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Neonatology, Perinatal and Pulmonary Biology

Division Photo

Neonatology, Perinatal and Pulmonary Biology

First Row: M. Koneru, B. Haberman, K. Wedig, K. Melton, Y. Xu, L. Nommsen-Rivers, V. Dave', A. Perl, A. Nathan, H. Kaplan, S. Kallapur; Second Row: T. Weaver, W. Rice, J. Steichen, L. Graf, K. Schibler, N. Hillman, T. Cahill, J. Shannon, M. Ikegami, C. Bachurski, T. Le Cras, L. Ward, J. Greenberg, A. Kenny, V. Narendran, J. Whitsett, B. Trapnell; Third Row: V. Kalinichenko, T. Bartman, E. Hall, A. South, S. Wexelblatt, P. Kingma, H. Falciglia, S. Glasser, S. Hoath, H. Akinbi, J. Reuter, T. Korfhagen, A. Jobe.

Division Data Summary
Research and Training Details
Number of Faculty45
Number of Research Fellows11
Number of Research Students9
Number of Support Personnel125
Peer Reviewed Publications67
Clinical Activities and Training
Number of Clinical Staff19
Number of Clinical Fellows12
Inpatient Encounters84,495
Outpatient Encounters6,172

Faculty Members

Jeffrey A. Whitsett, MD,  Professor ; Chief, Section of Neonatology, Perinatal and Pulmonary Biology
Research Interests: Lung Development; Surfactant
Ann Akeson, PhD,  Research Associate Professor
Research Interests: Pulmonary Vascular and Lymphatic Development
Henry Akinbi, MD,  Associate Professor Clinical
Cindy Bachurski, PhD,  Research Associate Professor ; Director, Research in Pulmonary Biology and Neonatology Elective, University of Cincinnati College of Medicine; Director, Summer Internship Program for High School Students, CCHMC
Research Interests: Gene Regulation in the Lung
Thomas Bartman, MD,  Assistant Professor
Research Interests: Cardiovascular Development
Tanya E. Cahill, MD,  Assistant Professor Clinical
Michael Crossman, MD, PhD,  Assistant Professor Clinical
Research Interests: Intestinal Function and Host-Microbial Interactions; Bioethics
Vrushank G. Dave', PhD,  Research Assistant Professor
Research Interests: Transcription, Lung Development and Cancer
Horacio Falciglia, MD,  Professor Clinical ; Medical Director, Bethesda North Hospital Normal Newborn Nursery
Research Interests: Seleniun Status and Neonatal Sepsis; Timing of Cord Clamping and Outcome; Vermont Oxford Data Base
Derek Fletcher, MD,  Assistant Professor Clinical
Stephan W. Glasser, PhD,  Associate Professor
Research Interests: Gene Regulation in the Lung
Lloyd Graf, Jr., PhD,  Research Assistant Professor
Research Interests: Dysregulated Gene Expression in Inflammatory Lung Diseases
James Greenberg, MD,  Associate Professor ; Director, Division of Neonatology; Medical Director, Regional Newborn Services
Research Interests: Pulmonary Vascular Development
Beth Haberman, MD,  Assistant Professor Clinical ; Medical Director, RCNIC & Mercy Anderson Hospital Nurseries; Director, High Risk Infant Follow-Up Clinic
Research Interests: Infant Follow-up
Eric Hall, PhD,  Research Instructor
Research Interests: Biostatistics
Noah Hillman, MD,  Research Instructor
Steven B. Hoath, MD,  Professor ; Director, Skin Sciences Institute
Research Interests: Skin Development
Machiko Ikegami, MD,  Professor ; Director, Surfactant and Metabolic Function Core
Research Interests: Surfactant Metabolism
Alan Jobe, MD, PhD,  Professor ; Director, Division of Perinatal Biology
Research Interests: Surfactant Physiology
Tanya Kalin, MD, PhD,  Research Assistant Professor
Vladimir Kalinichenko, MD, PhD,  Associate Professor
Research Interests: Fox Proteins in Lung Development
Suhas Kallapur, MD,  Associate Professor Clinical ; Director, Neonatology CME
Research Interests: Lung Development: BPD
Heather Kaplan, MD,  Research Assistant Professor
Research Interests: Epidemiology and Biostatistics
Alan Kenny, MD,  Research Instructor
Research Interests: Molecular Development of the Foregut Organs
Paul S. Kingma, MD, PhD,  Research Assistant Professor
Research Interests: Lung Defense; Surfactant
Madhavi Koneru, MD,  Assistant Professor Clinical
Thomas R. Korfhagen, MD, PhD,  Professor
Research Interests: Lung Defense
Timothy Le Cras, PhD,  Associate Professor ; Director of Graduate Student Recruiting, Molecular & Developmental Biology Graduate Program
Research Interests: Chronic Lung Disease; Lung Development
Ron Levin, MD,  Associate Professor Clinical
Kristin Melton, MD,  Associate Professor Clinical
Research Interests: Developmental Biology
Vivek Narendran, MD,  Associate Professor Clinical ; Director, Univ. Hosp. NICU & Newborn Nursery; Medical Director, The Christ Hospital Nursery
Research Interests: C-PAP
Amy Nathan, MD,  Research Assistant Professor
Research Interests: Immunobiology
Anne-Karina Perl, PhD,  Research Assistant Professor
Research Interests: FGF/PDGF Signaling in Alveolar Regeneration and EGFR Signaling in Bronchiolar Injury and Repair
John H. Reuter, MD,  Associate Professor Clinical
Ward R. Rice, MD, PhD,  Professor ; Director, Neonatal Fellowship Training Program; Director, Newborn Services, St. Elizabeth Medical Center
Research Interests: Lung Development
Kurt Schibler, MD,  Associate Professor ; Medical Director, Good Samaritan Hospital NICU; Director, Clinical Research Program
Research Interests: Neonatal Hematopoiesis
John Shannon, PhD,  Professor
Research Interests: Lung Development
Jean J. Steichen, MD,  Professor
Research Interests: Infant Follow-up
Bruce Trapnell, MD,  Professor ; Director, Rare Lung Diseases Clinical Research Consortium; Scientific Director, PAP Foundation; Director, Translational Pulmonary Research; Co-Director, Cystic Fibrosis TDN Center
Research Interests: Pulmonary Gene Delivery
Timothy E. Weaver, PhD,  Professor ; Co-Director, Division of Pulmonary Biology
Research Interests: Protein Processing in the Lung
Laura Ward, MD,  Adjunct Assistant Professor
Research Interests: Use of Human Milk in the NICU
Kathryn Wedig, MD,  Associate Professor Clinical ; Director, High Risk Clinic @ GSH; Medical Director, Mercy Hospital Fairfield
Research Interests: Infant Follow-up
Susan E. Wert, PhD,  Research Associate Professor ; Director, Molecular Morphology Core, Division of Pulmonary Biology
Research Interests: Lung Morphology
Scott Wexelblatt, MD,  Assistant Professor Clinical
Yan Xu, PhD,  Research Associate Professor ; Director, Microarray-Bioinformatics Core, Division of Pulmonary Biology
Research Interests: Bioinformatics, Systems Biology, Transcriptional Network

Clinical Staff Members

  • Shana Alexander, MD
  • Stephen Bird, MD
  • Thomas Catalanotto, MD
  • Diane Donley, MD
  • Michelle French, MD
  • Lisa Green, MD
  • Jennifer Hardie, MD
  • Evelyn Jones, MD
  • Jillian Klein, MD
  • Carrie Kluger, MD
  • Katie Loudermilk, MD
  • Alisa McGill, MD
  • Kenton Pate, MD
  • Ajay Ponkshe, MD
  • John Robinson, MD
  • Deborah Rufner, MD
  • Kathy Sorger, MD
  • Kara Tencza, MD
  • Kira Zimmerly, MD

Trainees

  • Valerie Besnard, PhD,  Universite Rene Descartes - Paris V
  • Stephanie Binder, MD,  PL6,  John H. Stroger Hospital Cook County, Chicago, IL
  • Jim Bridges, PhD,  University of Cincinnati
  • Brenna Carey, PhD,  University of Cincinnati
  • Gang Chen, MS ,  Yangzhou University, China
  • Fusheng Chou, MD,  National Taiwan University
  • Nikki Glenn, BS,  Miami University
  • David Hahn, BS,  Northern Kentucky University
  • Prakruti Jambula, MD,  PL4,  Univ. of Oklahoma HSC, Oklahoma City, OK
  • Amer Jameel, BS,  Ohio State University
  • Brooke King, MD,  PL5,  Cincinnati Children's Hospital Medical Center - UCMC, Cincinnati, OH
  • Elizabeth Kramer, BA, BS,  Miami University
  • Rishikesh Kulkarni, BPharmSc,  University of Mumbai, India
  • Venkata Kuppala, MD,  PL5,  The Cleveland Clinic, Cleveland, OH
  • Tara Lang, MD,  PL5,  Mayo School GME, Rochester, MN
  • Alexander Lange, PhD,  University of Cincinnati
  • Yutaka Maeda, PhD,  University of California
  • Karunyakanth Mandapaka, MS,  University of Cincinnati
  • Rafael Mena, MD,  PL4,  Cincinnati Children's Hospital Medical Center - UCMC, Cincinnati, OH
  • Stephanie Merhar, MD,  PL4,  Cincinnati Children's Hospital Medical Center - UCMC, Cincinnati, OH
  • Bhuvana Murali, BTech,  Vellore Institute of Technology, India
  • Elizabeth Mushaben, BS,  College of Mount St. Joseph
  • Ross Ridsdale, PhD,  University of Toronto
  • Chika Saegusa, PhD,  RIKEN, Japan
  • Takuro Sakagami, MD, PhD,  Niigata University, Japan
  • Christine Sarlone, MD,  PL4,  Univ. of Tennessee HSC, Memphis, TN
  • Tushar Shah, MD, MPH,  PL5,  Case Western Reserve Univ., Cleveland, OH
  • Jonathan Slaughter, MD, MSc.,  PL5,  Medical Univ. of South Carolina, Charleston, SC
  • Gareth Stewart, MB BCH BAO, MRCP, PhD,  Royal Infirmary of Edinburgh
  • Takuji Suzuki, MD, PhD,  Tohoku University, Japan
  • Holly Strike, MD,  PL6,  Indiana Univ. SOM, Indianapolis, IN
  • David Tompkins, MS,  University of Texas
  • Huajing Wan, PhD,  University of Cincinnati
  • Elizabeth Wetzel, MD,  PL4,  Indiana Univ. SOM, Indianapolis, IN

Significant Accomplishments in FY08

We wish to highlight the considerable progress we have made related to rare lung diseases and the effects of perinatal infection on prematurity.

The Rare Lung Disease Consortium, based at Cincinnati Children’s and funded by the NIH, links the basic science underlying the pathogenesis of several rare pulmonary diseases: pulmonary alveolar proteinosis (PAP), interstitial lung diseases (ILD) in children, lymphangioleiomyomatosis (LAM) and alpha-1 antitrypsin. Bringing together investigators and patients affected by rare lung diseases from the US, Japan and Europe, the group has made major advances in diagnosis and treatment.
    
Recently, researchers demonstrated that adult patients with PAP have high levels of autoimmune antibodies that cause the disease by blocking the protein GM-CSF and, therefore, macrophage function in the lung. Because early trials with GM-CSF inhalation have been effective, larger trials are under study.

 Perinatal Infection and Prematurity

In an NIH-funded collaborative with Australian colleagues, our researchers have shown that prenatal exposure of the fetus to bacterial endotoxin or ureaplasma, both commonly associated with preterm labor and perinatal infection, creates a fetal inflammatory syndrome. In the setting of perinatal infection and lung injury, the gentler methods of resuscitation and ventilation in the premature newborn  are effective and cause less injury to the lungs.  Their research studies are leading to improvements in the use of prenatal steroids, timing of delivery, resuscitation, ventilation methods and the use of pulmonary surfactant, all of which contribute to better care for preterm infants.

Significant Publications in FY08

Kallapur SG, Jobe AH, Ball MK, Nitsos I, Moss TJ, Hillman NH, Newnham JP, Kramer BW.  Pulmonary and systemic endotoxin tolerance in preterm fetal sheep exposed to chorioamnionitis. J Immunol. 2007; 179: 8491-8499

Intrauterine infection contributes to prematurity and to the many complications related to preterm birth.  In this publication, a model of intrauterine infection was developed to determine how the fetus is able to survive and adapt to bacterial infection prior to birth.  The work demonstrates remarkable differences in fetal as compared to adult immune responses that, in turn, have important consequences related to the postnatal problems associated with prematurity.

Bell SM, Schreiner CM, Wert SE, Mucenski ML, Scott WJ, Whitsett JA.  R-spondin 2 is required for normal laryngeal-tracheal, lung and limb morphogenesis. Development. 2008;135: 1049-1058

Congenital malformations account for nearly half of neonatal death.  This paper demonstrates a new mechanism that causes malformations of the trachea, lung, and limbs, and identifies a critical role of a secreted molecule (R-spondin 2) in the process of lung formation.  R-Spondin was found to regulate the Wnt pathway to influence organogenesis, being required for normal formation of the larynx, trachea, and lung.

Mason-Richie NA, Mistry MJ, Gettler CA, Elayyadi A, Wikenheiser-Brokamp KA.  Retinoblastoma function is essential for establishing lung epithelial quiescence after injury. Cancer Res. 2008; 68: 4068-4076

Since the lung is repeatedly exposed to infectious agents and toxicants, the cells lining the airways have a robust ability to repair, a process that must be terminated to avoid alterations in lung structure or cancer.  This work demonstrates a previously unknown role for Rb (Retinoblastoma associated factor) in termination of the repair process in cells lining the respiratory tract that is relevant to lung repair and cancer prevention.

Dong M, Bridges JP, Apsley K, Xu Y, Weaver TE.  ERdj4 and ERdj5 are required for endoplasmic reticulum-associated protein degradation of misfolded surfactant protein C. Mol Biol Cell. 2008; 19: 2620-2630

Misfolded proteins accumulate in cells causing injury or cellular dysfunction, a process related to a number of disorders, including Alzheimer’s disease, cystic fibrosis, and lung fibrosis, to name a few.  This work identifies the novel role of ERdj4 and ERdj5 in chaperoning the surfactant protein C precursor through the cell.  Mutations in surfactant protein C cause severe respiratory disease in infants and children.  Understanding the processes that help the protein fold and move normally through the cell will help guide new therapies for this lethal lung disease in children.

Lin S, Ikegami M, Xu Y, Bosserhoff AK, Malkinson AM, Shannon JM.  Misexpression of MIA disrupts lung morphogenesis and causes neonatal death. Dev Biol. 2008; 316: 441-455

This work demonstrates a novel role for MIA (Melanocyte Inhibitory Factor) in the regulation of lung maturation critical for survival after birth.  MIA inhibits the processes that determine function of the lung, regulating genes that are required for breathing at birth.  MIA suppresses lung maturation and its normal loss, prior to birth, is critical for the ability of the newborn to adapt to postnatal life.

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Division Publications

  1. Walker VP, Akinbi HT, Meinzen-Derr J, Narendran V, Visscher M, Hoath SB. Host defense proteins on the surface of neonatal skin: implications for innate immunity. J Pediatr. 2008; 152: 777-81.
  2. Maeda Y, Suzuki T, Pan X, Chen G, Pan S, Bartman T, Whitsett JA. CUL2 is required for the activity of hypoxia-inducible factor and vasculogenesis. J Biol Chem. 2008; 283: 16084-92.
  3. Crossman MW. For whom the bell tolls. J Pediatr. 2007; 151: 4-5.
  4. Dave V, Wert SE, Tanner T, Thitoff AR, Loudy DE, Whitsett JA. Conditional deletion of Pten causes bronchiolar hyperplasia. Am J Respir Cell Mol Biol. 2008; 38: 337-45.
  5. Hillman NH, Moss TJ, Kallapur SG, Bachurski C, Pillow JJ, Polglase GR, Nitsos I, Kramer BW, Jobe AH. Brief, large tidal volume ventilation initiates lung injury and a systemic response in fetal sheep. Am J Respir Crit Care Med. 2007; 176: 575-81.
  6. Hillman NH, Moss TJ, Nitsos I, Kramer BW, Bachurski CJ, Ikegami M, Jobe AH, Kallapur SG. Toll-like receptors and agonist responses in the developing fetal sheep lung. Pediatr Res. 2008; 63: 388-93.
  7. Pillow JJ, Hillman N, Moss TJ, Polglase G, Bold G, Beaumont C, Ikegami M, Jobe AH. Bubble continuous positive airway pressure enhances lung volume and gas exchange in preterm lambs. Am J Respir Crit Care Med. 2007; 176: 63-9.
  8. Gibbins S, Hoath SB, Coughlin M, Gibbins A, Franck L. The universe of developmental care: a new conceptual model for application in the neonatal intensive care unit. Adv Neonatal Care. 2008; 8: 141-7.
  9. Spitzmiller RE, Phillips T, Meinzen-Derr J, Hoath SB. Amplitude-integrated EEG is useful in predicting neurodevelopmental outcome in full-term infants with hypoxic-ischemic encephalopathy: a meta-analysis. J Child Neurol. 2007; 22: 1069-78.
  10. Tansirikongkol A, Hoath SB, Pickens WL, Visscher MO, Wickett RR. Equilibrium water content in native vernix and its cellular component. J Pharm Sci. 2008; 97: 985-94.
  11. Tansirikongkol A, Wickett RR, Visscher MO, Hoath SB. Effect of vernix caseosa on the penetration of chymotryptic enzyme: potential role in epidermal barrier development. Pediatr Res. 2007; 62: 49-53.
  12. Hardie WD, Davidson C, Ikegami M, Leikauf GD, Le Cras TD, Prestridge A, Whitsett JA, Korfhagen TR. EGF receptor tyrosine kinase inhibitors diminish transforming growth factor-alpha-induced pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2008; 294: L1217-25.
  13. Ikegami M, Falcone A, Whitsett JA. STAT-3 regulates surfactant phospholipid homeostasis in normal lung and during endotoxin-mediated lung injury. J Appl Physiol. 2008; 104: 1753-60.
  14. Ikegami M, Scoville EA, Grant S, Korfhagen T, Brondyk W, Scheule RK, Whitsett JA. Surfactant protein-D and surfactant inhibit endotoxin-induced pulmonary inflammation. Chest. 2007; 132: 1447-54.
  15. Kramer EL, Deutsch GH, Sartor MA, Hardie WD, Ikegami M, Korfhagen TR, Le Cras TD. Perinatal increases in TGF-{alpha} disrupt the saccular phase of lung morphogenesis and cause remodeling: microarray analysis. Am J Physiol Lung Cell Mol Physiol. 2007; 293: L314-27.
  16. Lin S, Ikegami M, Xu Y, Bosserhoff AK, Malkinson AM, Shannon JM. Misexpression of MIA disrupts lung morphogenesis and causes neonatal death. Dev Biol. 2008; 316: 441-55.
  17. McCurnin D, Seidner S, Chang LY, Waleh N, Ikegami M, Petershack J, Yoder B, Giavedoni L, Albertine KH, Dahl MJ, Wang ZM, Clyman RI. Ibuprofen-induced patent ductus arteriosus closure: physiologic, histologic, and biochemical effects on the premature lung. Pediatrics. 2008; 121: 945-56.
  18. Cheah FC, Jobe AH, Moss TJ, Newnham JP, Kallapur SG. Oxidative stress in fetal lambs exposed to intra-amniotic endotoxin in a chorioamnionitis model. Pediatr Res. 2008; 63: 274-9.
  19. Jobe AH. TPN as a source of oxidants. J Pediatr. 2007; 151: A3.
  20. Jobe AH. Neonatal dehydration and neurodevelopment. J Pediatr. 2007; 151: A1.
  21. Jobe AH. A "jaundiced" eye toward clinical assessments of bilirubin. J Pediatr. 2008; 152: A3.
  22. Jobe AH. What is ALTE?. J Pediatr. 2008; 152: A2.
  23. Jobe AH. "Surfactant: the basis for clinical treatment strategies.." In: E Bancalari, ed. The newborn lung: neonatology questions and controversies . Philadelphia: Saunders/Elsevier; 2008: 73-98.
  24. Jobe AH, Kallapur SG, Moss TJM. "Inflammation/infection: effects on the fetal/newborn lung." In: E Bancalari, RA Polin, eds. The newborn lung: neonatology questions and controversy. Philadelphia: Saunders/Elsevier; 2008: 119-140.
  25. Jobe AH, Moss TJ, Nitsos I, Ikegami M, Kallapur SG, Newnham JP. Betamethasone for lung maturation: testing dose and formulation in fetal sheep. Am J Obstet Gynecol. 2007; 197: 523 e1-6.
  26. Kramer BW, Joshi SN, Moss TJ, Newnham JP, Sindelar R, Jobe AH, Kallapur SG. Endotoxin-induced maturation of monocytes in preterm fetal sheep lung. Am J Physiol Lung Cell Mol Physiol. 2007; 293: L345-53.
  27. Pillow JJ, Jobe AH. "Respiratory disorders of neonates and infants: respiratory disorders of the newborn." In: LM Taussig, LI Landau, eds. Pediatric respiratory medicine. Philadelphia: Mosby/Elsevier; 2008: 365-386.
  28. Polglase GR, Nitsos I, Jobe AH, Newnham JP, Moss TJ. Maternal and intra-amniotic corticosteroid effects on lung morphometry in preterm lambs. Pediatr Res. 2007; 62: 32-6.
  29. Kallapur SG, Jobe AH, Ball MK, Nitsos I, Moss TJ, Hillman NH, Newnham JP, Kramer BW. Pulmonary and systemic endotoxin tolerance in preterm fetal sheep exposed to chorioamnionitis. J Immunol. 2007; 179: 8491-9.
  30. Moss TJ, Knox CL, Kallapur SG, Nitsos I, Theodoropoulos C, Newnham JP, Ikegami M, Jobe AH. Experimental amniotic fluid infection in sheep: effects of Ureaplasma parvum serovars 3 and 6 on preterm or term fetal sheep. Am J Obstet Gynecol. 2008; 198: 122 e1-8.
  31. Sweet DG, Huggett MT, Warner JA, Moss TJ, Kloosterboer N, Halliday HL, Newnham JP, Kallapur SG, Jobe AH, Kramer BW. Maternal Betamethasone and Chorioamnionitis Induce Different Collagenases during Lung Maturation in Fetal Sheep. Neonatology. 2008; 94: 79-86.
  32. Deshmukh HS, Shaver C, Case LM, Dietsch M, Wesselkamper SC, Hardie WD, Korfhagen TR, Corradi M, Nadel JA, Borchers MT, Leikauf GD. Acrolein-activated matrix metalloproteinase 9 contributes to persistent mucin production. Am J Respir Cell Mol Biol. 2008; 38: 446-54.
  33. Hardie WD, Korfhagen TR, Sartor MA, Prestridge A, Medvedovic M, Le Cras TD, Ikegami M, Wesselkamper SC, Davidson C, Dietsch M, Nichols W, Whitsett JA, Leikauf GD. Genomic profile of matrix and vasculature remodeling in TGF-alpha induced pulmonary fibrosis. Am J Respir Cell Mol Biol. 2007; 37: 309-21.
  34. Krakovsky G, Huth MM, Lin L, Levin RS. Functional changes in children, adolescents, and young adults with cerebral palsy. Res Dev Disabil. 2007; 28: 331-40.
  35. Kida H, Mucenski ML, Thitoff AR, Le Cras TD, Park KS, Ikegami M, Muller W, Whitsett JA. GP130-STAT3 regulates epithelial cell migration and is required for repair of the bronchiolar epithelium. Am J Pathol. 2008; 172: 1542-54.
  36. Jaggi F, Cabrita MA, Perl AK, Christofori G. Modulation of endocrine pancreas development but not beta-cell carcinogenesis by Sprouty4. Mol Cancer Res. 2008; 6: 468-82.
  37. Hintz SR, Van Meurs KP, Perritt R, Poole WK, Das A, Stevenson DK, Ehrenkranz RA, Lemons JA, Vohr BR, Heyne R, Childers DO, Peralta-Carcelen M, Dusick A, Johnson YR, Morris B, Dillard R, Vaucher Y, Steichen J, Adams-Chapman I, Konduri G, Myers GJ, de Ungria M, Tyson JE, Higgins RD. Neurodevelopmental outcomes of premature infants with severe respiratory failure enrolled in a randomized controlled trial of inhaled nitric oxide. J Pediatr. 2007; 151: 16-22, 22 e1-3.
  38. Ludwig S, Steichen J, Khoury J, Krieg P. Quality improvement analysis of developmental care in infants less than 1500 grams at birth. Newborn Infant Nurs Rev. 2008; 8: 94-100.
  39. Deutsch GH, Young LR, Deterding RR, Fan LL, Dell SD, Bean JA, Brody AS, Nogee LM, Trapnell BC, Langston C, Albright EA, Askin FB, Baker P, Chou PM, Cool CM, Coventry SC, Cutz E, Davis MM, Dishop MK, Galambos C, Patterson K, Travis WD, Wert SE, White FV. Diffuse lung disease in young children: application of a novel classification scheme. Am J Respir Crit Care Med. 2007; 176: 1120-8.
  40. Inoue Y, Trapnell BC, Tazawa R, Arai T, Takada T, Hizawa N, Kasahara Y, Tatsumi K, Hojo M, Ichiwata T, Tanaka N, Yamaguchi E, Eda R, Oishi K, Tsuchihashi Y, Kaneko C, Nukiwa T, Sakatani M, Krischer JP, Nakata K. Characteristics of a large cohort of patients with autoimmune pulmonary alveolar proteinosis in Japan. Am J Respir Crit Care Med. 2008; 177: 752-62.
  41. Kleff V, Sorg UR, Bury C, Suzuki T, Rattmann I, Jerabek-Willemsen M, Poremba C, Flasshove M, Opalka B, Trapnell B, Dirksen U, Moritz T. Gene therapy of beta(c)-deficient pulmonary alveolar proteinosis (beta(c)-PAP): studies in a murine in vivo model. Mol Ther. 2008; 16: 757-64.
  42. Ueno T, Elmberger G, Weaver TE, Toi M, Linder S. The aspartic protease napsin A suppresses tumor growth independent of its catalytic activity. Lab Invest. 2008; 88: 256-63.
  43. Wedig KE, Whitsett JA. Down the primrose path: petechiae in a neonate exposed to herbal remedy for parturition. J Pediatr. 2008; 152: 140, 140 e1.
  44. Bell SM, Schreiner CM, Wert SE, Mucenski ML, Scott WJ, Whitsett JA. R-spondin 2 is required for normal laryngeal-tracheal, lung and limb morphogenesis. Development. 2008; 135: 1049-58.
  45. Nogee LM, Wert SE. "Genetic abnormalities of surfactant metabolism.." In: DS Zander, HH Popper, J Jagirdaret al, eds. Molecular pathology of lung diseases. New York: Springer; 2008: 590-606.
  46. Wert SE. Does adiponectin play a role in pulmonary emphysema?. Am J Physiol Lung Cell Mol Physiol. 2008; 294: L1032-4.
  47. Besnard V, Xu Y, Whitsett JA. Sterol response element binding protein and thyroid transcription factor-1 (Nkx2.1) regulate Abca3 gene expression. Am J Physiol Lung Cell Mol Physiol. 2007; 293: L1395-405.
  48. Brandt EB, Mingler MK, Stevenson MD, Wang N, Khurana Hershey GK, Whitsett JA, Rothenberg ME. Surfactant protein D alters allergic lung responses in mice and human subjects. J Allergy Clin Immunol. 2008; 121: 1140-1147 e2.
  49. Ferri AL, Lin W, Mavromatakis YE, Wang JC, Sasaki H, Whitsett JA, Ang SL. Foxa1 and Foxa2 regulate multiple phases of midbrain dopaminergic neuron development in a dosage-dependent manner. Development. 2007; 134: 2761-9.
  50. Quinton LJ, Jones MR, Robson BE, Simms BT, Whitsett JA, Mizgerd JP. Alveolar epithelial STAT3, IL-6 family cytokines, and host defense during Escherichia coli pneumonia. Am J Respir Cell Mol Biol. 2008; 38: 699-706.
  51. Raj JU, Aliferis C, Caprioli RM, Cowley AW, Jr., Davies PF, Duncan MW, Erle DJ, Erzurum SC, Finn PW, Ischiropoulos H, Kaminski N, Kleeberger SR, Leikauf GD, Loyd JE, Martin TR, Matalon S, Moore JH, Quackenbush J, Sabo-Attwood T, Shapiro SD, Schnitzer JE, Schwartz DA, Schwiebert LM, Sheppard D, Ware LB, Weiss ST, Whitsett JA, Wurfel MM, Matthay MA. Genomics and proteomics of lung disease: conference summary. Am J Physiol Lung Cell Mol Physiol. 2007; 293: L45-51.
  52. Sun J, Chen H, Chen C, Whitsett JA, Mishina Y, Bringas P, Jr., Ma JC, Warburton D, Shi W. Prenatal lung epithelial cell-specific abrogation of Alk3-bone morphogenetic protein signaling causes neonatal respiratory distress by disrupting distal airway formation. Am J Pathol. 2008; 172: 571-82.
  53. Tichelaar JW, Wesselkamper SC, Chowdhury S, Yin H, Berclaz PY, Sartor MA, Leikauf GD, Whitsett JA. Duration-dependent cytoprotective versus inflammatory effects of lung epithelial fibroblast growth factor-7 expression. Exp Lung Res. 2007; 33: 385-417.
  54. Tran PT, Fan AC, Bendapudi PK, Koh S, Komatsubara K, Chen J, Horng G, Bellovin DI, Giuriato S, Wang CS, Whitsett JA, Felsher DW. Combined Inactivation of MYC and K-Ras oncogenes reverses tumorigenesis in lung adenocarcinomas and lymphomas. PLoS ONE. 2008; 3: e2125.
  55. Whitsett JA. Hereditary disorders of surfactant homeostasis cause acute and chronic lung disease in infancy. Thorax. 2008; 63: 295-6.
  56. Whitsett JA, Weaver TE. "Hereditary disorders of alveolar homeostasis in the newborn." In: E Bancalari, ed. The newborn lung: neonatology questions and controversy. Philadelphia: Saunders/Elsevier; 2008: 42-49.
  57. Yamamoto H, Jun Yun E, Gerber HP, Ferrara N, Whitsett JA, Vu TH. Epithelial-vascular cross talk mediated by VEGF-A and HGF signaling directs primary septae formation during distal lung morphogenesis. Dev Biol. 2007; 308: 44-53.
  58. Yanagi S, Kishimoto H, Kawahara K, Sasaki T, Sasaki M, Nishio M, Yajima N, Hamada K, Horie Y, Kubo H, Whitsett JA, Mak TW, Nakano T, Nakazato M, Suzuki A. Pten controls lung morphogenesis, bronchioalveolar stem cells, and onset of lung adenocarcinomas in mice. J Clin Invest. 2007; 117: 2929-40.
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Grants, Contracts, and Industry Agreements

Grant and Contract Awards Annual Direct / Project Period Direct

Akeson, A

Pulmonary Lymphatic Development and Neonatal Lung Disease
6-FY07-31706/01/07 - 05/31/10 $73,695 / $221,209

Bartman, T

Role of Chondronitin and Dermatan Sulfatation in Endocardial Cushion Morphogenesis
06/01/06 - 05/31/09 $74,545 / $218,181
Analysis of NFATc1 as the Mechanism by Which Early Heart Function Regulates Endocardial Cushion and Valve Morphogenesis
01/01/06 - 12/31/09 $59,091 / $236,364

Bridges, J

Characterization of LPCAT, a Lung LysoPC Acyltransferase: Identification of Catalytic Domains and Transcriptional Regulators
07/01/07 - 06/30/10 $46,000 / $144,000

Dave, V

Calcineurin Effectors in Pulmonary Homeostasis
083010N01/01/08 - 12/31/11 $70,000 / $280,000

Hill, K

ODH Division Of Family Services Regional Outreach Education Program
31-3-001-1-BM-0707/01/07 - 06/30/08 $90,000 / $90,000

Jobe, A

Postnatal Consequences of Fetal Inflammation
R21 AI 06971608/01/06 - 07/31/08 $153,651 / $290,360
New Mediators Of Clinical Lung Maturation
R01 HL 06539709/01/04 - 08/31/09 $281,401 / $1,457,632
Neonatal Resuscitation and Preterm Lung Injury
R01 HD 01271405/01/06 - 03/31/11 $232,541 / $954,405

Kalinichenko, T

Role of Foxm1 Protein in Macrophages During Lung Tumor
01/15/08 - 12/30/08 $20,000 / $20,000

Kalinichenko, V

Fox Transcription Factors in Development of Pulmonary Capillaries
FY05126607/01/07 - 05/31/08 $83,607 / $83,607
Foxm1 Transcription Factor in Development of Non-Small Lung Cancer
RSG-06-187-01-MGO07/01/07 - 06/30/10 $157,352 / $496,650
Fox Transcription Factors in Development of Pulmonary Capillaries
R01 HL 08415105/01/08 - 04/30/11 $242,750 / $728,250

Korfhagen, T

Role Of Surfactant Protein-A In Lung Defense
R01 HL 05879502/13/04 - 01/31/09 $237,045 / $1,250,000

Lecras, T

Pathogenesis of Neonatal Lung Disease
0740069N01/01/07 - 12/31/11 $90,909 / $454,545

Melton, K

Craniofacial Development: The Role of the Endothelium
K08 DE 01635511/01/07 - 08/31/08 $134,291 / $134,291

Perl, A

Role of FGF Signaling on PDGFRa Expression During Alveolar Myofibroblast Differentiation
075563B07/01/07 - 06/30/09 $55,000 / $110,000

Schibler, K

NICHD Cooperative Multi-Center Neonatal Research Network
U10 HD 02785304/01/06 - 03/31/11 $255,237 / $619,326

Shannon, J

Lung Epithelium in Development and Disease
FY0762206/01/08 - 11/30/08 $5,000 / $5,000
Alveolar Type II Cells: Effects Of KGF
R01 HL 02989104/01/06 - 03/31/10 $6,993 / $69,870
Role of HIF-1 in Fetal Lung Epithelial Differentiation
R01 HL 08437602/01/07 - 01/31/12 $349,155 / $1,832,879

Trapnell, B

Scientific Director Of Alpha1 Foundation
07/01/06 - 06/30/08 $50,000 / $100,000
Rare Disease Clinical Research Network
U54 RR 01949809/30/03 - 07/31/08 $0,000 / $4,498,194
Role of Anti-GM-CSF Antibodies in Myeloid Cell Function & Innate Immunity
R01 HL 08545304/01/07 - 03/31/11 $250,000 / $1,000,000

Weaver, T

Regulation Of Respiratory Epithelial Cell Homeostasis
P01 HL 06164608/10/04 - 06/30/09 $1,320,624 / $6,892,425
Weaver, TProject 1283,764
Prows, DProject 2169,307
Ikegami, MProject 3291,647
Whitsett, JProject 4298,425
Weaver, TCore A10,938
Xu, YCore B131,122
Wert, SCore C135,608
Structure/Function Analyses Of SP-B In Transgenic Mice
R37 HL 05628505/01/06 - 04/30/11 $358,472 / $1,885,203

Whitsett, J

Genetic Control of Gestation and Lung Maturation in the Mouse
21-FY08-50203/01/08 - 02/28/09 $25,100 / $25,100
Pulmonary And Cardiovascular Development Training Grant
T32 HL 00775207/01/04 - 06/30/09 $231,415 / $1,142,435
ABCA3 and Alveolar Homeostasis
R01 HL 08561007/10/06 - 06/30/11 $296,731 / $1,567,158
Transcriptional Control of Respiratory Epithelial Progenitor Cells
R01 HL 09015609/28/07 - 06/30/11 $329,638 / $1,372,968
Current Year Direct$5,580,243
Industry Contracts

Hoath, S

$ 326,705

Steichen, J

$ 12,025

Visscher, M

$ 185,462
Current Year Direct Receipts$524,192
Total$6,104,435
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