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2011 Research Annual Report

Cardiology

 

Division Data Summary

Research and Training Details

Number of Faculty34
Number of Joint Appointment Faculty2
Number of Research Fellows4
Number of Research Students1
Number of Support Personnel117
Direct Annual Grant Support$786,124
Direct Annual Industry Support$42,585
Peer Reviewed Publications109

Clinical Activities and Training

Number of Clinical Staff2
Number of Clinical Fellows12
Inpatient Encounters1,310
Outpatient Encounters13,860

Significant Publications

Division Highlights

Robert B. Hinton Jr., MD

Part of the Heart Institute’s mission is to facilitate meaningful translational research.  Robert B. Hinton, MD is studying the mechanisms of human valve disease.  Recent findings in human diseased aortic valves show that maladaptive angiogenic remodeling is an early finding in valve disease pathogenesis, which is surprising since this has long thought to be an end stage disease process associated with atherosclerosis. Further investigation in animal models of aortic valve disease has demonstrated that angiogenic remodeling is due in part to elastic fiber fragmentation.  This work provides further evidence that valve disease has its origins in dysregulation of developmental programs and provides an opportunity to test new treatment strategies.  It is not known if these early pathologic changes are identifiable by circulating biomarkers before the onset of overt clinical disease.  Preclinical studies are underway to test the ability of biomarkers to predict disease progression and the efficacy of angiogenesis inhibition to treat aortic valve disease.  Presently, there are no medical treatments for valve disease.  This work seeks to elucidate developmental mechanisms of valve disease and identify new therapeutic targets to treat heart valve disease and improve child health.

Elaine M. Urbina, MD

This year Preventative Cardiology successfully competed for an R01 grant from the National Heart Lung and Blood Institute of the National Institute of Health titled “Accelerated CV Aging in Youth Related to CV Risk Factors.”  Our previous data showed that youth with obesity were developing stiffer arteries and thicker hearts, risk factors for adult CV disease, well before they went on to develop type 2 diabetes.  This new grant will allow us to continue to follow these patients.  Not only will we determine the rate of ‘normal’ arterial aging in healthy, lean youth, we will also find out which clusters of CV risk factors such as obesity, type 2 diabetes, high blood pressure or cholesterol are more damaging to the arteries and heart.  These data will then be used to design more effective preventive and treatment strategies for high risk youth to prevent adult heart attack and stroke.

Preventative Cardiology is currently completing data collection on an ARRA (American Recovery & Reinvestment Act) stimulus grant.  Our preliminary data were presented at the national meeting of the American Diabetes Association in June 2011.  Our data demonstrated that youth with type 1 diabetes have thicker carotid arteries, stiffer central and peripheral arteries and have abnormal autonomic tone as measured by heart rate variability.  These findings will help us identify which youth with diabetes are developing early hardening of the arteries so more aggressive therapy can be started. 

CCHMC Preventive Cardiology also continues to demonstrate leadership in the field of Pediatric Vascular Function by providing the only training seminar in Non-invasive Assessment of Vascular Function in Children available in the United States.  We conduct the 2-day seminar 3 times yearly and have trained Pediatric researchers around the country with one international participant receiving training this year.  We are also the data coordinating center for many multi-center grants performing vascular assessment. 

Division Collaboration

Anderson Center » Uma Kotagal, MD
Quality dashboard and  Disease-specific dashboard
Anderson Center » Steve Muething, MD
Safety dashboard
Anesthesiology » Pornswan Ngamprasetwong, MD; Senthilkumar Sadhasivam, MD
An ovine model of maternal-fetal anesthesia and comparison of fetal cardiac function between two anesthetic regimens
Anesthesiology & Palliative/Hospice Care » Norbert Weidner, MD; Mark Meyer
Heart Failure Colloquium Milestone
Bariatric Surgery » Tom Inge, MD, PhD
Assisting in analyses of carotid thickness data collected in patients undergoing bariatric surgery
Biostatistics and Epidemiology » Jessica Woo, PhD
Role of DNA Methylation in Phenotype Variability
CBDI » Rajaram Nagarrajan, MD
Late Survivor Clinic and Cardiomyopathy/Heart Failure Clinic
CBDI » Cristina Tarango, MD
Coagulation Service and VAD Program
CBDI-Hematology » Charles Quinn, MD
Quinn PFAST Study: Aim- Multicenter controlled study to compare the prevalence of PFO or other potential intracardiac shunts detectible by TTE in sickle cell anemia Funded: Division
Clinical and Translation Research » Michael Spigarilli, MD
Propranolol Study: Aim- Drug Propranolol effect on facial hemangiomas Funded: industry
Critical Care »
Critical Care Fellow Training, CICU
Endocrinology » Larry Dolan, MD
Working on ARRA grant comparing vascular function between healthy controls and youth with type 1 diabetes
Endocrinology » Amy Shah, MD
Working on a study comparing HDL-cholesterol proteomics and carotid intima-media thickness
Endocrinology » Sarah Lawson, MD
Working on study evaluating arterial stiffness in youth with Turner Syndrome
Endocrinology » Meilan Rutter, MD; James Collins, MD, PhD; Hemant Sawnani, MD; Brenda Wong, MBBS, MRCP; Jessica Woo, MHSA, Phd
Growth Hormone in Duchenne Muscular Dystrophy Patients, affects on cardiac function using cardiac MRI
Endocrinology » Philippe Backeljaw, MD
Assess partial Anomalous Pulmonary Venous Return (PAPVR) in Adolescent and Young Adult Turner Syndrome (TS) Patients: Prevalence and Hemodynamic Significance as Determined by Cardiac Magnetic Resonance Imaging (CMR)
Endocrinology & Radiology » Philippe Backeljaw, MD; Robert Fleck, MD
Cardiovascular Anomalies in Turner Syndrome (TS): Spectru, Prevalence, and Cardiac MR Imaging (cMRI), Findings in Pediatric and Young Adult Populations
Endocrinology » Philippe Backeljaw, MD
Characterization and treatment of aortopathy in Turner syndrome
Endocrinology » Lawrence Dolan, MD
NIH Training Grant
Endocrinology » Nancy Crimmins, MD
Center for Better Health and Nutrition
Fetal Care » Timothy Crombleholme, MD; Foong-Yen Lim, MD; Mounira Habli, MD
Fetal Care: Cardiovascular Findings associated with Twin-twin Transfusion, Cardiac Finding in fetal cardiac tumors and TRAP, Cerebrovascular Findings in TRAP
Endocrinology » Larry Dolan, MD; Sarah Lawson, PhD
Young "Turner" Syndrome: Aim- Vasculopathy in Turner Syndrome Funded: Industry
Gastroenterology, Hepatology & Nutrition » Jaime Echartea-Gonzalez, MD
Liver Study: Aim- Hemodynamic profile and biochemical markers of Cardiomyopathy in children with chronic and end stage liver disease Funded: CTRC
Gastroenterology, Hepatology & Nutrition » Jaime Echartea Gonzalez, MD; James Heubi, MD
Characterization of cardiac disease in patients requiring liver transplantation
Hem & Cancer Bio. - Molecular Genetics » Punam Malik, MD
Sickle Cell Study: Aim- Evaluation Cardiovascular indices of subjects with Sickle Cell syndrome Funded: Insurance
Hem & Cancer Bio. - Molecular Genetics » Punam Malik, MD
Zileuton Study: Aim- Determine a safe and tolerable does of Zileuton in patients with SCD Funded:Division
Human Genetics » Lisa Martin, PhD
Quantitative Genetic Origins of Pediatric Heart Disease
Human Genetics » Robert Hopkin, MD
Amicus/Fabry study:  Aim-  A Double-Blind, randomized, placebo-controlled study to evaluate the efficacy, safety and pharmacodynamics of AT1001 in patients with Fabry disease and AT1001-responsive GLA mutations. Funded: Industry
Human Genetics » Thomas A. Burrow, MD
Encore Study: Aim- A phase 3, Randomized, Multi-Center, Multinational, Open –Label, Active Comparator study to evaluate the efficacy and safety in Genz-112638 in patients with Gaucher Disease Type 1 who have reached therapeutic goals with enzyme replacement therapy. Genzyme corporation-Funded: Industry
Human Genetics » Robert Hopkin, MD
Cardiocore Field Study: Aim-  Open label study to evaluate the efficacy (GL-3 clearance), PK and safety parameters for 2 alternative dose regimens of Fabrazyme in treatment-naïve make pediatric patients with Fabry disease without severe symptoms. Funded: Industry Genzyme Corporation sponsor
Human Genetics » Robert Hopkin, MD
Characterization of cardiac disease in Fabry's disease
Human Genetics » Raouf Samy Amin, MD
Amin VF Study: Aim- Mechanism Mediating Cardiac and Vascular Disease in children with obstructive sleep Apnea. 1) to compare inflammatory cardiovascular disease mechanisms d children with varying degrees of sleep disordered breathing SDB to those in normal controls; 2) to determine how cytokine levels in plasma relate to those in tonsils; 3) to examine the relationship between inflammatory markers and prognostically important cardiovascular measures such as carotid intimal thickness, carotid compliance, pulse pressure, aortic stiffness and left ventricular mass and function before and after adenotonsillectomy. Funded: Division
Infectious Disease » Margaret Hostetter, MD
Heart Transplantation
Interventional Cardiology Research Center University of Cincinnati » James Wilkin, MD
Helmy/AKA Capsaicin Study
Nephrology » Mark Mitsnefes, MD
The use of cardiac MR to describe the subtle cardiac abnormalities in chronic dialysis and renal transplant patients
Nephrology/Center for Acute Care Nephrology » Prasad Devarajan, MD; Stuart Goldstein, MD
Research in Acute Kidney Injury after Cardiopulmonary Bypass Related acute Kidney Injury
Nephrology/Center for Acute Care Nephrology » Stuart Goldstein, MD
(CACN) and CICU
Nephrology/Center for Acute Care Nephrology » Prasad Devarajan, MD; Stuart Goldstein, MD
Assessment of AKI and CRI in pediatric heart failure
Nephrology/Center for Acute Care Nephrology » Prasad Devarajan, MD
Faculty recruitment and new Program building (CACN)
Nephrology/Center for Acute Care Nephrology » Prasad Devarajan, MD
NIH Grant - Pediatric Heart Network
Nephrology/Center for Acute Care Nephrology » Stuart Goldstein, MD; Ahmad Kaddourah, MD
Submission of CCF grant regarding Cardiorenal syndrome in pediatric heart failure
Nephrology » Stuart Goldstein, MD
Consultant for his study on the vascular effects of peritoneal vs hemodialysis in children with chronic kidney disease
Nephrology » Mark Mitsnefes, MD
Working on a grant currently under review at NIH. This multi-center trail will follow youth with pre-hypertension longitudinally to evaluate risk for development of sustained hypertension and target organ damage.
Nephrology » Mark Mitnefes, MD; Benjamin Laskin, MD
Frequent Hemodialysis Study: Aim- Improve cardiovascular outcome with more frequent hemodialysis, improve BP and LVH Funded: Federal/Non profit sponsor CTRC
Nephrology » Mark Mitsnefes, MD; Janaka Wansapura, PhD
Study aimed at determining the markers of cardiac function in patients with renal disease on chronic dialysis or post renal transplant.
Neurology » Brenda Wong, MD
Neuromuscular Cardiology
Neurology » Donald Gilbert, MD
Neurodevelopmental Clinic
Pediatric Cardiothoracic Surgery; Behavioral Medicine and Clinical Psychology; Child Life; Developmental & Behavioral Pediatrics; Gastroenterology, Hepatology and Nutrition; Cancer & Blood Diseases Institute; Neurology; Nutrition Therapy; Occupational and Physical Therapy; Social Services; Speech Pathology » Betsy Adler, RN, CNP; Lori Stark, PhD, ABPP; Jessica Kichler, PhD; Dean Beebe, PhD, ABPP-Cn; David Baker; Miranda Shearer; Donna Murray, PhD, CCC-SLP; Ajay Kaul, MBBS, MD; Mary Kay Irwin; Patti Towbin; Joan Kiefer; Mark Schapiro, MD; Cameron Thomas, MD; Donald Gilbert, MD, MD; Megan Horsley, RD; Becky Reder, OTD, OTR/L; Lisa Dodd; Ann Kummer, PhD, CCC-SLP

The Heart Institute Neurodevelopmental Clinic (NDC)

Rationale:

Over the last several decades, new surgical techniques and advances in cardiopulmonary bypass, intensive care, cardiac catheterization, non-invasive imaging, and medical therapies have significantly lowered mortality rates for children and adolescents with complex congenital heart disease (CHD) and high-risk acquired heart disease (AHD) (i.e. heart failure and heart transplant patients). However, survivors are at risk for neurodevelopmental (ND) morbidity resulting from their underlying genotype, the circulatory system abnormalities specific to their heart defect, and the medical and surgical therapies they have received. The focus of clinical research in the pediatric cardiac population has paralleled this population shift and transitioned from short-term surgical survival to the assessment of long-term morbidity. Among pediatric patients with complex CHD and high-risk AHD, there is a distinctive pattern of ND and behavioral dysfunction characterized by mild cognitive impairment, impaired social interaction, and impairments in core communication skills including pragmatic language as well as inattention, impulsive behavior, and impaired executive function. In addition, these patients often have fine and gross motor skills and issues with anxiety and depression. Many school-age survivors of infant cardiac surgery require remedial services including tutoring, special education, and physical, occupational, and speech therapy. The sequelae of complex CHD and high-risk AHD and their treatment are likely to limit their ultimate educational achievements, employability, life-long earnings, insurability, and health-related quality of life (HRQOL). A significant proportion of these patients may need specialized services into adulthood. Incorporation of this knowledge into clinical practice may significantly improve ND and behavioral outcomes of patients with CHD.

Goals:

  • To identify a group of children with heart disease who are at high risk for neurodevelopmental abnormalities and have them follow-up in the HI Neurodevelopmental Follow-up clinic for surveillance, screening, evaluation, and management of their neurodevelopmental and behavioral problems
  • To prevent poor neurodevelopmental and behavioral outcomes in patients with complex heart disease and acquired heart disease when possible and treat those children and adolescents with deficits with interventions utilizing proven methodologies supported by research to maximize the Health-Related Quality of Life of the patient and minimize the potential impact on the family unit
  • To be able to answer clinically important hypothesis-driven research questions that will Increase funding opportunities to prevent and treat ND and behavioral disability
  • To educate the larger community of general pediatricians and family practitioners about the issues that these children and families face from an educational and social perspective and the potential ramifications on the family unit
  • To provide a resource that parents/guardians of children with neurodevelopmental and behavioral issues can partner with to assist with obtaining resources and services
    • Pediatric Surgery » Thomas Inge, MD
    Gastric Bypass/Bariatric: Aim- Evaluate the Cardiac indices of pre and post gastric bypass surgery Funded: Insurance
    Pediatric Surgery » Barb Tofani, RN
    Cardiac OR staffing and policies
    Perinatal Institute » James Greenberg, MD
    Neonatal Cardiology and  Perinatal Cardiology
    Pulmonology » Raouf Amin, MD
    Assisting in analyses of arterial stiffness data collected in a study of youth with obstructive sleep apnea
    Radiology/Imaging Research Center » Chuck Dumoulin, PhD
    We are developing a new dedicated infant cardiac MR imaging coil. The coil will be used in the newly dedicated neonatal MR system housed in the NICU. This system will allow novel cardiac MR imaging of critically ill neonates.
    Radiology » Chuck Dumoulin, PhD
    MRI Research on Electrophysiology
    Radiology » Janaka Wansapura, PhD
    Muscular dystrophy research
    Radiology » Robert Fleck, Jr., MD
    Cardiac MRI
    Rheumatology » John Harley, MD, PhD
    EMerge grant
    Sports Medicine » Nicholas Edwards
    Assisting in data analyses exploring the relationship between physical activity and CV risk factors in youth

    Faculty Members

    Jeffrey A. Towbin, MD, FAAP, FACC, FAHA, Professor
    Executive Co-Director, The Heart Institute
    Director and Chief, Division of Cardiology
    Research Interests Cardiomyopathy and Genetics
    Jeffrey B. Anderson, MD, MPH, Assistant Professor
    Research Interests Syncope, nutritional failure in congenital heart disease, quality improvement
    Robert Beekman, MD, Professor
    Research Interests Cardiac Catheterization & Intervention, Quality Improvement, Coarctation of the Aorta
    D. Woodrow Benson, MD, PhD, Professor
    Director, Cardiovascular Genetics
    Research Interests Cardiovascular Genetics
    James F. Cnota, MD, Associate Professor
    Research Interests Fetal Cardiology
    Linda H. Cripe, MD, Associate Professor
    Research Interests Cardiomyopathies, Neuromuscular Disorders, Echocardiography
    Richard Czosek, MD, Assistant Professor
    Research Interests Cardiac pacing devices in pediatric and congenital heart disease patients and arrhythmia risk stratification in the pediatric population
    Allison Divanovic, MD, Assistant Professor
    Research Interests Fetal Echocardiography
    Paula Goldenberg, MD, MSCE, MSW, FAAP, FACMG, Associate Professor
    Research Interests Cardiovascular Genetics
    Michelle Grenier, MD, Associate Professor
    Director, 3 Dimensional Echocardiography
    Research Interests Cardiomyopathy, Heart Failure, 3 Dimensional Echocardiography
    Haleh Heydarian, MD, Assistant Professor
    Research Interests Echocardiography Synchrony/Strain Imaging and Quality Improvement
    Robert B. Hinton, MD, Assistant Professor
    Research Interests Cardiovascular Genetics & Developmental Biology
    Russel Hirsch, MD, Associate Professor
    Director, Cardiac Catheterization and Intervention
    Research Interests Cardiac Catheterization & Intervention, Device Development
    Kan Hor, MD, Assistant Professor
    Research Interests MRI technology to diagnose and follow heart disease, in particular DMD cardiomyopathy.
    Holly M. Ippisch, MD, MS, FAAP, Assistant Professor
    Research Interests Echocardiography, preventive cardiology, exercise and pediatric obesity.
    John Lynn Jefferies, MD, MPH, FACC, FAAP, Associate Professor
    Director, Cardiomyopathy/Heart Failure & Transplantation
    Co-Director, CV Genetics
    Associate Director, HIRC
    Research Interests Cardiomyopathy, Heart Failure, Cardiovascular Genetics and drug trials
    Beth Ann Johnson, MD, MA, Assistant Professor
    Research Interests Premature infants with congenital heart defects, Fetal diagnosis
    Thomas R. Kimball, MD, Professor
    Medical Director, Heart Institute
    Director, Cardiac Echocardiography & Cardiovascular Core Imaging
    Research Interests Echocardiography, Ventricular function, Cardiovascular Effects of Obesity and Type II Diabetes.
    Shelley Kirk, PhD, RD, LD, Assistant Professor
    Research Interests The efficacy, safety and feasibility of interventions for the management of pediatric obesity.
    Timothy Knilans, MD, Professor
    Director, Clinical Cardiac Electrophysiology and Pacing
    Director, Pediatric Cardiac Electrophysiology Fellowship
    Research Interests Identification and risk stratification of causes of sudden death.
    Catherine Krawczeski, MD, Associate Professor
    Director, Heart Institute Quality Improvement and Clinical Effectiveness
    Co-Director, Center for Acute Care Nephrology
    Research Interests Bypass associated acute kidney injury (biomarkers, epidemiology, early therapy
    Cong Liu, PhD, Assistant Professor
    Associate Director of HIDL
    Research Interests Genetic etiology of cardiomyopathy, congenital heart disease and cardiovascular diseases. New technology development in clinical genetic testing and clinical viral testing.
    Angela Lorts, MD, Assistant Professor
    Research Interests Heart failure and myocardial remodeling
    Bradley S. Marino, MD, MPP, MSCE, Associate Professor
    Director, Heart Institute Research Core
    Research Interests Outcomes Research
    Erik Michelfelder, MD, Associate Professor
    Director, Fetal Cardiology
    Research Interests Fetal Cardiology and Echocardiography
    David Nelson, MD, PhD, Professor
    Medical Director, CICU
    Research Interests Inflammatory injury after cardiac surgery
    Enkhsaikhan Purevjav, MD, PhD, Assistant Professor
    Research Interests Genetics of Cardiovascular Disease
    Robert Siegel, MD, Professor
    Medical Director, The Center for Better Health and Nutrition
    Research Interests
    Robert Spicer, MD, Professor
    Director Fellowship Program
    Research Interests Heart Failure Transplant
    Arnold Strauss, MD, Professor
    BK Rachford Professor and Chair, Department of Pediatrics, University of Cincinnati College of Medicine
    Director, Cincinnati Children's Research Foundation
    Chief Medical Officer, Cincinnati Children's Hospital Medical Center
    Research Interests
    Michael Taylor, MD, PhD, Assistant Professor
    Director of Advanced Imaging Innovation and Cardiac MRI (CMR)
    Research Interests Non-invasive study of cardiovascular physiology and metabolism; Pre-clinical imaging of cardiomyopathy models with cardiac MR and positron emission tomography.
    Elaine Urbina, MD, MS, Associate Professor
    Director, Preventive Cardiology
    Research Interests Non-invasive assessment of vascular structure and function and relationship to CV risk factors, obesity, diabetes, renal disease and sleep disorders. Treatment of high blood pressure and cholesterol.
    Karen Uzark, PhD, CPNP, Associate Professor
    Director of Process Improvement and Outcomes Research
    Research Interests Heart Transplant, Quality of Life, Outcomes in Children with Heart Disease
    Gary Webb, MD, FRCP(C), FACC, FAHA, Professor
    Director, Adolescent and Adult Congenital Heart Disease Program
    Research Interests Adolescent and Adult Congenital Heart Disease

    Joint Appointment Faculty Members

    Jeanne James, MD, Associate Professor
    Molecular Cardiovascular Biology
    Research Interests Molecular cardiology and animal models of cardiac disease.
    Stephanie Ware, MD, Associate Professor
    Molecular Cardiovascular Biology
    Research Interests Cardiovascular Genetics

    Clinical Staff Members

    • Lisa Lee, MD
    • Chad Connor, MD

    Trainees

    • Christopher Cheng, MD, PhD, PL4, New York Methodist
    • David Crowley, MD, PL7, Barbara Bush Children's Hospital, Portland, ME
    • Sam Hanke, MD, PL5, Cincinnati Children's Hospital/University of Cincinnati
    • Chike Madueme, MD, PL6, Cincinnati Children's Hospital/University of Cincinnati
    • Mark Norris, MD, PL7, Cincinnati Children's Hosptial/University of Cincinnati
    • Thomas Ryan, MD,PhD, PL5, Cincinnati Children's Hospital/University of Cincinnati
    • Chistopher Statile, MD, PL5, Cincinnati Children's Hospital/University of Cincinnati
    • Tamara Thomas, MD, PL4, Vanderbilt University, Nashville, Tennessee
    • Chet Villa, MD, PL4, Cincinnati Children's Hospital/University of Cincinnati
    • Mark Walsh, ME, PL10, Hospital for Sick Children, Toronto, Canada
    • Dingding Xiong, MD, PhD, PL5, Driscoll Children's Hospital, Corpus Christi, TX
    • Matt Zussman, MD, PL6, UNC, Chapel Hill, North Carolina
    • Anne-Cecile Huby, PhD, UPMC (Pierre and Marie Curie University, Paris, France
    • Sarkies Ruben Mattheus, Martherus, PhD, Maastricht University, Maastricht, The Netherlands
    • Kathryn M. Rafferty, PhD, Cincinnati Children's Hospital/University of Cincinnati
    • Ken Takagi, MD, Baylor College of Medicine, Houston, TX
    • Varun Krishnamurthy, BS, PL5, University of Cincinnati, Cincinnati , Ohio
    Return to Top

    Division Publications

    1. Acehan D, Vaz F, Houtkooper RH, James J, Moore V, Tokunaga C, Kulik W, Wansapura J, Toth MJ, Strauss A, Khuchua Z. Cardiac and skeletal muscle defects in a mouse model of human Barth syndrome. The Journal of biological chemistry. 2011; 286:899-908.
    2. Anderson JB, Beekman RH, 3rd, Eghtesady P, Kalkwarf HJ, Uzark K, Kehl JE, Marino BS. Predictors of poor weight gain in infants with a single ventricle. The Journal of pediatrics. 2010; 157:407-13, 413 e1.
    3. Anderson JB, Benson DW. Genetics of sick sinus syndrome. Cardiac electrophysiology clinics. 2010; 2:499-507.
    4. Anderson JB, Kalkwarf HJ, Kehl JE, Eghtesady P, Marino BS. Low weight-for-age z-score and infection risk after the Fontan procedure. The Annals of thoracic surgery. 2011; 91:1460-6.
    5. Atz AM, Travison TG, Williams IA, Pearson GD, Laussen PC, Mahle WT, Cook AL, Kirsh JA, Sklansky M, Khaikin S, Goldberg C, Frommelt M, Krawczeski C, Puchalski MD, Jacobs JP, Baffa JM, Rychik J, Ohye RG. Prenatal diagnosis and risk factors for preoperative death in neonates with single right ventricle and systemic outflow obstruction: screening data from the Pediatric Heart Network Single Ventricle Reconstruction Trial( *). The Journal of thoracic and cardiovascular surgery. 2010; 140:1245-50.
    6. Baker-Smith CM, Neish SR, Klitzner TS, Beekman RH, 3rd, Kugler JD, Martin GR, Lannon C, Jenkins KJ, Rosenthal GL. Variation in postoperative care following stage I palliation for single-ventricle patients: a report from the Joint Council on Congenital Heart Disease National Quality Improvement Collaborative. Congenital heart disease. 2011; 6:116-27.
    7. Banchs J, Jefferies JL, Plana JC, Hundley WG. Imaging for cardiotoxicity in cancer patients. Texas Heart Institute journal / from the Texas Heart Institute of St. Luke's Episcopal Hospital, Texas Children's Hospital. 2011; 38:268-9.
    8. Baumgartner H, Bonhoeffer P, De Groot NM, de Haan F, Deanfield JE, Galie N, Gatzoulis MA, Gohlke-Baerwolf C, Kaemmerer H, Kilner P, Meijboom F, Mulder BJ, Oechslin E, Oliver JM, Serraf A, Szatmari A, Thaulow E, Vouhe PR, Walma E, Vahanian A, Auricchio A, Bax J, Ceconi C, Dean V, Filippatos G, Funck-Brentano C, Hobbs R, Kearney P, McDonagh T, Popescu BA, Reiner Z, Sechtem U, Sirnes PA, Tendera M, Vardas P, Widimsky P, Swan L, Andreotti F, Beghetti M, Borggrefe M, Bozio A, Brecker S, Budts W, Hess J, Hirsch R, Jondeau G, Kokkonen J, Kozelj M, Kucukoglu S, Laan M, Lionis C, Metreveli I, Moons P, Pieper PG, Pilossoff V, Popelova J, Price S, Roos-Hesselink J, Uva MS, Tornos P, Trindade PT, Ukkonen H, Walker H, Webb GD, Westby J. ESC Guidelines for the management of grown-up congenital heart disease (new version 2010). European heart journal. 2010; 31:2915-57.
    9. Beery TA, Smith CR, Kudel I, Knilans T. Measuring sports participation decisional conflict in youth with cardiac pacemakers and/or ICDs. Journal of advanced nursing. 2011; 67:821-8.
    10. Belmont JW, Craigen W, Martinez H, Jefferies JL. Genetic disorders with both hearing loss and cardiovascular abnormalities. Advances in oto-rhino-laryngology. 2011; 70:66-74.
    11. Bergersen L, Gauvreau K, Marshall A, Kreutzer J, Beekman R, Hirsch R, Foerster S, Balzer D, Vincent J, Hellenbrand W, Holzer R, Cheatham J, Moore J, Lock J, Jenkins K. Procedure-type risk categories for pediatric and congenital cardiac catheterization. Circulation. Cardiovascular interventions. 2011; 4:188-94.
    12. Boat A, Mahmoud M, Michelfelder EC, Lin E, Ngamprasertwong P, Schnell B, Kurth CD, Crombleholme TM, Sadhasivam S. Supplementing desflurane with intravenous anesthesia reduces fetal cardiac dysfunction during open fetal surgery. Paediatric anaesthesia. 2010; 20:748-56.
    13. Breinholt JP, Moulik M, Dreyer WJ, Denfield SW, Kim JJ, Jefferies JL, Rossano JW, Gates CM, Clunie SK, Bowles KR, Kearney DL, Bowles NE, Towbin JA. Viral epidemiologic shift in inflammatory heart disease: the increasing involvement of parvovirus B19 in the myocardium of pediatric cardiac transplant patients. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 2010; 29:739-46.
    14. Broberg CS, Aboulhosn J, Mongeon FP, Kay J, Valente AM, Khairy P, Earing MG, Opotowsky AR, Lui G, Gersony DR, Cook S, Ting JG, Webb G, Gurvitz MZ. Prevalence of left ventricular systolic dysfunction in adults with repaired tetralogy of fallot. The American journal of cardiology. 2011; 107:1215-20.
    15. Brown DW, Connor JA, Pigula FA, Usmani K, Klitzner TS, Beekman RH, 3rd, Kugler JD, Martin GR, Neish SR, Rosenthal GL, Lannon C, Jenkins KJ. Variation in preoperative and intraoperative care for first-stage palliation of single-ventricle heart disease: a report from the Joint Council on Congenital Heart Disease National Quality Improvement Collaborative. Congenital heart disease. 2011; 6:108-15.
    16. Brunetti-Pierri N, Pignatelli R, Fouladi N, Towbin JA, Belmont JW, Craigen WJ, Wong LJ, Jefferies JL, Scaglia F. Dilation of the aortic root in mitochondrial disease patients. Molecular genetics and metabolism. 2011; 103:167-70.
    17. Buber J, Mathew J, Moss AJ, Hall WJ, Barsheshet A, McNitt S, Robinson JL, Zareba W, Ackerman MJ, Kaufman ES, Luria D, Eldar M, Towbin JA, Vincent M, Goldenberg I. Risk of Recurrent Cardiac Events After Onset of Menopause in Women With Congenital Long-QT Syndrome Types 1 and 2. Circulation. 2011; 123:2784-91.
    18. Calloway TJ, Martin LJ, Zhang X, Tandon A, Benson DW, Hinton RB. Risk factors for aortic valve disease in bicuspid aortic valve: a family-based study. American journal of medical genetics. Part A. 2011; 155A:1015-20.
    19. Carlo WF, Nelson DP. Inhaled nitric oxide improves oxygen saturation in children with pulmonary arteriovenous malformations after the Fontan procedure. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. 2011; 12:e152-4.
    20. Chakraborty S, Wirrig EE, Hinton RB, Merrill WH, Spicer DB, Yutzey KE. Twist1 promotes heart valve cell proliferation and extracellular matrix gene expression during development in vivo and is expressed in human diseased aortic valves. Developmental biology. 2010; 347:167-79.
    21. Chio SS, Urbina EM, Lapointe J, Tsai J, Berenson GS. Korotkoff sound versus oscillometric cuff sphygmomanometers: comparison between auscultatory and DynaPulse blood pressure measurements. Journal of the American Society of Hypertension : JASH. 2011; 5:12-20.
    22. Costanzo MR, Dipchand A, Starling R, Anderson A, Chan M, Desai S, Fedson S, Fisher P, Gonzales-Stawinski G, Martinelli L, McGiffin D, Smith J, Taylor D, Meiser B, Webber S, Baran D, Carboni M, Dengler T, Feldman D, Frigerio M, Kfoury A, Kim D, Kobashigawa J, Shullo M, Stehlik J, Teuteberg J, Uber P, Zuckermann A, Hunt S, Burch M, Bhat G, Canter C, Chinnock R, Crespo-Leiro M, Delgado R, Dobbels F, Grady K, Kao W, Lamour J, Parry G, Patel J, Pini D, Towbin J, Wolfel G, Delgado D, Eisen H, Goldberg L, Hosenpud J, Johnson M, Keogh A, Lewis C, O'Connell J, Rogers J, Ross H, Russell S, Vanhaecke J. The International Society of Heart and Lung Transplantation Guidelines for the care of heart transplant recipients. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 2010; 29:914-56.
    23. Crombleholme TM, Lim FY, Habli M, Polzin W, Jaekle R, Michelfelder E, Cnota J, Liu C, Kim MO. Improved recipient survival with maternal nifedipine in twin-twin transfusion syndrome complicated by TTTS cardiomyopathy undergoing selective fetoscopic laser photocoagulation. American journal of obstetrics and gynecology. 2010; 203:397 e1-9.
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    Grants, Contracts, and Industry Agreements

    Grant and Contract AwardsAnnual Direct / Project Period Direct

    Anderson, J

    Nutritional Deficiencies in Infants with Single Ventricle
    10/01/10-09/30/12$12,500

    Benson, W

    Musculoskeletal Ancillary Study
    07/01/10-06/30/11$3,750
    Quality of Life Study-Pediatric Heart Network
    U01 HL 06827007/01/10-06/30/11$500
    Trial of Beta Blocker vs Angiotensin Receptor Blocker
    U01 HL 06827007/01/10-06/30/11$72,010

    Ippisch, H

    Effects of Dietary Fat and Exercise Challenges in Obese Children
    K23 HL 09117409/01/08-07/31/13$126,085

    Kimball, T

    Chronic Kidney Disease in Children
    U01 DK 06614308/01/08-07/31/13$55,222

    Marino, B

    Understanding Mechanisms of Fontan Failure and Key Predictors for Patient Outcome
    R01 HL 09825202/01/10-01/31/14$18,488

    Siegel, R

    Collaborative Community Based Initiative to Improve the Health of Overweight and Obese Children
    01/01/11-12/31/11$76,223

    Urbina, E

    Accelerated CV Aging in Youth Related to CV Risk Factor Clusters
    R01 HL 10559101/01/11-12/31/15$383,528
    Modifying Dietary Behavior in Adolescents with Elevated Blood Pressure
    R01HL08856702/01/08-01/31/12$37,818
    Current Year Direct$786,124
    Industry Contracts

    Beekman

    $4,177

    Hirsch

    $12,199

    Krawczeski

    $26,209
    Current Year Direct Receipts$42,585
    Total$828,709
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