2011 Research Annual Report

Division Data Summary

Research and Training Details

Number of Faculty48
Number of Joint Appointment Faculty2
Number of Research Fellows1
Number of Research Students3
Number of Support Personnel55
Direct Annual Grant Support$765,735
Direct Annual Industry Support$39,960
Peer Reviewed Publications18

Clinical Activities and Training

Number of Clinical Staff103
Number of Clinical Fellows9
Number of Clinical Students136
Number of Other Students36
Inpatient Encounters16,931
Outpatient Encounters32,297

Division Photo

anesthesiology-2011_450x

Row 1: M Kibelbek, A Tucker, V Chidambaran, M Baker, A Mueller, A Loepke, D Kurth, J McAuliffe III

Row 2: K Goldschneider, K Lewellyn, M Patino, B Hugus, J Spaeth

Row 3: S Danzer, J Estes, L Roeder, K Beutel, K Franic-Everhart, M Konig

Row 4: K Vicars, J Kondik, S Kennedy, J Moeller, K Callahan, N Andersen, R Blacklidge, J Beiersdorfer, C Opdycke

Row 5: P Samuels, L Pfaff, M Linker, S Sadhasivam, G Istaphanous, C Ward


Significant Publications

Boat A, Mahmoud M, et al. Supplementing desflurane with intravenous anesthesia reduces fetal cardiac dysfunction during open fetal surgery. Paediatr Anaesth. 20(8): 748-756. 2010.
The study objective was to lower the incidence and severity of fetal cardiovascular depression during maternal fetal surgery under general anesthesia.  The hypothesis states that SIVA technique would minimize prolonged fetal exposure to deep inhalational anesthetics and significant intraoperative fetal cardiovascular depression.  It was discovered that adequate uterine relaxation was achieved with about 1.5 MAC of desflurane in the SIVA group compared to about 2.5 MAC in the desflurane only anesthesia group. More fetuses in the high-dose desflurane group compared to the SIVA group developed moderate-severe left ventricular systolic dysfunction over time intraoperatively.  Furthermore, 61% of fetuses in the high-dose desflurane group received fetal resuscitative interventions compared to 26% of fetuses in the SIVA group.  In conclusion, SIVA as described provides adequate maternal anesthesia and uterine relaxation, and it allows for decreased use of desflurane during open fetal surgery. Thus a decreased use of desflurane may better preserve fetal cardiac function.
Istaphanous GK, Howard J, et al. Comparison of the neuroapoptotic properties of equipotent anesthetic concentrations of desflurane, isoflurane, or sevoflurane in neonatal mice. Anesthesiology. 114(3): 578-587. 2011.
Neuronal cell death after prolonged exposure to isoflurane in developing animals has raised serious concerns regarding its safe use in children. Using newborn mice, the study established the respective potencies of desflurane, isoflurane, and sevoflurane and then compared equipotent doses of these anesthetics regarding their effects on cortical neuroapoptosis.  Experiments indicate that , in neonatal mice, equipotent doses of the three commonly used inhaled anesthetics demonstrated similar neurotoxic profiles, suggesting that developmental neurotoxicity is a common feature of all three drugs and cannot be avoided by switching to newer agents.
McDole JR, Danzer SC, et al. Rapid formation of extended processes and engagement of Theiler's virus-infected neurons by CNS-infiltrating CD8 T cells. Am J Pathol. 177(4): 1823-1833. 2010.
A fundamental question in neuroimmunology is the extent to which CD8 T cells actively engage virus-infected neurons. In the Theiler's murine encephalomyelitis virus (TMEV) model of multiple sclerosis, an effective central nervous system (CNS)-infiltrating antiviral CD8 T cell response offers protection from this demyelinating disease. However, the specific CNS cell types engaged by these protective CD8 T cells in TMEV-resistant strains remains unknown. Using live tissue imaging, it was determined that these T cell-extended processes (TCEPs) could be rapidly formed and were associated with migratory behavior through CNS tissues. These studies provide evidence that antiviral CD8 T cells have the capacity to engage virus-infected neurons in vivo and are the first to document and measure the rapid formation of TCEPs on these brain-infiltrating lymphocytes using live tissue imaging.

Faculty Members

C. Dean Kurth, MD, Professor
Anesthesiologist-in-Chief and Chair, Department of Anesthesia
Research Interests
Elena Adler, MD, Adjunct
Medical Director, Anesthesia Supply Chain, Division of Anesthesia
Research Interests
Nancy Andersen, MD, Adjunct
Research Interests
Lori Aronson, MD, Adjunct
Research Interests
Anne Boat, MD, Assistant Professor
Director, Fetal Surgery Team, Division of Anesthesia
Research Interests
Vidya Chidambaran, MD, Assistant Professor
Research Interests
Smokey Clay, MD, Assistant Professor
Research Interests
Steve Danzer, PhD, Assistant Professor
Research Interests
Charles Eastwood, MD, Assistant Professor
Research Interests
Hilary Flint, DO, Assistant Professor
Research Interests
Lisa Francis, DO, Assistant Professor
Research Interests
Kenneth Goldschneider, MD, Associate Professor
Director, Medical Pain Service and Chronic Pain Clinic
Research Interests
Joel Gunter, MD, Professor
Research Interests
Nancy Hagerman, MD, Adjunct
Co-Medical Director, Same Day Surgery and Pre-Anesthesia Consultation Clinic, Division of Anesthesia
Research Interests
Elizabeth Hein, MD, Adjunct
Research Interests
Liana Hosu, MD, Adjunct
Research Interests
George Istaphanous, MD, Assistant Professor
Research Interests
Fay Jou, MD, Assistant Professor
Research Interests
Thomas Kabalin, MD, Associate Professor
Research Interests
Michael "Jack" Kibelbek, MD, Associate Professor
Research Interests
Matthias Konig, MD, Assistant Professor
Research Interests
Renee Kreeger, MD, Adjunct
Research Interests
Ik Lee, MD, Associate Professor
Director, Division of Anesthesia
Research Interests
Erica Lin, MD, Assistant Professor
Research Interests
Andreas Loepke, MD, PhD, Associate Professor
Research Interests
Mohamed Mahmoud, MD, Assistant Professor
Research Interests
Judy Margolis, MD, Adjunct
Research Interests
Alexander Matveevskii, MD, PhD, Associate Professor
Research Interests
John McAuliffe, MD, MBA, Associate Professor
Director, Research; Interim Director, Division of Neurobiology
Research Interests
Mark Meyer, MD, Assistant Professor
Director, Procedure Management, Division of Pain Management
Research Interests
David Moore, MD, Associate Professor
Clinical Coordinator, Anesthesia Fellow Pain Management Education, Division of Pain Management
Research Interests
Jacquelyn Morillo-Delerme, MD, Associate Professor
Director of Anesthesia, Liberty Campus, Division of Anesthesia
Research Interests
Mario Patino, MD, Assistant Professor
Research Interests
Jayant "Nick" Pratap, MD, Assistant Professor
Research Interests
Joseph Previte, MD, FAAP, Associate Professor
Director, Information Technology Services, Division of Anesthesia
Research Interests
David Richards, PhD, Assistant Professor
Research Interests
Senthilkumar Sadhasivam, MD, Associate Professor
Director, Perioperative Pain Management
Research Interests
Nancy Samol, MD, Adjunct
Research Interests
Paul Samuels, MD, Associate Professor
Director, Education, Department of Anesthesia
Research Interests
Ximena Soler, MD, Adjunct
Director, Liver Transplant Surgery Team, Division of Anesthesia
Research Interests
James Spaeth, MD, Associate Professor
Associate Chief, Division of Anesthesia; Director, Cardiac Anesthesia Team, Division of Anesthesia
Research Interests
Theodore Striker, MD, Adjunct
Research Interests
Alexandra Szabova, MD, Adjunct
Research Interests
Jon Tomasson, MD, Assistant Professor
Medical Director, Post Anesthesia Care Unit, Division of Anesthesia
Research Interests
Anna Varughese, MD, MPH, Associate Professor
Associate Chief, Division of Anesthesia; Director, Quality, Division of Anesthesia; Medical Director, Same Day Surgery and Pre-Anesthesia Consultation Clinic, Division of Anesthesia
Research Interests
Christopher Ward, MD, Assistant Professor
Research Interests
Norbert Weidner, MD, Associate Professor
Director, Palliative Care and Comfort Team
Research Interests
Eric Wittkugel, MD, Associate Professor
Research Interests
Junzheng Wu, MD, Assistant Professor
Research Interests

Joint Appointment Faculty Members

Susmita Kashikar-Zuck, PhD, Associate Professor
Behavioral Medicine & Clinical Psychology
Anne Lynch-Jordan, PhD, Assistant Professor
Behavioral Medicine & Clinical Psychology

Clinical Staff Members

  • Jasleen Goel, MD, Sedation Pediatrician
  • Clifford Hoffmann, MD, Staff Anesthesiologist

Trainees

  • Diane Gordon, MD, PGY-IV, University of Utah, SLC
  • Yul Kim, MD, PGY-IV, University of Minnesota
  • Ania Linkiewicz-Gawel, MD, PGY-IV, University of Texas Southwestern
  • David Martin, MD, PGY-IV, Duke University
  • Sharif Mohamed, MD, PGY-IV, Cairo, University, Egypt
  • Pornswan Ngamprasertwong, MD, PGY-IV, Chulalongkorn University
  • Michael Pettei, MD, PGY-IV, Mount Sinai HospitaL
  • Ryan Rowberry, MD, PGY-IV, Mayo in Rochester, NY
  • Caroline Ryan, MD, PGY-IV, Illinois Masonic Medical Center, Chicago
  • Da Wang, MD, PGY-IV, UMDNJ-New Jersey Medical School
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Significant Accomplishments

Exceptional Year for Education  

Our education program had an exceptional year.  Our pediatric anesthesia fellowship program,  led by Paul Samuels, MD, received RRC-ACGME re-accreditation for five years, the maximum time possible.  Kenneth Goldschneider, MD, FAAP,  and Eric Wittkugel , MD, edited a book on pediatric anesthesia with a faculty in the pediatric anesthesia department in Melbourne, Australia; 32 faculty in our department were authors.

Twenty four faculty in our department presented 74 national and international lectures on pediatric anesthesia, pain management, and developmental neurobiology, an all-time high. John McAuliffe III, MD, MBA, initiated a monthly teleconference on intraoperative neurophysiological monitoring with the University of Florida, the first such type of conference in the world.

Chronic Medical Pain Center

We launched a Chronic Medical Pain Center this year to expand a multidisciplinary clinic that had involved more than five divisions. The new center, led by Goldschneider and Alexandra Szabova, MD, also creates a basic science and clinical research program. The new center is better positioned to develop new therapies and offer improved in-patient service to children from throughout the Midwest with complex pain conditions. 

Noteworthy Leadership

C. Dean Kurth, MD,  was elected to the Board of the Society of Pediatric Anesthesia and to chair the Pediatric Anesthesia Leadership Council, the national body for our specialty. Paul Samuels, James Spaeth, MD, and Anna Varughese, MD, MPH, are members of the Pediatric Anesthesia Program Directors, Wake-up Safe Collaborative, and Quality Council, respectively, for the Society of Pediatric Anesthesia.  John McAuliffe was elected to the Board of the American Board Neurophysiological Monitoring, the national body for this specialty.  Meanwhile, Steve Danzer, PhD, and Andreas Loepke, MD, PhD, served on research study sections for the National Institute for Health and Society of Pediatric Anesthesia.

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Division Publications

  1. Boat A, Mahmoud M, Michelfelder EC, Lin E, Ngamprasertwong P, Schnell B, Kurth CD, Crombleholme TM, Sadhasivam S. Supplementing desflurane with intravenous anesthesia reduces fetal cardiac dysfunction during open fetal surgery. Paediatr Anaesth. 2010; 20:748-56.
  2. Goldschneider K, Lucky AW, Mellerio JE, Palisson F, del Carmen Vinuela Miranda M, Azizkhan RG. Perioperative care of patients with epidermolysis bullosa: proceedings of the 5th international symposium on epidermolysis bullosa, Santiago Chile, December 4-6, 2008. Paediatr Anaesth. 2010; 20:797-804.
  3. Goldschneider KR, Lucky AW. Pain management in epidermolysis bullosa. Dermatol Clin. 2010; 28:273-82, ix.
  4. Hoffmann CO, Samuels PJ, Beckman E, Hein EA, Shackleford TM, Overbey E, Berlin RE, Wang Y, Nick TG, Gunter JB. Insufflation vs intubation during esophagogastroduodenoscopy in children. Paediatr Anaesth. 2010; 20:821-30.
  5. Istaphanous GK, Howard J, Nan X, Hughes EA, McCann JC, McAuliffe JJ, Danzer SC, Loepke AW. Comparison of the neuroapoptotic properties of equipotent anesthetic concentrations of desflurane, isoflurane, or sevoflurane in neonatal mice. Anesthesiology. 2011; 114:578-87.
  6. Istaphanous GK, Ward CG, Loepke AW. The impact of the perioperative period on neurocognitive development, with a focus on pharmacological concerns. Best Pract Res Clin Anaesthesiol. 2010; 24:433-49.
  7. Lynch-Jordan AM, Kashikar-Zuck S, Goldschneider KR. Parent perceptions of adolescent pain expression: the adolescent pain behavior questionnaire. Pain. 2010; 151:834-42.
  8. Mahmoud M, McAuliffe J, Kim HY, Mishra P, Salisbury S, Schnell B, Hirsch P, Arbabi S, Donnelly LF. Oral contrast for abdominal computed tomography in children: the effects on gastric fluid volume. Anesth Analg. 2010; 111:1252-8.
  9. McAuliffe JJ, Bronson SL, Hester MS, Murphy BL, Dahlquist-Topala R, Richards DA, Danzer SC. Altered patterning of dentate granule cell mossy fiber inputs onto CA3 pyramidal cells in limbic epilepsy. Hippocampus. 2011; 21:93-107.
  10. McDole JR, Danzer SC, Pun RY, Chen Y, Johnson HL, Pirko I, Johnson AJ. Rapid formation of extended processes and engagement of Theiler's virus-infected neurons by CNS-infiltrating CD8 T cells. Am J Pathol. 2010; 177:1823-33.
  11. Murphy BL, Danzer SC. Somatic translocation: a novel mechanism of granule cell dendritic dysmorphogenesis and dispersion. J Neurosci. 2011; 31:2959-64.
  12. Murphy BL, Pun RY, Yin H, Faulkner CR, Loepke AW, Danzer SC. Heterogeneous integration of adult-generated granule cells into the epileptic brain. J Neurosci. 2011; 31:105-17.
  13. Newton PO, Harms Study Group. Anesthesia in Scoliosis Surgery. Idiopathic scoliosis : the Harms Study Group treatment guide. New York: Thieme; 2010.
  14. Spaeth JP, Loepke AW. Anesthesia for Left-Sided Obstructive Lesions. Anesthesia for congenital heart disease. Chichester, West Sussex ; Hoboken, NJ: Wiley-Blackwell; 2010.
  15. Szabova A, Sadhasivam S, Wang Y, Nick TG, Goldschneider K. Comparison of postoperative analgesia with epidural butorphanol/bupivacaine versus fentanyl/bupivacaine following pediatric urological procedures. J Opioid Manag. 2010; 6:401-7.
  16. Tokuda S, Mahaffey CL, Monks B, Faulkner CR, Birnbaum MJ, Danzer SC, Frankel WN. A novel Akt3 mutation associated with enhanced kinase activity and seizure susceptibility in mice. Hum Mol Genet. 2011; 20:988-99.
  17. Varughese AM, Hagerman NS, Kurth CD. Quality in pediatric anesthesia. Paediatr Anaesth. 2010; 20:684-96.
  18. Wise-Faberowski L, Loepke A. Anesthesia during surgical repair for congenital heart disease and the developing brain: neurotoxic or neuroprotective?. Paediatr Anaesth. 2011; 21:554-9.
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Grants, Contracts, and Industry Agreements

Grant and Contract AwardsAnnual Direct / Project Period Direct

Danzer, S

Contributions of Aberrant Granule Cells Integration to the Development of Epilepsy
R01 NS 06280608/05/09-07/31/14$216,563
Selective Disruption of Hippocampal Dentate Granule Cells in Autism: Impact of PT
R01 NS 06502005/01/09-04/30/14$225,000

Ngamprasertwong, P

Effects of Maternal Anesthesia on Fetal Outcomes
07/01/10-06/30/11$75,000

Richards, D

Regulation and Mechanisms of Synaptic Vesicle Exocytosis
R01 NS 05475011/09/08-06/30/12$216,563

Samuels, P

Pediatric Airway Skills
07/01/10-06/30/11$32,609
Current Year Direct$765,735
Industry Contracts

Kurth, D

$39,960
Current Year Direct Receipts$39,960
Total$805,695
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