthalmology

Collaborating Faculty: Richard Lang

Collaboration with Pediatric Ophthalmology

Collaborating Faculty: Tiffany Cook

Collaboration with Gastroenterology, Hepatology, and Nutrition

Collaborating Faculty: Jorge Bezerra

Collaboration with Hematology/Oncology

Collaborating Faculty: Joseph Palumbo

Collaboration with Rheumatology

Collaborating Faculty: Sherry Thornton

Collaboration with Nephrology and Hypertension

Collaborating Faculty: Prasad Devarajan

Collaboration with Nephrology and Hypertension

Collaborating Faculty: Prasad Devarajan

Collaboration with Immunobiology

Collaborating Faculty: Lee Grimes

Collaboration with Immunobiology

Collaborating Faculty: Lee Grimes

Collaboration with Human Genetics

Collaborating Faculty: Gregory Grabowski

Collaboration with Infectious Diseases

Collaborating Faculty: Jason Jiang

Collaboration with Molecular Immunology

Collaborating Faculty: Christopher Karp

Collaboration with Pediatric Ophthalmology

Collaborating Faculty: Richard Lang

Collaboration with Experimental Hematology

Collaborating Faculty: Shyra Miller

Collaboration with Experimental Hematology

Collaborating Faculty: Yi Zheng

Collaboration with Radiology

Collaborating Faculty: Scott Holland

Collaboration with Pulmonary Biology and Neonatology; Pediatric Neurology

Collaborating Faculty: Beth Haberman; Tonya Phillip

Collaboration with Pediatric Neurology

Collaborating Faculty: Tracy Glauser

Collaboration with Biomedical Informatics

Collaborating Faculty: Bruce Aronow

Collaboration with Pathology

Collaborating Faculty: Kevin Bove

Collaboration with Pulmonary Biology and Neonatology

Collaborating Faculty: James Greenberg; Anne Akeson; Jeffrey Whitsett

Collaboration with Gastroenterology, Hepatology, and Nutrition

Collaborating Faculty: Ajay Kaul

Collaboration with Gastroenterology, Hepatology, and Nutrition

Collaborating Faculty: Michael Bates

Collaboration with Pulmonary Biology and Neonatology

Collaborating Faculty: John Shannon

Collaboration with Pediatric Ophthalmology

Collaborating Faculty: Richard Lang

Collaboration with Experimental Hematology

Collaborating Faculty: Yi Zheng

Collaboration with Anesthesiology

Collaborating Faculty: Steve Danzer

Collaboration with Biomedical Informatics

Collaborating Faculty: Jun Ma

Collaboration with Pathology

Collaborating Faculty: Gail Deutsch

Collaboration with Gastroenterology, Hepatology, and Nutrition

Collaborating Faculty: Noah Shroyer

Collaboration with Hematology/Oncology

Collaborating Faculty: Susanne Wells

Collaboration with Pulmonary Biology and Neonatology

Collaborating Faculty: Jeffrey Whitsett

Collaboration with Experimental Hematology

Collaborating Faculty: Yi Zheng

Collaboration with Orthopedic Surgery

Collaborating Faculty: Atiq Durrani

Collaboration with Pathology

Collaborating Faculty: Gail Deustch

Collaboration with Pulmonary Biology and Neonatology

Collaborating Faculty: Jeffrey Whitsett

Collaboration with Biomedical Informatics

Collaborating Faculty: Bruce Aronow

Division Publications

1. Aronow BJ. Dysfunctional genomics: toward an integrative biology of disease and health--application to IBDs. J Pediatr Gastroenterol Nutr. 2008; 46 Suppl 1: E3-4.
2. Jegga AG, Inga A, Menendez D, Aronow BJ, Resnick MA. Functional evolution of the p53 regulatory network through its target response elements. Proc Natl Acad Sci U S A. 2008; 105: 944-9.
3. Wong HR, Shanley TP, Sakthivel B, Cvijanovich N, Lin R, Allen GL, Thomas NJ, Doctor A, Kalyanaraman M, Tofil NM, Penfil S, Monaco M, Tagavilla MA, Odoms K, Dunsmore K, Barnes M, Aronow BJ. Genome-level expression profiles in pediatric septic shock indicate a role for altered zinc homeostasis in poor outcome. Physiol Genomics. 2007; 30: 146-55.
4. Maeda Y, Suzuki T, Pan X, Chen G, Pan S, Bartman T, Whitsett JA. CUL2 is required for the activity of hypoxia-inducible factor and vasculogenesis. J Biol Chem. 2008; 283: 16084-92.
5. Hufnagel RB, Riesenberg AN, Saul SM, Brown NL. Conserved regulation of Math5 and Math1 revealed by Math5-GFP transgenes. Mol Cell Neurosci. 2007; 36: 435-48.
6. Allen ZJ, 2nd, Waclaw RR, Colbert MC, Campbell K. Molecular identity of olfactory bulb interneurons: transcriptional codes of periglomerular neuron subtypes. J Mol Histol. 2007; 38: 517-25.
7. Marsh ED, Minarcik J, Campbell KJ, Brooks-Kayal AR, Golden JA. FACS-array gene expression analysis during early development of mouse telencephalic interneurons. Dev Neurobiol. 2008; 68: 434-45.
8. Yokota Y, Gashghaei HT, Han C, Watson H, Campbell KJ, Anton ES. Radial glial dependent and independent dynamics of interneuronal migration in the developing cerebral cortex. PLoS ONE. 2007; 2: e794.
9. Zhou L, Bar I, Achouri Y, Campbell KJ, De Backer O, Hebert JM, Jones K, Kessaris N, de Rouvroit CL, O'Leary D, Richardson WD, Goffinet AM, Tissir F. Early forebrain wiring: genetic dissection using conditional Celsr3 mutant mice. Science. 2008; 320: 946-9.
10. Gabel CV, Antonie F, Chuang CF, Samuel AD, Chang C. Distinct cellular and molecular mechanisms mediate initial axon development and adult-stage axon regeneration in C. elegans. Development. 2008; 135: 1129-36.
11. Xie B, Charlton-Perkins M, McDonald E, Gebelein B, Cook T. Senseless functions as a molecular switch for color photoreceptor differentiation in Drosophila. Development. 2007; 134: 4243-53.
12. Degen JL, Bugge TH, Goguen JD. Fibrin and fibrinolysis in infection and host defense. J Thromb Haemost. 2007; 5 Suppl 1: 24-31.
13. Flick MJ, LaJeunesse CM, Talmage KE, Witte DP, Palumbo JS, Pinkerton MD, Thornton S, Degen JL. Fibrin(ogen) exacerbates inflammatory joint disease through a mechanism linked to the integrin alphaMbeta2 binding motif. J Clin Invest. 2007; 117: 3224-35.
14. Palumbo JS, Barney KA, Blevins EA, Shaw MA, Mishra A, Flick MJ, Kombrinck KW, Talmage KE, Souri M, Ichinose A, Degen JL. Factor XIII transglutaminase supports hematogenous tumor cell metastasis through a mechanism dependent on natural killer cell function. J Thromb Haemost. 2008; 6: 812-9.
15. Palumbo JS, Degen JL. Mechanisms linking tumor cell-associated procoagulant function to tumor dissemination. Semin Thromb Hemost. 2008; 34: 154-60.
16. Palumbo JS, Talmage KE, Massari JV, La Jeunesse CM, Flick MJ, Kombrinck KW, Hu Z, Barney KA, Degen JL. Tumor cell-associated tissue factor and circulating hemostatic factors cooperate to increase metastatic potential through natural killer cell-dependent and-independent mechanisms. Blood. 2007; 110: 133-41.
17. Roszell NJ, Danton MJ, Jiang M, Witte D, Daugherty C, Grimes T, Girdler B, Anderson KP, Franco RS, Degen JL, Joiner CH. Fibrinogen deficiency, but not plasminogen deficiency, increases mortality synergistically in combination with sickle hemoglobin SAD in transgenic mice. Am J Hematol. 2007; 82: 1044-8.
18. Souri M, Koseki-Kuno S, Takeda N, Degen JL, Ichinose A. Administration of factor XIII B subunit increased plasma factor XIII A subunit levels in factor XIII B subunit knock-out mice. Int J Hematol. 2008; 87: 60-8.
19. Souri M, Koseki-Kuno S, Takeda N, Yamakawa M, Takeishi Y, Degen JL, Ichinose A. Male-specific cardiac pathologies in mice lacking either the A or B subunit of factor XIII. Thromb Haemost. 2008; 99: 401-8.
20. Bagga A, Bakkaloglu A, Devarajan P, Mehta RL, Kellum JA, Shah SV, Molitoris BA, Ronco C, Warnock DG, Joannidis M, Levin A. Improving outcomes from acute kidney injury: report of an initiative. Pediatr Nephrol. 2007; 22: 1655-8.
21. Bennett M, Dent CL, Ma Q, Dastrala S, Grenier F, Workman R, Syed H, Ali S, Barasch J, Devarajan P. Urine NGAL predicts severity of acute kidney injury after cardiac surgery: a prospective study. Clin J Am Soc Nephrol. 2008; 3: 665-73.
22. Dent CL, Ma Q, Dastrala S, Bennett M, Mitsnefes MM, Barasch J, Devarajan P. Plasma neutrophil gelatinase-associated lipocalin predicts acute kidney injury, morbidity and mortality after pediatric cardiac surgery: a prospective uncontrolled cohort study. Crit Care. 2007; 11: R127.
23. Devarajan P. Proteomics for biomarker discovery in acute kidney injury. Semin Nephrol. 2007; 27: 637-51.
24. Devarajan P. Neutrophil gelatinase-associated lipocalin: new paths for an old shuttle. Cancer Ther. 2007; 5: 463-470.
25. Devarajan P. Proteomics for the investigation of acute kidney injury. Contrib Nephrol. 2008; 160: 1-16.
26. Devarajan P. Neutrophil gelatinase-associated lipocalin (NGAL): a new marker of kidney disease. Scand J Clin Lab Invest Suppl. 2008; 241: 89-94.
27. Devarajan P, Parikh C, Barasch J. Case 31-2007: a man with abdominal pain and elevated creatinine. N Engl J Med. 2008; 358: 312; author reply 313.
28. Han WK, Waikar SS, Johnson A, Betensky RA, Dent CL, Devarajan P, Bonventre JV. Urinary biomarkers in the early diagnosis of acute kidney injury. Kidney Int. 2008; 73: 863-9.
29. Hirsch R, Dent C, Pfriem H, Allen J, Beekman RH, 3rd, Ma Q, Dastrala S, Bennett M, Mitsnefes M, Devarajan P. NGAL is an early predictive biomarker of contrast-induced nephropathy in children. Pediatr Nephrol. 2007; 22: 2089-95.
30. Murray PT, Devarajan P, Levey AS, Eckardt KU, Bonventre JV, Lombardi R, Herget-Rosenthal S, Levin A. A framework and key research questions in AKI diagnosis and staging in different environments. Clin J Am Soc Nephrol. 2008; 3: 864-8.
31. Nickolas TL, Barasch J, Devarajan P. Biomarkers in acute and chronic kidney disease. Curr Opin Nephrol Hypertens. 2008; 17: 127-32.
32. Nickolas TL, O'Rourke MJ, Yang J, Sise ME, Canetta PA, Barasch N, Buchen C, Khan F, Mori K, Giglio J, Devarajan P, Barasch J. Sensitivity and specificity of a single emergency department measurement of urinary neutrophil gelatinase-associated lipocalin for diagnosing acute kidney injury. Ann Intern Med. 2008; 148: 810-9.
33. Parikh CR, Devarajan P. New biomarkers of acute kidney injury. Crit Care Med. 2008; 36: S159-65.
34. Parikh CR, Edelstein CL, Devarajan P, Cantley L. Biomarkers of acute kidney injury: early diagnosis, pathogenesis, and recovery. J Investig Med. 2007; 55: 333-40.
35. Portilla D, Dent C, Sugaya T, Nagothu KK, Kundi I, Moore P, Noiri E, Devarajan P. Liver fatty acid-binding protein as a biomarker of acute kidney injury after cardiac surgery. Kidney Int. 2008; 73: 465-72.
36. Suzuki M, Ross GF, Wiers K, Nelson S, Bennett M, Passo MH, Devarajan P, Brunner HI. Identification of a urinary proteomic signature for lupus nephritis in children. Pediatr Nephrol. 2007; 22: 2047-57.
37. Suzuki M, Wiers KM, Klein-Gitelman MS, Haines KA, Olson J, Onel KB, O'Neil K, Passo MH, Singer NG, Tucker L, Ying J, Devarajan P, Brunner HI. Neutrophil gelatinase-associated lipocalin as a biomarker of disease activity in pediatric lupus nephritis. Pediatr Nephrol. 2008; 23: 403-12.
38. Wheeler DS, Devarajan P, Ma Q, Harmon K, Monaco M, Cvijanovich N, Wong HR. Serum neutrophil gelatinase-associated lipocalin (NGAL) as a marker of acute kidney injury in critically ill children with septic shock. Crit Care Med. 2008; 36: 1297-303.
39. Zappitelli M, Washburn KK, Arikan AA, Loftis L, Ma Q, Devarajan P, Parikh CR, Goldstein SL. Urine neutrophil gelatinase-associated lipocalin is an early marker of acute kidney injury in critically ill children: a prospective cohort study. Crit Care. 2007; 11: R84.
40. Gebelein B, Mann RS. Compartmental modulation of abdominal Hox expression by engrailed and sloppy-paired patterns the fly ectoderm. Dev Biol. 2007; 308: 593-605.
41. Cha JY, Birsoy B, Kofron M, Mahoney E, Lang S, Wylie C, Heasman J. The role of FoxC1 in early Xenopus development. Dev Dyn. 2007; 236: 2731-41.
42. Tao Q, Nandadasa S, McCrea PD, Heasman J, Wylie C. G-protein-coupled signals control cortical actin assembly by controlling cadherin expression in the early Xenopus embryo. Development. 2007; 134: 2651-61.
43. White JA, Heasman J. Maternal control of pattern formation in Xenopus laevis. J Exp Zoolog B Mol Dev Evol. 2008; 310: 73-84.
44. Bu W, Mamedova A, Tan M, Xia M, Jiang X, Hegde RS. Structural basis for the receptor binding specificity of Norwalk virus. J Virol. 2008; 82: 5340-7.
45. Hu S, Mamedova A, Hegde RS. DNA-binding and regulation mechanisms of the SIX family of retinal determination proteins. Biochemistry. 2008; 47: 3586-94.
46. Liu Y, Henry GD, Hegde RS, Baleja JD. Solution structure of the hDlg/SAP97 PDZ2 domain and its mechanism of interaction with HPV-18 papillomavirus E6 protein. Biochemistry. 2007; 46: 10864-74.
47. Adhami F, Yu D, Yin W, Schloemer A, Burns KA, Liao G, Degen JL, Chen J, Kuan CY. Deleterious effects of plasminogen activators in neonatal cerebral hypoxia-ischemia. Am J Pathol. 2008; 172: 1704-16.
48. Burns KA, Ayoub AE, Breunig JJ, Adhami F, Weng WL, Colbert MC, Rakic P, Kuan CY. Nestin-CreER mice reveal DNA synthesis by nonapoptotic neurons following cerebral ischemia hypoxia. Cereb Cortex. 2007; 17: 2585-92.
49. Kennedy NJ, Martin G, Ehrhardt AG, Cavanagh-Kyros J, Kuan CY, Rakic P, Flavell RA, Treistman SN, Davis RJ. Requirement of JIP scaffold proteins for NMDA-mediated signal transduction. Genes Dev. 2007; 21: 2336-46.
50. Klionsky DJ, Abeliovich H, Agostinis P, Agrawal DK, Aliev G, Askew DS, Baba M, Baehrecke EH, Bahr BA, Ballabio A, Bamber BA, Bassham DC, Bergamini E, Bi X, Biard-Piechaczyk M, Blum JS, Bredesen DE, Brodsky JL, Brumell JH, Brunk UT, Bursch W, Camougrand N, Cebollero E, Cecconi F, Chen Y, Chin LS, Choi A, Chu CT, Chung J, Clarke PG, Clark RS, Clarke SG, Clave C, Cleveland JL, Codogno P, Colombo MI, Coto-Montes A, Cregg JM, Cuervo AM, Debnath J, Demarchi F, Dennis PB, Dennis PA, Deretic V, Devenish RJ, Di Sano F, Dice JF, Difiglia M, Dinesh-Kumar S, Distelhorst CW, Djavaheri-Mergny M, Dorsey FC, Droge W, Dron M, Dunn WA, Jr., Duszenko M, Eissa NT, Elazar Z, Esclatine A, Eskelinen EL, Fesus L, Finley KD, Fuentes JM, Fueyo J, Fujisaki K, Galliot B, Gao FB, Gewirtz DA, Gibson SB, Gohla A, Goldberg AL, Gonzalez R, Gonzalez-Estevez C, Gorski S, Gottlieb RA, Haussinger D, He YW, Heidenreich K, Hill JA, Hoyer-Hansen M, Hu X, Huang WP, Iwasaki A, Jaattela M, Jackson WT, Jiang X, Jin S, Johansen T, Jung JU, Kadowaki M, Kang C, Kelekar A, Kessel DH, Kiel JA, Kim HP, Kimchi A, Kinsella TJ, Kiselyov K, Kitamoto K, Knecht E, Komatsu M, Kominami E, Kondo S, Kovacs AL, Kroemer G, Kuan CY, Kumar R, Kundu M, Landry J, Laporte M, Le W, Lei HY, Lenardo MJ, Levine B, Lieberman A, Lim KL, Lin FC, Liou W, Liu LF, Lopez-Berestein G, Lopez-Otin C, Lu B, Macleod KF, Malorni W, Martinet W, Matsuoka K, Mautner J, Meijer AJ, Melendez A, Michels P, Miotto G, Mistiaen WP, Mizushima N, Mograbi B, Monastyrska I, Moore MN, Moreira PI, Moriyasu Y, Motyl T, Munz C, Murphy LO, Naqvi NI, Neufeld TP, Nishino I, Nixon RA, Noda T, Nurnberg B, Ogawa M, Oleinick NL, Olsen LJ, Ozpolat B, Paglin S, Palmer GE, Papassideri I, Parkes M, Perlmutter DH, Perry G, Piacentini M, Pinkas-Kramarski R, Prescott M, Proikas-Cezanne T, Raben N, Rami A, Reggiori F, Rohrer B, Rubinsztein DC, Ryan KM, Sadoshima J, Sakagami H, Sakai Y, Sandri M, Sasakawa C, Sass M, Schneider C, Seglen PO, Seleverstov O, Settleman J, Shacka JJ, Shapiro IM, Sibirny A, Silva-Zacarin EC, Simon HU, Simone C, Simonsen A, Smith MA, Spanel-Borowski K, Srinivas V, Steeves M, Stenmark H, Stromhaug PE, Subauste CS, Sugimoto S, Sulzer D, Suzuki T, Swanson MS, Tabas I, Takeshita F, Talbot NJ, Talloczy Z, Tanaka K, Tanaka K, Tanida I, Taylor GS, Taylor JP, Terman A, Tettamanti G, Thompson CB, Thumm M, Tolkovsky AM, Tooze SA, Truant R, Tumanovska LV, Uchiyama Y, Ueno T, Uzcategui NL, van der Klei I, Vaquero EC, Vellai T, Vogel MW, Wang HG, Webster P, Wiley JW, Xi Z, Xiao G, Yahalom J, Yang JM, Yap G, Yin XM, Yoshimori T, Yu L, Yue Z, Yuzaki M, Zabirnyk O, Zheng X, Zhu X, Deter RL. Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy. 2008; 4: 151-75.
51. Weng DY, Zhang Y, Hayashi Y, Kuan CY, Liu CY, Babcock G, Weng WL, Schwemberger S, Kao WW. Promiscuous recombination of LoxP alleles during gametogenesis in cornea Cre driver mice. Mol Vis. 2008; 14: 562-71.
52. Rao S, Lobov IB, Vallance JE, Tsujikawa K, Shiojima I, Akunuru S, Walsh K, Benjamin LE, Lang RA. Obligatory participation of macrophages in an angiopoietin 2-mediated cell death switch. Development. 2007; 134: 4449-58.
53. Belenkaya TY, Wu Y, Tang X, Zhou B, Cheng L, Sharma YV, Yan D, Selva EM, Lin X. The retromer complex influences Wnt secretion by recycling wntless from endosomes to the trans-Golgi network. Dev Cell. 2008; 14: 120-31.
54. Yan D, Lin X. Drosophila glypican Dally-like acts in FGF-receiving cells to modulate FGF signaling during tracheal morphogenesis. Dev Biol. 2007; 312: 203-16.
55. Song Y, He F, Xie G, Guo X, Xu Y, Chen Y, Liang X, Stagljar I, Egli D, Ma J, Jiao R. CAF-1 is essential for Drosophila development and involved in the maintenance of epigenetic memory. Dev Biol. 2007; 311: 213-22.
56. Markey MP, Bergseid J, Bosco EE, Stengel K, Xu H, Mayhew CN, Schwemberger SJ, Braden WA, Jiang Y, Babcock GF, Jegga AG, Aronow BJ, Reed MF, Wang JY, Knudsen ES. Loss of the retinoblastoma tumor suppressor: differential action on transcriptional programs related to cell cycle control and immune function. Oncogene. 2007; 26: 6307-18.
57. Mayhew CN, Carter SL, Fox SR, Sexton CR, Reed CA, Srinivasan SV, Liu X, Wikenheiser-Brokamp K, Boivin GP, Lee JS, Aronow BJ, Thorgeirsson SS, Knudsen ES. RB loss abrogates cell cycle control and genome integrity to promote liver tumorigenesis. Gastroenterology. 2007; 133: 976-84.
58. Skaggs HS, Xing H, Wilkerson DC, Murphy LA, Hong Y, Mayhew CN, Sarge KD. HSF1-TPR interaction facilitates export of stress-induced HSP70 mRNA. J Biol Chem. 2007; 282: 33902-7.
59. Srinivasan SV, Mayhew CN, Schwemberger S, Zagorski W, Knudsen ES. RB loss promotes aberrant ploidy by deregulating levels and activity of DNA replication factors. J Biol Chem. 2007; 282: 23867-77.
60. Stengel KR, Dean JL, Seeley SL, Mayhew CN, Knudsen ES. RB status governs differential sensitivity to cytotoxic and molecularly-targeted therapeutic agents. Cell Cycle. 2008; 7: 1095-103.
61. Nakafuku M, Nagao M, Grande A, Cancelliere A. Revisiting neural stem cell identity. Proc Natl Acad Sci U S A. 2008; 105: 829-30.
62. Sugimori M, Nagao M, Parras CM, Nakatani H, Lebel M, Guillemot F, Nakafuku M. Ascl1 is required for oligodendrocyte development in the spinal cord. Development. 2008; 135: 1271-81.
63. Adam M, Murali B, Glenn NO, Potter SS. Epigenetic inheritance based evolution of antibiotic resistance in bacteria. BMC Evol Biol. 2008; 8: 52.
64. Bennett MR, Czech KA, Arend LJ, Witte DP, Devarajan P, Potter SS. Laser capture microdissection-microarray analysis of focal segmental glomerulosclerosis glomeruli. Nephron Exp Nephrol. 2007; 107: e30-40.
65. McMahon AP, Aronow BJ, Davidson DR, Davies JA, Gaido KW, Grimmond S, Lessard JL, Little MH, Potter SS, Wilder EL, Zhang P. GUDMAP: the genitourinary developmental molecular anatomy project. J Am Soc Nephrol. 2008; 19: 667-71.
66. Potter SS, Hartman HA, Kwan KM, Behringer RR, Patterson LT. Laser capture-microarray analysis of Lim1 mutant kidney development. Genesis. 2007; 45: 432-9.
67. Bell SM, Schreiner CM, Wert SE, Mucenski ML, Scott WJ, Whitsett JA. R-spondin 2 is required for normal laryngeal-tracheal, lung and limb morphogenesis. Development. 2008; 135: 1049-58.
68. Sumanas S, Gomez G, Zhao Y, Park C, Choi K, Lin S. Interplay among Etsrp/ER71, Scl, and Alk8 signaling controls endothelial and myeloid cell formation. Blood. 2008; 111: 4500-10.
69. Moore-Scott BA, Opoka R, Lin SC, Kordich JJ, Wells JM. Identification of molecular markers that are expressed in discrete anterior-posterior domains of the endoderm from the gastrula stage to mid-gestation. Dev Dyn. 2007; 236: 1997-2003.
70. Sinner D, Kordich JJ, Spence JR, Opoka R, Rankin S, Lin SC, Jonatan D, Zorn AM, Wells JM. Sox17 and Sox4 differentially regulate beta-catenin/T-cell factor activity and proliferation of colon carcinoma cells. Mol Cell Biol. 2007; 27: 7802-15.
71. Spence JR, Wells JM. Translational embryology: using embryonic principles to generate pancreatic endocrine cells from embryonic stem cells. Dev Dyn. 2007; 236: 3218-27.
72. Besnard V, Xu Y, Whitsett JA. Sterol response element binding protein and thyroid transcription factor-1 (Nkx2.1) regulate Abca3 gene expression. Am J Physiol Lung Cell Mol Physiol. 2007; 293: L1395-405.
73. Brandt EB, Mingler MK, Stevenson MD, Wang N, Khurana Hershey GK, Whitsett JA, Rothenberg ME. Surfactant protein D alters allergic lung responses in mice and human subjects. J Allergy Clin Immunol. 2008; 121: 1140-1147 e2.
74. Dave V, Wert SE, Tanner T, Thitoff AR, Loudy DE, Whitsett JA. Conditional deletion of Pten causes bronchiolar hyperplasia. Am J Respir Cell Mol Biol. 2008; 38: 337-45.
75. Hardie WD, Davidson C, Ikegami M, Leikauf GD, Le Cras TD, Prestridge A, Whitsett JA, Korfhagen TR. EGF receptor tyrosine kinase inhibitors diminish transforming growth factor-alpha-induced pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2008; 294: L1217-25.
76. Hardie WD, Korfhagen TR, Sartor MA, Prestridge A, Medvedovic M, Le Cras TD, Ikegami M, Wesselkamper SC, Davidson C, Dietsch M, Nichols W, Whitsett JA, Leikauf GD. Genomic profile of matrix and vasculature remodeling in TGF-alpha induced pulmonary fibrosis. Am J Respir Cell Mol Biol. 2007; 37: 309-21.
77. Ikegami M, Falcone A, Whitsett JA. STAT-3 regulates surfactant phospholipid homeostasis in normal lung and during endotoxin-mediated lung injury. J Appl Physiol. 2008; 104: 1753-60.
78. Ikegami M, Scoville EA, Grant S, Korfhagen T, Brondyk W, Scheule RK, Whitsett JA. Surfactant protein-D and surfactant inhibit endotoxin-induced pulmonary inflammation. Chest. 2007; 132: 1447-54.
79. Kida H, Mucenski ML, Thitoff AR, Le Cras TD, Park KS, Ikegami M, Muller W, Whitsett JA. GP130-STAT3 regulates epithelial cell migration and is required for repair of the bronchiolar epithelium. Am J Pathol. 2008; 172: 1542-54.
80. Matsuzaki Y, Besnard V, Clark JC, Xu Y, Wert SE, Ikegami M, Whitsett JA. STAT3 regulates ABCA3 expression and influences lamellar body formation in alveolar type II cells. Am J Respir Cell Mol Biol. 2008; 38: 551-8.
81. Tichelaar JW, Wesselkamper SC, Chowdhury S, Yin H, Berclaz PY, Sartor MA, Leikauf GD, Whitsett JA. Duration-dependent cytoprotective versus inflammatory effects of lung epithelial fibroblast growth factor-7 expression. Exp Lung Res. 2007; 33: 385-417.
82. Wedig KE, Whitsett JA. Down the primrose path: petechiae in a neonate exposed to herbal remedy for parturition. J Pediatr. 2008; 152: 140, 140 e1.
83. Xu Y, Ikegami M, Wang Y, Matsuzaki Y, Whitsett JA. Gene expression and biological processes influenced by deletion of Stat3 in pulmonary type II epithelial cells. BMC Genomics. 2007; 8: 455.
84. Mir A, Kofron M, Heasman J, Mogle M, Lang S, Birsoy B, Wylie C. Long- and short-range signals control the dynamic expression of an animal hemisphere-specific gene in Xenopus. Dev Biol. 2008; 315: 161-72.
85. Runyan C, Gu Y, Shoemaker A, Looijenga L, Wylie C. The distribution and behavior of extragonadal primordial germ cells in Bax mutant mice suggest a novel origin for sacrococcygeal germ cell tumors. Int J Dev Biol. 2008; 52: 333-44.
86. Ajima R, Akiyama T, Usui M, Yoneda M, Yoshida Y, Nakamura T, Minowa O, Noda M, Tanaka S, Noda T, Yamamoto T. Osteoporotic bone formation in mice lacking tob2; involvement of Tob2 in RANK ligand expression and osteoclasts differentiation. FEBS Lett. 2008; 582: 1313-8.
87. Arlotta P, Molyneaux BJ, Jabaudon D, Yoshida Y, Macklis JD. Ctip2 controls the differentiation of medium spiny neurons and the establishment of the cellular architecture of the striatum. J Neurosci. 2008; 28: 622-32.
88. Kanda T, Yoshida Y, Izu Y, Nifuji A, Ezura Y, Nakashima K, Noda M. PlexinD1 deficiency induces defects in axial skeletal morphogenesis. J Cell Biochem. 2007; 101: 1329-37.
89. Kirilenko P, Weierud FK, Zorn AM, Woodland HR. The efficiency of Xenopus primordial germ cell migration depends on the germplasm mRNA encoding the PDZ domain protein Grip2. Differentiation. 2008; 76: 392-403.
90. Kirk EP, Sunde M, Costa MW, Rankin SA, Wolstein O, Castro ML, Butler TL, Hyun C, Guo G, Otway R, Mackay JP, Waddell LB, Cole AD, Hayward C, Keogh A, Macdonald P, Griffiths L, Fatkin D, Sholler GF, Zorn AM, Feneley MP, Winlaw DS, Harvey RP. Mutations in cardiac T-box factor gene TBX20 are associated with diverse cardiac pathologies, including defects of septation and valvulogenesis and cardiomyopathy. Am J Hum Genet. 2007; 81: 280-91.

Grants, Contracts, and Industry Agreements

Allen, Z

Brown, N.

Campbell, K

Degen, J.

Gebelein, B

Heasman, J

Hegde, R

Kuan, C

Lessard, J

Lin, X

Potter, S

Wells, J.

Wylie, C

Zorn, A

Degen, J

Hegde R

Kuan, C-Y

Zorn, A

Molecular and Developmental Biology Graduate Program

The Graduate Program in Molecular and Developmental Biology is an interdepartmental program within the University of Cincinnati that offers the Ph.D. degree. It has been based in the Department of Pediatrics for over 35 years. Drs. Kenneth Campbell and Katherine Yutzey served as Directors of the Program with co-directors Drs. Jeffrey Whitsett - finance, Richard Lang - academics, Tim Le Cras - admissions, Tiffany Cook – recruitment, Jeff Robbins – faculty membership, and Tim Weaver– graduate studies.

There are 68 faculty members in the program. During the past year, there were 54 predoctoral students in the program, 7 of whom are pursuing M.D./Ph.D. degrees. Students and faculty continue to be productive as measured by their numbers of publications, presentations at meetings, honors and awards received. Grant support to faculty remains high.

During the past year, the University of Cincinnati continued to support the program by providing University Graduate Assistantships and funds appropriated from the Dean's office to support 9 first year students. The remaining students are supported through a variety of sources including Yates (1), Ryan Fellowships (3), American Heart Fellowships (3), NIH NRSA (2), NIH training grants (10), external grants to their advisors (16), and CHRF Special Purpose Funds to their advisors (9).

The MDB Program provides an excellent research educational experience for students and has an excellent record in the placement of its graduates in scientific careers.

Molecular and Developmental Biology Graduate Program Students, 2007-2008

Students completing their PhD work

• Faisal Adhami "Differential Adult and Neonatal Response to Cerebral Ischemia-Hypoxia," August 7, 2007
• Kevin Burns "Genetic Detection of Neurogenesis and Astrocytic Transformation of Radial Glia," November 2, 2007
• Katherine Eaton "Neuropeptides in the Amygdala: Relevance to Stress," September 4, 2007
• Gabriel Ghiaur "The Role of Rho GTPases in Hematopoietic Stem Cell Biology: RhoA GTPase Regulates Adult HSC Engraftment and Rac1 GTPase is Important for Embryonic HSC Migration," November 12, 2007
• Yonatan Mahller "Development of Oncolytic HSV as an Anticancer Therapeutic for Extracranial Neural Tumors and Cancer Stem Cells," July 30, 2007
• David Metzger "The Role of the ETS Transcription Factor Elf5 in Lung Development," December 5, 2007
• Christopher Runyan "The Importance of Cell Death is Germ Cell Migration," August 15, 2007
• Elaine Shelton "The Roles of Twist1 and Tbx20 in Endocardial Cell Proliferation, Migration, and Differentiation During Endocardial Cushion Development," December 14, 2007.

Student Publications

During the past year, students from the Program authored or co-authored 29 articles.

1. Adhami F, Yu D, Yin W, Schloemer A, Burns KA, Liao G, Degen JL, Chen J, Kuan CY. Deleterious effects of plasminogen activators in neonatal cerebral hypoxia-ischemia. Am J Pathol. 2008 Jun;172(6):1704-16. Epub 2008 May 8.
2. Allen ZJ 2nd, Waclaw RR, Colbert MC, Campbell K. Molecular identity of olfactory bulb interneurons: transcriptional codes of periglomerular neuron subtypes. J Mol Histol. 2007 Dec;38(6):517-25. Epub 2007 Jul 12.
3. Burns KA, Ayoub AE, Breunig JJ, Adhami F, Weng WL, Colbert MC, Rakic P, Kuan CY. Nestin-CreER mice reveal DNA synthesis by nonapoptotic neurons following cerebral ischemia hypoxia. Cereb Cortex. 2007 Nov;17(11):2585-92. Epub 2007 Jan 27.
4. Maeda Y, Suzuki T, Pan X, Chen G, Pan S, Bartman T, Whitsett JA. CUL2 is required for the activity of hypoxia-inducible factor and vasculogenesis. J Biol Chem. 2008 Jun 6;283(23):16084-92. Epub 2008 Mar 27.
5. Akbar H, Kim J, Funk K, Cancelas JA, Shang X, Chen L, Johnson JF, Williams DA, Zheng Y. Genetic and pharmacologic evidence that Rac1 GTPase is involved in regulation of platelet secretion and aggregation. J Thromb Haemost. 2007 Aug;5(8):1747-55.
6. Eaton K, Sallee FR, Sah R. Relevance of neuropeptide Y (NPY) in psychiatry. Curr Top Med Chem. 2007;7(17):1645-59. Review.
7. Ghiaur G, Ferkowicz MJ, Milsom MD, Bailey J, Witte D, Cancelas JA, Yoder MC, Williams DA. Rac1 is essential for intraembryonic hematopoiesis and for the initial seeding of fetal liver with definitive hematopoietic progenitor cells. Blood. 2008 Apr 1;111(7):3313-21. Epub 2007 Dec 14.
8. Grace CE, Schaefer TL, Herring NR, Skelton MR, McCrea AE, Vorhees CV, Williams MT. (+)-Methamphetamine increases corticosterone in plasma and BDNF in brain more than forced swim or isolation in neonatal rats. Synapse. 2008 Feb;62(2):110-21.
9. Sinner D, Kordich JJ, Spence JR, Opoka R, Rankin S, Lin SC, Jonatan D, Zorn AM, Wells JM. Sox17 and Sox4 differentially regulate beta-catenin/T-cell factor activity and proliferation of colon carcinoma cells. Mol Cell Biol. 2007 Nov;27(22):7802-15. Epub 2007 Sep 17.
10. Blanchard C, Mingler MK, Vicario M, Abonia JP, Wu YY, Lu TX, Collins MH, Putnam PE, Wells SI, Rothenberg ME. IL-13 involvement in eosinophilic esophagitis: transcriptome analysis and reversibility with glucocorticoids. J Allergy Clin Immunol. 2007 Dec;120(6):1292-300.
11. Divanovic S, Trompette A, Petiniot LK, Allen JL, Flick LM, Belkaid Y, Madan R, Haky JJ, Karp CL. Regulation of TLR4 signaling and the host interface with pathogens and danger: the role of RP105. J Leukoc Biol. 2007 Aug;82(2):265-71. Epub 2007 Apr 30. Review.
12. Machado FS, Esper L, Dias A, Madan R, Gu Y, Hildeman D, Serhan CN, Karp CL, Aliberti J. Native and aspirin-triggered lipoxins control innate immunity by inducing proteasomal degradation of TRAF6. J Exp Med. 2008 May 12;205(5):1077-86. Epub 2008 Apr 14.
13. Dragin N, Shi Z, Madan R, Karp CL, Sartor MA, Chen C, Gonzalez FJ, Nebert DW. Phenotype of the Cyp1a1/1a2/1b1-/- triple-knockout mouse. Mol Pharmacol. 2008 Jun;73(6):1844-56. Epub 2008 Mar 27.
14. Mahller YY, Vaikunth SS, Ripberger MC, Baird WH, Saeki Y, Cancelas JA, Crombleholme TM, Cripe TP. Tissue inhibitor of metalloproteinase-3 via oncolytic herpesvirus inhibits tumor growth and vascular progenitors. Cancer Res. 2008 Feb 15;68(4):1170-9.
15. Mahller YY, Sakthivel B, Baird WH, Aronow BJ, Hsu YH, Cripe TP, Mehrian-Shai R. Molecular analysis of human cancer cells infected by an oncolytic HSV-1 reveals multiple upregulated cellular genes and a role for SOCS1 in virus replication. Cancer Gene Ther. 2008 Jun 13.
16. Parvadia JK, Keswani SG, Vaikunth S, Maldonado AR, Marwan A, Stehr W, Erwin C, Uzvolgyi E, Warner BW, Yamano S, Taichman N, Crombleholme TM. Role of VEGF in small bowel adaptation after resection: the adaptive response is angiogenesis dependent. Am J Physiol Gastrointest Liver Physiol. 2007 Sep;293(3):G591-8. Epub 2007 Jun 21.
17. Xie B, Charlton-Perkins M, McDonald E, Gebelein B, Cook T. Senseless functions as a molecular switch for color photoreceptor differentiation in Drosophila. Development. 2007 Dec;134(23):4243-53. Epub 2007 Oct 31.
18. Metzger DE, Stahlman MT, Shannon JM. Misexpression of ELF5 disrupts lung branching and inhibits epithelial differentiation. Dev Biol. 2008 Aug 1;320(1):149-60. Epub 2008 May 10.
19. Mir A, Kofron M, Heasman J, Mogle M, Lang S, Birsoy B, Wylie C. Long- and short-range signals control the dynamic expression of an animal hemisphere-specific gene in Xenopus. Dev Biol. 2008 Mar 1;315(1):161-72. Epub 2007 Dec 27.
20. Tao Q, Nandadasa S, McCrea PD, Heasman J, Wylie C. G-protein-coupled signals control cortical actin assembly by controlling cadherin expression in the early Xenopus embryo. Development. 2007 Jul;134(14):2651-61. Epub 2007 Jun 13.
21. Runyan C, Gu Y, Shoemaker A, Looijenga L, Wylie C. The distribution and behavior of extragonadal primordial germ cells in Bax mutant mice suggest a novel origin for sacrococcygeal germ cell tumors. Int J Dev Biol. 2008;52(4):333-44.
22. Skelton MR, Williams MT, Schaefer TL, Vorhees CV. Neonatal (+)-methamphetamine increases brain derived neurotrophic factor, but not nerve growth factor, during treatment and results in long-term spatial learning deficits. Psychoneuroendocrinology. 2007 Jul;32(6):734-45. Epub 2007 Jul 2.
23. Schaefer TL, Skelton MR, Herring NR, Gudelsky GA, Vorhees CV, Williams MT. Short- and long-term effects of (+)-methamphetamine and (+/-)-3,4-methylenedioxymethamphetamine on monoamine and corticosterone levels in the neonatal rat following multiple days of treatment. J Neurochem. 2008 Mar;104(6):1674-85. Epub 2007 Nov 6.
24. Herring NR, Schaefer TL, Tang PH, Skelton MR, Lucot JP, Gudelsky GA, Vorhees CV, Williams MT. Comparison of time-dependent effects of (+)-methamphetamine or forced swim on monoamines, corticosterone, glucose, creatine, and creatinine in rats. BMC Neurosci. 2008 May 30;9:49.
25. Vorhees CV, Schaefer TL, Williams MT. Developmental effects of +/-3,4-methylenedioxymethamphetamine on spatial versus path integration learning: effects of dose distribution. Synapse. 2007 Jul;61(7):488-99.
26. Shelton EL, Yutzey KE. Twist1 function in endocardial cushion cell proliferation, migration, and differentiation during heart valve development. Dev Biol. 2008 May 1;317(1):282-95. Epub 2008 Feb 29.
27. Belenkaya TY, Wu Y, Tang X, Zhou B, Cheng L, Sharma YV, Yan D, Selva EM, Lin X. The retromer complex influences Wnt secretion by recycling wntless from endosomes to the trans-Golgi network. Dev Cell. 2008 Jan;14(1):120-31. Epub 2007 Dec 20.
28. Yan D, Lin X. Drosophila glypican Dally-like acts in FGF-receiving cells to modulate FGF signaling during tracheal morphogenesis. Dev Biol. 2007 Dec 1;312(1):203-16. Epub 2007 Sep 20.
29. Yang L, Wang L, Kalfa TA, Cancelas JA, Shang X, Pushkaran S, Mo J, Williams DA, Zheng Y. Cdc42 critically regulates the balance between myelopoiesis and erythropoiesis. Blood. 2007 Dec 1;110(12):3853-61. Epub 2007 Aug 16.

Student Honors

• Allen, Z Supported by Individual NRSA Fellowship
• Baird, W Supported by NIH Training Grant (UC-Stambrook)
• Burns, K Supported by Individual NRSA Fellowship
• Chapman, H Supported by Yates Fellowship
• Combs, M Supported by American Heart Fellowship
• Grace, C Supported by NIH Training Grant (Teratology)
• Hottinger, S Supported by NIH Training Grant (UC-Schwartz)
• Kramer, E Supported by NIH Training Grant (Pulmonary and Cardiovascular Biology) and Ryan Fellowship
• Lipscomb, K Supported by American Heart Association Fellowship
• Lu, T Supported by NIH Training Grant (Organogenesis)
• Maynard, C Supported by NIH Training Grant (Pulmonary and Cardiovascular Biology)
• McDonald, E Supported by NIH Training Grant (Organogenesis)
• Mead, T Supported by NIH Training Grant (Teratology)
• Metzger, D Supported by NIH Training Grant (Pulmonary and Cardiovascular Biology)
• Schaefer, TSupported by NIH Training Grant (Teratology) and Ryan Fellowship
• Shelton, E Supported by American Heart Association Fellowship
• Sites, E Supported by NIH Training Grant (UC-Khan)
• Yan, D Supported by Ryan Fellowship

Richard A. Akeson Fellowship Fund

The Richard A. Akeson Fellowship and Memorial Lectureship Fund continues to support the Annual Richard Akeson Memorial Lectureship and travel by students in our graduate program to relevant courses and meetings in which they are presenting results of their research. Dr. Barry Gumbiner presented the Fourteenth Annual Richard Akeson Memorial Lectureship in conjunction with the annual Molecular and Developmental Biology Graduate Student Symposium in 2007.

The following students received funding from the Richard A. Akeson Fellowship and Memorial Fund for travel in 2007 - 2008: