Division Data Summary

Research and Training Details

Number of Faculty24
Number of Joint Appointment Faculty10
Number of Research Fellows52
Number of Research Students32
Number of Support Personnel42
Direct Annual Grant Support$7,568,608
Direct Annual Industry Support$62,761
Peer Reviewed Publications100

Clinical Activities and Training

Number of Clinical Fellows3
Number of Other Students22

Division Photo

Developmental Biology Division.

Row 1: R Jiang, S Brugmann, SK Dey

Row 2: T Cook, G Guasch, J Wells, R Waclaw, Y Yoshida

Row 3: M Nakafuku, B Gebelein, J Ma, C Wylie

Row 4: D Wiginton, J Lessard, S Potter, V Kalinichenko


Significant Publications

Katayama K, Melendez J, Baumann JM, Leslie JR, Chauhan BK, Nemkul N, Lang RA, Kuan CY, Zheng Y, Yoshida Y. Loss of RhoA in neural progenitor cells causes the disruption of adherens junctions and hyperproliferation. Proc Natl Acad Sci U S A. [Research Support, Non-U.S. Gov't]. 108(18):7607-12. May 3, 2011.
Pei Z, Wang B, Chen G, Nagao M, Nakafuku M, Campbell K. Homeobox genes Gsx1 and Gsx2 differentially regulate telencephalic progenitor maturation. Proc Natl Acad Sci U S A. [Research Support, N.I.H., Extramural]. 108(4):1675-80. Jan 25, 2011.
Spence JR, Mayhew CN, Rankin SA, Kuhar MF, Vallance JE, Tolle K, Hoskins EE, Kalinichenko VV, Wells SI, Zorn AM, Shroyer NF, Wells JM. Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro. Nature. [Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't]. 470(7332):105-9. Feb 3, 2011.
Lin SC, Wani MA, Whitsett JA, Wells JM. Klf5 regulates lineage formation in the pre-implantation mouse embryo. Development. [Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't]. 137(23):3953-63. Dec 2010.
Runck LA, Kramer M, Ciraolo G, Lewis AG, Guasch G. Identification of epithelial label-retaining cells at the transition between the anal canal and the rectum in mice. Cell Cycle. [Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.]. 9(15):3039-45. Aug 1, 2010.

Division Highlights

Developmental Biology and Plastic Surgery

The divisions of Plastic Surgery and Developmental Biology have established a new interdivisional Center for Craniofacial Development. Drs. Rulang Jiang (Professor) and Samantha Brugmann (Assistant Professor) have been recruited from the University of Rochester Medical Center and Stanford University, respectively, to establish this research group.

Developmental Biology and Urology

The divisions of Pediatric Urology and Developmental Biology have jointly recruited Dr. Joo-Seop Park, from Harvard University. Dr. Park will work on the development of the urinary tract.

Christopher Wylie

Chris Wylie was awarded the Waddington Medal by the British Society for Developmental Biology. The medal is awarded for “outstanding research performance as well as services to the research community”.

Midwest Society for Developmental Biology Meeting

The Midwest regional meeting of the Society for Developmental Biology was hosted by CCHMC in May 2010. The local committee; Vladimir Kalinichenko (Neonatology/Pulmonary Biology), Vaughn Cleghon (Developmental Biology), Debora Sinner (Neonatology/Pulmonary Biology), and Nadean Brown (Chair, Developmental Biology), did an outstanding job. The meeting was a great success, and attracted the largest audience ever for this regional meeting.

Trainee accomplishments

Trainees in the division gained some significant awards this year. Jason Spence (postdoctoral fellow, Wells lab) gained an NIH career transition award. Ying Gu (graduate student, Wylie/Heasman lab) gained a Ryan Fellowship, the most prestigious University award for graduate students. Jennifer Tucker (postdoctoral fellow, Chuang lab) gained an American Cancer Society Postdoctoral Fellowship. Kate Maurer (graduate student, Brown lab) gained a Young Investigator Student Fellowship Award for Female Scholars in Vision Research, from Prevent Blindness Ohio. Xiaofei Sun (postdoctoral fellow, Dey lab) was awarded a Lalor Foundation Postdoctoral Fellowship. Alejandro Lopez Juarez (postdoctoral fellow, Nakafuku lab) gained a postdoctoral fellowship from the National Science and Technology Board of Mexico. Andrea Pardo (neurology resident trainee, Nakafuku lab) gained an Outstanding Junior Member Award from the Child Neurology Society. We are very proud of our trainees, whose awards indicate the increasing strength in depth of the developmental biology matrix.

Geraldine Guasch

Geraldine Guasch, a young faculty member in the division, gained a prestigious Sydney Kimmel Scholar’s award, one of only fifteen awarded in the USA for her work in cancer research. Geraldine is the first Kimmel awardee at CCHMC. Geraldine also gained a Basil O’Connor Starter Scholar Award from the March of Dimes.

Samantha Brugmann

Samantha Brugmann, a new faculty member Plastic Surgery/Developmental Biology, gained an NIH Pathway to Independence (PI) award (K99/R00).

Tiffany Cook

Tiffany Cook (Ophthalmology/Developmental Biology) gained an Outstanding Achievement Award from the Schmidlapp Women Scholars Program at CCHMC.

Division Collaboration

Pediatric Ophthalmology » Tiffany Cook
Conserved and divergent mechanisms of lens development with Nadean Brown
Molecular Cardiovascular Biology » Katherine Yutzey
Notch mutations that cause congenital eye, heart and liver defects with Nadean Brown
Experimental Hematology » Ronald Waclaw
Molecular mechanisms of amygdalar development with Kenneth Campbell
Colorectal Center » Alberto Pena; Marc Levitt
Defining the nature of the epithelium of persistent cloacas in human with Geraldine Guasch
Pathology and Laboratory Medicine » Keith Stringer
Defining the nature of the epithelium of persistent cloacas in human. Characterizing the role of stem cells in a mouse model of transitional epithelia tumor with Geraldine Guasch
Urology » Shumyle Alam
Defining the nature of the epithelium of persistent cloacas in human with Geraldine Guasch
Anesthesiology » Steve Danzer
Roles of postnatal neural stem cells and epilepsy with Alex Kuan
Experimental Hematology » Yi Zheng
Roles of small GTPases in mammalian brain development with Alex Kuan
Neurology » Mark Schapiro
Roles of S1P receptor signaling in perinatal brain injury with Alex Kuan
Pulmonary Biology » John Shannon and James Bridges
Roles of HIF1 signaling in oligodendrocytes and perinatal white-matter injury with Alex Kuan
Radiology » Diana Lindquist
Diffusion tensor imaging and white-matter protection in stroke with Alex Kuan
Pediatric Bioinformatics » Bruce Aronow
Gene expression and function in the developing mouse lower urinary tract with James Lessard
Pulmonary Biology » John Shannon
Smooth muscle formation in the developing mouse lung with James Lessard
Pulmonary Biology » Jeffrey Whitsett
Role of Klf5 in bladder urothelial development and repair with James Lessard
Experimental Hematology » Nancy Ratner
Molecular mechanism for myelin formation in the postnatal brain with Masato Nakafuku
Experimental Hematology » Ronald Waclaw
Molecular mechanism underlying white matter injury in premature brains with Masato Nakafuku
Biomedical Informatics » Bruce Aronow
GUDMAP and FACEBASE projects with Steve Potter
Nephrology » Prasad Devarajan
Role of Hox genes in uterine biology with Steve Potter
Biomedical Informatics; Plastic Surgery » Bruce Aronow; Christopher Gordon
Micro RNA role in craniofacial development with Saulius Sumanas
Hematology/Oncology » Denise Adams
Investigating genetic mechanisms of vascular disorders in children with Saulius Sumanas
Oncology » Timothy Cripe
Inhibiting tumor growth in a zebrafish model with Saulius Sumanas
Endocrinology » Stuart Handwerger
Wnt pathway function in placental development with James Wells
Gastroenterology » Noah Shroyer
Function of human intestinal tissue from Pluripotent Stem Cells with James Wells
Hematology/Oncology » Susanne Wells
Reprogramming pathways mediated by HPV oncogenes with James Wells
Infectious Diseases » Jason Jiang
Norovirus growth in human intestinal tissue from Pluripotent Stem Cells with James Wells
Ophthalmology » Richard Lang
Role of macrophage-derived Wnt ligands in beta cell regeneration with James Wells
Pediatric Surgery » Michael Helmrath
Function of human intestinal tissue from Pluripotent Stem Cells in vivo with James Wells
Pulmonary Biology » Jeffrey Whitsett
Directed differentiation of Pluripotent Stem Cells into respiratory lineages with James Wells
Orthopedics » Roger Cornwall
Intercellular signaling pathways active during and after growth and differentiation of lumbar vertebral growth plate with Christopher Wylie
Experimental Hematology » Nancy Ratner
EM analysis of sensory-motor connections with Yutaka Yoshida
Experimental Hematology » Yi Zheng
Roles of Rho GTPases in nervous system with Yutaka Yoshida
Pediatric Ophthalmology » Richard Lang
Roles of wntless in sensory-motor connections with Yutaka Yoshida
Gastroenterology » Noah Shroyer
Digestive system development with Aaron Zorn
Pulmonary Biology » Jeffrey Whitsett
Lung development and repair with Aaron Zorn

Faculty Members

Christopher C. Wylie, PhD, Professor
Director; Associate Chair for Basic Science
Research Interests Early Vertebrate Development, Xenopus, Mammal
Nadean Brown, PhD, Associate Professor
Research Interests Eye Development, Mouse And Drosophila
Kenneth Campbell, PhD, Professor
Director, Molecular and Developmental Biology Graduate Program; Associate Director
Research Interests CNS Patterning, Mammal
Chieh Chang, PhD, Assistant Professor
Research Interests Nervous System, C. Elegans
Chiou-Fen Chuang, PhD, Assistant Professor
Research Interests Nervous System, C. Elegans, Laterality
Vaughn Cleghon, PhD, Associate Professor
Research Interests Kinase Function In Development, Signaling
Brian Gebelein, PhD, Assistant Professor
Research Interests Transcriptional Regulation, Drosophila, Body Patterning, Nervous System
Geraldine Guasch, PhD, Assistant Professor
Research Interests Stem Cells in Epithelial Tissues and Their Role in Tumorigenesis, Transitional Epithelium and Anorectal Malformations
Janet Heasman, PhD, Professor
Research Interests Early Vertebrate Development, Xenopus
Rashmi S. Hegde, PhD, Professor
Research Interests Protein Structure/Function
J. Matthew Kofron, PhD, Assistant Professor
Research Interests Imaging Manager, Ectodermal Organ Development In Vertebrates, Xenopus
Chia-Yi Kuan, MD, PhD, Associate Professor
Research Interests Nervous System Patterning, Stroke, Cell Death, Mammal
James L. Lessard, PhD, Professor
Research Interests Muscle Development, Mammal
Hung-Chi Liang, PhD, Instructor
Research Interests Affymetrix Core Manager
Xinhua Lin, PhD, Professor
Research Interests Cell Signaling, Drosophila
Christopher Mayhew, PhD, Assistant Professor
Co-Director, Stem Cell Core
Research Interests Human ES Biology and Differentiation
Masato Nakafuku, MD, PhD, Professor
Research Interests Nervous System Patterning And Stem Cells, Mammal
S. Steven Potter, PhD, Professor
Director, Affymetrix Core
Research Interests Transcription Regulation And Kidney Development, Mammal
Jason Spence, PhD, Assistant Professor
Research Interests Vertebrate Gut Development, Stem Cells
Saulius Sumanas, PhD, Assistant Professor
Research Interests Vascular Development, Zebrafish
James M. Wells, PhD, Associate Professor
Co-Director, Stem Cell Core
Research Interests Vertebrate Gut Development, Stem Cells, Mammal
Dan A. Wiginton, PhD, Associate Professor
Research Interests Gut Differentiation, Mammal
Yutaka Yoshida, PhD, Assistant Professor
Research Interests Nervous System, Cell Migration, Mammal, Chicken
Aaron Zorn, PhD, Associate Professor
Research Interests Vertebrate Gut Development, Xenopus, Mammal

Joint Appointment Faculty Members

Bruce Aronow, PhD, Professor
Pediatric Bioinformatics
Research Interests Bioinformatics
Samantha Brugmann, PhD, Assistant Professor
Plastic Surgery
Research Interests Molecular Basis for Craniofacial Development and Disease
Tiffany Cook, PhD, Assistant Professor
Pediatric Ophthalmology
Research Interests Eye Development, Drosophila
Sudhansu Dey, PhD, Professor
Director, Reproductive Sciences
Research Interests Reproductive Biology
Prasad Devarajan, MD, Professor
Director, Nephrology and Hypertension
Research Interests Urinary Tract Differentiation, Mammal
Vladimir Kalinichenko, MD PhD, Associate Professor
Pulmonary Biology and Neonatology
Research Interests Transcriptional Regulation of Lung Embryonic Development
Richard A. Lang, PhD, Professor
Director, Transgenic Core Facility, Pediatric Opthalmology
Research Interests Visual System Development, Mammal
Jun Ma, PhD, Professor
Pediatric Bioinformatics
Research Interests Transcriptional Regulation, Drosophila
Noah F. Shroyer, PhD, Assistant Professor
Gastroenterology, Hepatology, and Nutrition
Research Interests Vertebrate Gut Development, Mammal
Jeffrey A. Whitsett, MD, Professor
Chief, Section of Neonatology, Perinatal, and Pulmonary Biology
Research Interests Respiratory System, Mammal

Trainees

  • Chitra Dahia*, PhD, Facult, Indian Institute of Science
  • Larry Patterson, MD, Facult, College of Medicine of Pennsylvania State University, Assoc. Prof., Nephrology (end 6/30/11)
  • Pramod Reddy, MBBS, Facult, Guntur Medical College and Siddhartha, Assoc. Prof., Urology
  • Kei-Ichi Katayama, PhD, DVM, Vis Re, University of Tokyo
  • Tatyana Belenkaya, PhD, Res. A, Russian Academy of Science
  • Eric Brunskill, PhD, Res. A, University of Maryland
  • Sang-Wook Cha, PhD, Res. A, Kyungpook National University, Korea
  • Bharesh Chauhan*, PhD, Res. A, Oxford University, United Kingdom
  • Lisa Ehrman, PhD, Res. A, University of Cincinnati (end 2/25/11)
  • Christina James-Zorn, PhD, Res. A, University of Queenland, Australia
  • Guoqing Lin, PhD, Res. A, University of Luebeck, Germany (end 2/25/11)
  • Junbo Lui*, PhD, Res. A, Fudan University
  • Adrian McNairn, PhD, Res. A, SUNY Upstate Medical University (end 6/3/11)
  • Motoshi Nagao, PhD, Res. A, Tokyo Institute of Technology (end 9/9/10)
  • Virgilio Ponferrada, PhD, Res. A, Wright State University
  • Sujata Rao*, PhD, Res. A, Cornell University
  • Emmanuel Tadjuidje, PhD, Res. A, University of Göttingen, Germany
  • Huirong Xie*, PhD, Res. A, Vanderbilt University
  • Dianer Yang, PhD, Res. A, Chinese Academy of Sciences
  • Sivan Bezalel*, PhD, Res. F, University Medical School, Isreal
  • Kevin Burns, PhD, Res. F, University of Cincinnati
  • Yuqi Cai, PhD, Res. F, Zhejiang University School of Medicine, Taiwan
  • Zheng Chen, PhD, Res. F, University of Groningen, Germany
  • Jun-Huei Fan, PhD, Res. F, University of Texas, Dallas (end 1/14/11)
  • Amy Gresser, PhD, Res. F, Harvard University
  • Jing-Fen Han, PhD, Res. F, University of Medicine and Dentistry of New Jersey (end 1/14/11)
  • Yi-Wen Hsieh, PhD, Res. F, University of California, Los Angeles
  • Fumiyasu Imai, PhD, Res. F, Yokohama City University of Medicine, Japan
  • Maximiliano Jimenez-Dalmaroni, PhD, Res. F, University of Oxford, UK
  • Avedis Kazanjian*, PhD, Res. F, University of Louisville
  • Vikram Kohli, PhD, Res. F, University of Alberta, Canada
  • Suh-Chin Lin, PhD, Res. F, University of Texas Health Sciences, San Antonio (end 12/30/10)
  • Chia-Feng Liu, PhD, Res. F, University of Chicago at Urbana
  • Alejandro Lopez Juarez, PhD, Res. F, University of Mexico
  • Mayur Madhavan, PhD, Res. F, Miami University
  • Sumathra Manokaran, PhD, Res. F, North Dakota State University
  • Paloma Merchan Sala, PhD, Res. F, University of Murcia, Spain
  • Myung-Soon Moon, PhD, Res. F, University of Wisconsin-Madison
  • Sumeda Nandadasa, PhD, Res. F, University of Cincinnati
  • Athanasia Nikolaou, PhD, Res. F, University of Melbourne, Australia
  • Taeko Noah*, PhD, Res. F, University of Nevada
  • Timothy Plageman*, PhD, Res. F, University of Cincinnati
  • Anna Raines, PhD, Res. F, University of Wisconsin
  • Latasha Redmond, PhD, Res. F, Virginia Commonwealth University
  • Emily Shifley, PhD, Res. F, Ohio State University
  • Jason Spence, PhD, Res. F, Miami University, Ohio (end 3/31/11)
  • Xiaofei Sun*, PhD, Res. F, Vanderbilt University
  • Yu-Yo Sun, PhD, Res. F, Taipei Medial University, Taiwan
  • Kaori Takeshima, PhD, Res. F, Miyazaki University, Japan (end 5/11/11)
  • Jun Tang, PhD, Res. F, Third Military Medical University, China
  • Jennifer Tucker, PhD, Res. F, University of Pennsylvania
  • Ronald Waclaw, PhD, Res. F, University of Cincinnati (end 8/31/11)
  • Baotang Xie*, PhD, Res. F, Chinese Academy of Sciences
  • Ying Ye, PhD, Res. F, University of Pennsylvania (end 1/16/11)
  • Eun-Jin Yeo*, PhD, Res. F, Seoul National University, South Korea
  • Yan Zou, PhD, Res. F, Chinese Academy of Sciences
  • Jonathan Howell, MD PhD, Clin. , Indiana University
  • Alan Kenny, MD PhD, Clin. , University of Rochester, School of Medicine and Dentistry
  • Andrea Pardo, MD, Clin. , Johns Hopkins University
  • Sarah Ehrman, , Med. S, University of Cincinnati
  • Douglas Brown*, , Grad., University of Cincinnati - College of Medicine
  • Hui Chiu, , Grad., National Taiwan University, Taiwan (end 3/11/11)
  • Xiaolan Fan, , Grad., Wenzhou Medical College, China (11/30/10)
  • Jonathan Fletcher, , Grad., University of Cincinnati
  • Qinzhu Huang, , Grad., Wenzhou Medical College, China (end 1/14/11)
  • Robert Hufnagel, , Grad. , University of Cincinnati - PSTP and Neuroscience (end 7/13/10)
  • Hyon Kim, , Grad., University of Cincinnati
  • Rohit Rao, , Grad., University of Cincinnati Medical School
  • Brittany Bayne, , Underg, University of Cincinnati
  • Kalyn Campbell, , Underg, Xavier University
  • Matthew Carter, , Underg, Miami University, Oxford, OH
  • Felicia Ciamacco, , Underg, University of Cincinnati (end 8/27/10)
  • Karmela Dalisay, , Underg, University of Notre Dame
  • Yanne Doucet, , Underg, University of Mediterranee, France
  • Elizabeth Eichhold, , Underg, Xavier University (end 4/15/11)
  • Abigail Evans, , Underg, Ohio State University
  • Alyssa Gallas, , Underg, Xavier University (end 4/29/11)
  • M. Victoria Gomez, , Underg, Xavier University
  • Matthew Grazyk, , Underg, Xavier University
  • Amaleah Hartman, , Underg, University of Cincinnati
  • Lauren Head, , Underg, Xavier University (end 7/30/10)
  • Rachel Helping, , Underg, University of Cincinnati
  • Tiffany Hoang, , Underg, California State University - Fullerton (PSTP Summer Student)
  • Sarah Kastner, , Underg, Cincinnati State (end 6/17/11)
  • Ryan Lauf, , Underg, Xavier University
  • Marianna Luga, , Underg, University of Cincinnati
  • Doug Meyer, , Underg, College of Mount St. Joseph
  • Ashley Riesenberg, , Underg, University of Cincinnati (end 8/27/10)
  • Alex Roth, , Underg, Miami University, Oxford, OH
  • Blair Wissel, , Underg, Xavier University
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Significant Accomplishments

Growing intestinal tissue

A recent paper in Nature documented the first example of organogenesis into intestinal tissue from human pluripotent stem cell cultures. The team of principal investigators, including Chris Mayhew, PhD, and Aaron Zorn, PhD (Developmental biology), Vladimir Kalinichenko, MD, PhD (Neonatology/Pulmonary Biology), Susanne Wells, PhD (Hematology/Oncology), and Noah Shroyer, PhD (Gastroenterology), was headed up by James Wells, PhD (Developmental biology). The paper was first-authored by postdoctoral fellow Jason Spence, PhD.

Studying neuron development

A team including including Richard Lang, PhD (Ophthalmology), Alex Kuan, MD, PhD (Developmental Biology), Yi Zheng, PhD (Experimental Hematology), and headed by Yutaka Yoshida, PhD, (Developmental Biology), published a paper in Proceedings of the National Academy of Sciences showing that disruption of the intracellular signal RhoA altered the balance between differentiation and proliferation in the progenitor cells of neurons in the central nervous system. The paper is first-authored by Kei-ichi Katayama, PhD, DVM, a trainee in the Yoshida laboratory.

Understanding abnormal hematopoiesis

In a recent issue of Current Opinion in Hematology, Noah Shroyer, PhD (Gastroenterology), Tiffany Cook, PhD (Ophthalmology), Brian Gebelein, PhD (Developmental Biology), and H. Leighton Grimes, PhD (Immunobiology), discuss the roles of a specific transcription factor (Gfi1) whose actions are conserved in evolution from fruit fly development to human hematopoiesis. In humans, Gfi1 is a component of transcriptional regulatory pathways whose disregulation leads to abnormal hematopoiesis and malignancy. Such pathways represent key targets for clinical intervention. The article is first-authored by James Phelan, a graduate student in the immunology graduate program. 

Neonatal trauma and muscle growth

In a paper in the Journal of Bone and Joint Surgery, Chris Wylie, PhD (Developmental Biology), and Roger Cornwall, MD (Orthopaedic Surgery) identify a failure of normal satellite cell function and muscle growth as the primary defect in the contractures caused by neonatal trauma to the brachial plexus. The paper is first-authored by Sia Nikolaou, PhD, a postdoctoral fellow in Orthopaedic Surgery.

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Division Publications

  1. Balli D, Zhang Y, Snyder J, Kalinichenko VV, Kalin TV. Endothelial cell-specific deletion of transcription factor FoxM1 increases urethane-induced lung carcinogenesis. Cancer research. 2011; 71:40-50.
  2. Basu RK, Devarajan P, Wong H, Wheeler DS. An update and review of acute kidney injury in pediatrics. Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies. 2011; 12:339-47.
  3. Bennett MR, Devarajan P. Proteomic analysis of acute kidney injury: biomarkers to mechanisms. Proteomics. Clinical applications. 2011; 5:67-77.
  4. Blythe SA, Cha SW, Tadjuidje E, Heasman J, Klein PS. beta-Catenin primes organizer gene expression by recruiting a histone H3 arginine 8 methyltransferase, Prmt2. Developmental cell. 2010; 19:220-31.
  5. Borok Z, Whitsett JA, Bitterman PB, Thannickal VJ, Kotton DN, Reynolds SD, Krasnow MA, Bianchi DW, Morrisey EE, Hogan BL, Kurie JM, Walker DC, Radisky DC, Nishimura SL, Violette SM, Noble PW, Shapiro SD, Blaisdell CJ, Chapman HA. Cell Plasticity in Lung Injury and Repair: Report from an NHLBI Workshop, April 19-20, 2010. Proceedings of the American Thoracic Society. 2011; 8:215-22.
  6. Brunskill EW, Lai HL, Jamison DC, Potter SS, Patterson LT. Microarrays and RNA-Seq identify molecular mechanisms driving the end of nephron production. BMC developmental biology. 2011; 11:15.
  7. Brunskill EW, Potter SS. Gene expression programs of mouse endothelial cells in kidney development and disease. PloS one. 2010; 5:e12034.
  8. Carpenter AC, Rao S, Wells JM, Campbell K, Lang RA. Generation of mice with a conditional null allele for Wntless. Genesis. 2010; 48:554-8.
  9. Charlton-Perkins M, Cook TA. Building a fly eye: terminal differentiation events of the retina, corneal lens, and pigmented epithelia. Current topics in developmental biology. 2010; 93:129-73.
  10. Charlton-Perkins M, Whitaker SL, Fei Y, Xie B, Li-Kroeger D, Gebelein B, Cook TA. Prospero and Pax2 combinatorially control neural cell fate decisions by modulating Ras- and Notch-dependent signaling. Neural development. 2011; 6:20.
  11. Chen S, Rong M, Platteau A, Hehre D, Smith H, Ruiz P, Whitsett J, Bancalari E, Wu S. CTGF disrupts alveolarization and induces pulmonary hypertension in neonatal mice: implication in the pathogenesis of severe bronchopulmonary dysplasia. American journal of physiology. Lung cellular and molecular physiology. 2011; 300:L330-40.
  12. Chiu HS, Szucsik JC, Georgas KM, Jones JL, Rumballe BA, Tang D, Grimmond SM, Lewis AG, Aronow BJ, Lessard JL, Little MH. Comparative gene expression analysis of genital tubercle development reveals a putative appendicular Wnt7 network for the epidermal differentiation. Developmental biology. 2010; 344:1071-87.
  13. Comstock CE, Augello MA, Schiewer MJ, Karch J, Burd CJ, Ertel A, Knudsen ES, Jessen WJ, Aronow BJ, Knudsen KE. Cyclin D1 is a selective modifier of androgen-dependent signaling and androgen receptor function. The Journal of biological chemistry. 2011; 286:8117-27.
  14. Cook T, Zelhof A, Mishra M, Nie J. 800 facets of retinal degeneration. Progress in molecular biology and translational science. 2011; 100:331-68.
  15. Dahia CL, Mahoney EJ, Durrani AA, Wylie C. Intercellular signaling pathways active during and after growth and differentiation of the lumbar vertebral growth plate. Spine. 2011; 36:1071-80.
  16. Devarajan P. Biomarkers for the early detection of acute kidney injury. Current opinion in pediatrics. 2011; 23:194-200.
  17. Devarajan P. The use of targeted biomarkers for chronic kidney disease. Advances in chronic kidney disease. 2010; 17:469-79.
  18. Devarajan P, Krawczeski CD, Nguyen MT, Kathman T, Wang Z, Parikh CR. Proteomic identification of early biomarkers of acute kidney injury after cardiac surgery in children. American journal of kidney diseases : the official journal of the National Kidney Foundation. 2010; 56:632-42.
  19. Flick MJ, Chauhan AK, Frederick M, Talmage KE, Kombrinck KW, Miller W, Mullins ES, Palumbo JS, Zheng X, Esmon NL, Esmon CT, Thornton S, Becker A, Pelc LA, Di Cera E, Wagner DD, Degen JL. The development of inflammatory joint disease is attenuated in mice expressing the anticoagulant prothrombin mutant W215A/E217A. Blood. 2011; 117:6326-37.
  20. Fukushima Y, Okada M, Kataoka H, Hirashima M, Yoshida Y, Mann F, Gomi F, Nishida K, Nishikawa S, Uemura A. Sema3E-PlexinD1 signaling selectively suppresses disoriented angiogenesis in ischemic retinopathy in mice. The Journal of clinical investigation. 2011; 121:1974-85.
  21. Galambos C, Levy H, Cannon CL, Vargas SO, Reid LM, Cleveland R, Lindeman R, deMello DE, Wert SE, Whitsett JA, Perez-Atayde AR, Kozakewich H. Pulmonary pathology in thyroid transcription factor-1 deficiency syndrome. American journal of respiratory and critical care medicine. 2010; 182:549-54.
  22. Goldstein SL, Devarajan P. Acute kidney injury in childhood: should we be worried about progression to CKD?. Pediatric nephrology. 2011; 26:509-22.
  23. Gordon EJ, Rao S, Pollard JW, Nutt SL, Lang RA, Harvey NL. Macrophages define dermal lymphatic vessel calibre during development by regulating lymphatic endothelial cell proliferation. Development. 2010; 137:3899-910.
  24. Gower WA, Wert SE, Ginsberg JS, Golan A, Whitsett JA, Nogee LM. Fatal familial lung disease caused by ABCA3 deficiency without identified ABCA3 mutations. The Journal of pediatrics. 2010; 157:62-8.
  25. Gutzwiller LM, Witt LM, Gresser AL, Burns KA, Cook TA, Gebelein B. Proneural and abdominal Hox inputs synergize to promote sensory organ formation in the Drosophila abdomen. Developmental biology. 2010; 348:231-43.
  26. Hamada N, Miyata M, Eto H, Ikeda Y, Shirasawa T, Akasaki Y, Miyauchi T, Furusho Y, Nagaki A, Aronow BJ, Tei C. Loss of clusterin limits atherosclerosis in apolipoprotein E-deficient mice via reduced expression of Egr-1 and TNF-alpha. Journal of atherosclerosis and thrombosis. 2011; 18:209-16.
  27. Hardie WD, Hagood JS, Dave V, Perl AK, Whitsett JA, Korfhagen TR, Glasser S. Signaling pathways in the epithelial origins of pulmonary fibrosis. Cell cycle. 2010; 9:2769-76.
  28. He F, Ren J, Wang W, Ma J. A multiscale investigation of bicoid-dependent transcriptional events in Drosophila embryos. PloS one. 2011; 6:e19122.
  29. He F, Saunders TE, Wen Y, Cheung D, Jiao R, ten Wolde PR, Howard M, Ma J. Shaping a morphogen gradient for positional precision. Biophysical journal. 2010; 99:697-707.
  30. He F, Wen Y, Cheung D, Deng J, Lu LJ, Jiao R, Ma J. Distance measurements via the morphogen gradient of Bicoid in Drosophila embryos. BMC developmental biology. 2010; 10:80.
  31. Hirota Y, Acar N, Tranguch S, Burnum KE, Xie H, Kodama A, Osuga Y, Ustunel I, Friedman DB, Caprioli RM, Daikoku T, Dey SK. Uterine FK506-binding protein 52 (FKBP52)-peroxiredoxin-6 (PRDX6) signaling protects pregnancy from overt oxidative stress. Proceedings of the National Academy of Sciences of the United States of America. 2010; 107:15577-82.
  32. Huang H, Du G, Chen H, Liang X, Li C, Zhu N, Xue L, Ma J, Jiao R. Drosophila Smt3 negatively regulates JNK signaling through sequestering Hipk in the nucleus. Development. 2011; 138:2477-85.
  33. Huang H, Yu Z, Zhang S, Liang X, Chen J, Li C, Ma J, Jiao R. Drosophila CAF-1 regulates HP1-mediated epigenetic silencing and pericentric heterochromatin stability. Journal of cell science. 2010; 123:2853-61.
  34. Hummel TR, Jessen WJ, Miller SJ, Kluwe L, Mautner VF, Wallace MR, Lazaro C, Page GP, Worley PF, Aronow BJ, Schorry EK, Ratner N. Gene expression analysis identifies potential biomarkers of neurofibromatosis type 1 including adrenomedullin. Clinical cancer research : an official journal of the American Association for Cancer Research. 2010; 16:5048-57.
  35. Jeong Y, Dolson DK, Waclaw RR, Matise MP, Sussel L, Campbell K, Kaestner KH, Epstein DJ. Spatial and temporal requirements for sonic hedgehog in the regulation of thalamic interneuron identity. Development. 2011; 138:531-41.
  36. Johnston RJ, Jr., Otake Y, Sood P, Vogt N, Behnia R, Vasiliauskas D, McDonald E, Xie B, Koenig S, Wolf R, Cook TA, Gebelein B, Kussell E, Nakagoshi H, Desplan C. Interlocked feedforward loops control cell-type-specific rhodopsin expression in the Drosophila eye. Cell. 2011; 145:956-68.
  37. Kaimal V, Bardes EE, Tabar SC, Jegga AG, Aronow BJ. ToppCluster: a multiple gene list feature analyzer for comparative enrichment clustering and network-based dissection of biological systems. Nucleic acids research. 2010; 38:W96-102.
  38. Kalin TV, Ustiyan V, Kalinichenko VV. Multiple faces of FoxM1 transcription factor: lessons from transgenic mouse models. Cell cycle. 2011; 10:396-405.
  39. Katayama K, Melendez J, Baumann JM, Leslie JR, Chauhan BK, Nemkul N, Lang RA, Kuan CY, Zheng Y, Yoshida Y. Loss of RhoA in neural progenitor cells causes the disruption of adherens junctions and hyperproliferation. Proceedings of the National Academy of Sciences of the United States of America. 2011; 108:7607-12.
  40. Kazanjian A, Noah T, Brown D, Burkart J, Shroyer NF. Atonal homolog 1 is required for growth and differentiation effects of notch/gamma-secretase inhibitors on normal and cancerous intestinal epithelial cells. Gastroenterology. 2010; 139:918-28, 928 e1-6.
  41. Kehat I, Accornero F, Aronow BJ, Molkentin JD. Modulation of chromatin position and gene expression by HDAC4 interaction with nucleoporins. The Journal of cell biology. 2011; 193:21-9.
  42. Kohli R, Kirby M, Setchell KD, Jha P, Klustaitis K, Woollett LA, Pfluger PT, Balistreri WF, Tso P, Jandacek RJ, Woods SC, Heubi JE, Tschoep MH, D'Alessio DA, Shroyer NF, Seeley RJ. Intestinal adaptation after ileal interposition surgery increases bile acid recycling and protects against obesity-related comorbidities. American journal of physiology. Gastrointestinal and liver physiology. 2010; 299:G652-60.
  43. Krawczeski CD, Vandevoorde RG, Kathman T, Bennett MR, Woo JG, Wang Y, Griffiths RE, Devarajan P. Serum cystatin C is an early predictive biomarker of acute kidney injury after pediatric cardiopulmonary bypass. Clinical journal of the American Society of Nephrology : CJASN. 2010; 5:1552-7.
  44. Krawczeski CD, Woo JG, Wang Y, Bennett MR, Ma Q, Devarajan P. Neutrophil gelatinase-associated lipocalin concentrations predict development of acute kidney injury in neonates and children after cardiopulmonary bypass. The Journal of pediatrics. 2011; 158:1009-1015 e1.
  45. Le Cras TD, Acciani TH, Mushaben EM, Kramer EL, Pastura PA, Hardie WD, Korfhagen TR, Sivaprasad U, Ericksen M, Gibson AM, Holtzman MJ, Whitsett JA, Hershey GK. Epithelial EGF receptor signaling mediates airway hyperreactivity and remodeling in a mouse model of chronic asthma. American journal of physiology. Lung cellular and molecular physiology. 2011; 300:L414-21.
  46. Lee JE, Oh HA, Song H, Jun JH, Roh CR, Xie H, Dey SK, Lim HJ. Autophagy regulates embryonic survival during delayed implantation. Endocrinology. 2011; 152:2067-75.
  47. Lee S, Hong SW, Min BH, Shim YJ, Lee KU, Lee IK, Bendayan M, Aronow BJ, Park IS. Essential role of clusterin in pancreas regeneration. Developmental dynamics : an official publication of the American Association of Anatomists. 2011; 240:605-15.
  48. Li S, Krawczeski CD, Zappitelli M, Devarajan P, Thiessen-Philbrook H, Coca SG, Kim RW, Parikh CR. Incidence, risk factors, and outcomes of acute kidney injury after pediatric cardiac surgery: A prospective multicenter study. Critical care medicine. 2011; 39:1493-1499.
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  52. Liu CF, Aschbacher-Smith L, Barthelery NJ, Dyment N, Butler D, Wylie C. What we should know before using tissue engineering techniques to repair injured tendons: a developmental biology perspective. Tissue engineering. Part B, Reviews. 2011; 17:165-76.
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  54. Maldonado AR, Klanke C, Jegga AG, Aronow BJ, Mahller YY, Cripe TP, Crombleholme TM. Molecular engineering and validation of an oncolytic herpes simplex virus type 1 transcriptionally targeted to midkine-positive tumors. The journal of gene medicine. 2010; 12:613-23.
  55. Margolis DJ, Hoffstad O, Thom S, Bilker W, Maldonado AR, Cohen RM, Aronow BJ, Crombleholme T. The differential effect of angiotensin-converting enzyme inhibitors and angiotensin receptor blockers with respect to foot ulcer and limb amputation in those with diabetes. Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society. 2010; 18:445-51.
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  60. Meyer SE, Hasenstein JR, Baktula A, Velu CS, Xu Y, Wan H, Whitsett JA, Gilks CB, Grimes HL. Kruppel-like factor 5 is not required for K-RasG12D lung tumorigenesis, but represses ABCG2 expression and is associated with better disease-specific survival. The American journal of pathology. 2010; 177:1503-13.
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  62. Pei Z, Wang B, Chen G, Nagao M, Nakafuku M, Campbell K. Homeobox genes Gsx1 and Gsx2 differentially regulate telencephalic progenitor maturation. Proceedings of the National Academy of Sciences of the United States of America. 2011; 108:1675-80.
  63. Perkins C, Yanase N, Smulian G, Gildea L, Orekov T, Potter C, Brombacher F, Aronow B, Wills-Karp M, Finkelman FD. Selective stimulation of IL-4 receptor on smooth muscle induces airway hyperresponsiveness in mice. The Journal of experimental medicine. 2011; 208:853-67.
  64. Perl AK, Riethmacher D, Whitsett JA. Conditional depletion of airway progenitor cells induces peribronchiolar fibrosis. American journal of respiratory and critical care medicine. 2011; 183:511-21.
  65. Phelan JD, Shroyer NF, Cook T, Gebelein B, Grimes HL. Gfi1-cells and circuits: unraveling transcriptional networks of development and disease. Current opinion in hematology. 2010; 17:300-7.
  66. Piyaphanee N, Ma Q, Kremen O, Czech K, Greis K, Mitsnefes M, Devarajan P, Bennett MR. Discovery and initial validation of alpha 1-B glycoprotein fragmentation as a differential urinary biomarker in pediatric steroid-resistant nephrotic syndrome. Proteomics. Clinical applications. 2011; 5:334-42.
  67. Popkie AP, Zeidner LC, Albrecht AM, D'Ippolito A, Eckardt S, Newsom DE, Groden J, Doble BW, Aronow B, McLaughlin KJ, White P, Phiel CJ. Phosphatidylinositol 3-kinase (PI3K) signaling via glycogen synthase kinase-3 (Gsk-3) regulates DNA methylation of imprinted loci. The Journal of biological chemistry. 2010; 285:41337-47.
  68. Potter SS, Brunskill EW, Patterson LT. Defining the genetic blueprint of kidney development. Pediatric nephrology. 2011; .
  69. Potter SS, Brunskill EW, Patterson LT. Microdissection of the gene expression codes driving nephrogenesis. Organogenesis. 2010; 6:263-9.
  70. Prasov L, Brown NL, Glaser T. A critical analysis of Atoh7 (Math5) mRNA splicing in the developing mouse retina. PloS one. 2010; 5:e12315.
  71. Proulx K, Lu A, Sumanas S. Cranial vasculature in zebrafish forms by angioblast cluster-derived angiogenesis. Developmental biology. 2010; 348:34-46.
  72. Rajkumar P, Rollmann SM, Cook TA, Layne JE. Molecular evidence for color discrimination in the Atlantic sand fiddler crab, Uca pugilator. The Journal of experimental biology. 2010; 213:4240-8.
  73. Rankin SA, Kormish J, Kofron M, Jegga A, Zorn AM. A gene regulatory network controlling hhex transcription in the anterior endoderm of the organizer. Developmental biology. 2011; 351:297-310.
  74. Rankin SA, Zorn AM, Buchholz DR. New doxycycline-inducible transgenic lines in Xenopus. Developmental dynamics : an official publication of the American Association of Anatomists. 2011; 240:1467-74.
  75. Ren X, Zhang Y, Snyder J, Cross ER, Shah TA, Kalin TV, Kalinichenko VV. Forkhead box M1 transcription factor is required for macrophage recruitment during liver repair. Molecular and cellular biology. 2010; 30:5381-93.
  76. Riazuddin S, Ahmed ZM, Hegde RS, Khan SN, Nasir I, Shaukat U, Butman JA, Griffith AJ, Friedman TB, Choi BY. Variable expressivity of FGF3 mutations associated with deafness and LAMM syndrome. BMC medical genetics. 2011; 12:21.
  77. Runck LA, Kramer M, Ciraolo G, Lewis AG, Guasch G. Identification of epithelial label-retaining cells at the transition between the anal canal and the rectum in mice. Cell cycle. 2010; 9:3039-45.
  78. Sakagami T, Beck D, Uchida K, Suzuki T, Carey BC, Nakata K, Keller G, Wood RE, Wert SE, Ikegami M, Whitsett JA, Luisetti M, Davies S, Krischer JP, Brody A, Ryckman F, Trapnell BC. Patient-derived granulocyte/macrophage colony-stimulating factor autoantibodies reproduce pulmonary alveolar proteinosis in nonhuman primates. American journal of respiratory and critical care medicine. 2010; 182:49-61.
  79. Sardana D, Vasa S, Vepachedu N, Chen J, Gudivada RC, Aronow BJ, Jegga AG. PhenoHM: human-mouse comparative phenome-genome server. Nucleic acids research. 2010; 38:W165-74.
  80. Shearn JT, Kinneberg KR, Dyment NA, Galloway MT, Kenter K, Wylie C, Butler DL. Tendon tissue engineering: Progress, challenges, and translation to the clinic. Journal of musculoskeletal & neuronal interactions. 2011; 11:163-73.
  81. Shereen A, Nemkul N, Yang D, Adhami F, Dunn RS, Hazen ML, Nakafuku M, Ning G, Lindquist DM, Kuan CY. Ex vivo diffusion tensor imaging and neuropathological correlation in a murine model of hypoxia-ischemia-induced thrombotic stroke. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. 2011; 31:1155-69.
  82. Sivaprasad U, Askew DJ, Ericksen MB, Gibson AM, Stier MT, Brandt EB, Bass SA, Daines MO, Chakir J, Stringer KF, Wert SE, Whitsett JA, Le Cras TD, Wills-Karp M, Silverman GA, Khurana Hershey GK. A nonredundant role for mouse Serpinb3a in the induction of mucus production in asthma. The Journal of allergy and clinical immunology. 2011; 127:254-61, 261 e1-6.
  83. Spence JR, Mayhew CN, Rankin SA, Kuhar MF, Vallance JE, Tolle K, Hoskins EE, Kalinichenko VV, Wells SI, Zorn AM, Shroyer NF, Wells JM. Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro. Nature. 2011; 470:105-9.
  84. Srikiatkhachorn A, Chintapalli J, Liu J, Jamaluddin M, Harrod KS, Whitsett JA, Enelow RI, Ramana CV. Interference with intraepithelial TNF-alpha signaling inhibits CD8(+) T-cell-mediated lung injury in influenza infection. Viral immunology. 2010; 23:639-45.
  85. Stefater JA, 3rd, Lewkowich I, Rao S, Mariggi G, Carpenter AC, Burr AR, Fan J, Ajima R, Molkentin JD, Williams BO, Wills-Karp M, Pollard JW, Yamaguchi T, Ferrara N, Gerhardt H, Lang RA. Regulation of angiogenesis by a non-canonical Wnt-Flt1 pathway in myeloid cells. Nature. 2011; 474:511-5.
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Grants, Contracts, and Industry Agreements

Grant and Contract AwardsAnnual Direct / Project Period Direct

Brown, N

Cell-Cell Signaling During Mammalian Early Eye Formation
R01 EY 01809704/01/08-03/31/12$247,500
Investigation of Mammalian Retinal Neuron Development
R01 EY 01361208/01/09-07/31/13$222,750

Campbell, K

Roles of Gsh1 & Gsh2 in Telencephalic Neurogenesis
R01 NS 04408007/01/08-06/30/13$216,563
Molecular Mechanisms Controlling Formation of Basal Ganglia Circuitry
R01 MH 09074004/01/10-01/31/15$247,500

Chang, C

Understanding MicroRNA Mechanisms for Age-Related Decline in Neuronal Regeneration
10/01/09-09/30/12$69,653
Understanding MicroRNA Mechanisms for Developmental Decline in Axon Growth Ability
06/01/10-05/31/13$58,993

Chuang, C

Molecular Mechanisms of Gap Junction-Mediated Olfactory Signaling
07/01/08-06/15/12$71,363
Developmental Control of Olfactory Signaling in C. Elegance
09/16/10-09/15/12$25,000

Cleghon, V

Fundamental Mechanisms of Protein Kinase Activation Loop Autophosphorylation
R01 GM 087347404/15/10-02/28/14$193,050

Gebelein, B

Hox Regulation of Sensory Organ Development in Drosophila
R01 GM 07942804/01/08-02/28/13$186,219

Guasch Grangeon, G

Defining Transitional Zones Associated with Squamous Cell Carcinoma Development
07/01/10-06/30/12$50,000
Defining the Role of Sox2 in Vaginal Atresia Disorder
02/01/11-01/31/13$68,182

Hegde, R

Eyes Absent Phosphatase Inhibitors In Eye Disease
R21 EY 01912508/01/09-07/31/11$123,750
Molecular Mechanisms of Retinal Determination Proteins
R01 EY 01464804/01/10-03/31/13$240,000

Kuan, C

Rac GTPases in the Mammalian Brain Development
R01 NS 05643507/01/08-06/30/12$198,000

Lin, X

Regulation of Wingless (Wg) Signaling and Morphogen Gradient Formation
R01 GM 06389107/01/07-06/30/11$188,100
Roles of Retromer Complex in Development
R01 GM 08751703/01/10-02/28/14$188,100

Nakafuku, M / Campbell, K

Molecular Control of Neurogenesis in the Adult Subventricular Zone
R01 NS 06989304/01/10-03/31/15$290,274
Endogenous CNTF Receptors and Adult, In Vivo Neurogenesis
R01 NS06605107/01/09-06/30/13$11,370

Nakafuku, M

Endogenous CNTF Receptors and Adult, In Vivo Neurogenesis
R01 NS06605107/01/09-06/30/13$11,825

Potter, S

Glomerulosclerosis in Human FSGS and Animal Models
R01 DK 08148909/14/09-09/13/11$231,506
Nextgen Dissection of the Genomic Basis of Kidney Development
RC4 DK 09089109/30/10-09/29/13$1,186,072
Global Gene Expression Atlas of Craniofacial Development
U01 DE 02004909/21/09-04/30/14$184,987

Spence, J

Developmental Paradigms to Direct Human Endoderm into Foregut
F32 DK 08320209/01/09-08/31/11$52,154
Mechanisms of Intestine Development
K01 DK09141506/28/11-03/31/16$128,000
Digestive Health Center: Bench to Bedside in Pediatric Digestive Disease (Pilot & Feasibility Study)
P30 DK 07839208/01/07-05/31/12$50,000

Sumanas, S

Molecular Mechanisms of Arterial-Venous Differentiation in Zebrafish
R01 HL 10736904/01/11-03/31/16$250,000
Role of Hedgehog Signaling in Endocardium Formation
07/01/09-06/30/11$60,000

Tucker, J

Molecular Mechanisms of Gap Junctional Intercellular Communication
01/01/11-12/31/12$50,000

Wylie , C

The Roles of Steel Factor in Germ Cell Behavior in the Mouse
R01 HD 06057807/27/09-06/30/11$248,698
Cadherin-based Actin Assembly in the Xenopus Embryo
R01 HD 04476403/12/09-01/31/14$197,208
Ectoderm Formation in the Early Xenopus Embryo
R01 HD 04573704/01/10-03/31/15$199,200
A Developmentally-Based Tissue Engineering Approach to Improve Tendon Repair
R01 AR 05694307/10/09-06/30/14$181,255

Wylie, J

Wnts Interacting With Wnts: Mechanism and Biological Significance
R01 GM 08495103/15/10-02/28/13$193,050

Yang , D

Effects of PAI1 on the tPA-JNK-Bim Pathway in Neonatal Cerebral Hypoxia-Ischemia
07/01/10-06/30/12$43,000

Yoshida, Y

Regulation of Sensory-Motor Connectivity by Semaphorin-Plexin Signaling
R01 NS 06504804/01/09-03/31/14$216,563

Zorn, A / Wells, J

Mammalian Foregut and Liver Development
R01 DK 08082301/01/09-12/31/12$240,572
Mammalian Foregut and Liver Development
R01 DK 08082308/20/09-07/31/11$33,333

Zorn, A

Molecular Basis of Liver Development
R01 DK 07085804/01/07-03/31/12$179,002
Xenbase: a Xenopus Model Organism Database
P41 HD06455606/01/10-05/31/15$735,816
Current Year Direct$7,568,608
Industry Contracts

Guasch Grangeon

$62,761
Current Year Direct Receipts$62,761
Total$7,631,369
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Molecular and Developmental Biology Graduate Program

The Graduate Program in Molecular and Developmental Biology is an interdepartmental program within the University of Cincinnati that offers the Ph.D. degree. It has been based in the Department of Pediatrics for over 35 years. Drs. Kenneth Campbell and Timothy Weaver served as Directors of the Program with co-directors Drs. Jeffrey Whitsett - finance, Richard Lang- curriculum, Tim LeCras - admissions, Edith Markoff – recruitment, Jeff Robbins – faculty membership, and John Shannon– graduate studies.

There are 85 faculty members in the program.  During the past year, there were 65 pre-doctoral students in the program, 8 of whom are pursuing M.D./Ph.D. degrees.  Students and faculty continue to be productive as measured by their numbers of publications, presentations at meetings, honors and awards received.  Grant support to faculty remains high.

During the past year, the University of Cincinnati continued to support the program by providing University Graduate Assistantships and funds appropriated from the Dean's office to support 6 first year students.  The remaining students are supported through a variety of sources including Ryan Fellowships (3), American Heart Fellowships (2), NIH training grants (14), external grants to their advisors (28), CHRF Special Purpose Funds to their advisors (19) and funds from the Children's Hospital Research Foundation to the Graduate Program (7).

The MDB Program provides an excellent research educational experience for students and has an excellent record in the placement of its graduates in scientific careers. 

Molecular and Developmental Biology Graduate Program Students, 2009-2010

Student Faculty Mentor Admission
Thomas Acciani Timothy LeCras 2009
Shailaja Akunuru Yi Zheng 2006
Amel Alqadah Rotating 2010
Robyn Amos-Kroohs Michael Williams 2009
Aria Attia Rotating 2010
William Baird** Timothy Cripe 2006
David Balli Vladimir Kalinichenko 2008
Kristin Bell Rotating 2010
Gregory Bick Paul Andreassen 2010
Abigail Bower Steve Potter 2008
Caitlin (Maynard) Braitsch Katherine Yutzey 2006
Adam Burr** Jeff Molkentin 2009
Ashley Cast Stephanie Ware 2007
Jeeyeon Cha** Sudhansu K. Dey 2009
Heather Chapman Kenneth Campbell 2007
Mark Charlton-Perkins Rotating 2010
Mikah Coffindaffer-Wilson Jaye Hove 2007
Michelle Combs Katherine Yutzey 2004
Jason Cowan Stephanie Ware 2009
Sharina Desai Saulius Sumanas 2008
Tracy Dohn Joshua Waxman 2009
Jieqing Fan Richard Lang 2007
Ming Fang Rotating 2010
Chen Gao Rotating 2010
Margaret Gardner Rotating 2010
Nicole Glenn Saulius Sumanas 2006
Ying Gu Christopher Wylie 2006
Zirong Gu Yutaka Yoshida 2008
David Hahn Timothy Weaver 2006
Jamie Havrilak John Shannon 2008
Michael Hester Steve Danzer 2009
Mary Horn Katherine Yutzey 2007
Diva Jonatan James Wells 2006
David Li-Kroeger Brian Gebelein 2008
Shan Lin James Mulloy 2009
Wei Liu Yi Zheng 2005
Mariana Louza Rotating 2010
Thomas Lu** Marc Rothenberg 2007
Arturo Maldonado Timothy Crombleholme 2004
Karunyakanth Mandapaka Timothy Weaver 2005
Kate Maurer Nadean Brown 2009
Heather McCauley Geraldine Guasch 2009
Kyle McCracken** James Wells 2010
Elizabeth McDonald Tiffany Cook 2004
Timothy Mead Katherine Yutzey 2006
Anna (Hake) Method James Wells 2007
Monique Morrison Susanne Wells 2005
Elizabeth Mushaben Timothy LeCras 2007
Diana Nardini Katherine Yutzey 2009
Zhenglei Pei Kenneth Campbell 2004
Megan Rost Saulius Sumanas 2008
Shatrunjai Singh Rotating 2010
Tony Stefater** Richard Lang 2008
Mardi Sutherland Stephanie Ware 2008
Xiaofang Tang Xinhua Lin 2006
David Terrell** Jeffrey Robbins/Tiffany Cook 2008
Chelsea Tolentino Rotating 2010
Juli Uhl Brian Gebelein 2008
Sha Wang Christopher Wylie 2009
Jiadi Xu Rotating 2010
Jia You Xinhua Lin 2007
Inuk Zandvakili** Yi Zheng 2009
Zheng Zhang Aaron Zorn 2008
Bo Zhou Xinhua Lin 2006
Xuan Zhou Yi Zheng 2007
Hongyan Zhu Marc Rothenberg 2004
**MD/PhD Students


Students completing their Masters work

  • Elizabeth McDonald – “A study of Drosophila Orthodenticle:  Mapping the functional domains and proposing a post-developmental role in the Drosophila eye,” April 29, 2010.
  • Diana Nardini – “The impact of conditional MMP-13 overexpression on mouse cardiac valve development and disease,” September 7, 2010.
  • Ashley Cast – “An essential and highly conserved role for Zic3 in left-right patterning, gastrulation  and convergent extension morphogenesis,” October 19, 2010.
  • William Baird – “Development of a Novel Model for Exploring the Role of Regulatory T-cells in Oncolytic HSV Cancer Therapy,” May 2, 2011. 

Students completing their PhD work

  • Hongyan Zhu – “Deep breath and relax:  a study of NPS/NPSR1,” August 20, 2010.
  • Michelle Combs – “NFATc1 in cardiac valve development and EPDC invasion,” November 30, 2010.
  • Zhenglei Pei – “The role of Gsx homeobox genes in the specification and differentiation of mouse lateral ganglionic eminence progenitors,” December 17, 2010.
  • Arturo Maldonado – “Molecular Targeting and Enhancing Anticancer Efficacy of Oncolytic HSV-1 to Midkine Expressing Tumors,” December 20, 2010.
  • Timothy Mead – “Notch pathway regulation of skeletal development and neural crest cell lineages in vivo,” February 3, 2011.

Student Publications

During the past year, students from the Program authored or co-authored 22 articles.

Akunuru S, Palumbo J, Zhai QJ, Zheng Y. Rac1 targeting suppresses human non-small cell lung adenocarcinoma cancer stem cell activity. PLoS One.6(2):e16951. PMCID: 3036726.  2011.

Balli D, Zhang Y, Snyder J, Kalinichenko VV, Kalin TV. Endothelial cell-specific deletion of transcription factor FoxM1 increases urethane-induced lung carcinogenesis. Cancer Res.71(1):40-50. PMCID: 3075588.  2011.

Charlton-Perkins M, Cook TA. Building a fly eye: terminal differentiation events of the retina, corneal lens, and pigmented epithelia. Curr Top Dev Biol.93:129-73. 2010.

Charlton-Perkins M, Whitaker SL, Fei Y, Xie B, Li-Kroeger D, Gebelein B, Cook T. Prospero and Pax2 combinatorially control neural cell fate decisions by modulating Ras- and Notch-dependent signaling. Neural Dev.6:20. PMCID: 3123624.  2011.

Coffindaffer-Wilson M, Craig MP, Hove JR. Determination of lymphatic vascular identity and developmental timecourse in zebrafish (Danio rerio). Lymphology.44(1):1-1.  2011.

Combs MD, Braitsch CM, Lange AW, James JF, Yutzey KE. NFATC1 promotes epicardium-derived cell invasion into myocardium. Development.138(9):1747-57. PMCID: 3074451.  2011.

Kavanaugh GM, Wise-Draper TM, Morreale RJ, Morrison MA, Gole B, Schwemberger S, Tichy ED, Lu L, Babcock GF, Wells JM, Drissi R, Bissler JJ, Stambrook PJ, Andreassen PR, Wiesmuller L, Wells SI. The human DEK oncogene regulates DNA damage response signaling and repair. Nucleic Acids Res.  2011.

Le Cras TD, Acciani TH, Mushaben EM, Kramer EL, Pastura PA, Hardie WD, Korfhagen TR, Sivaprasad U, Ericksen M, Gibson AM, Holtzman MJ, Whitsett JA, Hershey GK. Epithelial EGF receptor signaling mediates airway hyperreactivity and remodeling in a mouse model of chronic asthma. Am J Physiol Lung Cell Mol Physiol.300(3):L414-21. PMCID: 3064289.  2010.

Lim EJ, Lu TX, Blanchard C, Rothenberg ME. Epigenetic regulation of the IL-13-induced human eotaxin-3 gene by CREB-binding protein-mediated histone 3 acetylation. J Biol Chem.286(15):13193-204. PMCID: 3075666.  2011.

Liu W, Feng Y, Shang X, Zheng Y. Rho GTPases in hematopoietic stem/progenitor cell migration. Methods Mol Biol.750:307-19.  2011.

McAuliffe JJ, Bronson SL, Hester MS, Murphy BL, Dahlquist-Topala R, Richards DA, Danzer SC. Altered patterning of dentate granule cell mossy fiber inputs onto CA3 pyramidal cells in limbic epilepsy. Hippocampus.21(1):93-107. PMCID: 2888689.  2011.

McDonald EC, Xie B, Workman M, Charlton-Perkins M, Terrell DA, Reischl J, Wimmer EA, Gebelein BA, Cook TA. Separable transcriptional regulatory domains within Otd control photoreceptor terminal differentiation events. Dev Biol.347(1):122-32. PMCID: 2969183.  2010.

Melendez J, Stengel K, Zhou X, Chauhan BK, Debidda M, Andreassen P, Lang RA, Zheng Y. RhoA GTPase is dispensable for actomyosin regulation but is essential for mitosis in primary mouse embryonic fibroblasts. J Biol Chem.286(17):15132-7. PMCID: 3083211.  2011.

Pei Z, Wang B, Chen G, Nagao M, Nakafuku M, Campbell K. Homeobox genes Gsx1 and Gsx2 differentially regulate telencephalic progenitor maturation. Proc Natl Acad Sci U S A.108(4):1675-80. PMCID: 3029701.  2011.

Ryan MA, Nattamai KJ, Xing E, Schleimer D, Daria D, Sengupta A, Kohler A, Liu W, Gunzer M, Jansen M, Ratner N, Le Cras TD, Waterstrat A, Van Zant G, Cancelas JA, Zheng Y, Geiger H. Pharmacological inhibition of EGFR signaling enhances G-CSF-induced hematopoietic stem cell mobilization. Nat Med.16(10):1141-6.  2010.

Shang X, Cancelas JA, Li L, Guo F, Liu W, Johnson JF, Ficker A, Daria D, Geiger H, Ratner N, Zheng Y. R-Ras and Rac GTPase Cross-talk Regulates Hematopoietic Progenitor Cell Migration, Homing, and Mobilization. J Biol Chem.286(27):24068-78. PMCID: 3129188.  2011.

Skelton MR, Graham DL, Schaefer TL, Grace CE, Braun AA, Burns LN, Amos-Kroohs RM, Williams MT, Vorhees CV. Distinct periods of developmental sensitivity to the effects of 3,4-(+/-)-methylenedioxymethamphetamine (MDMA) on behavior and monoamines in rats. Int J Neuropsychopharmacol.1-14.  2011.

Stefater JA, 3rd, Lewkowich I, Rao S, Mariggi G, Carpenter AC, Burr AR, Fan J, Ajima R, Molkentin JD, Williams BO, Wills-Karp M, Pollard JW, Yamaguchi T, Ferrara N, Gerhardt H, Lang RA. Regulation of angiogenesis by a non-canonical Wnt-Flt1 pathway in myeloid cells. Nature.474(7352):511-5.  2011.

Tadjuidje E, Cha SW, Louza M, Wylie C, Heasman J. The functions of maternal Dishevelled 2 and 3 in the Early Xenopus embryo. Dev Dyn.240(7):1727-36.  2011.

Vorhees CV, He E, Skelton MR, Graham DL, Schaefer TL, Grace CE, Braun AA, Amos-Kroohs R, Williams MT. Comparison of (+)-methamphetamine, +/--methylenedioxymethamphetamine, (+)-amphetamine and +/--fenfluramine in rats on egocentric learning in the Cincinnati water maze. Synapse.65(5):368-78. PMCID: 2994999.  2011.

Wang IC, Zhang Y, Snyder J, Sutherland MJ, Burhans MS, Shannon JM, Park HJ, Whitsett JA, Kalinichenko VV. Increased expression of FoxM1 transcription factor in respiratory epithelium inhibits lung sacculation and causes Clara cell hyperplasia. Dev Biol.347(2):301-14. PMCID: 2957513.  2010.

Zhu H, Perkins C, Mingler MK, Finkelman FD, Rothenberg ME. The role of neuropeptide S and neuropeptide S receptor 1 in regulation of respiratory function in mice. Peptides.32(4):818-25. PMCID: 3073698.  2011.

Student Honors

  • Acciani, T. – Supported by Choose Ohio First Scholarship
  • Akunuru, S. – Supported by NIH Training Grant (Hematologic and Oncologic Diseases)
  • Alqadah, A. – Supported by Choose Ohio First Scholarship
  • Amos-Kroohs, R. –Supported by NIH Training Grant (Teratology)
  • Baird, W. – Supported by NIH Training Grant (UC Cancer Therapeutics)
  • Bick, G. – Supported by Choose Ohio First Scholarship
  • Bower, A. – Supported by NIH Training Grant (Teratology)
  • Braitsch, C. – Supported by AHA Fellowship
  • Burr, A. – Supported by NIH Training Grant (Organogenesis)
  • Cha, J. – Supported by NIH Training Grant (Perinatal Endocrinology)
  • Chapman, H. – Supported by NIH Training Grant (Teratology)
  • Dohn, T. – Supported by Choose Ohio First Scholarship
  • Gu, Y. – Supported by Ryan Fellowship
  • Li-Kroeger, D. – Supported by Ryan Fellowship; Supported by NIH Training Grant (Organogenesis)
  • Lu, T. – Supported by Ryan Fellowship; NHLBI Ruth L. Kirchenstein National Research Service Award for Individual Pre-doctoral MD/PhD Fellows
  • McCracken, K. – Supported by NIH Training Grant (Organogenesis)
  • Mead, T. – Supported by AHA Fellowship
  • Method, A. – Supported by NIH Training Grant (Perinatal & Developmental Biology)
  • Mushaben, E. – Supported by NIH Training Grant (Pulmonary & Cardiovascular Biology)
  • Nardini, D. – Supported by Choose Ohio First Scholarship
  • Stefater, T. – Supported by NIH Training Grant (UC MSTP)
  • Sutherland, M. – Supported by NIH Training Grant (Pulmonary & Cardiovascular Biology)

Rchard A. Akeson Fellowship Fund

The Richard A. Akeson Fellowship and Memorial Lectureship Fund continues to support the Annual Richard Akeson Memorial Lectureship and travel by students in our graduate program to relevant courses and meetings in which they are presenting results of their research. Dr. Takashi Mikawa presented the Sixteenth Annual Richard Akeson Memorial Lectureship in conjunction with the annual Molecular and Developmental Biology Graduate Student Symposium in 2010.

The following students received funding from the Richard A. Akeson Fellowship and Memorial Fund for travel in 2010 - 2011:

Student Meeting Presentation    Date
Zheng Zhang 13th International Xenopus Conference
Lake Louise, Alberta, Canada
Poster 9/12/10-9/17/10
Robyn Amos-Kroohs Society for Neuroscience
San Diego, California
Poster 11/13/10-11/17/10
Heather Chapman Society for Neuroscience
San Diego, California
Poster 11/12/10-11/18/10
Michael Hester Society for Neuroscience
San Diego, California
Poster 11/13/10-11/17/10
Wei Liu 52nd ASH Annual Meeting
Orlando, Florida
Poster 12/4/10-12/7/10
Xuan Zhou 52nd ASH Annual Meeting
Orlando, Florida
Poster 12/4/10-12/7/10
Kyle McCracken Keystone Symposium:  Stem Cells
Santa Fe, New Mexico
Poster 1/30/11-2/4/11
Jamie Havrilak Keystone Symposium:  Lung Development and Repair
Santa Fe, New Mexico
Poster 2/6/11-2/11/11
Thomas Acciani Keystone Symposium:  Immunity in the Respiratory Tract
Vancouver, British Columbia, Canada
Poster 2/26/11-3/3/11
Elizabeth Mushaben Keystone Symposium:  Immunity in the Respiratory Tract
Vancouver, British Columbia, Canada
Poster 2/26/11-3/3/11
Bo Zhou 52nd Drosophila Conference
San Diego, California
Poster 3/30/11-4/4/11
David Li-Kroeger 52nd Drosophila Conference
San Diego, California
Poster 3/30/11-4/4/11
Xiaofang Tang 52nd Drosophila Conference
San Diego, California
Poster 3/30/11-4/4/11
David Terrell ARVO 2011 Annual Meeting
Ft. Lauderdale, Florida
Poster 4/29/11-5/4/11

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