2011 Research Annual Report

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Critical Care Medicine

 

Division Data Summary

Research and Training Details

Number of Faculty13
Number of Joint Appointment Faculty2
Number of Support Personnel20
Direct Annual Grant Support$1,039,599
Direct Annual Industry Support$42,541
Peer Reviewed Publications23

Clinical Activities and Training

Number of Clinical Staff10
Number of Clinical Fellows12
Inpatient Encounters8369

Division Photo

Critical Care Medicine Division.

Row 1: K Page, J Kaplan, E Stalets

Row 2: R Chima, L Doughty, B Varisco

Row 3: D Wheeler, H Wong, K Tegtmeyer, R Basu

Significant Publications

Faculty Members

Hector Wong, MD, Professor
Director
Research Interests Septic shock, Genomics, Biomarkers
Ranjit Chima, MD, Assistant Professor
Research Interests Lung Injury/Inflammation, Hemorrhagic Shock
Lesley Doughty, MD, Associate Professor
Fellowship Director
Research Interests Sepsis
Jennifer Kaplan, MD, MS, Assistant Professor
Research Interests Sepsis and obesity
Kristen Page, PhD, Associate Professor
Research Interests Asthma, airway inflammation, inflammatory mediators, innate and adaptive immune response
Sue E. Poynter, MD, Assistant Professor
Medical Director Division of Respiratory Care
Associate Director Pediatric Residency Training Program
Research Interests Acute lung injury, resident education
Erika Stalets, MD, Instructor
Research Interests Quality Improvement and Patient Safety
Ken Tegtmeyer, MD, Associate Professor
Research Interests Multimedia Medical Education
Rajit Basu, MD, Instructor
Research Interests The role of kidney injury in distal organ function
Derek S. Wheeler, MD, Associate Professor
Clinical Director PICU
Research Interests Sepsis,Stress preconditioning, Quality Improvement
Basilia Zingarelli, MD, Ph.D., Associate Professor
Research Interests Sepsis, hemorrhage and ischemia and reperfusion injury

Joint Appointment Faculty Members

Bradley Marino, MD, Associate Professor
Cardiology
Research Interests Long-term outcomes in children and adolescents with CHD, Resuscitation of children with CHD

Trainees

  • Gabriela Botez, MD, PL4, Universitatea deMedicine "GR.T.Popa"
  • Ma-Bernardita Gamallo, MD, PL4, Jersey Shore University Medical Center
  • Rodney Daniels, MD, PL6, Eastern Virginia Medical School
  • Michael Hobson, MD, PL5, Indiana University School of Medicine
  • Riad Lutfi, MD, PL6, University of Damascus
  • Carrie Morgan, MD, PL5, University of Kentucky College of Medicine
  • Carley Riley, MD, PL5, Children's Hospital of Los Angeles
  • Ravi Ramraj, MD, PL4, Driscoll Children's Hospital
  • Stephen Standage, MD, PL6, The Children's Hospital of Philadelphia
  • Shilpa Shah, MD, PL4, The University of Texas Medical Branch
  • Siahei Slinko, MD, PL5, University of Buffalo
  • John Whitt, MD, PL4, University of Alabama School of Medicine at Birmingham
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Significant Accomplishments

Studying pediatric septic shock

Jennifer Kaplan, MD, MS, received an Investigational New Drug approval from the Food and Drug Administration to conduct a Phase-1 trial of PPAR-gamma agonism in pediatric septic shock.  This study reflects a natural progression of basic science research efforts in the division. The concept of PPAR-gamma agonism as therapeutic strategy in sepsis was demonstrated in pre-clinical studies led by Basilia Zingarelli, PhD. Kaplan’s Phase-1 study is the first direct translation of our basic science research to the bedside of critically ill children.

New director for basic research 

Zingarelli, a nationally recognized researcher who has been with our Division since it formed in 1994, has been appointed director of basic research to provide expanded oversight for our growing research portfolio. She also has been named president - elect of the Shock Society, an international organization dedicated to improving the care of victims of trauma, shock, and sepsis. 

Mechanisms of chronic lung disease 

Brian Varisco, MD, who was recruited to Cincinnati Children’s to serve as a physician-scientist in pediatric critical care medicine, has secured K-level funding to continue his studies of the mechanisms of chronic lung disease.  He achieved this milestone under the mentorship of Jeffrey Whitsett, MD, director of the Division of Pulmonary Biology and Chief of the Section of Neonatology, Perinatal and Pulmonary Biology.

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Division Publications

  1. Aneja RK, Sjodin H, Gefter JV, Zingarelli B, Delude RL. Small interfering RNA mediated Poly (ADP-ribose) Polymerase-1 inhibition upregulates the heat shock response in a murine fibroblast cell line. J Inflamm (Lond). 2011; 8:3.
  2. Basu RK, Devarajan P, Wong H, Wheeler DS. An update and review of acute kidney injury in pediatrics. Pediatr Crit Care Med. 2011; 12:339-47.
  3. Basu RK, Hubchak S, Hayashida T, Runyan CE, Schumacker PT, Schnaper HW. Interdependence of HIF-1alpha and TGF-beta/Smad3 signaling in normoxic and hypoxic renal epithelial cell collagen expression. Am J Physiol Renal Physiol. 2011; 300:F898-905.
  4. Basu RK, Wheeler D. Effects of ischemic acute kidney injury on lung water balance: nephrogenic pulmonary edema?. Pulm Med. 2011; 2011:414253.
  5. Basu RK, Wheeler DS, Goldstein S, Doughty L. Acute renal replacement therapy in pediatrics. Int J Nephrol. 2011; 2011:785392.
  6. Chima RS, LaMontagne T, Piraino G, Hake PW, Denenberg A, Zingarelli B. C-peptide, a novel inhibitor of lung inflammation following hemorrhagic shock. Am J Physiol Lung Cell Mol Physiol. 2011; 300:L730-9.
  7. Chima RS, Maltese G, Lamontagne T, Piraino G, Denenberg A, O'Connor M, Zingarelli B. C-peptide ameliorates kidney injury following hemorrhagic shock. Shock. 2011; 35:524-9.
  8. Fan H, Bitto A, Zingarelli B, Luttrell LM, Borg K, Halushka PV, Cook JA. Beta-arrestin 2 negatively regulates sepsis-induced inflammation. Immunology. 2010; 130:344-51.
  9. Fan H, Li P, Zingarelli B, Borg K, Halushka PV, Birnbaumer L, Cook JA. Heterotrimeric Galpha(i) proteins are regulated by lipopolysaccharide and are anti-inflammatory in endotoxemia and polymicrobial sepsis. Biochim Biophys Acta. 2011; 1813:466-72.
  10. Istaphanous GK, Wheeler DS, Lisco SJ, Shander A. Red blood cell transfusion in critically ill children: A narrative review. Pediatr Crit Care Med. 2011; 12:174-183.
  11. Kaplan JM, Hake PW, Denenberg A, Nowell M, Piraino G, Zingarelli B. Phosphorylation of extracellular signal-regulated kinase (ERK)-1/2 Is associated with the downregulation of peroxisome proliferator-activated receptor (PPAR)-gamma during polymicrobial sepsis. Mol Med. 2010; 16:491-7.
  12. Le TM, Willis AS, Barr FE, Cunningham GR, Canter JA, Owens SE, Apple RK, Ayodo G, Reich D, Summar ML. An ethnic-specific polymorphism in the catalytic subunit of glutamate-cysteine ligase impairs the production of glutathione intermediates in vitro. Mol Genet Metab. 2010; 101:55-61.
  13. Mack EH, Wheeler DS, Hirsch R. Endovascular treatment of near-fatal neonatal superior vena cava syndrome. Pediatr Crit Care Med. 2010; .
  14. Mahabeleshwar GH, Kawanami D, Sharma N, Takami Y, Zhou G, Shi H, Nayak L, Jeyaraj D, Grealy R, White M, McManus R, Ryan T, Leahy P, Lin Z, Haldar SM, Atkins GB, Wong HR, Lingrel JB, Jain MK. The Myeloid Transcription Factor KLF2 Regulates the Host Response to Polymicrobial Infection and Endotoxic Shock. Immunity. 2011; 34:715-28.
  15. Ortega RA, Andreoli MT, Chima RS. Is there a place for music in medical school?. Med Teach. 2011; 33:76-7.
  16. Smith HA, Boyd J, Fuchs DC, Melvin K, Berry P, Shintani A, Eden SK, Terrell MK, Boswell T, Wolfram K, Sopfe J, Barr FE, Pandharipande PP, Ely EW. Diagnosing delirium in critically ill children: Validity and reliability of the Pediatric Confusion Assessment Method for the Intensive Care Unit. Crit Care Med. 2011; 39:150-7.
  17. Solan PD, Piraino G, Hake PW, Denenberg A, O'Connor M, Lentsch A, Zingarelli B. Liver X receptor alpha activation with the synthetic ligand T0901317 reduces lung injury and inflammation after hemorrhage and resuscitation via inhibition of the nuclear factor kappaB pathway. Shock. 2011; 35:367-74.
  18. Standage SW, Wong HR. Biomarkers for pediatric sepsis and septic shock. Expert Rev Anti Infect Ther. 2011; 9:71-9.
  19. Varisco BM. The pharmacology of acute lung injury in sepsis. Adv Pharmacol Sci. 2011; 2011:254619.
  20. Varisco BM, Palmatier CM, Alten JA. Reversal of intractable hypoxemia with exogenous surfactant (calfactant) facilitating complete neurological recovery in a pediatric drowning victim. Pediatr Emerg Care. 2010; 26:571-3.
  21. Wheeler DS, Giuliano JS, Jr., Lahni PM, Denenberg A, Wong HR, Zingarelli B. The immunomodulatory effects of albumin in vitro and in vivo. Adv Pharmacol Sci. 2011; 2011:691928.
  22. Wong HR, Wheeler DS, Tegtmeyer K, Poynter SE, Kaplan JM, Chima RS, Stalets E, Basu RK, Doughty LA. Toward a clinically feasible gene expression-based subclassification strategy for septic shock: proof of concept. Crit Care Med. 2010; 38:1955-61.
  23. Zingarelli B, Piraino G, Hake PW, O'Connor M, Denenberg A, Fan H, Cook JA. Peroxisome proliferator-activated receptor {delta} regulates inflammation via NF-{kappa}B signaling in polymicrobial sepsis. Am J Pathol. 2010; 177:1834-47.
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Grants, Contracts, and Industry Agreements

Grant and Contract AwardsAnnual Direct / Project Period Direct

Wheeler, D

Therapeutic Hypothermia after Pediatric Cardiac Arrest
U01 HL 09434509/01/09-02/28/11$21,334
Therapeutic Hypothermia after Pediatric Cardiac Arrest (per patient)
U01 HL 09434507/01/10-06/30/11$2,579

Wong, H

Pediatric Sepsis Biomarker Risk Model
RC1 HL 10047409/30/09-08/30/11$333,062
MMP-8 as a Novel Therapeutic Target in Sepsis
R01 GM 09699404/01/11-03/31/15$190,000

Zingarelli, B

PPARgamma and PPARgamma Agonists in Septic Shock
R01 GM 06720207/01/08-06/30/12$244,609
Role of Eicosanoids in Shock
R01 GM 02767307/03/08-06/30/13$49,124
Mechanisms of Age-Related Inflammatory Response in Hemorrhagic Shock
R01 AG 02799009/01/07-08/31/12$198,891
Current Year Direct$1,039,599
Industry Contracts

Barr, F

$25,322
$17,219
Current Year Direct Receipts$42,541
Total$1,082,140
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